{"id":"https://openalex.org/W2005294321","doi":"https://doi.org/10.1093/infdis/jiv128","title":"The Fall of a Dogma? Unexpected High T-Cell Memory Response toStaphylococcus aureusin Humans","display_name":"The Fall of a Dogma? Unexpected High T-Cell Memory Response toStaphylococcus aureusin Humans","publication_year":2015,"publication_date":"2015-03-03","ids":{"openalex":"https://openalex.org/W2005294321","doi":"https://doi.org/10.1093/infdis/jiv128","mag":"2005294321","pmid":"https://pubmed.ncbi.nlm.nih.gov/25737563"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiv128","doi":"https://doi.org/10.1093/infdis/jiv128","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiv128","pdf_url":"https://academic.oup.com/jid/article-pdf/212/5/830/13807075/jiv128.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jid/article-pdf/212/5/830/13807075/jiv128.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066513351","display_name":"Julia Kolata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Julia B. Kolata","raw_affiliation_strings":["Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald","institution_ids":["https://openalex.org/I2799318839","https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055774725","display_name":"Iris K\u00fchbandner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Iris K\u00fchbandner","raw_affiliation_strings":["Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald","institution_ids":["https://openalex.org/I2799318839","https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109108043","display_name":"Christopher Link","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christopher Link","raw_affiliation_strings":["Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald","institution_ids":["https://openalex.org/I2799318839","https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012561942","display_name":"Nicole Normann","orcid":"https://orcid.org/0000-0001-6267-6450","observed_orcids":["https://orcid.org/0000-0001-6267-6450"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Normann","raw_affiliation_strings":["Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald","institution_ids":["https://openalex.org/I2799318839","https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051331307","display_name":"Chi Hai Vu","orcid":"https://orcid.org/0000-0003-2232-8536","observed_orcids":["https://orcid.org/0000-0003-2232-8536"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Chi Hai Vu","raw_affiliation_strings":["Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald","institution_ids":["https://openalex.org/I2799318839","https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022720360","display_name":"Leif Steil","orcid":"https://orcid.org/0000-0002-0733-8421","observed_orcids":["https://orcid.org/0000-0002-0733-8421"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leif Steil","raw_affiliation_strings":["Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030667206","display_name":"Christopher Weidenmaier","orcid":"https://orcid.org/0000-0003-4107-739X","observed_orcids":["https://orcid.org/0000-0003-4107-739X"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christopher Weidenmaier","raw_affiliation_strings":["Interfaculty Institute for Microbiology and Infection Medicine T\u00fcbingen, Eberhard-Karls-University, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interfaculty Institute for Microbiology and Infection Medicine T\u00fcbingen, Eberhard-Karls-University, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081073059","display_name":"Barbara M. Br\u00f6ker","orcid":"https://orcid.org/0000-0002-5020-8542","observed_orcids":["https://orcid.org/0000-0002-5020-8542"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Barbara M. Br\u00f6ker","raw_affiliation_strings":["Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Transfusion Medicine, Department of Immunology, University Medicine Greifswald","institution_ids":["https://openalex.org/I2799318839","https://openalex.org/I36522303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066513351"],"corresponding_institution_ids":["https://openalex.org/I2799318839","https://openalex.org/I36522303"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":5.6705,"has_fulltext":true,"cited_by_count":119,"citation_normalized_percentile":{"value":0.96702612,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"212","issue":"5","first_page":"830","last_page":"838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7480000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.2290000021457672,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/t-cell-memory","display_name":"T cell memory","score":0.8830000162124634},{"id":"https://openalex.org/keywords/immunological-memory","display_name":"immunological memory","score":0.7260000109672546},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.6710000038146973},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/th1-th17-cytokines","display_name":"Th1/Th17 cytokines","score":0.8420000076293945},{"id":"https://openalex.org/keywords/vaccine-design","display_name":"vaccine design","score":0.6610000133514404},{"id":"https://openalex.org/keywords/natural-immunity","display_name":"natural immunity","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8812069296836853},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6486860513687134},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6306626796722412},{"id":"https://openalex.org/C2777367678","wikidata":"https://www.wikidata.org/wiki/Q2304808","display_name":"Memory T cell","level":4,"score":0.6276577115058899},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5986201763153076},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5655319094657898},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5372049808502197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5159550309181213},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4171043038368225},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.38823041319847107},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20809027552604675},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.09234759211540222},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/infdis/jiv128","doi":"https://doi.org/10.1093/infdis/jiv128","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiv128","pdf_url":"https://academic.oup.com/jid/article-pdf/212/5/830/13807075/jiv128.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:25737563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25737563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/infdis/jiv128","doi":"https://doi.org/10.1093/infdis/jiv128","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiv128","pdf_url":"https://academic.oup.com/jid/article-pdf/212/5/830/13807075/jiv128.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1526075977","display_name":null,"funder_award_id":"GRK-840","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G936075895","display_name":null,"funder_award_id":"SFB-TR34","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005294321.pdf","grobid_xml":"https://content.openalex.org/works/W2005294321.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1565619760","https://openalex.org/W1768372676","https://openalex.org/W1977484115","https://openalex.org/W1990395781","https://openalex.org/W1990740789","https://openalex.org/W1991323622","https://openalex.org/W1995163064","https://openalex.org/W1995690439","https://openalex.org/W2001885083","https://openalex.org/W2004917278","https://openalex.org/W2005192852","https://openalex.org/W2008588566","https://openalex.org/W2011531123","https://openalex.org/W2013588352","https://openalex.org/W2015114099","https://openalex.org/W2033192925","https://openalex.org/W2035158221","https://openalex.org/W2039607959","https://openalex.org/W2040052393","https://openalex.org/W2041309650","https://openalex.org/W2049478058","https://openalex.org/W2052831663","https://openalex.org/W2057910559","https://openalex.org/W2059674129","https://openalex.org/W2078504495","https://openalex.org/W2078559874","https://openalex.org/W2085207687","https://openalex.org/W2086165685","https://openalex.org/W2087432776","https://openalex.org/W2092239030","https://openalex.org/W2092252407","https://openalex.org/W2100033891","https://openalex.org/W2106141910","https://openalex.org/W2111157195","https://openalex.org/W2116037635","https://openalex.org/W2118302891","https://openalex.org/W2124254554","https://openalex.org/W2138113489","https://openalex.org/W2139294087","https://openalex.org/W2139875170","https://openalex.org/W2141987596","https://openalex.org/W2144288685","https://openalex.org/W2144890743","https://openalex.org/W2145489399","https://openalex.org/W2149132843","https://openalex.org/W2156778552","https://openalex.org/W2165016327","https://openalex.org/W2170107546","https://openalex.org/W2399912942"],"related_works":["https://openalex.org/W2331760418","https://openalex.org/W4281790352","https://openalex.org/W4243501567","https://openalex.org/W276237299","https://openalex.org/W2384305430","https://openalex.org/W2073641733","https://openalex.org/W2342726987","https://openalex.org/W4290404627","https://openalex.org/W4315709065","https://openalex.org/W1914555825"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Though":[1],"Staphylococcus":[2,89],"aureus":[3,19,67,90,118,144,163,175],"is":[4,167],"a":[5,28,105],"major":[6],"pathogen,":[7],"vaccine":[8,180],"trials":[9],"have":[10],"failed.":[11],"In":[12],"contrast,":[13],"class-switched":[14],"antibodies":[15],"specific":[16],"to":[17,65,128,142,169,189],"S.":[18,32,43,66,73,117,122,143,162,174],"are":[20],"common,":[21],"implying":[22],"immune":[23,45],"memory":[24,106,165,187],"formation":[25],"and":[26,69,92],"suggesting":[27],"large":[29,159],"pool":[30,125],"of":[31,42,58,72,100,111,131,161,173],"aureus-reactive":[33],"helper":[34,154],"T-cells.":[35],"OBJECTIVE:":[36],"To":[37,177],"elucidate":[38],"the":[39,47,70,146,171,182],"cellular":[40],"arm":[41],"aureus-specific":[44,74,123],"memory,":[46],"T-cell":[48,124,186],"response":[49,57,107],"in":[50,98],"humans":[51],"was":[52,83,126],"characterized.":[53],"METHODS:":[54],"The":[55,120,158],"proliferative":[56],"human":[59,185],"peripheral":[60],"blood":[61],"mononuclear":[62],"cells":[63],"(PBMCs)":[64],"antigens":[68],"frequency":[71],"T-cells":[75,112,132,147],"were":[76],"quantified":[77],"by":[78,85,115],"(3)H-thymidine":[79],"incorporation;":[80],"cytokine":[81],"release":[82],"measured":[84],"flow":[86],"cytometry.":[87],"RESULTS:":[88],"particles":[91],"extracellular":[93],"proteins":[94],"elicited":[95],"pronounced":[96],"proliferation":[97],"PBMCs":[99],"healthy":[101],"adults.":[102],"This":[103],"reflected":[104],"with":[108,133],"high":[109,193],"frequencies":[110],"being":[113],"activated":[114],"single":[116],"antigens.":[119],"whole":[121],"estimated":[127],"comprise":[129],"3.6%":[130],"35-fold":[134],"differences":[135],"between":[136],"individuals":[137],"(range,":[138],"0.2%-5.7%).":[139],"When":[140],"exposed":[141],"antigens,":[145],"released":[148],"predominantly":[149],"but":[150],"not":[151],"solely":[152],"T":[153],"(Th)1/Th17":[155],"cytokines.":[156],"CONCLUSIONS:":[157],"number":[160],"antigen-reactive":[164],"T-lymphocytes":[166],"likely":[168],"influence":[170],"course":[172],"infection.":[176],"enable":[178],"rational":[179],"design,":[181],"naturally":[183],"acquired":[184],"needs":[188],"be":[190],"explored":[191],"at":[192],"priority.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2016-06-24T00:00:00"}
