{"id":"https://openalex.org/W2005302551","doi":"https://doi.org/10.1074/jbc.m112.359612","title":"Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1","display_name":"Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1","publication_year":2012,"publication_date":"2012-04-13","ids":{"openalex":"https://openalex.org/W2005302551","doi":"https://doi.org/10.1074/jbc.m112.359612","mag":"2005302551","pmid":"https://pubmed.ncbi.nlm.nih.gov/22500018","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3370221"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112.359612","doi":"https://doi.org/10.1074/jbc.m112.359612","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.359612","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925820499089/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021925820499089/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053506144","display_name":"Volodymyr Rybalchenko","orcid":"https://orcid.org/0000-0003-4092-0779","observed_orcids":["https://orcid.org/0000-0003-4092-0779"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volodymyr Rybalchenko","raw_affiliation_strings":["Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA","Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049417648","display_name":"Malini Ahuja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malini Ahuja","raw_affiliation_strings":["Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026664615","display_name":"Jessica Coblentz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Coblentz","raw_affiliation_strings":["Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051592206","display_name":"Dev Churamani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dev Churamani","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086481218","display_name":"Sandip Patel","orcid":"https://orcid.org/0000-0001-7247-2013","observed_orcids":["https://orcid.org/0000-0001-7247-2013"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sandip Patel","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068621771","display_name":"Kirill I. Kiselyov","orcid":"https://orcid.org/0000-0001-6683-2895","observed_orcids":["https://orcid.org/0000-0001-6683-2895"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krill Kiselyov","raw_affiliation_strings":["Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068367436","display_name":"Shmuel Muallem","orcid":"https://orcid.org/0000-0002-6189-4947","observed_orcids":["https://orcid.org/0000-0002-6189-4947"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shmuel Muallem","raw_affiliation_strings":["Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068367436"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":7.5083,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.98781761,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"287","issue":"24","first_page":"20407","last_page":"20416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tpc1","display_name":"TPC1","score":0.972000002861023},{"id":"https://openalex.org/keywords/two-pore-channels","display_name":"two-pore channels","score":0.8309999704360962},{"id":"https://openalex.org/keywords/naadp","display_name":"NAADP","score":0.9860000014305115},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.9319999814033508},{"id":"https://openalex.org/keywords/voltage-control","display_name":"voltage regulation","score":0.5220000147819519},{"id":"https://openalex.org/keywords/open-time","display_name":"open time","score":0.7080000042915344},{"id":"https://openalex.org/keywords/ligand-binding-affinity","display_name":"ligand binding affinity","score":0.5519999861717224},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.878000020980835},{"id":"https://openalex.org/keywords/lipid-bilayer-reconstitution","display_name":"lipid bilayer reconstitution","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.6271991729736328},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5841280221939087},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.5280355215072632},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5033707022666931},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46800556778907776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32592710852622986},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.23807868361473083},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000097903","descriptor_name":"Two-Pore Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1074/jbc.m112.359612","doi":"https://doi.org/10.1074/jbc.m112.359612","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.359612","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925820499089/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2672981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3370221","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3370221","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3370221","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:22500018","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22500018","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1350118","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1350118/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry , 287 pp. 20407-20416. (2012)","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1521651","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1521651/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF BIOLOGICAL CHEMISTRY , 287 (24) pp. 20407-20416. (2012)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112.359612","doi":"https://doi.org/10.1074/jbc.m112.359612","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.359612","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925820499089/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1160018997","display_name":null,"funder_award_id":"DE-000735","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G2741465026","display_name":"The molecular basis for calcium release by NAADP","funder_award_id":"BB/G013721/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5453468603","display_name":null,"funder_award_id":"HD058577","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5897304297","display_name":null,"funder_award_id":"ES01678","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5944297779","display_name":null,"funder_award_id":"ES01678","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8883621238","display_name":"The TRPML1 Role in Lysosomes","funder_award_id":"R01HD058577","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000892794","display_name":"Ca2+ signaling and HCO3- secretion by exocrine glands","funder_award_id":"ZIADE000735","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005302551.pdf","grobid_xml":"https://content.openalex.org/works/W2005302551.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1485297825","https://openalex.org/W1968004900","https://openalex.org/W1969637387","https://openalex.org/W1972080672","https://openalex.org/W1974460908","https://openalex.org/W1975832881","https://openalex.org/W1978263877","https://openalex.org/W1979201146","https://openalex.org/W1979482249","https://openalex.org/W1981728824","https://openalex.org/W1984638411","https://openalex.org/W1988252217","https://openalex.org/W1990708583","https://openalex.org/W1993480617","https://openalex.org/W2025511475","https://openalex.org/W2029205502","https://openalex.org/W2031790758","https://openalex.org/W2036346731","https://openalex.org/W2036626782","https://openalex.org/W2046752189","https://openalex.org/W2061131331","https://openalex.org/W2061436416","https://openalex.org/W2062422342","https://openalex.org/W2065368005","https://openalex.org/W2073308483","https://openalex.org/W2078502414","https://openalex.org/W2079010149","https://openalex.org/W2083375033","https://openalex.org/W2085642554","https://openalex.org/W2093649371","https://openalex.org/W2093716452","https://openalex.org/W2095201918","https://openalex.org/W2106115106","https://openalex.org/W2108629058","https://openalex.org/W2112045725","https://openalex.org/W2120740717","https://openalex.org/W2122496105","https://openalex.org/W2132320808","https://openalex.org/W2143695671","https://openalex.org/W2146712305","https://openalex.org/W2150388442","https://openalex.org/W2150832037","https://openalex.org/W2158003732","https://openalex.org/W4238996218"],"related_works":["https://openalex.org/W2022545119","https://openalex.org/W2259800837","https://openalex.org/W1994675145","https://openalex.org/W1972080672","https://openalex.org/W4288471547","https://openalex.org/W2112045725","https://openalex.org/W2075094914","https://openalex.org/W2073308483","https://openalex.org/W7154505252","https://openalex.org/W2132186237"],"abstract_inverted_index":{"Nicotinic":[0],"acid":[1],"adenine":[2],"dinucleotide":[3],"phosphate":[4],"(NAADP)":[5],"is":[6,42,147,163],"a":[7,194],"potent":[8],"second":[9],"messenger":[10],"that":[11,145],"mobilizes":[12],"Ca(2+)":[13,83,187,200,214],"from":[14,128],"the":[15,21,46,79,113,118,136,139,152,169],"acidic":[16,69],"endolysosomes":[17],"by":[18,64,149,159,176,185,189],"activation":[19,156],"of":[20,30,90,101,112,157,172,182,207],"two-pore":[22],"channels":[23,61],"TPC1":[24,32,51,60,66,85,93,146,158,173,183,208],"and":[25,38,58,72,105,138,142,188,216],"TPC2.":[26],"The":[27,56,179],"channel":[28],"properties":[29,206],"human":[31],"have":[33],"not":[34,43,164],"been":[35],"studied":[36],"before,":[37],"its":[39,160,211],"cellular":[40],"function":[41],"known.":[44],"In":[45],"present":[47],"study,":[48],"we":[49],"characterized":[50],"incorporated":[52],"into":[53],"lipid":[54],"bilayers.":[55],"native":[57],"recombinant":[59],"are":[62],"activated":[63],"NAADP.":[65],"activity":[67,184],"requires":[68],"luminal":[70,74,82,186],"pH":[71],"high":[73],"Ca(2+).":[75],"With":[76],"Ba(2+)":[77],"as":[78],"permeable":[80],"ion,":[81],"activates":[84],"with":[86],"an":[87],"apparent":[88,153,170],"K(m)":[89],"180":[91],"\u03bcm.":[92],"operates":[94],"in":[95,125,213],"two":[96],"tightly":[97],"coupled":[98],"conductance":[99,115,120],"states":[100],"47":[102],"\u00b1":[103,107],"8":[104],"200":[106],"9":[108],"picosiemens.":[109],"Importantly,":[110],"opening":[111],"large":[114,140],"markedly":[116],"increases":[117,168],"small":[119,137],"mean":[121],"open":[122],"time.":[123],"Changes":[124],"membrane":[126,190],"potential":[127,191,195],"0":[129],"to":[130,197,209],"-60":[131],"mV":[132],"increased":[133],"linearly":[134],"both":[135],"conductances":[141],"NP(o),":[143],"indicating":[144],"regulated":[148],"voltage.":[150],"Intriguingly,":[151],"affinity":[154,171],"for":[155,174],"ligand":[161],"NAADP":[162,175],"constant.":[165],"Rather,":[166],"hyperpolarization":[167],"10":[177],"nm/mV.":[178],"concerted":[180],"regulation":[181],"thus":[192],"provides":[193],"mechanism":[196],"explain":[198,210],"NAADP-induced":[199],"oscillations.":[201],"These":[202],"findings":[203],"reveal":[204],"unique":[205],"role":[212],"oscillations":[215],"cell":[217],"function.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
