{"id":"https://openalex.org/W2005293755","doi":"https://doi.org/10.1073/pnas.1503152112","title":"STAT3-driven transcription depends upon the dimethylation of K49 by EZH2","display_name":"STAT3-driven transcription depends upon the dimethylation of K49 by EZH2","publication_year":2015,"publication_date":"2015-03-12","ids":{"openalex":"https://openalex.org/W2005293755","doi":"https://doi.org/10.1073/pnas.1503152112","mag":"2005293755","pmid":"https://pubmed.ncbi.nlm.nih.gov/25767098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4386339"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1503152112","doi":"https://doi.org/10.1073/pnas.1503152112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1503152112","pdf_url":"https://www.pnas.org/content/pnas/112/13/3985.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/112/13/3985.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029808409","display_name":"Maupali Dasgupta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maupali Dasgupta","raw_affiliation_strings":["Department of Molecular Genetics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058391665","display_name":"Josephine Kam Tai Dermawan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josephine Kam Tai Dermawan","raw_affiliation_strings":["Department of Molecular Genetics and","aDepartment of Molecular Genetics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and","institution_ids":[]},{"raw_affiliation_string":"aDepartment of Molecular Genetics and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013491797","display_name":"Belinda B. Willard","orcid":"https://orcid.org/0000-0001-6884-6369","observed_orcids":["https://orcid.org/0000-0001-6884-6369"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Belinda Willard","raw_affiliation_strings":["Proteomics Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080998429","display_name":"George Robert Stark","orcid":"https://orcid.org/0000-0002-8776-9597","observed_orcids":["https://orcid.org/0000-0002-8776-9597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George R. Stark","raw_affiliation_strings":["Department of Molecular Genetics and","aDepartment of Molecular Genetics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and","institution_ids":[]},{"raw_affiliation_string":"aDepartment of Molecular Genetics and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.6772,"has_fulltext":true,"cited_by_count":135,"citation_normalized_percentile":{"value":0.97769898,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"112","issue":"13","first_page":"3985","last_page":"3990"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.7461000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.17749999463558197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9449999928474426},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/histone-modifying-enzymes","display_name":"histone-modifying enzymes","score":0.7889999747276306},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5609999895095825},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.6985146403312683},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6604508757591248},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.5899620652198792},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.553638219833374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5377118587493896},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.4787987172603607},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4560742974281311},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41013574600219727},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29205358028411865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12643641233444214},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09159886837005615},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076983","descriptor_name":"Histone Methyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.1503152112","doi":"https://doi.org/10.1073/pnas.1503152112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1503152112","pdf_url":"https://www.pnas.org/content/pnas/112/13/3985.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4386339","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4386339","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:25767098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25767098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1503152112","doi":"https://doi.org/10.1073/pnas.1503152112","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1503152112","pdf_url":"https://www.pnas.org/content/pnas/112/13/3985.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5062867232","display_name":"Integrated EGFR function in cytokine-driven inflammation and cancer","funder_award_id":"P01CA062220","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6912916513","display_name":null,"funder_award_id":"STAT3","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7503541592","display_name":"LTQ-Orbitrap Velos instrument","funder_award_id":"S10RR031537","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8441272977","display_name":"Clinical and Translational Science Collaborative of Cleveland","funder_award_id":"UL1TR000439","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000159006","display_name":null,"funder_award_id":"CA 062220","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000254528","display_name":null,"funder_award_id":"PO1 CA062220","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309680","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005293755.pdf","grobid_xml":"https://content.openalex.org/works/W2005293755.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1965262464","https://openalex.org/W1973279069","https://openalex.org/W1985003152","https://openalex.org/W1996487270","https://openalex.org/W2014596538","https://openalex.org/W2020230403","https://openalex.org/W2027877663","https://openalex.org/W2030865745","https://openalex.org/W2033478449","https://openalex.org/W2038676786","https://openalex.org/W2054464764","https://openalex.org/W2056828106","https://openalex.org/W2057061888","https://openalex.org/W2060042138","https://openalex.org/W2061741685","https://openalex.org/W2062005942","https://openalex.org/W2069027997","https://openalex.org/W2072669480","https://openalex.org/W2073189570","https://openalex.org/W2078929930","https://openalex.org/W2082998819","https://openalex.org/W2094051261","https://openalex.org/W2096551654","https://openalex.org/W2100365251","https://openalex.org/W2100543217","https://openalex.org/W2102883893","https://openalex.org/W2103226094","https://openalex.org/W2110413857","https://openalex.org/W2116704835","https://openalex.org/W2145872889","https://openalex.org/W2154787712","https://openalex.org/W2160689782","https://openalex.org/W2160767552","https://openalex.org/W2739174192"],"related_works":["https://openalex.org/W4405209022","https://openalex.org/W2014596538","https://openalex.org/W2560629364","https://openalex.org/W2056828106","https://openalex.org/W4392914437","https://openalex.org/W2568336831","https://openalex.org/W2089747326","https://openalex.org/W2594637333","https://openalex.org/W3029316033","https://openalex.org/W2794842946"],"abstract_inverted_index":{"Several":[0],"transcription":[1],"factors,":[2],"including":[3],"p53,":[4],"NF-\u03baB,":[5],"and":[6,98,101],"STAT3,":[7,77],"are":[8],"modified":[9],"by":[10,44],"the":[11,37,45,88,91],"same":[12],"enzymes":[13],"that":[14,33],"also":[15,102],"modify":[16],"histones,":[17],"with":[18],"important":[19,74],"functional":[20],"consequences.":[21],"We":[22],"have":[23],"identified":[24],"a":[25,72],"previously":[26],"unrecognized":[27],"dimethylation":[28],"of":[29,31,39,49,55,76,90,94],"K49":[30],"STAT3":[32],"is":[34,57,64,79],"crucial":[35],"for":[36],"expression":[38],"many":[40,83],"IL-6-dependent":[41],"genes,":[42],"catalyzed":[43],"histone-modifying":[46],"enzyme":[47],"enhancer":[48],"zeste":[50],"homolog":[51],"2":[52],"(EZH2).":[53],"Loss":[54],"EZH2":[56,70,95],"protumorigenic":[58,65],"in":[59,66,82,96],"leukemias,":[60],"but":[61],"its":[62],"overexpression":[63],"solid":[67,99],"cancers.":[68],"Connecting":[69],"to":[71],"functionally":[73],"methylation":[75],"which":[78],"constitutively":[80],"activated":[81],"tumors,":[84],"may":[85,103],"help":[86],"reveal":[87],"basis":[89],"opposing":[92],"roles":[93],"liquid":[97],"tumors":[100],"identify":[104],"novel":[105],"therapeutic":[106],"opportunities.":[107]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
