{"id":"https://openalex.org/W2005335464","doi":"https://doi.org/10.1074/jbc.m111.306852","title":"Human Mitochondrial DNA Polymerase \u03b3 Exhibits Potential for Bypass and Mutagenesis at UV-induced Cyclobutane Thymine Dimers","display_name":"Human Mitochondrial DNA Polymerase \u03b3 Exhibits Potential for Bypass and Mutagenesis at UV-induced Cyclobutane Thymine Dimers","publication_year":2011,"publication_date":"2011-12-23","ids":{"openalex":"https://openalex.org/W2005335464","doi":"https://doi.org/10.1074/jbc.m111.306852","mag":"2005335464","pmid":"https://pubmed.ncbi.nlm.nih.gov/22194617","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3308766"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.306852","doi":"https://doi.org/10.1074/jbc.m111.306852","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.306852","pdf_url":"http://www.jbc.org/article/S002192582060881X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192582060881X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029174983","display_name":"Rajesh Kasiviswanathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Kasiviswanathan","raw_affiliation_strings":["Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA","Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"raw_affiliation_string":"Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044500273","display_name":"Margaret A. Gustafson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Gustafson","raw_affiliation_strings":["Nicholas School of the Environment, Duke University, Durham, North Carolina 27708"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nicholas School of the Environment, Duke University, Durham, North Carolina 27708","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075186269","display_name":"William C. Copeland","orcid":"https://orcid.org/0000-0002-0359-0953","observed_orcids":["https://orcid.org/0000-0002-0359-0953"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Copeland","raw_affiliation_strings":["Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015141183","display_name":"Joel N. Meyer","orcid":"https://orcid.org/0000-0003-1219-0983","observed_orcids":["https://orcid.org/0000-0003-1219-0983"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joel N. Meyer","raw_affiliation_strings":["Nicholas School of the Environment, Duke University, Durham, North Carolina 27708"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nicholas School of the Environment, Duke University, Durham, North Carolina 27708","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015141183"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.8189,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.84797294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"287","issue":"12","first_page":"9222","last_page":"9229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna-polymerase-gamma","display_name":"mitochondrial DNA polymerase gamma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cyclobutane-thymine-dimers","display_name":"cyclobutane thymine dimers","score":0.9789999723434448},{"id":"https://openalex.org/keywords/uv-induced-dna-damage","display_name":"UV-induced DNA damage","score":0.9120000004768372},{"id":"https://openalex.org/keywords/translesion-synthesis","display_name":"translesion synthesis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/exonuclease-activity","display_name":"exonuclease activity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/misincorporation","display_name":"misincorporation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.6039999723434448},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C167975912","wikidata":"https://www.wikidata.org/wiki/Q1018722","display_name":"Pyrimidine dimer","level":4,"score":0.8521142601966858},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.7388832569122314},{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.6549367904663086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5715522170066833},{"id":"https://openalex.org/C131140672","wikidata":"https://www.wikidata.org/wiki/Q2031164","display_name":"Processivity","level":4,"score":0.5555117726325989},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.5411476492881775},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5394229888916016},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5325545072555542},{"id":"https://openalex.org/C150777479","wikidata":"https://www.wikidata.org/wiki/Q176783","display_name":"AP site","level":4,"score":0.5019400119781494},{"id":"https://openalex.org/C2777501222","wikidata":"https://www.wikidata.org/wiki/Q411664","display_name":"Exonuclease","level":4,"score":0.4827936887741089},{"id":"https://openalex.org/C88354546","wikidata":"https://www.wikidata.org/wiki/Q3502973","display_name":"DNA polymerase II","level":5,"score":0.4816835820674896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46568337082862854},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4499798119068146},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.44639503955841064},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.432079553604126},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4185492992401123},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39213085174560547},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.2593408226966858},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.15935468673706055},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.08443909883499146},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0820070207118988}],"mesh":[{"descriptor_ui":"D000074002","descriptor_name":"DNA Polymerase gamma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003503","descriptor_name":"Cyclobutanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003503","descriptor_name":"Cyclobutanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m111.306852","doi":"https://doi.org/10.1074/jbc.m111.306852","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.306852","pdf_url":"http://www.jbc.org/article/S002192582060881X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2596431","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3308766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3308766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3308766","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:22194617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22194617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"mag:2611568643","doi":null,"is_oa":false,"landing_page_url":"https://www.jbc.org/content/287/12/9222.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.306852","doi":"https://doi.org/10.1074/jbc.m111.306852","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.306852","pdf_url":"http://www.jbc.org/article/S002192582060881X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5299955960","display_name":"The Role of Mitochondrial DNA Damage in Neurodegeneration","funder_award_id":"R01ES017540","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G619007558","display_name":"Molecular Characterization Of The Mitochondrial Dna Polymerase","funder_award_id":"Z01ES065078","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6825775859","display_name":"Molecular and Physiological Responses to Persistent Mitochondrial DNA Damage","funder_award_id":"R21NS065468","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005335464.pdf","grobid_xml":"https://content.openalex.org/works/W2005335464.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1491876634","https://openalex.org/W1526826406","https://openalex.org/W1561118137","https://openalex.org/W1581236180","https://openalex.org/W1642306226","https://openalex.org/W1680634601","https://openalex.org/W1965126369","https://openalex.org/W1966572647","https://openalex.org/W1967231939","https://openalex.org/W1967935080","https://openalex.org/W1971824586","https://openalex.org/W1972320876","https://openalex.org/W1974539462","https://openalex.org/W1983496282","https://openalex.org/W1987207427","https://openalex.org/W1992294575","https://openalex.org/W1992727297","https://openalex.org/W1997892688","https://openalex.org/W1997972400","https://openalex.org/W2001256046","https://openalex.org/W2010001472","https://openalex.org/W2014204923","https://openalex.org/W2021037627","https://openalex.org/W2023092740","https://openalex.org/W2028374636","https://openalex.org/W2029064649","https://openalex.org/W2029707526","https://openalex.org/W2030018073","https://openalex.org/W2035727529","https://openalex.org/W2035825200","https://openalex.org/W2041024018","https://openalex.org/W2051702116","https://openalex.org/W2052703170","https://openalex.org/W2053619432","https://openalex.org/W2062487397","https://openalex.org/W2068456988","https://openalex.org/W2072328142","https://openalex.org/W2077132202","https://openalex.org/W2078991170","https://openalex.org/W2084449087","https://openalex.org/W2086154401","https://openalex.org/W2086693919","https://openalex.org/W2089539412","https://openalex.org/W2090369699","https://openalex.org/W2090567656","https://openalex.org/W2091151750","https://openalex.org/W2094325460","https://openalex.org/W2095752149","https://openalex.org/W2109099295","https://openalex.org/W2117612604","https://openalex.org/W2127684100","https://openalex.org/W2128223919","https://openalex.org/W2135426914","https://openalex.org/W2136418717","https://openalex.org/W2138190884","https://openalex.org/W2165245853","https://openalex.org/W2167452957","https://openalex.org/W2922395101","https://openalex.org/W3027412010","https://openalex.org/W4239403073","https://openalex.org/W4317676266"],"related_works":["https://openalex.org/W2611568643","https://openalex.org/W4220660677","https://openalex.org/W1991924773","https://openalex.org/W2020118122","https://openalex.org/W2128968369","https://openalex.org/W2188342745","https://openalex.org/W2066648180","https://openalex.org/W2021037627","https://openalex.org/W4405843838","https://openalex.org/W2526091616"],"abstract_inverted_index":{"Cyclobutane":[0],"thymine":[1,97],"dimers":[2,98],"(T-T)":[3],"comprise":[4],"the":[5,36,51,74,79,84,125,128,140,146,155,158,161,164,173,181,199,202,220,228],"majority":[6],"of":[7,76,83,127,154,157,166,177,201,222,231],"DNA":[8,21,54,69,212],"damage":[9],"caused":[10],"by":[11,26,32,86],"short":[12],"wavelength":[13],"ultraviolet":[14],"radiation.":[15],"These":[16],"lesions":[17,61],"generally":[18],"block":[19],"replicative":[20],"polymerases":[22,34],"and":[23,43,81,225],"are":[24],"repaired":[25],"nucleotide":[27,40],"excision":[28,41],"repair":[29],"or":[30,194],"bypassed":[31,96],"translesion":[33],"in":[35,67,160,227],"nucleus.":[37],"Mitochondria":[38],"lack":[39],"repair,":[42],"therefore,":[44],"it":[45,135],"is":[46],"important":[47],"to":[48,72],"understand":[49],"how":[50],"sole":[52],"mitochondrial":[53,211,229],"polymerase,":[55],"pol":[56,87,94,112,118,141,170],"\u03b3,":[57],"interacts":[58],"with":[59,89,99,183,188],"irreparable":[60],"such":[62],"as":[63],"T-T.":[64,203],"We":[65],"performed":[66],"vitro":[68],"polymerization":[70],"assays":[71],"measure":[73],"kinetics":[75],"incorporation":[77,176],"opposite":[78,124,180,198],"lesion":[80,85,182],"bypass":[82,103,115],"\u03b3":[88,95,119,142,171],"a":[90,121,195,217],"dimer-containing":[91],"template.":[92,162],"Exonuclease-deficient":[93],"low":[100],"relative":[101],"efficiency;":[102],"was":[104],"attenuated":[105],"but":[106,214],"still":[107],"detectable":[108],"when":[109],"using":[110],"exonuclease-proficient":[111,143],"\u03b3.":[113],"When":[114],"did":[116],"occur,":[117],"misincorporated":[120],"guanine":[122,149,196],"residue":[123],"3'-thymine":[126,200],"dimer":[129],"only":[130],"4-fold":[131],"less":[132],"efficiently":[133],"than":[134],"incorporated":[136,148,197],"an":[137,192],"adenine.":[138],"Surprisingly,":[139],"enzyme":[144],"excised":[145],"incorrectly":[147],"at":[150],"similar":[151],"rates":[152],"irrespective":[153],"nature":[156],"thymines":[159],"In":[163],"presence":[165],"all":[167],"four":[168],"dNTPs,":[169],"extended":[172],"primer":[174],"after":[175],"two":[178],"adenines":[179],"relatively":[184],"higher":[185],"efficiency":[186],"compared":[187],"extension":[189],"past":[190],"either":[191],"adenine":[193],"Our":[204],"results":[205],"suggest":[206,216],"that":[207],"T-T":[208],"usually":[209],"stalls":[210],"replication":[213],"also":[215],"mechanism":[218],"for":[219],"introduction":[221],"point":[223],"mutations":[224],"deletions":[226],"genomes":[230],"chronically":[232],"UV-exposed":[233],"cells.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
