{"id":"https://openalex.org/W2005287961","doi":"https://doi.org/10.1074/jbc.m609293200","title":"RNA Interference Silencing of the Adaptor Molecules ShcC and Fe65 Differentially Affect Amyloid Precursor Protein Processing and A\u03b2 Generation","display_name":"RNA Interference Silencing of the Adaptor Molecules ShcC and Fe65 Differentially Affect Amyloid Precursor Protein Processing and A\u03b2 Generation","publication_year":2006,"publication_date":"2006-12-15","ids":{"openalex":"https://openalex.org/W2005287961","doi":"https://doi.org/10.1074/jbc.m609293200","mag":"2005287961","pmid":"https://pubmed.ncbi.nlm.nih.gov/17170108"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m609293200","doi":"https://doi.org/10.1074/jbc.m609293200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609293200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m609293200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001382132","display_name":"Zhongcong Xie","orcid":"https://orcid.org/0000-0002-0720-1759","observed_orcids":["https://orcid.org/0000-0002-0720-1759"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongcong Xie","raw_affiliation_strings":["Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060; Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060; Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001604763","display_name":"Yuanlin Dong","orcid":"https://orcid.org/0000-0002-4760-0519","observed_orcids":["https://orcid.org/0000-0002-4760-0519"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanlin Dong","raw_affiliation_strings":["Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060; Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060; Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036283361","display_name":"Uta Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uta Maeda","raw_affiliation_strings":["Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060; Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060; Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129-2060, and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080838669","display_name":"Weiming Xia","orcid":"https://orcid.org/0000-0002-7463-3295","observed_orcids":["https://orcid.org/0000-0002-7463-3295"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiming Xia","raw_affiliation_strings":["Center for Neurologic Diseases, Harvard Institute of Medicine and Harvard Medical School, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurologic Diseases, Harvard Institute of Medicine and Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050004777","display_name":"Rudolph E. Tanzi","orcid":"https://orcid.org/0000-0002-7032-1454","observed_orcids":["https://orcid.org/0000-0002-7032-1454"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rudolph E. Tanzi","raw_affiliation_strings":["Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060. Electronic address: tanzi@helix.mgh.harvard.edu","Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060. Electronic address: tanzi@helix.mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Charlestown, Massachusetts 02129-2060","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050004777"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.4316,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.87120603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"282","issue":"7","first_page":"4318","last_page":"4325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.847000002861023},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8669999837875366},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7739999890327454},{"id":"https://openalex.org/keywords/engineered-cementitious-composites","display_name":"engineered cementitious composites","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fe65","display_name":"Fe65","score":0.9010000228881836},{"id":"https://openalex.org/keywords/shca","display_name":"ShcA","score":0.9610000252723694},{"id":"https://openalex.org/keywords/app-processing","display_name":"APP processing","score":0.7480000257492065},{"id":"https://openalex.org/keywords/beta-secretase","display_name":"beta-secretase","score":0.7850000262260437},{"id":"https://openalex.org/keywords/app-c99","display_name":"APP C99","score":0.7549999952316284},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.7149999737739563},{"id":"https://openalex.org/keywords/p3","display_name":"P3","score":0.5619999766349792},{"id":"https://openalex.org/keywords/app-c-terminal-fragments","display_name":"APP C-terminal fragments","score":0.7039999961853027},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.6970000267028809},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.8718681335449219},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.8032979965209961},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.7857160568237305},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.7818514108657837},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5914580225944519},{"id":"https://openalex.org/C36103677","wikidata":"https://www.wikidata.org/wiki/Q4749551","display_name":"Amyloid precursor protein secretase","level":5,"score":0.5060901045799255},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.4881370961666107},{"id":"https://openalex.org/C41007966","wikidata":"https://www.wikidata.org/wiki/Q908080","display_name":"Alpha secretase","level":5,"score":0.43694227933883667},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4192928671836853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41293469071388245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33405163884162903},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3120046854019165},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.24205777049064636},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.1873214840888977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15048784017562866},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07226899266242981},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06527870893478394},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071425","descriptor_name":"Src Homology 2 Domain-Containing, Transforming Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071427","descriptor_name":"Src Homology 2 Domain-Containing, Transforming Protein 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055765","descriptor_name":"Shc Signaling Adaptor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m609293200","doi":"https://doi.org/10.1074/jbc.m609293200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609293200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17170108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17170108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1074/jbc.m609293200","doi":"https://doi.org/10.1074/jbc.m609293200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609293200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5199999809265137}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1651251695","display_name":null,"funder_award_id":"R01MH 60009-03","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1961774357","display_name":"Functional Analysis of Alzheimer's Disease Genes","funder_award_id":"K08NS048140","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2429680874","display_name":"Harvard Older Americans Independence Center","funder_award_id":"P60AG008812","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2864780472","display_name":"Identification of Functional Genomic Variants in Alzheimer's Disease","funder_award_id":"R01MH060009","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6939193396","display_name":"HARVARD MENTORED CLINICAL SCIENTIST DEVELOPMENT PROGRAM","funder_award_id":"K12AG000294","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8096162791","display_name":"Alzheimer's BACE1 inhibition regulates neuronal contactin function","funder_award_id":"R01AG014713","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1567546374","https://openalex.org/W1578226087","https://openalex.org/W1943916690","https://openalex.org/W1971963229","https://openalex.org/W1985596271","https://openalex.org/W1994346902","https://openalex.org/W1999977743","https://openalex.org/W2001870435","https://openalex.org/W2005739560","https://openalex.org/W2015675204","https://openalex.org/W2032232498","https://openalex.org/W2038012168","https://openalex.org/W2039750814","https://openalex.org/W2051646172","https://openalex.org/W2057709960","https://openalex.org/W2057840062","https://openalex.org/W2062283435","https://openalex.org/W2069270527","https://openalex.org/W2071691905","https://openalex.org/W2078195794","https://openalex.org/W2082852872","https://openalex.org/W2085882792","https://openalex.org/W2088881960","https://openalex.org/W2091316116","https://openalex.org/W2115963048","https://openalex.org/W2131065520","https://openalex.org/W2131819352","https://openalex.org/W2133019124","https://openalex.org/W2138784057","https://openalex.org/W2149492645","https://openalex.org/W2162815565","https://openalex.org/W2169798557","https://openalex.org/W4211132147"],"related_works":["https://openalex.org/W2091316116","https://openalex.org/W1971395280","https://openalex.org/W2154625798","https://openalex.org/W315753411","https://openalex.org/W613380324","https://openalex.org/W2748270159","https://openalex.org/W2002914082","https://openalex.org/W2133420188","https://openalex.org/W2060916513","https://openalex.org/W6901926519"],"abstract_inverted_index":{"The":[0],"amyloid":[1],"precursor":[2],"protein":[3,10],"(APP)":[4],"and":[5,27,32,46,56,79,85,114,120,137,215],"its":[6],"pathogenic":[7],"by-product":[8],"amyloid-beta":[9],"(Abeta)":[11],"play":[12],"central":[13],"roles":[14],"in":[15,65,92,130,139,152,166,169,201],"Alzheimer":[16],"disease":[17],"(AD)":[18],"neuropathogenesis.":[19],"APP":[20,68,118,147,184,212],"can":[21,37,82],"be":[22,39],"cleaved":[23,40],"by":[24,41],"beta-secretase":[25],"(BACE)":[26],"alpha-secretase":[28],"to":[29,43,53,84,128,164],"produce":[30,44],"APP-C99":[31,155],"APP-C83.":[33],"These":[34,204],"C-terminal":[35],"fragments":[36,135],"then":[38],"gamma-secretase":[42],"Abeta":[45,57,121,138,187,199],"p3,":[47],"respectively.":[48],"p3":[49],"has":[50],"been":[51],"reported":[52],"promote":[54],"apoptosis,":[55],"is":[58],"the":[59,88,93,101,104,131,177],"key":[60],"component":[61],"of":[62,106,111,125,133,160,176,191,211],"senile":[63],"plaques":[64],"AD":[66],"brain.":[67],"adaptor":[69],"proteins":[70],"with":[71,87,213],"phosphotyrosine-binding":[72],"domains,":[73],"including":[74],"ShcA":[75,179],"(SHC1),":[76],"ShcC":[77,126,161,214],"(SHC3),":[78],"Fe65":[80,115,192,216],"(APBB1),":[81],"bind":[83],"interact":[86],"conserved":[89],"YENPTY":[90],"motif":[91],"APP-C":[94],"terminus.":[95],"Here":[96],"we":[97],"have":[98],"described":[99],"for":[100],"first":[102],"time":[103],"effects":[105],"RNA":[107],"interference":[108],"(RNAi)":[109],"silencing":[110,124,159,175,190],"ShcA,":[112],"ShcC,":[113],"expression":[116],"on":[117,183],"processing":[119,185],"production.":[122],"RNAi":[123,158,174,189],"led":[127,163],"reductions":[129,165],"levels":[132,168,200],"APP-C-terminal":[134],"(APP-CTFs)":[136],"H4":[140],"human":[141],"neuroglioma":[142],"cells":[143],"stably":[144],"overexpressing":[145],"full-length":[146],"(H4-FL-APP":[148],"cells)":[149],"but":[150],"not":[151],"those":[153],"expressing":[154],"(H4-APP-C99":[156],"cells).":[157],"also":[162,197],"BACE":[167],"H4-FL-APP":[170,202],"cells.":[171,203],"In":[172],"contrast,":[173],"homologue":[178],"had":[180],"no":[181],"effect":[182],"or":[186],"levels.":[188],"increased":[193],"APP-CTF":[194],"levels,":[195],"although":[196],"decreasing":[198],"findings":[205],"suggest":[206],"that":[207],"pharmacologically":[208],"blocking":[209],"interaction":[210],"may":[217],"provide":[218],"novel":[219],"therapeutic":[220],"strategies":[221],"against":[222],"AD.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
