{"id":"https://openalex.org/W2005297494","doi":"https://doi.org/10.1016/j.clim.2009.07.001","title":"Depletion of B lymphocytes in rheumatoid arthritis patients modifies IL-8-anti-IL-8 autoantibody network","display_name":"Depletion of B lymphocytes in rheumatoid arthritis patients modifies IL-8-anti-IL-8 autoantibody network","publication_year":2009,"publication_date":"2009-07-26","ids":{"openalex":"https://openalex.org/W2005297494","doi":"https://doi.org/10.1016/j.clim.2009.07.001","mag":"2005297494","pmid":"https://pubmed.ncbi.nlm.nih.gov/19632157"},"language":"en","primary_location":{"id":"doi:10.1016/j.clim.2009.07.001","doi":"https://doi.org/10.1016/j.clim.2009.07.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2009.07.001","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052010770","display_name":"Keren Zohar","orcid":"https://orcid.org/0009-0006-0407-9969","observed_orcids":["https://orcid.org/0009-0006-0407-9969"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Zohar Keren","raw_affiliation_strings":["Technion, Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technion, Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070813771","display_name":"Yolanda Braun\u2010Moscovici","orcid":"https://orcid.org/0000-0001-7706-9346","observed_orcids":["https://orcid.org/0000-0001-7706-9346"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yolanda Braun-Moscovici","raw_affiliation_strings":["The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006348084","display_name":"Doron Markovits","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Doron Markovits","raw_affiliation_strings":["The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030157131","display_name":"Alexander P. Rozin","orcid":"https://orcid.org/0000-0002-1220-8488","observed_orcids":["https://orcid.org/0000-0002-1220-8488"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alexander Rozin","raw_affiliation_strings":["The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111921007","display_name":"Menahem A. Nahir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Menahem Nahir","raw_affiliation_strings":["Technion, Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel","The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technion, Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017010569","display_name":"Alexandra Balbir\u2010Gurman","orcid":"https://orcid.org/0000-0003-4694-6099","observed_orcids":["https://orcid.org/0000-0003-4694-6099"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alexandra Balbir-Gurman","raw_affiliation_strings":["The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The B. Shine Department of Rheumatology, Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029405421","display_name":"Doron Melamed","orcid":"https://orcid.org/0009-0004-6032-6499","observed_orcids":["https://orcid.org/0009-0004-6032-6499"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Doron Melamed","raw_affiliation_strings":["Technion, Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technion, Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029405421"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.9434,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.76104318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"133","issue":"1","first_page":"108","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/b-cell-depletion-therapy","display_name":"B-cell depletion therapy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":1.0},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.871999979019165},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cytokine-autoantibodies","display_name":"cytokine autoantibodies","score":0.7829999923706055},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.9490000009536743},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8195047378540039},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.8117787837982178},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7218619585037231},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.7007229924201965},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6792391538619995},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6371326446533203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6170415282249451},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5602136254310608},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5076316595077515},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.49823474884033203},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.22826936841011047}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013582","descriptor_name":"Synovial Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D058846","descriptor_name":"Antibodies, Monoclonal, Murine-Derived","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.clim.2009.07.001","doi":"https://doi.org/10.1016/j.clim.2009.07.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2009.07.001","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:19632157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19632157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical immunology (Orlando, Fla.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W112367184","https://openalex.org/W134539962","https://openalex.org/W1547450219","https://openalex.org/W1575529010","https://openalex.org/W1760630901","https://openalex.org/W1968889356","https://openalex.org/W1977206110","https://openalex.org/W1987692041","https://openalex.org/W1996584569","https://openalex.org/W1997452174","https://openalex.org/W2001711326","https://openalex.org/W2011520765","https://openalex.org/W2023819715","https://openalex.org/W2024644107","https://openalex.org/W2053669192","https://openalex.org/W2054200797","https://openalex.org/W2061381932","https://openalex.org/W2064593825","https://openalex.org/W2077939324","https://openalex.org/W2085486259","https://openalex.org/W2101840353","https://openalex.org/W2108787411","https://openalex.org/W2116210034","https://openalex.org/W2118994799","https://openalex.org/W2125038143","https://openalex.org/W2134714663","https://openalex.org/W2136060817","https://openalex.org/W2141111992","https://openalex.org/W2152808869","https://openalex.org/W2314052274","https://openalex.org/W2319957449","https://openalex.org/W2395395639","https://openalex.org/W2411719742","https://openalex.org/W2795449522"],"related_works":["https://openalex.org/W2122507029","https://openalex.org/W2299452718","https://openalex.org/W7220538966","https://openalex.org/W2108787411","https://openalex.org/W2885646147","https://openalex.org/W2034157604","https://openalex.org/W4237273913","https://openalex.org/W2126618201","https://openalex.org/W3206144656","https://openalex.org/W2103598175"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}