{"id":"https://openalex.org/W2005298869","doi":"https://doi.org/10.1055/s-2001-11513","title":"Modulatory Effect of Aliphatic Acid Amides from Zanthoxylum piperitum on Isolated Gastrointestinal Tract","display_name":"Modulatory Effect of Aliphatic Acid Amides from Zanthoxylum piperitum on Isolated Gastrointestinal Tract","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2005298869","doi":"https://doi.org/10.1055/s-2001-11513","mag":"2005298869","pmid":"https://pubmed.ncbi.nlm.nih.gov/11301873"},"language":"en","primary_location":{"id":"doi:10.1055/s-2001-11513","doi":"https://doi.org/10.1055/s-2001-11513","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2001-11513","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kazunori Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127889","display_name":"Tsumura (Japan)","ror":"https://ror.org/02r19bt50","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210127889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Hashimoto","raw_affiliation_strings":["Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan","institution_ids":["https://openalex.org/I4210127889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111412898","display_name":"Kazuko Satoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuko Satoh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088840185","display_name":"Yoshio Kase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127889","display_name":"Tsumura (Japan)","ror":"https://ror.org/02r19bt50","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210127889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Kase","raw_affiliation_strings":["Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan","institution_ids":["https://openalex.org/I4210127889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001163839","display_name":"Atsushi Ishige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127889","display_name":"Tsumura (Japan)","ror":"https://ror.org/02r19bt50","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210127889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Ishige","raw_affiliation_strings":["Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan","institution_ids":["https://openalex.org/I4210127889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081725935","display_name":"Masayoshi Kubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127889","display_name":"Tsumura (Japan)","ror":"https://ror.org/02r19bt50","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210127889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayoshi Kubo","raw_affiliation_strings":["Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan","institution_ids":["https://openalex.org/I4210127889"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroshi Sasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127889","display_name":"Tsumura (Japan)","ror":"https://ror.org/02r19bt50","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210127889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Sasaki","raw_affiliation_strings":["Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan","institution_ids":["https://openalex.org/I4210127889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018838856","display_name":"Shigeto Nishikawa","orcid":"https://orcid.org/0000-0003-4485-2179","observed_orcids":["https://orcid.org/0000-0003-4485-2179"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeto Nishikawa","raw_affiliation_strings":["The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005231642","display_name":"Susumu Kurosawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu Kurosawa","raw_affiliation_strings":["The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050203519","display_name":"Koji Yakabi","orcid":"https://orcid.org/0000-0002-9917-5542","observed_orcids":["https://orcid.org/0000-0002-9917-5542"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Yakabi","raw_affiliation_strings":["The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103015927","display_name":"Takashi Nakamura","orcid":"https://orcid.org/0000-0001-9904-1037","observed_orcids":["https://orcid.org/0000-0001-9904-1037"]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nakamura","raw_affiliation_strings":["The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Teikyo University, School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2775,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.93576569,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"67","issue":"2","first_page":"179","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.20999999344348907,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.20999999344348907,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.15539999306201935,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.10140000283718109,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zanthoxylum-piperitum","display_name":"Zanthoxylum piperitum","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.703000009059906},{"id":"https://openalex.org/keywords/gastric-smooth-muscle-relaxation","display_name":"gastric smooth muscle relaxation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/ileal-smooth-muscle-contraction","display_name":"ileal smooth muscle contraction","score":0.8799999952316284},{"id":"https://openalex.org/keywords/colonic-smooth-muscle-contraction","display_name":"colonic smooth muscle contraction","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pericarp","display_name":"pericarp","score":0.5709999799728394},{"id":"https://openalex.org/keywords/rutaceae","display_name":"Rutaceae","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C2779296160","wikidata":"https://www.wikidata.org/wiki/Q147050","display_name":"Zanthoxylum","level":2,"score":0.7766904830932617},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.6878141164779663},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.6467663645744324},{"id":"https://openalex.org/C2781353486","wikidata":"https://www.wikidata.org/wiki/Q146030","display_name":"Rutaceae","level":2,"score":0.5990580320358276},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5908997654914856},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.39451849460601807},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3572050631046295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3221122920513153},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29044559597969055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23374173045158386},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.1841447353363037}],"mesh":[{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2001-11513","doi":"https://doi.org/10.1055/s-2001-11513","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2001-11513","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},{"id":"pmid:11301873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11301873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta medica","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2376770840","https://openalex.org/W2781662252","https://openalex.org/W7204107117","https://openalex.org/W2998026189","https://openalex.org/W2413143743","https://openalex.org/W3104428034","https://openalex.org/W3137124384","https://openalex.org/W2181864191","https://openalex.org/W2791247036","https://openalex.org/W2963705404"],"abstract_inverted_index":{"beta-Sanshool":[0],"and":[1,35],"gamma-sanshool,":[2],"unsaturated":[3],"aliphatic":[4],"acid":[5],"amides":[6],"isolated":[7,46],"from":[8,47],"the":[9,18,22,29,33,43],"pericarpium":[10],"of":[11,21,32],"Zanthoxylum":[12],"piperitum":[13],"De":[14],"Candolle":[15],"(Rutaceae),":[16],"relax":[17],"circular":[19],"muscle":[20,31],"gastric":[23],"body,":[24],"as":[25,27],"well":[26],"contract":[28],"longitudinal":[30],"ileum":[34],"distal":[36],"colon":[37],"in":[38],"an":[39],"experimental":[40],"system":[41],"using":[42],"gastrointestinal":[44],"tract":[45],"a":[48],"guinea":[49],"pig.":[50]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}