{"id":"https://openalex.org/W2005333955","doi":"https://doi.org/10.1126/science.166.3911.1433","title":"Compulsive Sexual Activity Induced by p -Chlorophenylalanine in Normal and Pinealectomized Male Rats","display_name":"Compulsive Sexual Activity Induced by p -Chlorophenylalanine in Normal and Pinealectomized Male Rats","publication_year":1969,"publication_date":"1969-12-12","ids":{"openalex":"https://openalex.org/W2005333955","doi":"https://doi.org/10.1126/science.166.3911.1433","mag":"2005333955","pmid":"https://pubmed.ncbi.nlm.nih.gov/5307630"},"language":"en","primary_location":{"id":"doi:10.1126/science.166.3911.1433","doi":"https://doi.org/10.1126/science.166.3911.1433","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.166.3911.1433","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111569477","display_name":"Alessandro Tagliamonte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandro Tagliamonte","raw_affiliation_strings":["Laboratory of Clinical Pharmacology, National Heart Institute, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmacology, National Heart Institute, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008781685","display_name":"Paola Tagliamonte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Tagliamonte","raw_affiliation_strings":["Laboratory of Clinical Pharmacology, National Heart Institute, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmacology, National Heart Institute, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024422484","display_name":"Gian Luigi Gessa","orcid":"https://orcid.org/0000-0002-9242-7663","observed_orcids":["https://orcid.org/0000-0002-9242-7663"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gian L. Gessa","raw_affiliation_strings":["Laboratory of Clinical Pharmacology, National Heart Institute, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmacology, National Heart Institute, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110028872","display_name":"Bernard B. Brodie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard B. Brodie","raw_affiliation_strings":["Laboratory of Clinical Pharmacology, National Heart Institute, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmacology, National Heart Institute, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":11.7238,"has_fulltext":false,"cited_by_count":255,"citation_normalized_percentile":{"value":0.99544808,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"166","issue":"3911","first_page":"1433","last_page":"1435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12335","display_name":"Sexuality, Behavior, and Technology","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-chlorophenylalanine","display_name":"p-chlorophenylalanine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/serotonin-depletion","display_name":"serotonin depletion","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sexual-excitation","display_name":"sexual excitation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/compulsive-sexual-behavior","display_name":"compulsive sexual behavior","score":0.8059999942779541},{"id":"https://openalex.org/keywords/pinealectomy","display_name":"pinealectomy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pargyline","display_name":"pargyline","score":0.9580000042915344},{"id":"https://openalex.org/keywords/5-hydroxytryptophan","display_name":"5-hydroxytryptophan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.8600000143051147},{"id":"https://openalex.org/keywords/male-rats","display_name":"male rats","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2777067607","wikidata":"https://www.wikidata.org/wiki/Q781329","display_name":"Pargyline","level":4,"score":0.9270800352096558},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7815225124359131},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7651016116142273},{"id":"https://openalex.org/C2779399491","wikidata":"https://www.wikidata.org/wiki/Q238544","display_name":"5-Hydroxytryptophan","level":4,"score":0.7291780710220337},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6772284507751465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43369102478027344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28775590658187866},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002700","descriptor_name":"Chloramines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003192","descriptor_name":"Compulsive Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006916","descriptor_name":"5-Hydroxytryptophan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010293","descriptor_name":"Pargyline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010870","descriptor_name":"Pineal Gland","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012726","descriptor_name":"Sexual Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.166.3911.1433","doi":"https://doi.org/10.1126/science.166.3911.1433","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.166.3911.1433","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:5307630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5307630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1977407286","https://openalex.org/W2010397914","https://openalex.org/W2022628559","https://openalex.org/W2036759076","https://openalex.org/W2056112038","https://openalex.org/W2078261559","https://openalex.org/W2090982552","https://openalex.org/W2110323242","https://openalex.org/W2149330955","https://openalex.org/W2287714691","https://openalex.org/W2400647632"],"related_works":["https://openalex.org/W2017556008","https://openalex.org/W2000174886","https://openalex.org/W2055586160","https://openalex.org/W1993637006","https://openalex.org/W2050955919","https://openalex.org/W2057505846","https://openalex.org/W1573761087","https://openalex.org/W2031654002","https://openalex.org/W2081079196","https://openalex.org/W174358179"],"abstract_inverted_index":{"p-Chlorophenylalanine":[0,34],"depletes":[1],"brain":[2,67],"serotonin":[3],"and":[4,68,74],"induces":[5],"longlasting":[6],"sexual":[7,32,37],"excitation":[8,38],"in":[9,39,53,65,77],"male":[10],"rats.":[11],"The":[12],"effect":[13,43],"of":[14,21,50,61,63],"p-chlorophenylalanine":[15,27],"is":[16,44],"potentiated":[17],"by":[18,47],"pargyline.":[19],"Administration":[20],"5-hydroxytryptophan":[22,64,73],"to":[23],"rats":[24],"treated":[25],"with":[26],"plus":[28],"pargyline":[29],"blocks":[30],"the":[31,48,54,59,66,69,78],"excitation.":[33],"also":[35],"elicits":[36],"pinealectomized":[40],"rats;":[41],"this":[42],"not":[45],"mediated":[46],"lack":[49],"indole":[51],"hormones":[52],"pineal":[55],"but":[56],"may":[57],"be":[58],"consequence":[60],"depletion":[62],"resulting":[70],"imbalance":[71],"between":[72],"catecholamine":[75],"activity":[76],"central":[79],"nervous":[80],"system.":[81]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
