{"id":"https://openalex.org/W2005303938","doi":"https://doi.org/10.1111/j.1432-1033.1995.tb20220.x_1","title":"Cloning and Characterization of cDNA for Adenosine Kinase from Mammalian (Chinese Hamster, Mouse, Human and Rat) Species","display_name":"Cloning and Characterization of cDNA for Adenosine Kinase from Mammalian (Chinese Hamster, Mouse, Human and Rat) Species","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W2005303938","doi":"https://doi.org/10.1111/j.1432-1033.1995.tb20220.x_1","mag":"2005303938","pmid":"https://pubmed.ncbi.nlm.nih.gov/8917457"},"language":"en","primary_location":{"id":"doi:10.1111/j.1432-1033.1995.tb20220.x_1","doi":"https://doi.org/10.1111/j.1432-1033.1995.tb20220.x_1","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1995.tb20220.x_1","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113562887","display_name":"Bhag Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bhag Singh","raw_affiliation_strings":["Department of Biochemistry, McMaster University, Hamilton, Canada","Dept. of Biochemistry, McMaster University, Hamilton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, McMaster University, Hamilton, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Dept. of Biochemistry, McMaster University, Hamilton, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001676364","display_name":"Weihua Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Weihua Hao","raw_affiliation_strings":["Department of Biochemistry, McMaster University, Hamilton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, McMaster University, Hamilton, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029685097","display_name":"Zai-Chuan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zai\u2010chuan Wu","raw_affiliation_strings":["Department of Biochemistry, McMaster University, Hamilton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, McMaster University, Hamilton, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089306688","display_name":"Bernhard J. Eigl","orcid":"https://orcid.org/0000-0003-1653-6929","observed_orcids":["https://orcid.org/0000-0003-1653-6929"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bernhard Eigl","raw_affiliation_strings":["Department of Biochemistry, McMaster University, Hamilton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, McMaster University, Hamilton, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085988586","display_name":"Radhey S. Gupta","orcid":"https://orcid.org/0000-0001-7034-4018","observed_orcids":["https://orcid.org/0000-0001-7034-4018"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Radhey S. Gupta","raw_affiliation_strings":["Department of Biochemistry, McMaster University, Hamilton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, McMaster University, Hamilton, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085988586"],"corresponding_institution_ids":["https://openalex.org/I98251732"],"apc_list":null,"apc_paid":null,"fwci":0.4221,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.54155159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"241","issue":"2","first_page":"564","last_page":"571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-kinase","display_name":"adenosine kinase","score":1.0},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adenosine-metabolism","display_name":"adenosine metabolism","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mouse-3t3-cells","display_name":"mouse 3T3 cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.6510000228881836},{"id":"https://openalex.org/keywords/sequence-similarity","display_name":"sequence similarity","score":0.5680000185966492},{"id":"https://openalex.org/keywords/sugar-kinase","display_name":"sugar kinase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ribokinase","display_name":"ribokinase","score":0.7710000276565552},{"id":"https://openalex.org/keywords/fructokinase","display_name":"fructokinase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/evolutionary-origin","display_name":"evolutionary origin","score":0.3700000047683716},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2780876210","wikidata":"https://www.wikidata.org/wiki/Q4682277","display_name":"Adenosine kinase","level":4,"score":0.8116614818572998},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.774206817150116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7006820440292358},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.678308367729187},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5759090185165405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4693875014781952},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.42208096385002136},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3632294535636902},{"id":"https://openalex.org/C34628245","wikidata":"https://www.wikidata.org/wiki/Q356093","display_name":"Adenosine deaminase","level":3,"score":0.28036773204803467},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000248","descriptor_name":"Adenosine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1432-1033.1995.tb20220.x_1","doi":"https://doi.org/10.1111/j.1432-1033.1995.tb20220.x_1","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1995.tb20220.x_1","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"doi:10.1111/j.1432-1033.1996.00564.x","doi":"https://doi.org/10.1111/j.1432-1033.1996.00564.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1996.00564.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:8917457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8917457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W87799074","https://openalex.org/W133846736","https://openalex.org/W195270458","https://openalex.org/W564246031","https://openalex.org/W975718057","https://openalex.org/W1509404295","https://openalex.org/W1525751756","https://openalex.org/W1550696452","https://openalex.org/W1556895011","https://openalex.org/W1587133637","https://openalex.org/W1605472440","https://openalex.org/W1636953413","https://openalex.org/W1661394574","https://openalex.org/W1685609652","https://openalex.org/W1795669324","https://openalex.org/W1923300221","https://openalex.org/W1963540850","https://openalex.org/W1964194602","https://openalex.org/W1965310277","https://openalex.org/W1982422283","https://openalex.org/W1989976890","https://openalex.org/W1998162329","https://openalex.org/W1999246494","https://openalex.org/W2009509515","https://openalex.org/W2012841352","https://openalex.org/W2014808835","https://openalex.org/W2015374912","https://openalex.org/W2021652636","https://openalex.org/W2025913817","https://openalex.org/W2028804351","https://openalex.org/W2036108519","https://openalex.org/W2036548004","https://openalex.org/W2041652393","https://openalex.org/W2044783124","https://openalex.org/W2052622700","https://openalex.org/W2055043387","https://openalex.org/W2058869004","https://openalex.org/W2065884525","https://openalex.org/W2070240680","https://openalex.org/W2074231493","https://openalex.org/W2090518535","https://openalex.org/W2101253062","https://openalex.org/W2208106150","https://openalex.org/W2227434034","https://openalex.org/W2312065962","https://openalex.org/W2396823324","https://openalex.org/W2401448113","https://openalex.org/W2748101318","https://openalex.org/W4242816210","https://openalex.org/W4301131015"],"related_works":["https://openalex.org/W2090518535","https://openalex.org/W7096226301","https://openalex.org/W2062934114","https://openalex.org/W2075897418","https://openalex.org/W2003094664","https://openalex.org/W1570048226","https://openalex.org/W2065739243","https://openalex.org/W1964504620","https://openalex.org/W2590323780","https://openalex.org/W2009434133"],"abstract_inverted_index":{"The":[0,75,162,187,307],"enzyme":[1],"adenosine":[2,21,36,64,109,134,148,155,163,189,203,216,227,257,305,315],"kinase":[3,37,65,110,149,156,164,190,217,258,316],"constitutes":[4],"the":[5,32,103,133,146,159,177,180,256,286,303,312],"major":[6],"purine":[7],"nucleoside":[8],"phosphorylating":[9],"activity":[10,157,218],"in":[11,20,57,79,158,199,202,266],"mammalian":[12,304],"cells.":[13,74,186],"In":[14,101,205],"view":[15],"of":[16,31,35,39,83,92,125,137,154,212,223,239,249,269,285],"its":[17],"central":[18],"role":[19],"metabolism,":[22],"which":[23,271],"is":[24,38,229],"an":[25,29,126,232],"important":[26],"physiological":[27],"regulator,":[28],"understanding":[30],"primary":[33],"structure":[34],"much":[40],"interest.":[41],"Using":[42],"microsequence":[43],"information":[44],"from":[45,48,66,111],"peptides":[46],"derived":[47],"purified":[49],"Syrian":[50],"hamster":[51,68,139,184,207],"liver":[52,117],"enzyme,":[53],"we":[54],"have":[55,118],"succeeded":[56],"isolating":[58],"full":[59],"length":[60],"cDNA":[61,191],"clones":[62,81],"encoding":[63],"Chinese":[67,138,183,206],"ovary":[69,140,185,208],"cells":[70,141],"and":[71,85,89,97,105,115,122,172,219,241,288,294],"mouse":[72],"3T3":[73],"open":[76],"reading":[77],"frames":[78],"these":[80,323],"consist":[82],"334":[84],"335":[86],"amino":[87],"acids":[88],"encode":[90],"proteins":[91],"molecular":[93],"masses":[94],"37364":[95],"Da":[96],"37489":[98],"Da,":[99],"respectively.":[100],"addition,":[102],"coding":[104],"upstream":[106],"sequences":[107],"for":[108,130],"human":[112],"(HeLa":[113],"cells)":[114],"rat":[116],"also":[119,166,193],"been":[120],"cloned":[121,147,188],"sequenced.":[123],"Transfection":[124],"adenosine-kinase-deficient":[127],"mutant":[128,213,270],"(selected":[129],"resistance":[131,171,224,274],"to":[132,152,176,195,225,276,302],"analog":[135,178],"toyocamycin)":[136],"with":[142,322],"a":[143,318],"plasmid":[144],"containing":[145],"cDNA,":[150],"leads":[151],"regaining":[153],"transformed":[160],"cell.":[161],"transformants":[165],"simultaneously":[167],"lost":[168],"their":[169],"toyocamycin":[170],"became":[173],"similarly":[174],"sensitive":[175],"as":[179],"parental":[181],"wild-type":[182],"was":[192],"used":[194],"examine":[196],"structural":[197,253,261],"changes":[198],"mutants":[200,250],"affected":[201],"kinase.":[204,306],"cells,":[209],"one":[210],"type":[211,268],"that":[214,246,283,314],"lacks":[215],"displays":[220],"high":[221,234],"degree":[222],"various":[226],"analogs,":[228],"obtained":[230],"at":[231],"unusually":[233],"spontaneous":[235],"frequency":[236],"(10(-4)-10(-3)).":[237],"Results":[238],"Southern":[240],"northern-blot":[242],"analysis":[243],"provide":[244],"evidence":[245],"this":[247],"group":[248],"involves":[251],"gross":[252],"alterations":[254,262],"affecting":[255],"gene.":[259],"Such":[260],"are":[263],"not":[264],"observed":[265],"another":[267],"exhibits":[272],"increased":[273],"only":[275],"C-adenosine":[277],"analogs.":[278],"Sequence":[279],"similarity":[280,301,309],"searches":[281],"indicate":[282],"several":[284],"bacterial":[287],"yeast":[289],"sugar":[290],"kinases":[291],"(ribokinase,":[292],"fructokinase":[293],"inosine-guanosine":[295],"kinase)":[296],"exhibit":[297],"limited":[298],"but":[299],"significant":[300],"sequence":[308],"data":[310],"support":[311],"possibility":[313],"shares":[317],"common":[319],"evolutionary":[320],"ancestor":[321],"protein":[324],"sequences.":[325]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
