{"id":"https://openalex.org/W2005333997","doi":"https://doi.org/10.1002/jcb.1982.240180306","title":"Function of the Carbohydrate Moieties of Glycoproteins","display_name":"Function of the Carbohydrate Moieties of Glycoproteins","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2005333997","doi":"https://doi.org/10.1002/jcb.1982.240180306","mag":"2005333997","pmid":"https://pubmed.ncbi.nlm.nih.gov/7068785"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.1982.240180306","doi":"https://doi.org/10.1002/jcb.1982.240180306","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.1982.240180306","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040833722","display_name":"Kenneth Olden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Olden","raw_affiliation_strings":["Howard University Cancer Center, Department of Oncology, Howard University Medical School, Washington, DC 20060","Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University Cancer Center, Department of Oncology, Howard University Medical School, Washington, DC 20060","institution_ids":["https://openalex.org/I137853757"]},{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081917130","display_name":"Bruno Alain Bernard","orcid":"https://orcid.org/0000-0002-4182-4802","observed_orcids":["https://orcid.org/0000-0002-4182-4802"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruno A. Bernard","raw_affiliation_strings":["Howard University Cancer Center, Department of Oncology, Howard University Medical School, Washington, DC 20060","Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University Cancer Center, Department of Oncology, Howard University Medical School, Washington, DC 20060","institution_ids":["https://openalex.org/I137853757"]},{"raw_affiliation_string":"Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107521855","display_name":"Sandra L. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra L. White","raw_affiliation_strings":["Department of Microbiology, Howard University Medical School, Washington, DC 20060","Howard University Cancer Center, Department of Oncology, Howard University Medical School, Washington, DC 20060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Howard University Medical School, Washington, DC 20060","institution_ids":["https://openalex.org/I137853757"]},{"raw_affiliation_string":"Howard University Cancer Center, Department of Oncology, Howard University Medical School, Washington, DC 20060","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061503003","display_name":"James B. Parent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Brian Parent","raw_affiliation_strings":["Howard University Cancer Center, Department of Oncology, Howard University Medical School, Washington, DC 20060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University Cancer Center, Department of Oncology, Howard University Medical School, Washington, DC 20060","institution_ids":["https://openalex.org/I137853757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":5.7812,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.97259129,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"3","first_page":"313","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycoprotein-glycosylation","display_name":"glycoprotein glycosylation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tunicamycin","display_name":"tunicamycin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.843999981880188},{"id":"https://openalex.org/keywords/acetylcholine-receptor","display_name":"acetylcholine receptor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7799999713897705},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.4359999895095825},{"id":"https://openalex.org/keywords/myoblast-fusion","display_name":"myoblast fusion","score":0.8999999761581421},{"id":"https://openalex.org/keywords/n-acetylglucosamine","display_name":"N-acetylglucosamine","score":0.7519999742507935},{"id":"https://openalex.org/keywords/chicken-embryo-fibroblasts","display_name":"chicken embryo fibroblasts","score":0.8849999904632568},{"id":"https://openalex.org/keywords/leupeptin","display_name":"leupeptin","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cell-surface-glycoproteins","display_name":"cell surface glycoproteins","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2777575526","wikidata":"https://www.wikidata.org/wiki/Q3542091","display_name":"Tunicamycin","level":4,"score":0.9798333644866943},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.8291735649108887},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.8272546529769897},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.6986767053604126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.585478663444519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4302913546562195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3739798665046692},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3576832115650177},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.053945302963256836},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002459","descriptor_name":"Cell Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011784","descriptor_name":"Quail","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011950","descriptor_name":"Receptors, Cholinergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014415","descriptor_name":"Tunicamycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jcb.1982.240180306","doi":"https://doi.org/10.1002/jcb.1982.240180306","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.1982.240180306","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:7068785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7068785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:dh.howard.edu:hucancer_fac-1308","doi":null,"is_oa":false,"landing_page_url":"https://dh.howard.edu/hucancer_fac/309","pdf_url":null,"source":{"id":"https://openalex.org/S4377196566","display_name":"Digital Howard (Howard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I137853757","host_organization_name":"Howard University","host_organization_lineage":["https://openalex.org/I137853757"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Howard University Cancer Center Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":109,"referenced_works":["https://openalex.org/W20915926","https://openalex.org/W22798818","https://openalex.org/W56261581","https://openalex.org/W80434486","https://openalex.org/W128768011","https://openalex.org/W166732129","https://openalex.org/W592806300","https://openalex.org/W604857360","https://openalex.org/W1021544618","https://openalex.org/W1435995923","https://openalex.org/W1491202632","https://openalex.org/W1494861823","https://openalex.org/W1495836317","https://openalex.org/W1496034005","https://openalex.org/W1513175127","https://openalex.org/W1515529788","https://openalex.org/W1517636854","https://openalex.org/W1523592797","https://openalex.org/W1534475664","https://openalex.org/W1558104881","https://openalex.org/W1567011995","https://openalex.org/W1569589672","https://openalex.org/W1576773728","https://openalex.org/W1579455946","https://openalex.org/W1597917005","https://openalex.org/W1604355742","https://openalex.org/W1605005256","https://openalex.org/W1607415505","https://openalex.org/W1640965504","https://openalex.org/W1648237278","https://openalex.org/W1775749144","https://openalex.org/W1829478524","https://openalex.org/W1965584996","https://openalex.org/W1967488474","https://openalex.org/W1971242913","https://openalex.org/W1972690266","https://openalex.org/W1975601791","https://openalex.org/W1977069602","https://openalex.org/W1977889413","https://openalex.org/W1979746181","https://openalex.org/W1985178880","https://openalex.org/W1986100495","https://openalex.org/W1987077239","https://openalex.org/W1987567260","https://openalex.org/W1988158452","https://openalex.org/W1990836064","https://openalex.org/W1993582348","https://openalex.org/W1996297374","https://openalex.org/W1997564781","https://openalex.org/W1997683256","https://openalex.org/W2000657631","https://openalex.org/W2002699686","https://openalex.org/W2004699574","https://openalex.org/W2007479961","https://openalex.org/W2008700086","https://openalex.org/W2009822449","https://openalex.org/W2014595483","https://openalex.org/W2016417523","https://openalex.org/W2016465422","https://openalex.org/W2016923418","https://openalex.org/W2017592191","https://openalex.org/W2019783927","https://openalex.org/W2020185487","https://openalex.org/W2020511578","https://openalex.org/W2021651210","https://openalex.org/W2021874355","https://openalex.org/W2022157763","https://openalex.org/W2027943432","https://openalex.org/W2029527866","https://openalex.org/W2036326457","https://openalex.org/W2036896268","https://openalex.org/W2038280040","https://openalex.org/W2038283726","https://openalex.org/W2046342570","https://openalex.org/W2046487578","https://openalex.org/W2046836026","https://openalex.org/W2051288172","https://openalex.org/W2058435714","https://openalex.org/W2059243096","https://openalex.org/W2062817483","https://openalex.org/W2067646403","https://openalex.org/W2067668127","https://openalex.org/W2070564324","https://openalex.org/W2073426767","https://openalex.org/W2074001992","https://openalex.org/W2075740646","https://openalex.org/W2076845293","https://openalex.org/W2081820227","https://openalex.org/W2082435269","https://openalex.org/W2085805591","https://openalex.org/W2086040101","https://openalex.org/W2086473258","https://openalex.org/W2090107903","https://openalex.org/W2092013502","https://openalex.org/W2092174368","https://openalex.org/W2094343302","https://openalex.org/W2104955253","https://openalex.org/W2113746427","https://openalex.org/W2125213900","https://openalex.org/W2167948410","https://openalex.org/W2173078011","https://openalex.org/W2323982055","https://openalex.org/W2395745311","https://openalex.org/W2411798943","https://openalex.org/W2418609941","https://openalex.org/W2484928073","https://openalex.org/W2503923837","https://openalex.org/W4231785375","https://openalex.org/W4249553124"],"related_works":["https://openalex.org/W2022157763","https://openalex.org/W2075740646","https://openalex.org/W1547107876","https://openalex.org/W2021874355","https://openalex.org/W2046101107","https://openalex.org/W2002654986","https://openalex.org/W2036326457","https://openalex.org/W2336285644","https://openalex.org/W3008464362","https://openalex.org/W1523592797"],"abstract_inverted_index":{"Abstract":[0],"To":[1,117,430],"determine":[2],"the":[3,6,21,30,36,63,68,86,93,98,113,119,127,130,151,156,204,214,237,243,255,261,269,278,283,288,293,298,302,323,328,358,382,390,405,408,412,424,432,436,450,455,476,483,524,545,555,568],"function":[4],"of":[5,9,17,23,32,43,49,67,89,112,122,129,135,155,163,170,181,211,216,226,239,257,268,275,285,287,295,310,325,339,348,360,379,411,438,440,452,458,462,478,527,557,571],"carbohydrate":[7,409,525,569],"moiety":[8,426,526,570],"glycoproteins,":[10],"we":[11,28,125,448],"have":[12,144],"used":[13],"tunicamycin,":[14,447],"an":[15],"analog":[16],"N\u2010acetylglucosamine,":[18],"to":[19,105,108,175,184,192,196,242,265,337,344,375,415,422,543],"inhibit":[20,236],"glycosylation":[22,212,369],"N\u2010glycosidically":[24,305],"linked":[25,306],"glycoproteins.":[26],"First,":[27],"examined":[29],"effect":[31,451],"this":[33,136,240],"drug":[34],"on":[35,92,260,297,327,454,497],"intracellular":[37,456,578],"processing,":[38],"export":[39,64,215,238],"and":[40,62,96,132,165,173,178,291,331,366,370,502,562],"biological":[41,120,152,538],"activity":[42,121,480,488],"fibronectin\u2013the":[44],"major":[45],"cell":[46,94,182,244,262,299,329,441],"surface":[47,95,330,399,442,528],"glycoprotein":[48,413],"chick":[50,463],"embryo":[51,464],"fibroblasts.":[52],"Chick":[53],"fibroblasts":[54,465],"treated":[55],"with":[56,203,232,247,277,401,446,466,504,554],"tunicamycin":[57,233,354,380,453,467],"produced":[58],"only":[59],"nonglycosylated":[60,90,114,123,133,148,188,270,289],"fibronectin":[61,91,149],"or":[65,537],"secretion":[66,536],"carbohydrate\u2010free":[69],"protein":[70,115,137,189,241,425,546],"species":[71],"was":[72,81,103,190,219,250,318,350,355],"not":[73,235,531],"totally":[74],"impaired.":[75],"We":[76,143,222],"did":[77,234],"observe":[78],"that":[79,146,224,392,419,523],"there":[80,249],"a":[82,251,472],"substantial":[83,252],"decrease":[84,102,253],"in":[85,97,139,201,230,254,357,418,469,475,552],"absolute":[87],"amount":[88,256,477],"culture":[99,231,484],"medium.":[100,383,485],"This":[101],"shown":[104,145,191],"be":[106,193,416],"due":[107,264],"increased":[109],"proteolytic":[110,199,428,459,548],"degradation":[111,197,286],"species.":[116],"examine":[118],"fibronectin,":[124,248],"compared":[126],"activities":[128],"glycosylated":[131,157],"forms":[134],"utilizing":[138],"vitro":[140],"assay":[141],"procedures.":[142],"isolated,":[147,187],"retained":[150],"properties":[153],"characteristic":[154],"protein;":[158],"they":[159],"are:":[160],"1)":[161],"promotion":[162,180],"cell\u2010cell":[164],"cell\u2010substratum":[166],"adhesion,":[167],"2)":[168],"restoration":[169],"normal":[171,376],"behavior":[172],"phenotype":[174],"transformed":[176],"cells,":[177],"3)":[179],"binding":[183],"collagen.":[185],"The":[186,209,272,346,486],"more":[194,470],"sensitive":[195],"by":[198,398,513],"enzymes,":[200],"agreement":[202,553],"data":[205],"obtained":[206],"\u201cin":[207],"vivo.\u201d":[208],"requirement":[210,303,406],"for":[213,304,389,407,435,519,533,576],"acetylcholine":[217],"receptor":[218,258,290,296],"also":[220,319],"examined.":[221],"found":[223],"treatment":[225,274,445],"embryonic":[227,311],"muscle":[228,316,341],"cells":[229,276,342],"surface.":[245,300],"As":[246],"present":[259],"surface,":[263],"enhanced":[266],"proteolysis":[267,439],"protein.":[271],"simultaneous":[273],"protease":[279,361,479],"inhibitor":[280],"leupeptin":[281,365],"diminished":[282],"rate":[284],"restored":[292,374],"expression":[294,324],"Finally,":[301],"glycoproteins":[307,326,400,443,529],"during":[308],"differentiation":[309],"myoblasts":[312],"into":[313,482],"multinucleated,":[314],"functional":[315],"fibers":[317],"investigated.":[320],"Tunicamycin":[321],"blocked":[322],"strongly":[332],"inhibited":[333],"fusion":[334,349,371,394],"when":[335,353],"added":[336],"cultures":[338],"differentiating":[340],"prior":[343],"fusion.":[345],"inhibition":[347,503],"partially":[351,396],"prevented":[352],"administered":[356],"presence":[359],"inhibitors":[362],"such":[363],"as":[364,493,508,510],"pepstatin.":[367],"Both":[368],"were":[372],"completely":[373],"after":[377],"removal":[378],"from":[381],"These":[384,506],"studies":[385],"provide":[386],"strong":[387],"support":[388],"idea":[391],"myoblast":[393],"is":[395,530,574],"mediated":[397],"asparagine\u2010linked":[402],"oligosaccharides.":[403],"However,":[404],"portion":[410],"appears":[414],"indirect":[417],"it":[420],"acts":[421],"stabilize":[423],"against":[427,547],"degradation.":[429,549],"elucidate":[431],"mechanism":[433],"responsible":[434],"enhancement":[437],"following":[444],"investigated":[449],"processing":[457],"enzymes.":[460],"Treatment":[461],"resulted":[468],"than":[471],"10\u2010fold":[473],"increase":[474],"released":[481],"enzyme":[487],"has":[489],"been":[490],"tentatively":[491],"identified":[492],"cathepsin":[494],"B":[495],"based":[496],"substrate":[498],"specificity,":[499],"pH":[500],"optimum":[501],"leupeptin.":[505],"results":[507,556],"well":[509],"extensive":[511],"work":[512],"other":[514],"investigators":[515],"[see":[516],"references":[517],"[1\u201311]":[518],"recent":[520],"reviews]":[521],"suggest":[522],"required":[532,575],"their":[534,577],"synthesis,":[535],"function,":[539],"but":[540],"instead":[541],"helps":[542],"protect":[544],"In":[550],"contrast,":[551],"Neufeld":[558],"et":[559,564],"al":[560,565],"[12\u201324]":[561],"Sly":[563],"[15,":[566],"16],":[567],"lysosomal":[572],"enzymes":[573],"retention.":[579]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
