{"id":"https://openalex.org/W2005309418","doi":"https://doi.org/10.1007/s12195-014-0342-y","title":"Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments","display_name":"Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments","publication_year":2014,"publication_date":"2014-06-19","ids":{"openalex":"https://openalex.org/W2005309418","doi":"https://doi.org/10.1007/s12195-014-0342-y","mag":"2005309418","pmid":"https://pubmed.ncbi.nlm.nih.gov/25436017","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4243304"},"language":"en","primary_location":{"id":"doi:10.1007/s12195-014-0342-y","doi":"https://doi.org/10.1007/s12195-014-0342-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12195-014-0342-y","pdf_url":null,"source":{"id":"https://openalex.org/S77874066","display_name":"Cellular and Molecular Bioengineering","issn_l":"1865-5025","issn":["1865-5025","1865-5033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4243304/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103212457","display_name":"Patricia M. Davidson","orcid":"https://orcid.org/0000-0002-3939-3601","observed_orcids":["https://orcid.org/0000-0002-3939-3601"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia M. Davidson","raw_affiliation_strings":["Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering Cornell University, Ithaca, NY 14853; USA","Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering Cornell University, Ithaca, NY 14853; USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053925509","display_name":"C\u00e9line Denais","orcid":"https://orcid.org/0000-0001-5539-3786","observed_orcids":["https://orcid.org/0000-0001-5539-3786"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celine Denais","raw_affiliation_strings":["Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering Cornell University, Ithaca, NY 14853; USA","Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering Cornell University, Ithaca, NY 14853; USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004384450","display_name":"Maya C. Bakshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maya C. Bakshi","raw_affiliation_strings":["Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering Cornell University, Ithaca, NY 14853; USA","Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering Cornell University, Ithaca, NY 14853; USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Cornell University","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002335286","display_name":"Jan Lammerding","orcid":"https://orcid.org/0000-0003-4335-8611","observed_orcids":["https://orcid.org/0000-0003-4335-8611"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jan Lammerding","raw_affiliation_strings":["Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering Cornell University, Ithaca, NY 14853; USA","Cornell University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Institute for Cell and Molecular Biology, Department of Biomedical Engineering Cornell University, Ithaca, NY 14853; USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Cornell University","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002335286"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":6.9103,"has_fulltext":false,"cited_by_count":324,"citation_normalized_percentile":{"value":0.98423923,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"7","issue":"3","first_page":"293","last_page":"306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.2921999990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-deformability","display_name":"nuclear deformability","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nuclear-stiffness","display_name":"nuclear stiffness","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lamin-a-c","display_name":"lamin A/C","score":0.8040000200271606},{"id":"https://openalex.org/keywords/nuclear-envelope-proteins","display_name":"nuclear envelope proteins","score":0.7580000162124634},{"id":"https://openalex.org/keywords/constriction","display_name":"constriction","score":0.6299999952316284},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.6650000214576721},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8759999871253967},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C179093185","wikidata":"https://www.wikidata.org/wiki/Q424506","display_name":"Lamin","level":3,"score":0.858293890953064},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.7283241152763367},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.6170034408569336},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6168098449707031},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5953831672668457},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5929626226425171},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5196953415870667},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.5186589956283569},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5067511200904846},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4891100525856018},{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.48543745279312134},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.46548548340797424},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4304957091808319},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43011674284935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4274364113807678},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.4206749200820923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3694037199020386},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.26265913248062134},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2505488991737366},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11175283789634705},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.10384723544120789},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s12195-014-0342-y","doi":"https://doi.org/10.1007/s12195-014-0342-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12195-014-0342-y","pdf_url":null,"source":{"id":"https://openalex.org/S77874066","display_name":"Cellular and Molecular Bioengineering","issn_l":"1865-5025","issn":["1865-5025","1865-5033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Bioengineering","raw_type":"journal-article"},{"id":"pmid:25436017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25436017","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular bioengineering","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4243304","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4243304/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Mol Bioeng","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1517355","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1517355/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CELLULAR AND MOLECULAR BIOENGINEERING , 7 (3) pp. 293-306. (2014)","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4243304","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4243304/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Mol Bioeng","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3921419375","display_name":"Center on the Microenvironment and Metastasis","funder_award_id":"U54CA143876","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4549113687","display_name":"Nuclear mechanics and mechanotransduction in muscular laminopathies","funder_award_id":"R01HL082792","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6172534942","display_name":"Nuclear-cytoskeletal coupling in muscular laminopathies","funder_award_id":"R01NS059348","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W176922019","https://openalex.org/W1566703732","https://openalex.org/W1967931285","https://openalex.org/W1972081065","https://openalex.org/W1976541550","https://openalex.org/W1992125801","https://openalex.org/W1999646178","https://openalex.org/W2009109627","https://openalex.org/W2013718744","https://openalex.org/W2021913972","https://openalex.org/W2025245313","https://openalex.org/W2029517875","https://openalex.org/W2030637965","https://openalex.org/W2031920140","https://openalex.org/W2035838778","https://openalex.org/W2036565798","https://openalex.org/W2041651184","https://openalex.org/W2052373675","https://openalex.org/W2052940791","https://openalex.org/W2055099137","https://openalex.org/W2058436824","https://openalex.org/W2060336384","https://openalex.org/W2063456960","https://openalex.org/W2075573465","https://openalex.org/W2080232352","https://openalex.org/W2086886614","https://openalex.org/W2091817614","https://openalex.org/W2108290422","https://openalex.org/W2110344693","https://openalex.org/W2111227784","https://openalex.org/W2112401372","https://openalex.org/W2116269551","https://openalex.org/W2118898403","https://openalex.org/W2119526996","https://openalex.org/W2122867798","https://openalex.org/W2124633704","https://openalex.org/W2133054656","https://openalex.org/W2136490523","https://openalex.org/W2138579711","https://openalex.org/W2154155687","https://openalex.org/W2163504716","https://openalex.org/W2172002964","https://openalex.org/W2402649360","https://openalex.org/W4211058615","https://openalex.org/W4247425028","https://openalex.org/W6682872008"],"related_works":["https://openalex.org/W2106226359","https://openalex.org/W2277592932","https://openalex.org/W2039218183","https://openalex.org/W4283070958","https://openalex.org/W7025021139","https://openalex.org/W2955324589","https://openalex.org/W4408929064","https://openalex.org/W4220724090","https://openalex.org/W4401724351","https://openalex.org/W2104153065"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":33},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}