{"id":"https://openalex.org/W2005337156","doi":"https://doi.org/10.1007/s10637-012-9843-5","title":"Phase I study of PM00104 (Zalypsis\u00ae) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors","display_name":"Phase I study of PM00104 (Zalypsis\u00ae) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors","publication_year":2012,"publication_date":"2012-06-10","ids":{"openalex":"https://openalex.org/W2005337156","doi":"https://doi.org/10.1007/s10637-012-9843-5","mag":"2005337156","pmid":"https://pubmed.ncbi.nlm.nih.gov/22688291"},"language":"en","primary_location":{"id":"doi:10.1007/s10637-012-9843-5","doi":"https://doi.org/10.1007/s10637-012-9843-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-012-9843-5","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090082356","display_name":"Christophe Massard","orcid":"https://orcid.org/0000-0001-5505-0564","observed_orcids":["https://orcid.org/0000-0001-5505-0564"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Christophe Massard","raw_affiliation_strings":["SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France. christophe.massard@igr.fr","SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France. christophe.massard@igr.fr","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109165251","display_name":"Jane Margetts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jane Margetts","raw_affiliation_strings":["Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062974425","display_name":"Nadia Amellal","orcid":"https://orcid.org/0000-0002-6171-6729","observed_orcids":["https://orcid.org/0000-0002-6171-6729"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nadia Amellal","raw_affiliation_strings":["SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France","SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060573126","display_name":"Yvette Drew","orcid":"https://orcid.org/0000-0001-6676-9224","observed_orcids":["https://orcid.org/0000-0001-6676-9224"]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yvette Drew","raw_affiliation_strings":["Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002783930","display_name":"Ratislav Bahleda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ratislav Bahleda","raw_affiliation_strings":["SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France","SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Stevens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Stevens","raw_affiliation_strings":["Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103498511","display_name":"Jean Pierre Armand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Pierre Armand","raw_affiliation_strings":["SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France","SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047677453","display_name":"Hilary Calvert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hilary Calvert","raw_affiliation_strings":["Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021624793","display_name":"Jean\u2010Charles Soria","orcid":"https://orcid.org/0000-0001-9597-0701","observed_orcids":["https://orcid.org/0000-0001-9597-0701"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Charles Soria","raw_affiliation_strings":["SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France","SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"SITEP (Service des Innovations Th\u00e9rapeutiques Pr\u00e9coces), Institute Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111838860","display_name":"Cinthya Coronado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cinthya Coronado","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","PharmaMar, Clinical R&D, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]},{"raw_affiliation_string":"PharmaMar, Clinical R&D, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048766168","display_name":"Carmen Maria Kahatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Kahatt","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","PharmaMar, Clinical R&D, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]},{"raw_affiliation_string":"PharmaMar, Clinical R&D, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048398150","display_name":"Vicente Alfaro","orcid":"https://orcid.org/0000-0002-0150-2390","observed_orcids":["https://orcid.org/0000-0002-0150-2390"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vicente Alfaro","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","PharmaMar, Clinical R&D, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]},{"raw_affiliation_string":"PharmaMar, Clinical R&D, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011500924","display_name":"Mariano Siguero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mariano Siguero","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","PharmaMar, Clinical R&D, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]},{"raw_affiliation_string":"PharmaMar, Clinical R&D, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090638552","display_name":"Carlos Fern\u00e1ndez\u2010Teruel","orcid":"https://orcid.org/0000-0002-1473-2267","observed_orcids":["https://orcid.org/0000-0002-1473-2267"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Fern\u00e1ndez-Teruel","raw_affiliation_strings":["PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","PharmaMar, Clinical R&D, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PharmaMar, Clinical R&D, Colmenar Viejo, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]},{"raw_affiliation_string":"PharmaMar, Clinical R&D, Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048419838","display_name":"Ruth Plummer","orcid":"https://orcid.org/0000-0003-0107-1444","observed_orcids":["https://orcid.org/0000-0003-0107-1444"]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth Plummer","raw_affiliation_strings":["Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle Upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Northern Centre for Cancer Care, Freeman Hospital, Newcastle-upon-Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090082356"],"corresponding_institution_ids":["https://openalex.org/I2801843802"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":1.6317,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.82537983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"3","first_page":"623","last_page":"630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.15770000219345093,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-solid-tumors","display_name":"advanced solid tumors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7960000038146973},{"id":"https://openalex.org/keywords/recommended-dose","display_name":"recommended dose","score":0.953000009059906},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8610000014305115},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.5680000185966492},{"id":"https://openalex.org/keywords/lipase-elevation","display_name":"lipase elevation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8109999895095825},{"id":"https://openalex.org/keywords/stable-disease","display_name":"stable disease","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6961385011672974},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3629242181777954}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10637-012-9843-5","doi":"https://doi.org/10.1007/s10637-012-9843-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10637-012-9843-5","pdf_url":null,"source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmid:22688291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22688291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1025756728","https://openalex.org/W1258757042","https://openalex.org/W1969396690","https://openalex.org/W1977447667","https://openalex.org/W1982516608","https://openalex.org/W1984206494","https://openalex.org/W2025595410","https://openalex.org/W2031140365","https://openalex.org/W2063260310","https://openalex.org/W2065872693","https://openalex.org/W2069511586","https://openalex.org/W2071079046","https://openalex.org/W2109389763","https://openalex.org/W2139248078","https://openalex.org/W2141086589","https://openalex.org/W2141873955","https://openalex.org/W2160419151","https://openalex.org/W2261445845","https://openalex.org/W2275361039","https://openalex.org/W2421776409","https://openalex.org/W2784043644","https://openalex.org/W2995667761"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2025-10-10T00:00:00"}
