{"id":"https://openalex.org/W2005294922","doi":"https://doi.org/10.1007/bf01172876","title":"Inhibition of epidermal growth factor binding to Swiss 3T3 cells by human platelet release-products","display_name":"Inhibition of epidermal growth factor binding to Swiss 3T3 cells by human platelet release-products","publication_year":1983,"publication_date":"1983-07-01","ids":{"openalex":"https://openalex.org/W2005294922","doi":"https://doi.org/10.1007/bf01172876","mag":"2005294922","pmid":"https://pubmed.ncbi.nlm.nih.gov/6313091"},"language":"en","primary_location":{"id":"doi:10.1007/bf01172876","doi":"https://doi.org/10.1007/bf01172876","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01172876","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109214321","display_name":"Kenneth D. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth D. Brown","raw_affiliation_strings":["ARC Institute of Animal Physiology, Babraham, Cambridge CB2 4AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARC Institute of Animal Physiology, Babraham, Cambridge CB2 4AT, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111757736","display_name":"Diane M. Blakeley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diane M. Blakeley","raw_affiliation_strings":["ARC Institute of Animal Physiology, Babraham, Cambridge CB2 4AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARC Institute of Animal Physiology, Babraham, Cambridge CB2 4AT, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037330302","display_name":"Moira MacDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88981905","display_name":"Scottish National Blood Transfusion Service","ror":"https://ror.org/05ydk8712","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I88981905"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Moira MacDonald","raw_affiliation_strings":["Headquarters Laboratory, Scottish National Blood Transfusion Service, 2 Forrest Road, Edinburgh EH1 2QN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headquarters Laboratory, Scottish National Blood Transfusion Service, 2 Forrest Road, Edinburgh EH1 2QN, UK","institution_ids":["https://openalex.org/I88981905"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037330302"],"corresponding_institution_ids":["https://openalex.org/I88981905"],"apc_list":{"value":1960,"currency":"USD","value_usd":1960},"apc_paid":null,"fwci":2.3142,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.88459129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"7","first_page":"659","last_page":"666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.7950000166893005},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/receptor-downregulation","display_name":"receptor down-regulation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/swiss-3t3-cells","display_name":"Swiss 3T3 cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.8722939491271973},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.7905374765396118},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7461154460906982},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.6309281587600708},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.6276240348815918},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5548848509788513},{"id":"https://openalex.org/C2776746612","wikidata":"https://www.wikidata.org/wiki/Q68153243","display_name":"3T3 cells","level":4,"score":0.5031401515007019},{"id":"https://openalex.org/C2779014961","wikidata":"https://www.wikidata.org/wiki/Q415168","display_name":"Ionophore","level":3,"score":0.46091228723526},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.4559744596481323},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.42980003356933594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4214509129524231},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.41094881296157837},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3880021274089813},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3518869876861572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32009029388427734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3110171854496002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05481180548667908},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.05052274465560913},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.040449053049087524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01172876","doi":"https://doi.org/10.1007/bf01172876","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01172876","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},{"id":"pmid:6313091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6313091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1464779590","https://openalex.org/W1498071142","https://openalex.org/W1519494647","https://openalex.org/W1525062255","https://openalex.org/W1543283875","https://openalex.org/W1969702279","https://openalex.org/W1972012253","https://openalex.org/W1972811633","https://openalex.org/W1978868657","https://openalex.org/W1988681657","https://openalex.org/W1990366861","https://openalex.org/W2039281296","https://openalex.org/W2072054054","https://openalex.org/W2088046252","https://openalex.org/W2396332006"],"related_works":["https://openalex.org/W1601327747","https://openalex.org/W2086714902","https://openalex.org/W7098938949","https://openalex.org/W2303695898","https://openalex.org/W2088046252","https://openalex.org/W1525062255","https://openalex.org/W1563405664","https://openalex.org/W2040883652","https://openalex.org/W2889073982","https://openalex.org/W1998049117"],"abstract_inverted_index":{"Human":[0],"platelet":[1],"ionophore":[2],"release-products":[3],"(IRP)":[4],"inhibit":[5],"the":[6,33,41,71],"binding":[7,76],"of":[8,44,74,95],"125I-labelled":[9],"epidermal":[10],"growth":[11,29],"factor":[12,30],"(125I-EGF)":[13],"to":[14,24,59],"its":[15],"receptors":[16,46,84,88],"on":[17],"Swiss":[18],"3T3":[19],"cells.":[20],"The":[21],"inhibition":[22,73,94],"appears":[23],"be":[25],"caused":[26],"by":[27],"platelet-derived":[28],"(PDGF)":[31],"in":[32,40],"IRP":[34],"and":[35],"results":[36,51],"from":[37],"a":[38,92],"decrease":[39],"apparent":[42],"affinity":[43],"cellular":[45],"for":[47],"125I-EGF.":[48],"However,":[49],"our":[50],"indicate":[52],"that":[53],"PDGF":[54,64,87],"does":[55,65],"not":[56,66,90],"bind":[57],"directly":[58],"EGF":[60,68,83],"receptors,":[61],"since":[62],"(1)":[63],"down-regulate":[67],"receptors;":[69],"(2)":[70],"PDGF-mediated":[72,93],"125I-EGF":[75,96],"is":[77],"temperature-dependent;":[78],"(3)":[79],"cells":[80],"which":[81],"possess":[82],"but":[85],"lack":[86],"do":[89],"exhibit":[91],"binding.":[97]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
