{"id":"https://openalex.org/W2005288968","doi":"https://doi.org/10.1021/jo0009954","title":"Fast Microwave-Assisted Preparation of Aryl and Vinyl Nitriles and the Corresponding Tetrazoles from Organo-halides","display_name":"Fast Microwave-Assisted Preparation of Aryl and Vinyl Nitriles and the Corresponding Tetrazoles from Organo-halides","publication_year":2000,"publication_date":"2000-10-21","ids":{"openalex":"https://openalex.org/W2005288968","doi":"https://doi.org/10.1021/jo0009954","mag":"2005288968","pmid":"https://pubmed.ncbi.nlm.nih.gov/11073607"},"language":"en","primary_location":{"id":"doi:10.1021/jo0009954","doi":"https://doi.org/10.1021/jo0009954","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo0009954","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110028978","display_name":"Mathias Alterman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mathias Alterman","raw_affiliation_strings":["Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108389244","display_name":"Anders Hallberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Hallberg","raw_affiliation_strings":["Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":9.7471,"has_fulltext":false,"cited_by_count":286,"citation_normalized_percentile":{"value":0.99189047,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"65","issue":"23","first_page":"7984","last_page":"7989"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13265","display_name":"Synthesis of Tetrazole Derivatives","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13265","display_name":"Synthesis of Tetrazole Derivatives","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12270","display_name":"Microwave-Assisted Synthesis and Applications","score":0.41749998927116394,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microwave-assisted-synthesis","display_name":"microwave-assisted synthesis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/aryl-nitriles","display_name":"aryl nitriles","score":0.9380000233650208},{"id":"https://openalex.org/keywords/palladium-catalysis","display_name":"palladium catalysis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cyanation","display_name":"cyanation","score":0.593999981880188},{"id":"https://openalex.org/keywords/aryl-bromides","display_name":"aryl bromides","score":0.7020000219345093},{"id":"https://openalex.org/keywords/flash-heating","display_name":"flash heating","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cycloaddition","display_name":"cycloaddition","score":0.8339999914169312},{"id":"https://openalex.org/keywords/one-pot-synthesis","display_name":"one-pot synthesis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/solid-phase-synthesis","display_name":"solid-phase synthesis","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hiv-1-protease-inhibitors","display_name":"HIV-1 protease inhibitors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/time-temperature-profiles","display_name":"time-temperature profiles","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9220075607299805},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.8672144412994385},{"id":"https://openalex.org/C2779664164","wikidata":"https://www.wikidata.org/wiki/Q898648","display_name":"Cycloaddition","level":3,"score":0.8293783664703369},{"id":"https://openalex.org/C2779240715","wikidata":"https://www.wikidata.org/wiki/Q333936","display_name":"Nitrile","level":2,"score":0.7220713496208191},{"id":"https://openalex.org/C2780827033","wikidata":"https://www.wikidata.org/wiki/Q58826308","display_name":"Tetrazole","level":2,"score":0.6935185194015503},{"id":"https://openalex.org/C171560689","wikidata":"https://www.wikidata.org/wiki/Q193086","display_name":"Halide","level":2,"score":0.61934494972229},{"id":"https://openalex.org/C2779380150","wikidata":"https://www.wikidata.org/wiki/Q5197391","display_name":"Cyanation","level":3,"score":0.463569700717926},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4213183522224426},{"id":"https://openalex.org/C2984548686","wikidata":"https://www.wikidata.org/wiki/Q905377","display_name":"Microwave irradiation","level":3,"score":0.4193081855773926},{"id":"https://openalex.org/C2776241998","wikidata":"https://www.wikidata.org/wiki/Q418088","display_name":"Aryl halide","level":4,"score":0.41335248947143555},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3576667904853821},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.2606029510498047},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.11631539463996887}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/jo0009954","doi":"https://doi.org/10.1021/jo0009954","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo0009954","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:11073607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11073607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of organic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1965920593","https://openalex.org/W1974918044","https://openalex.org/W1975813862","https://openalex.org/W1983828810","https://openalex.org/W1992850824","https://openalex.org/W2001304056","https://openalex.org/W2002625833","https://openalex.org/W2014958964","https://openalex.org/W2016808090","https://openalex.org/W2032031628","https://openalex.org/W2032392383","https://openalex.org/W2034920536","https://openalex.org/W2050629815","https://openalex.org/W2064635496","https://openalex.org/W2087625299","https://openalex.org/W2090178505","https://openalex.org/W2093818957","https://openalex.org/W2098418737","https://openalex.org/W2122167307","https://openalex.org/W2141494760","https://openalex.org/W2149996025","https://openalex.org/W2329804857","https://openalex.org/W2914618566","https://openalex.org/W2949479581","https://openalex.org/W2950674426","https://openalex.org/W2951061630","https://openalex.org/W2951411853","https://openalex.org/W3004817605"],"related_works":["https://openalex.org/W2953291078","https://openalex.org/W2950913092","https://openalex.org/W2335130484","https://openalex.org/W2012907751","https://openalex.org/W2475010967","https://openalex.org/W2057486842","https://openalex.org/W1987982391","https://openalex.org/W1570751303","https://openalex.org/W2016420267","https://openalex.org/W2113716400"],"abstract_inverted_index":{"Aryl":[0],"and":[1,40,62,118,129],"vinyl":[2,41],"nitriles":[3,37],"have":[4],"been":[5],"prepared":[6,107],"in":[7,60,70,74,108,135],"very":[8,88],"high":[9],"yields":[10],"from":[11],"the":[12,23,33,53,82],"corresponding":[13],"bromides":[14],"using":[15],"palladium-catalyzed":[16],"reactions":[17,67],"with":[18,81],"microwave":[19],"irradiation":[20],"employed":[21],"as":[22,78,102],"energy":[24],"source.":[25],"Furthermore,":[26],"flash":[27],"heating":[28,85],"was":[29,106],"used":[30],"successfully":[31],"for":[32],"conversion":[34],"of":[35,48,114],"these":[36],"into":[38],"aryl":[39,49,54],"tetrazoles":[42,55],"by":[43,111],"cycloaddition":[44,121],"reactions.":[45],"One-pot":[46],"transformation":[47],"halides":[50],"directly":[51],"to":[52],"could":[56],"be":[57],"accomplished":[58],"both":[59],"solution":[61],"on":[63],"solid":[64],"support.":[65],"All":[66],"were":[68],"completed":[69],"minutes":[71],"rather":[72],"than":[73],"hours":[75],"or":[76],"days":[77],"previously":[79],"reported":[80],"standard":[83],"thermal":[84],"technique.":[86],"A":[87],"potent":[89],"HIV-1":[90],"protease":[91],"inhibitor":[92],"(K(i)":[93],"=":[94],"0.":[95],"56":[96],"nM),":[97],"comprising":[98],"two":[99],"tetrazole":[100],"heterocycles":[101],"carboxyl":[103],"group":[104],"bioisosteres,":[105],"one":[109],"pot":[110],"microwave-promoted":[112],"cyanation":[113],"a":[115,119],"bromo":[116],"precursor":[117],"subsequent":[120],"reaction.":[122],"The":[123],"temperature-time":[124],"profiles":[125],"at":[126],"13,":[127],"20,":[128],"60":[130],"W":[131],"magnetron":[132],"input":[133],"power":[134],"DMF":[136],"are":[137],"presented.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
