{"id":"https://openalex.org/W2005289376","doi":"https://doi.org/10.1210/endo.140.1.6441","title":"Expression of Hepatocyte Growth Factor-Like Protein Is Repressed by Retinoic Acid and Enhanced by Cyclic Adenosine 3\u2032,5\u2032-Monophosphate Response Element-Binding Protein (CREB)-Binding Protein (CBP)**This work was supported in part by USPHS Grant DK-47003 from the NIDDK, NIH (to S.J.F.D.), NIH Training Grant HL-07527 (to R.S.M.), National Research Scientist Award Postdoctoral Fellowship (to S.E.W.), and a Board of Trustees Fellowship from the Children\u2019s Hospital Research Foundation (to S.E.W.).","display_name":"Expression of Hepatocyte Growth Factor-Like Protein Is Repressed by Retinoic Acid and Enhanced by Cyclic Adenosine 3\u2032,5\u2032-Monophosphate Response Element-Binding Protein (CREB)-Binding Protein (CBP)**This work was supported in part by USPHS Grant DK-47003 from the NIDDK, NIH (to S.J.F.D.), NIH Training Grant HL-07527 (to R.S.M.), National Research Scientist Award Postdoctoral Fellowship (to S.E.W.), and a Board of Trustees Fellowship from the Children\u2019s Hospital Research Foundation (to S.E.W.).","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2005289376","doi":"https://doi.org/10.1210/endo.140.1.6441","mag":"2005289376","pmid":"https://pubmed.ncbi.nlm.nih.gov/9886825"},"language":"en","primary_location":{"id":"doi:10.1210/endo.140.1.6441","doi":"https://doi.org/10.1210/endo.140.1.6441","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.140.1.6441","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014920554","display_name":"Rebecca S. Muraoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca S. Muraoka","raw_affiliation_strings":["Graduate Program in Developmental Biology, University of Cincinnati College of Medicine (R.S.M.), Cincinnati, Ohio 45229-3039"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Developmental Biology, University of Cincinnati College of Medicine (R.S.M.), Cincinnati, Ohio 45229-3039","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031387848","display_name":"Susan E. Waltz","orcid":"https://orcid.org/0000-0003-3572-4642","observed_orcids":["https://orcid.org/0000-0003-3572-4642"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan E. Waltz","raw_affiliation_strings":["Division of Developmental Biology, Children\u2019s Hospital Research Foundation (S.E.W., S.J.F.D.), Cincinnati, Ohio 45229-3039","Division of Developmental Biology, Children's Hospital Research Foundation (S.E.W., S.J.F.D.), Cincinnati, Ohio 45229-3039"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Developmental Biology, Children\u2019s Hospital Research Foundation (S.E.W., S.J.F.D.), Cincinnati, Ohio 45229-3039","institution_ids":[]},{"raw_affiliation_string":"Division of Developmental Biology, Children's Hospital Research Foundation (S.E.W., S.J.F.D.), Cincinnati, Ohio 45229-3039","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112252558","display_name":"Sandra J. Friezner Degen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandra J. Friezner Degen","raw_affiliation_strings":["Division of Developmental Biology, Children\u2019s Hospital Research Foundation (S.E.W., S.J.F.D.), Cincinnati, Ohio 45229-3039","Division of Developmental Biology, Children's Hospital Research Foundation (S.E.W., S.J.F.D.), Cincinnati, Ohio 45229-3039"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Developmental Biology, Children\u2019s Hospital Research Foundation (S.E.W., S.J.F.D.), Cincinnati, Ohio 45229-3039","institution_ids":[]},{"raw_affiliation_string":"Division of Developmental Biology, Children's Hospital Research Foundation (S.E.W., S.J.F.D.), Cincinnati, Ohio 45229-3039","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112252558"],"corresponding_institution_ids":["https://openalex.org/I1285204247"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.6532,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.64371237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"140","issue":"1","first_page":"187","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.5928000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.5928000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.17350000143051147,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.1136000007390976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9139999747276306},{"id":"https://openalex.org/keywords/creb-binding-protein","display_name":"CREB-binding protein","score":0.972000002861023},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hnf4","display_name":"HNF4","score":0.8240000009536743},{"id":"https://openalex.org/keywords/retinoic-acid-receptor","display_name":"retinoic acid receptor","score":0.9120000004768372},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.7570000290870667},{"id":"https://openalex.org/keywords/5-flanking-region","display_name":"5'-flanking region","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.7365012764930725},{"id":"https://openalex.org/C120197328","wikidata":"https://www.wikidata.org/wiki/Q2838685","display_name":"Retinoic acid receptor","level":4,"score":0.6832717061042786},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.626585066318512},{"id":"https://openalex.org/C89364313","wikidata":"https://www.wikidata.org/wiki/Q7316795","display_name":"Retinoic acid-inducible orphan G protein-coupled receptor","level":5,"score":0.6030600666999817},{"id":"https://openalex.org/C2776603820","wikidata":"https://www.wikidata.org/wiki/Q906517","display_name":"CREB-binding protein","level":5,"score":0.5352134704589844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5282981395721436},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.5271180272102356},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47499480843544006},{"id":"https://openalex.org/C119775778","wikidata":"https://www.wikidata.org/wiki/Q18031040","display_name":"Retinoic acid receptor alpha","level":5,"score":0.444252073764801},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4281895160675049},{"id":"https://openalex.org/C139522298","wikidata":"https://www.wikidata.org/wiki/Q18031042","display_name":"Retinoic acid receptor gamma","level":5,"score":0.4275376796722412},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.41595587134361267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35133084654808044},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2991558015346527},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2335711419582367}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051557","descriptor_name":"Hepatocyte Nuclear Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051557","descriptor_name":"Hepatocyte Nuclear Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051557","descriptor_name":"Hepatocyte Nuclear Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051778","descriptor_name":"Basic Helix-Loop-Helix Leucine Zipper Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051778","descriptor_name":"Basic Helix-Loop-Helix Leucine Zipper Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051778","descriptor_name":"Basic Helix-Loop-Helix Leucine Zipper Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo.140.1.6441","doi":"https://doi.org/10.1210/endo.140.1.6441","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.140.1.6441","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:9886825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9886825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"sustainable_development_goals_aurora":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.5099999904632568}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1202211146","display_name":null,"funder_award_id":"DK-47003","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G841756724","display_name":null,"funder_award_id":"HL07527","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W62114904","https://openalex.org/W117902596","https://openalex.org/W1502579708","https://openalex.org/W1547271398","https://openalex.org/W1556916009","https://openalex.org/W1565881767","https://openalex.org/W1585747919","https://openalex.org/W1607589687","https://openalex.org/W1613446635","https://openalex.org/W1762546725","https://openalex.org/W1766657157","https://openalex.org/W1964337986","https://openalex.org/W1967720940","https://openalex.org/W1969533764","https://openalex.org/W1972811330","https://openalex.org/W1975732704","https://openalex.org/W1981022538","https://openalex.org/W1981304601","https://openalex.org/W1981981787","https://openalex.org/W1985063313","https://openalex.org/W1990939350","https://openalex.org/W1995754186","https://openalex.org/W1996613017","https://openalex.org/W1999508213","https://openalex.org/W2004988279","https://openalex.org/W2005638713","https://openalex.org/W2012808819","https://openalex.org/W2013279950","https://openalex.org/W2016049443","https://openalex.org/W2022527563","https://openalex.org/W2024721474","https://openalex.org/W2039307052","https://openalex.org/W2039969393","https://openalex.org/W2046764234","https://openalex.org/W2054042846","https://openalex.org/W2071068525","https://openalex.org/W2079156086","https://openalex.org/W2088534912","https://openalex.org/W2089766601","https://openalex.org/W2092528800","https://openalex.org/W2115034716","https://openalex.org/W2123898551","https://openalex.org/W2129923536","https://openalex.org/W2143241514","https://openalex.org/W2143923628","https://openalex.org/W2165427270","https://openalex.org/W2172256092","https://openalex.org/W2398346137","https://openalex.org/W2398969482","https://openalex.org/W2415882902","https://openalex.org/W2416912094","https://openalex.org/W6712660929"],"related_works":["https://openalex.org/W1596810679","https://openalex.org/W1581075759","https://openalex.org/W2143087546","https://openalex.org/W2357981711","https://openalex.org/W2067228831","https://openalex.org/W2079048746","https://openalex.org/W2326252610","https://openalex.org/W4235139606","https://openalex.org/W2092282234","https://openalex.org/W2053701943"],"abstract_inverted_index":{"In":[0],"an":[1,122],"effort":[2],"to":[3,70,92,105],"understand":[4],"the":[5,10,15,33,48,56,60,72,85,110,126,146,154,189,194],"molecular":[6],"mechanisms":[7],"involved":[8],"in":[9,37,55,133],"regulation":[11],"of":[12,14,32,59,103,118,131,140,150,177,187,191],"expression":[13,31,117,143,169],"gene":[16,36,120,142,157,168,196],"encoding":[17],"hepatocyte":[18,75],"growth":[19],"factor-like":[20],"protein":[21,114],"(HGFL),":[22],"it":[23],"was":[24],"found":[25],"that":[26,65,84,96,166],"all-trans-retinoic":[27],"acid":[28,87,98,138,181],"dramatically":[29],"represses":[30],"endogenous":[34,155],"HGFL":[35,61,147,156,167,195],"HepG2":[38,134],"cells,":[39],"a":[40,63,185],"human":[41],"hepatocyte-derived":[42],"cell":[43],"line.":[44],"This":[45],"repression":[46,139],"requires":[47,170],"sequence":[49,58],"between":[50],"nucleotides":[51],"-135":[52],"and":[53,95,129,172],"-105":[54],"5'-flanking":[57],"gene,":[62],"site":[64],"has":[66],"previously":[67],"been":[68],"shown":[69],"bind":[71,91],"transcription":[73],"factor":[74],"nuclear":[76],"factor-4":[77],"(HNF-4).":[78],"Electrophoretic":[79],"mobility":[80],"shift":[81],"analysis":[82],"suggests":[83],"retinoic":[86,97,137,161,180],"receptor":[88,182],"does":[89,99],"not":[90,100],"this":[93,106,119],"site,":[94,128],"alter":[101],"binding":[102],"HNF-4":[104,192],"DNA":[107],"site.":[108],"However,":[109],"transcriptional":[111],"coactivator,":[112],"CREB-binding":[113],"(CBP)":[115],"coactivates":[116],"through":[121],"indirect":[123],"interaction":[124],"with":[125],"HNF-4-binding":[127],"overexpression":[130],"CBP":[132,151,178],"cells":[135],"eliminates":[136],"reporter":[141],"driven":[144],"by":[145,160,179],"promoter.":[148,197],"Overexpression":[149],"also":[152],"protects":[153],"from":[158],"down-regulation":[159],"acid.":[162],"These":[163],"results":[164],"suggest":[165],"CBP,":[171],"competition":[173],"for":[174],"limiting":[175],"amounts":[176],"may":[183],"be":[184],"means":[186],"modifying":[188],"activity":[190],"at":[193]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
