{"id":"https://openalex.org/W2005304850","doi":"https://doi.org/10.1007/s12013-009-9046-7","title":"Fluorescence Lifetime Imaging of Endogenous Fluorophores in Histopathology Sections Reveals Differences Between Normal and Tumor Epithelium in Carcinoma In Situ of the Breast","display_name":"Fluorescence Lifetime Imaging of Endogenous Fluorophores in Histopathology Sections Reveals Differences Between Normal and Tumor Epithelium in Carcinoma In Situ of the Breast","publication_year":2009,"publication_date":"2009-03-03","ids":{"openalex":"https://openalex.org/W2005304850","doi":"https://doi.org/10.1007/s12013-009-9046-7","mag":"2005304850","pmid":"https://pubmed.ncbi.nlm.nih.gov/19259625"},"language":"en","primary_location":{"id":"doi:10.1007/s12013-009-9046-7","doi":"https://doi.org/10.1007/s12013-009-9046-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12013-009-9046-7","pdf_url":null,"source":{"id":"https://openalex.org/S188545443","display_name":"Cell Biochemistry and Biophysics","issn_l":"1085-9195","issn":["1085-9195","1559-0283"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5575754","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065554744","display_name":"Matthew W. Conklin","orcid":"https://orcid.org/0000-0001-7087-4561","observed_orcids":["https://orcid.org/0000-0001-7087-4561"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew W. Conklin","raw_affiliation_strings":["Department of Pharmacology, University of Wisconsin, 1525 Linden Dr., Madison, WI 53706, USA","Department of Pharmacology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Wisconsin, 1525 Linden Dr., Madison, WI 53706, USA","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Pharmacology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070953226","display_name":"Paolo P. Provenzano","orcid":"https://orcid.org/0000-0002-9313-1370","observed_orcids":["https://orcid.org/0000-0002-9313-1370"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paolo P. Provenzano","raw_affiliation_strings":["Department of Pharmacology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","Laboratory for Optical and Computational Instrumentation (LOCI), Laboratory for Molecular Biology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Laboratory for Optical and Computational Instrumentation (LOCI), Laboratory for Molecular Biology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010413374","display_name":"Kevin W. Eliceiri","orcid":"https://orcid.org/0000-0001-8678-670X","observed_orcids":["https://orcid.org/0000-0001-8678-670X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin W. Eliceiri","raw_affiliation_strings":["Laboratory for Optical and Computational Instrumentation (LOCI), Laboratory for Molecular Biology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Optical and Computational Instrumentation (LOCI), Laboratory for Molecular Biology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085389542","display_name":"Ruth Sullivan","orcid":"https://orcid.org/0000-0001-8276-8109","observed_orcids":["https://orcid.org/0000-0001-8276-8109"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Sullivan","raw_affiliation_strings":["Laboratory for Optical and Computational Instrumentation (LOCI), Laboratory for Molecular Biology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Optical and Computational Instrumentation (LOCI), Laboratory for Molecular Biology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002848732","display_name":"Patricia J. Keely","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia J. Keely","raw_affiliation_strings":["Department of Pharmacology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","Laboratory for Optical and Computational Instrumentation (LOCI), Laboratory for Molecular Biology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Laboratory for Optical and Computational Instrumentation (LOCI), Laboratory for Molecular Biology, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin, 1525 Linden Dr., Madison, WI, 53706, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002848732"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":5.2486,"has_fulltext":false,"cited_by_count":138,"citation_normalized_percentile":{"value":0.96328825,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"53","issue":"3","first_page":"145","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.6011000275611877,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.6011000275611877,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.2709999978542328,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.10260000079870224,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"fluorescence lifetime imaging","score":0.9710000157356262},{"id":"https://openalex.org/keywords/endogenous-fluorophores","display_name":"endogenous fluorophores","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.878000020980835},{"id":"https://openalex.org/keywords/fad","display_name":"FAD","score":0.9980000257492065},{"id":"https://openalex.org/keywords/breast-carcinoma-in-situ","display_name":"breast cancer in situ","score":0.8930000066757202},{"id":"https://openalex.org/keywords/optical-biomarkers","display_name":"optical biomarkers","score":0.7260000109672546},{"id":"https://openalex.org/keywords/multiphoton-excitation","display_name":"multiphoton excitation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/photon-counting","display_name":"photon counting","score":0.6830000281333923},{"id":"https://openalex.org/keywords/histopathology-slides","display_name":"histopathology slides","score":0.6380000114440918},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.4000000059604645},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.70822674036026},{"id":"https://openalex.org/C179687394","wikidata":"https://www.wikidata.org/wiki/Q4826281","display_name":"Autofluorescence","level":3,"score":0.6759954690933228},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.5591468811035156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47346583008766174},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.46560579538345337},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4568607807159424},{"id":"https://openalex.org/C2779751288","wikidata":"https://www.wikidata.org/wiki/Q422637","display_name":"Eosin","level":3,"score":0.43850177526474},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.41767433285713196},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.41371771693229675},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38426682353019714},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3159336447715759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2764604091644287},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.17577749490737915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17249637842178345},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08903035521507263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004801","descriptor_name":"Eosine Yellowish-(YS)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005182","descriptor_name":"Flavin-Adenine Dinucleotide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005182","descriptor_name":"Flavin-Adenine Dinucleotide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005182","descriptor_name":"Flavin-Adenine Dinucleotide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006416","descriptor_name":"Hematoxylin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006416","descriptor_name":"Hematoxylin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006416","descriptor_name":"Hematoxylin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s12013-009-9046-7","doi":"https://doi.org/10.1007/s12013-009-9046-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12013-009-9046-7","pdf_url":null,"source":{"id":"https://openalex.org/S188545443","display_name":"Cell Biochemistry and Biophysics","issn_l":"1085-9195","issn":["1085-9195","1559-0283"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:19259625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19259625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biochemistry and biophysics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4468952","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5575754","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5575754","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5575754","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Biochem Biophys","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5575754","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5575754","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Biochem Biophys","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2915585786","display_name":null,"funder_award_id":"CA 076537","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3345150521","display_name":"R-Ras and Integrin Signaling in Breast Cell Phenotype","funder_award_id":"R01CA076537","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G556306122","display_name":null,"funder_award_id":"R29 CA076537","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6026724201","display_name":"Spectral/FLIM strategies for FRET based analysis of signal transduction pathways","funder_award_id":"R21EB008811","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306206","display_name":"Mary Kay Foundation","ror":"https://ror.org/05snapr15"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1490797465","https://openalex.org/W1600325497","https://openalex.org/W1979968811","https://openalex.org/W1983259239","https://openalex.org/W1986163455","https://openalex.org/W1987715194","https://openalex.org/W1992416281","https://openalex.org/W1995202709","https://openalex.org/W1996582791","https://openalex.org/W1997595809","https://openalex.org/W1998997336","https://openalex.org/W2002752049","https://openalex.org/W2003588363","https://openalex.org/W2005720644","https://openalex.org/W2015072959","https://openalex.org/W2015271852","https://openalex.org/W2018153154","https://openalex.org/W2020895105","https://openalex.org/W2020980454","https://openalex.org/W2025568741","https://openalex.org/W2026883019","https://openalex.org/W2029918421","https://openalex.org/W2051297402","https://openalex.org/W2058861159","https://openalex.org/W2061464631","https://openalex.org/W2063134036","https://openalex.org/W2072227605","https://openalex.org/W2072376785","https://openalex.org/W2076815583","https://openalex.org/W2077136301","https://openalex.org/W2077723879","https://openalex.org/W2089258206","https://openalex.org/W2091385781","https://openalex.org/W2100392590","https://openalex.org/W2105274638","https://openalex.org/W2109495211","https://openalex.org/W2111449140","https://openalex.org/W2111518741","https://openalex.org/W2111920179","https://openalex.org/W2112454443","https://openalex.org/W2114953817","https://openalex.org/W2118604693","https://openalex.org/W2128231056","https://openalex.org/W2129827453","https://openalex.org/W2129995310","https://openalex.org/W2130503287","https://openalex.org/W2135174215","https://openalex.org/W2136737404","https://openalex.org/W2154852947","https://openalex.org/W2154939445","https://openalex.org/W2163127244","https://openalex.org/W2166168429","https://openalex.org/W2167267427","https://openalex.org/W2312296163","https://openalex.org/W2491458126","https://openalex.org/W4237403746"],"related_works":["https://openalex.org/W3163749585","https://openalex.org/W2992854078","https://openalex.org/W2350197823","https://openalex.org/W2059128522","https://openalex.org/W2410925429","https://openalex.org/W3080438050","https://openalex.org/W4388348771","https://openalex.org/W136918693","https://openalex.org/W4387765297","https://openalex.org/W2125258876"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}