{"id":"https://openalex.org/W2005309563","doi":"https://doi.org/10.1159/000019581","title":"A Randomized Study of Short-v ersus Long-Term Intravesical Epirubicin Instillation for Superficial Bladder Cancer","display_name":"A Randomized Study of Short-v ersus Long-Term Intravesical Epirubicin Instillation for Superficial Bladder Cancer","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2005309563","doi":"https://doi.org/10.1159/000019581","mag":"2005309563","pmid":"https://pubmed.ncbi.nlm.nih.gov/9555553"},"language":"en","primary_location":{"id":"doi:10.1159/000019581","doi":"https://doi.org/10.1159/000019581","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000019581","pdf_url":null,"source":{"id":"https://openalex.org/S96871409","display_name":"European Urology","issn_l":"0302-2838","issn":["0302-2838","1421-993X","1873-7560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014100477","display_name":"Kikuo Okamura","orcid":"https://orcid.org/0000-0002-6014-7202","observed_orcids":["https://orcid.org/0000-0002-6014-7202"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kikuo Okamura","raw_affiliation_strings":["Department of Urology, Nagoya University School of Medicine, Japan","Nagoya University School of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Nagoya University School of Medicine, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Nagoya University School of Medicine,","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113733864","display_name":"Tsuneo Kinukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114349","display_name":"Okazaki City Hospital","ror":"https://ror.org/01z9vrt66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114349"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneo Kinukawa","raw_affiliation_strings":["Okazaki City Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okazaki City Hospital,","institution_ids":["https://openalex.org/I4210114349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080891803","display_name":"Yoshio Tsumura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098921","display_name":"Kariya Toyota General Hospital","ror":"https://ror.org/00vzw9736","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210098921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Tsumura","raw_affiliation_strings":["Kariya General Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kariya General Hospital,","institution_ids":["https://openalex.org/I4210098921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057278320","display_name":"Toshikazu Otani","orcid":"https://orcid.org/0000-0001-7865-0247","observed_orcids":["https://orcid.org/0000-0001-7865-0247"]},"institutions":[{"id":"https://openalex.org/I4210091385","display_name":"Chubu Rosai Hospital","ror":"https://ror.org/00av3hs56","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210091385"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshikazu Otani","raw_affiliation_strings":["Chubu Rosai Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chubu Rosai Hospital,","institution_ids":["https://openalex.org/I4210091385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080521687","display_name":"Hiroshi Itoh","orcid":"https://orcid.org/0000-0002-6434-1184","observed_orcids":["https://orcid.org/0000-0002-6434-1184"]},"institutions":[{"id":"https://openalex.org/I4210113086","display_name":"Ichinomiya Municipal City Hospital","ror":"https://ror.org/026a4qe69","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210113086"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Itoh","raw_affiliation_strings":["Ichinomiya Municipal Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ichinomiya Municipal Hospital,","institution_ids":["https://openalex.org/I4210113086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048342878","display_name":"Hiroaki Kobayashi","orcid":"https://orcid.org/0000-0003-2491-2189","observed_orcids":["https://orcid.org/0000-0003-2491-2189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroaki Kobayashi","raw_affiliation_strings":["Nagoya Second Red Cross Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya Second Red Cross Hospital,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046889204","display_name":"Osamu Matsuura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146922","display_name":"Chukyo Hospital","ror":"https://ror.org/03j56s085","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210146922"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Matsuura","raw_affiliation_strings":["Shakaihoken Chukyo Hospital, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shakaihoken Chukyo Hospital, and","institution_ids":["https://openalex.org/I4210146922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103760897","display_name":"Mineo Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124402","display_name":"Handa City Hospital","ror":"https://ror.org/037a76178","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124402"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mineo Kobayashi","raw_affiliation_strings":["Handa Municipal Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Handa Municipal Hospital","institution_ids":["https://openalex.org/I4210124402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046446109","display_name":"Toshiaki Fukatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Fukatsu","raw_affiliation_strings":["Department of Central Laboratories, Nagoya University School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Central Laboratories, Nagoya University School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112146067","display_name":"Shinichi Ohshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichi Ohshima","raw_affiliation_strings":["Departments of Urology Nagoya University School of Medicine,","Nagoya University School of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology Nagoya University School of Medicine,","institution_ids":["https://openalex.org/I4210090647","https://openalex.org/I60134161"]},{"raw_affiliation_string":"Nagoya University School of Medicine,","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":2.5904,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.89202034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"33","issue":"3","first_page":"285","last_page":"289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superficial-bladder-cancer","display_name":"superficial bladder cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":0.8980000019073486},{"id":"https://openalex.org/keywords/intravesical-chemotherapy","display_name":"intravesical chemotherapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.6179999709129333},{"id":"https://openalex.org/keywords/transurethral-resection-of-bladder-tumor","display_name":"transurethral resection of bladder tumor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hematuria","display_name":"hematuria","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9752341508865356},{"id":"https://openalex.org/C2780835546","wikidata":"https://www.wikidata.org/wiki/Q425122","display_name":"Epirubicin","level":4,"score":0.9719405770301819},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6417324542999268},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5528624653816223},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5110539197921753},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4613713026046753},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4470521807670593},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4391043782234192},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.43330222368240356},{"id":"https://openalex.org/C2910508445","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder Neoplasm","level":4,"score":0.41322553157806396},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3725203573703766},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3101475238800049},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22831153869628906},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.05219978094100952}],"mesh":[{"descriptor_ui":"D000283","descriptor_name":"Administration, Intravesical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000019581","doi":"https://doi.org/10.1159/000019581","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000019581","pdf_url":null,"source":{"id":"https://openalex.org/S96871409","display_name":"European Urology","issn_l":"0302-2838","issn":["0302-2838","1421-993X","1873-7560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Urology","raw_type":"journal-article"},{"id":"pmid:9555553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9555553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European urology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2178939","https://openalex.org/W84859026","https://openalex.org/W1578797961","https://openalex.org/W2090829201","https://openalex.org/W2092331566","https://openalex.org/W2123614023","https://openalex.org/W2221618400","https://openalex.org/W2229398429","https://openalex.org/W2333193688","https://openalex.org/W2412526367","https://openalex.org/W2414445522","https://openalex.org/W2417407414","https://openalex.org/W3174771246"],"related_works":["https://openalex.org/W2463612468","https://openalex.org/W2019102539","https://openalex.org/W2092331566","https://openalex.org/W2105014482","https://openalex.org/W2393665185","https://openalex.org/W1983956345","https://openalex.org/W2031011443","https://openalex.org/W2374332006","https://openalex.org/W7025925992","https://openalex.org/W2349958226"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}