{"id":"https://openalex.org/W2005293946","doi":"https://doi.org/10.1111/j.1474-9726.2009.00502.x","title":"Aging\u2010dependent upregulation of IL\u201023p19 gene expression in dendritic cells is associated with differential transcription factor binding and histone modifications","display_name":"Aging\u2010dependent upregulation of IL\u201023p19 gene expression in dendritic cells is associated with differential transcription factor binding and histone modifications","publication_year":2009,"publication_date":"2009-07-14","ids":{"openalex":"https://openalex.org/W2005293946","doi":"https://doi.org/10.1111/j.1474-9726.2009.00502.x","mag":"2005293946","pmid":"https://pubmed.ncbi.nlm.nih.gov/19624579"},"language":"en","primary_location":{"id":"doi:10.1111/j.1474-9726.2009.00502.x","doi":"https://doi.org/10.1111/j.1474-9726.2009.00502.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2009.00502.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2009.00502.x","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2009.00502.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110093541","display_name":"Rabab Elmezayen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rabab El Mezayen","raw_affiliation_strings":["Section of Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. relmezay@wfubmc.edu","Section of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. relmezay@wfubmc.edu","institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Section of Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110208170","display_name":"Mohamed El Gazzar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed El Gazzar","raw_affiliation_strings":["Section of Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076506166","display_name":"Rebecca G. Myer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca Myer","raw_affiliation_strings":["Section of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infectious Diseases","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035175377","display_name":"Kevin P. High","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin P. High","raw_affiliation_strings":["Section of Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Infectious Diseases","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110093541"],"corresponding_institution_ids":["https://openalex.org/I1282516798","https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":2.2911,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.87902727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"553","last_page":"565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.2215999960899353,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.2215999960899353,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.19300000369548798,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.17910000681877136,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-23p19","display_name":"IL-23p19","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8880000114440918},{"id":"https://openalex.org/keywords/c-rel","display_name":"c-Rel","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.9909999966621399},{"id":"https://openalex.org/keywords/histone-h3k4-methylation","display_name":"histone H3 lysine 4 methylation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.7639999985694885},{"id":"https://openalex.org/keywords/transcription-factor-binding","display_name":"transcription factor binding","score":0.7789999842643738},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/il-12p40","display_name":"IL-12p40","score":0.875},{"id":"https://openalex.org/keywords/age-associated-inflammation","display_name":"age-associated inflammation","score":0.5180000066757202},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7465647459030151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7400890588760376},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5885060429573059},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5216560363769531},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5197467803955078},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4702284038066864},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4286540150642395},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4220065474510193},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4217890501022339},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4128198027610779},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2657323479652405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1126815676689148}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020569","descriptor_name":"Proto-Oncogene Proteins c-rel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020569","descriptor_name":"Proto-Oncogene Proteins c-rel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020569","descriptor_name":"Proto-Oncogene Proteins c-rel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053760","descriptor_name":"Interleukin-23 Subunit p19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053760","descriptor_name":"Interleukin-23 Subunit p19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053760","descriptor_name":"Interleukin-23 Subunit p19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053760","descriptor_name":"Interleukin-23 Subunit p19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053760","descriptor_name":"Interleukin-23 Subunit p19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053760","descriptor_name":"Interleukin-23 Subunit p19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1474-9726.2009.00502.x","doi":"https://doi.org/10.1111/j.1474-9726.2009.00502.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2009.00502.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2009.00502.x","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmid:19624579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19624579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2687271","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3693943","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3693943","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3693943","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aging Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1474-9726.2009.00502.x","doi":"https://doi.org/10.1111/j.1474-9726.2009.00502.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2009.00502.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9726.2009.00502.x","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7599999904632568,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3891426691","display_name":null,"funder_award_id":"AI057952","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8323603393","display_name":null,"funder_award_id":"R21 AI057952","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005293946.pdf","grobid_xml":"https://content.openalex.org/works/W2005293946.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1545719335","https://openalex.org/W1575516231","https://openalex.org/W1578776025","https://openalex.org/W1579961340","https://openalex.org/W1583940016","https://openalex.org/W1756169576","https://openalex.org/W1868478050","https://openalex.org/W1885912605","https://openalex.org/W1904705252","https://openalex.org/W1918221273","https://openalex.org/W1936409022","https://openalex.org/W1968687456","https://openalex.org/W1984155824","https://openalex.org/W1985364817","https://openalex.org/W1987631879","https://openalex.org/W1991718508","https://openalex.org/W1994963996","https://openalex.org/W1996948576","https://openalex.org/W2001750225","https://openalex.org/W2002797826","https://openalex.org/W2004335766","https://openalex.org/W2006249161","https://openalex.org/W2014503303","https://openalex.org/W2022936129","https://openalex.org/W2023999210","https://openalex.org/W2027588033","https://openalex.org/W2029223147","https://openalex.org/W2032736838","https://openalex.org/W2035027025","https://openalex.org/W2045357708","https://openalex.org/W2049118388","https://openalex.org/W2049372707","https://openalex.org/W2049868369","https://openalex.org/W2055593542","https://openalex.org/W2061867473","https://openalex.org/W2061937637","https://openalex.org/W2067487392","https://openalex.org/W2070359888","https://openalex.org/W2072769860","https://openalex.org/W2074067501","https://openalex.org/W2076889715","https://openalex.org/W2077468629","https://openalex.org/W2085924636","https://openalex.org/W2091695331","https://openalex.org/W2095148075","https://openalex.org/W2096083625","https://openalex.org/W2096589599","https://openalex.org/W2096707410","https://openalex.org/W2097544920","https://openalex.org/W2106117017","https://openalex.org/W2106877484","https://openalex.org/W2109467381","https://openalex.org/W2116828514","https://openalex.org/W2120492945","https://openalex.org/W2120594989","https://openalex.org/W2121158501","https://openalex.org/W2125751034","https://openalex.org/W2127532387","https://openalex.org/W2132619798","https://openalex.org/W2133452708","https://openalex.org/W2133982451","https://openalex.org/W2144806790","https://openalex.org/W2146336227","https://openalex.org/W2150195134","https://openalex.org/W2151892297","https://openalex.org/W2153840275","https://openalex.org/W2162007651","https://openalex.org/W2166781237","https://openalex.org/W2170068902"],"related_works":["https://openalex.org/W3103789129","https://openalex.org/W4213065871","https://openalex.org/W4386799875","https://openalex.org/W3157667906","https://openalex.org/W4361818220","https://openalex.org/W3048105303","https://openalex.org/W2904239912","https://openalex.org/W4247833810","https://openalex.org/W4242240318","https://openalex.org/W3127487613"],"abstract_inverted_index":{"Age-associated":[0],"changes":[1,251],"in":[2,15,45,95,121,124,171,199,208,214,221,252,265,282],"immune":[3],"response":[4],"increase":[5,120],"the":[6,25,57,63,119,146,152,212,218,227,234,261,270,273],"risk":[7],"of":[8,29,50,56,112,137,142,272],"infection":[9],"and":[10,13,27,52,69,87,135,140,159,164,196,243,255,257,267,277,288,295],"promote":[11,33],"inflammation":[12],"autoimmunity":[14],"older":[16],"adults.":[17],"The":[18],"newly":[19],"discovered":[20],"cytokine":[21],"IL-23":[22,48,84,278],"contributes":[23],"to":[24,202,205,226,233,269,292],"maintenance":[26],"expansion":[28],"Th-17":[30,41],"cells,":[31],"which":[32],"proinflammatory":[34],"responses.":[35],"Our":[36,246],"preliminary":[37],"findings":[38],"suggested":[39],"that":[40,83,118,181,249],"responses":[42,297],"are":[43,92],"increased":[44,94],"aged":[46,98,125,172,283],"mice.":[47,115,284],"consists":[49],"p40":[51],"p19":[53,58,88,122,147,178,186,197,219,228,262,274],"subunits.":[54],"Expression":[55],"subunit":[59,89,275],"is":[60,127,154,183],"regulated":[61],"at":[62,145,157,217,260],"transcriptional":[64,289],"level":[65],"by":[66,133,161],"NF-kappaB":[67],"p65":[68,163,169,190,215,231,258],"c-Rel":[70,144,182,194,256],"transcription":[71],"factors.":[72],"Using":[73],"bone-marrow-derived":[74],"dendritic":[75],"cells":[76,126,173],"(DCs)":[77],"from":[78,97],"C57BL/6":[79],"mice,":[80],"we":[81],"show":[82],"protein":[85,279],"production":[86,280],"mRNA":[90],"levels":[91,203],"significantly":[93,192,239],"DCs":[96,111,201,223,266],"mice":[99],"after":[100],"activation":[101],"with":[102,110,129,299],"TLR":[103],"ligands":[104],"(LPS":[105],"+":[106],"R848)":[107],"when":[108],"compared":[109],"young":[113,150,200,244],"adult":[114],"We":[116],"found":[117],"expression":[123,198,276],"associated":[128,298],"chromatin":[130],"remodeling":[131],"characterized":[132],"di-":[134],"tri-methylation":[136],"histone":[138],"H3K4":[139,158,253],"binding":[141,170,195,216,232,259],"mainly":[143],"promoter.":[148],"In":[149,188],"DCs,":[151],"promoter":[153,220,236,263],"tri-methylated":[155],"only":[156],"bound":[160],"both":[162],"c-Rel.":[165],"C-Rel":[166],"knockdown":[167,191],"restores":[168],"but":[174],"does":[175],"not":[176,238],"activate":[177],"expression,":[179],"suggesting":[180],"critical":[184],"for":[185],"expression.":[187],"addition,":[189],"increases":[193],"close":[204],"those":[206],"detected":[207],"old":[209,222,242],"cells.":[210],"Furthermore,":[211],"decrease":[213],"was":[224,237],"specific":[225],"gene":[229],"since":[230],"IL-12p40":[235],"different":[240],"between":[241],"DCs.":[245],"results":[247],"demonstrate":[248],"selective":[250],"methylation,":[254],"occur":[264],"contribute":[268,291],"upregulation":[271],"observed":[281],"This":[285],"suggests":[286],"epigenetic":[287],"mechanisms":[290],"dysregulated":[293],"inflammatory":[294],"autoimmune":[296],"aging.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}