{"id":"https://openalex.org/W2005294016","doi":"https://doi.org/10.1128/aac.35.11.2306","title":"Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome","display_name":"Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W2005294016","doi":"https://doi.org/10.1128/aac.35.11.2306","mag":"2005294016","pmid":"https://pubmed.ncbi.nlm.nih.gov/1725100"},"language":"en","primary_location":{"id":"doi:10.1128/aac.35.11.2306","doi":"https://doi.org/10.1128/aac.35.11.2306","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.35.11.2306","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/245376","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110103792","display_name":"B A Rasmussen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Rasmussen","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110193624","display_name":"H F Noller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H F Noller","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035635875","display_name":"Gary Daubresse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Daubresse","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080921801","display_name":"Brunello Oliva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Oliva","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062234987","display_name":"Ziva Misulovin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Misulovin","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"D M Rothstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M Rothstein","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025925692","display_name":"George A. Ellestad","orcid":"https://orcid.org/0000-0002-4468-397X","observed_orcids":["https://orcid.org/0000-0002-4468-397X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G A Ellestad","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109192843","display_name":"Y Gluzman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Gluzman","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111642979","display_name":"Francis P. Tally","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F P Tally","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114012886","display_name":"I. Chopra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Chopra","raw_affiliation_strings":["Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease/Molecular Biology Research Section, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3886,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.80677186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"35","issue":"11","first_page":"2306","last_page":"2311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.5073000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.39430001378059387,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetracycline-analogs","display_name":"tetracycline analogs","score":0.8790000081062317},{"id":"https://openalex.org/keywords/antibiotic-mechanism-of-action","display_name":"antibiotic mechanism of action","score":0.734000027179718},{"id":"https://openalex.org/keywords/ribosome-binding","display_name":"ribosome binding","score":0.6159999966621399},{"id":"https://openalex.org/keywords/16s-rrna","display_name":"16S rRNA","score":0.8619999885559082},{"id":"https://openalex.org/keywords/anhydrotetracycline","display_name":"anhydrotetracycline","score":0.8989999890327454},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.6650000214576721},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.7443228960037231},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.5830904245376587},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.5765717625617981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5154493451118469},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5120111107826233},{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.5020079612731934},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4695760905742645},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.4648427367210388},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.4388643503189087},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.40286073088645935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37168169021606445},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2680923342704773},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1653270125389099},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13481202721595764},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005696","descriptor_name":"Galactosidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005696","descriptor_name":"Galactosidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005696","descriptor_name":"Galactosidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008566","descriptor_name":"Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013754","descriptor_name":"Tetracyclines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.35.11.2306","doi":"https://doi.org/10.1128/aac.35.11.2306","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.35.11.2306","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:1725100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1725100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:18318","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC245376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:245376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/245376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:245376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/245376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/1","display_name":"No poverty","score":0.6299999952316284}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1486369891","https://openalex.org/W1546783991","https://openalex.org/W1745892296","https://openalex.org/W1818316430","https://openalex.org/W1838789895","https://openalex.org/W2018429609","https://openalex.org/W2026358434","https://openalex.org/W2042814467","https://openalex.org/W2053328600","https://openalex.org/W2056495121","https://openalex.org/W2060657665","https://openalex.org/W2092541352","https://openalex.org/W2100329115","https://openalex.org/W2174331966","https://openalex.org/W2230785030","https://openalex.org/W2413245171"],"related_works":["https://openalex.org/W2411786503","https://openalex.org/W1985435370","https://openalex.org/W2059063383","https://openalex.org/W163195836","https://openalex.org/W2470961128","https://openalex.org/W1964880459","https://openalex.org/W2472109262","https://openalex.org/W2023273456","https://openalex.org/W4250625136","https://openalex.org/W1886368312"],"abstract_inverted_index":{"Tetracycline":[0],"analogs":[1,36,118,165,183],"fell":[2],"into":[3,71],"two":[4],"classes":[5],"on":[6,151],"the":[7,59,65,94,108,112,114,125,152,167],"basis":[8],"of":[9,12,35,58,69,87,107,116,132,136,155,169],"their":[10,129,149],"mode":[11,86],"action.":[13,133],"Tetracycline,":[14],"chlortetracycline,":[15],"minocycline,":[16],"doxycycline,":[17],"and":[18,43,73,139,186,189],"6-demethyl-6-deoxytetracycline":[19],"inhibited":[20,64],"cell-free":[21],"translation":[22],"directed":[23],"by":[24,147],"either":[25],"Escherichia":[26],"coli":[27],"or":[28,52],"Bacillus":[29],"subtilis":[30],"extracts.":[31],"A":[32],"second":[33,60,109],"class":[34,80,95,110,137,140,177],"tested,":[37],"including":[38],"chelocardin,":[39],"anhydrotetracycline,":[40],"6-thiatetracycline,":[41],"anhydrochlortetracycline,":[42],"4-epi-anhydrochlortetracycline,":[44],"failed":[45],"to":[46,119,160,171],"inhibit":[47,120],"protein":[48],"synthesis":[49,122],"in":[50,66,157],"vitro":[51],"were":[53],"very":[54],"poor":[55],"inhibitors.":[56],"Tetracyclines":[57],"class,":[61],"however,":[62],"rapidly":[63],"vivo":[67],"incorporation":[68],"precursors":[70],"DNA":[72],"RNA":[74],"as":[75,77,99],"well":[76],"protein.":[78],"The":[79,134,174],"2":[81,141,178],"compounds":[82],"therefore":[83],"have":[84],"a":[85],"action":[88],"that":[89,101,124],"is":[90,128],"entirely":[91],"distinct":[92],"from":[93],"1":[96,138,164],"compounds,":[97],"such":[98],"tetracycline":[100],"are":[102],"used":[103],"clinically.":[104],"Although":[105],"tetracyclines":[106,142,179],"entered":[111],"cytoplasm,":[113],"ability":[115],"these":[117],"macromolecular":[121],"suggests":[123],"cytoplasmic":[126],"membrane":[127],"primary":[130],"site":[131],"interaction":[135],"with":[143,176,181],"ribosomes":[144],"was":[145],"studied":[146],"examining":[148],"effects":[150],"chemical":[153],"reactivity":[154,168,185],"bases":[156,170],"16S":[158],"rRNA":[159],"dimethyl":[161,172],"sulfate.":[162,173],"Class":[163],"affected":[166],"response":[175],"varied,":[180],"some":[182],"affecting":[184],"others":[187],"(chelocardin":[188],"4-epi-anhydrotetracycline)":[190],"not.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
