{"id":"https://openalex.org/W2005282401","doi":"https://doi.org/10.1002/bip.1975.360140202","title":"Melting and premelting phenomenon in DNA by laser Raman scattering","display_name":"Melting and premelting phenomenon in DNA by laser Raman scattering","publication_year":1975,"publication_date":"1975-02-01","ids":{"openalex":"https://openalex.org/W2005282401","doi":"https://doi.org/10.1002/bip.1975.360140202","mag":"2005282401","pmid":"https://pubmed.ncbi.nlm.nih.gov/1174661"},"language":"en","primary_location":{"id":"doi:10.1002/bip.1975.360140202","doi":"https://doi.org/10.1002/bip.1975.360140202","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bip.1975.360140202","pdf_url":null,"source":{"id":"https://openalex.org/S56808608","display_name":"Biopolymers","issn_l":"0006-3525","issn":["0006-3525","1097-0282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014084913","display_name":"Stephen C. Erfurth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen C. Erfurth","raw_affiliation_strings":["Department of Chemistry, University of Oregon, Eugene, Oregon 97403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Oregon, Eugene, Oregon 97403","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109534461","display_name":"Warner L. Peticolas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warner L. Peticolas","raw_affiliation_strings":["Department of Chemistry, University of Oregon, Eugene, Oregon 97403"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Oregon, Eugene, Oregon 97403","institution_ids":["https://openalex.org/I181233156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181233156"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":3.6788,"has_fulltext":false,"cited_by_count":180,"citation_normalized_percentile":{"value":0.936665,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"2","first_page":"247","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-melting","display_name":"DNA melting","score":0.9739999771118164},{"id":"https://openalex.org/keywords/premelting","display_name":"premelting","score":0.890999972820282},{"id":"https://openalex.org/keywords/calf-thymus-dna","display_name":"calf thymus DNA","score":0.9679999947547913},{"id":"https://openalex.org/keywords/temperature-dependent-raman-spectra","display_name":"temperature-dependent Raman spectra","score":0.7770000100135803},{"id":"https://openalex.org/keywords/base-vibration","display_name":"base vibration","score":0.5550000071525574},{"id":"https://openalex.org/keywords/deuterium-isotope-effect","display_name":"deuterium isotope effect","score":0.6809999942779541},{"id":"https://openalex.org/keywords/b-dna-conformation","display_name":"B-DNA conformation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/dna-conformational-change","display_name":"DNA conformational change","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2780916728","wikidata":"https://www.wikidata.org/wiki/Q7240247","display_name":"Premelting","level":3,"score":0.9856874942779541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8449902534484863},{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.8442531824111938},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.6945319771766663},{"id":"https://openalex.org/C13530604","wikidata":"https://www.wikidata.org/wiki/Q15318","display_name":"Melting point","level":2,"score":0.6403527855873108},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.6350982189178467},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.6155916452407837},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.6065569519996643},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.5233896374702454},{"id":"https://openalex.org/C39353612","wikidata":"https://www.wikidata.org/wiki/Q5283759","display_name":"Atmospheric temperature range","level":2,"score":0.47320765256881714},{"id":"https://openalex.org/C4839761","wikidata":"https://www.wikidata.org/wiki/Q212111","display_name":"Spectral line","level":2,"score":0.4547031819820404},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4140876531600952},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.37482893466949463},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.2379765808582306},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.10998746752738953},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1093115508556366},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.10399475693702698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bip.1975.360140202","doi":"https://doi.org/10.1002/bip.1975.360140202","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bip.1975.360140202","pdf_url":null,"source":{"id":"https://openalex.org/S56808608","display_name":"Biopolymers","issn_l":"0006-3525","issn":["0006-3525","1097-0282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"journal-article"},{"id":"pmid:1174661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1174661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W5849850","https://openalex.org/W1523809297","https://openalex.org/W1531398626","https://openalex.org/W1542577506","https://openalex.org/W1569362357","https://openalex.org/W1987201861","https://openalex.org/W1988786731","https://openalex.org/W1990202546","https://openalex.org/W1992879866","https://openalex.org/W1995008811","https://openalex.org/W1999294006","https://openalex.org/W2005320619","https://openalex.org/W2005565791","https://openalex.org/W2006007199","https://openalex.org/W2011365136","https://openalex.org/W2014310063","https://openalex.org/W2026350837","https://openalex.org/W2030597011","https://openalex.org/W2044803491","https://openalex.org/W2048478201","https://openalex.org/W2052902762","https://openalex.org/W2053626108","https://openalex.org/W2059364771","https://openalex.org/W2060993396","https://openalex.org/W2061748968","https://openalex.org/W2063311279","https://openalex.org/W2066279452","https://openalex.org/W2071860070","https://openalex.org/W2079203736","https://openalex.org/W2085315694","https://openalex.org/W2085865914","https://openalex.org/W2086420147","https://openalex.org/W2088790062","https://openalex.org/W2090208413","https://openalex.org/W2117829029","https://openalex.org/W2322150416","https://openalex.org/W2323754398","https://openalex.org/W4237167703"],"related_works":["https://openalex.org/W2168580805","https://openalex.org/W1990025216","https://openalex.org/W2085887851","https://openalex.org/W2951767808","https://openalex.org/W1993285281","https://openalex.org/W2047972624","https://openalex.org/W2329079694","https://openalex.org/W2354382163","https://openalex.org/W2050388485","https://openalex.org/W2082415603"],"abstract_inverted_index":{"Abstract":[0],"Raman":[1,32,131],"spectra":[2,33,229],"of":[3,16,26,30,39,44,114,121,125,136,173,208,225],"DNA":[4,8,235,253],"from":[5,134],"calf":[6],"thymus":[7],"have":[9,145],"been":[10,146],"taken":[11,230],"over":[12],"a":[13,58,69,150,184,188,256],"wide":[14],"range":[15],"temperatures":[17],"(25\u00b0\u201395\u00b0)":[18],"in":[19,61,102,110,128,153,166,176,196,205,239,266],"both":[20,183],"D2O":[21],"and":[22,42,105,116,143],"H2O.":[23],"A":[24],"study":[25],"the":[27,31,36,40,45,65,94,122,137,157,177,206,209,222,228,234,240,244,252,267,270],"temperature":[28,37,81,90],"dependence":[29,91],"shows":[34],"that":[35,56,76,87,202],"profiles":[38],"intensities":[41],"frequencies":[43],"various":[46,232],"bands":[47,55,75,132],"fall":[48],"into":[49,255],"four":[50,138],"different":[51],"categories:":[52],"(1)":[53],"base":[54,74],"show":[57,77,88],"reversible":[59],"increase":[60,152,195],"intensity":[62,103,154,167],"prior":[63,155],"to":[64,93,119,148,156,187,212,216,237],"melting":[66,95,158,223,245,271],"region,":[67,96],"i.e.,":[68],"definite":[70],"premelting":[71,268],"phenomenon;":[72],"(2)":[73],"little":[78],"or":[79,269],"no":[80,89],"dependence;":[82],"(3)":[83],"deoxyribose\u2010phosphate":[84],"backbone":[85],"vibrations":[86,113],"up":[92],"at":[97,160,231,249],"which":[98,161,250],"point":[99,162,246],"large":[100],"decreases":[101],"occur;":[104],"(4)":[106],"slow":[107],"frequency":[108,190],"changes":[109,199],"certain":[111],"in\u2010plane":[112],"guanine":[115],"adenine":[117],"due":[118],"deuteration":[120],"C\u20108":[123],"hydrogen":[124,179],"these":[126],"purines":[127],"D2O.":[129],"Certain":[130],"arising":[133],"each":[135,213],"bases,":[139],"adenine,":[140],"thymine,":[141,174],"guanine,":[142],"cytosine":[144],"found":[147,264],"undergo":[149],"gradual":[151,185],"region":[159,224],"large,":[163],"abrupt":[164],"increases":[165],"occur.":[168],"The":[169],"carbonyl":[170],"stretching":[171],"band":[172],"involved":[175],"interbase":[178],"bonding":[180],"actually":[181],"undergoes":[182],"shift":[186],"lower":[189],"as":[191,193],"well":[192,220],"an":[194],"intensity.":[197],"These":[198],"provide":[200],"evidence":[201],"some":[203],"change":[204],"geometry":[207],"bases":[210],"relative":[211],"other":[214],"begins":[215],"occur":[217],"around":[218],"50\u00b0C,":[219],"below":[221],"70\u00b0\u201385\u00b0C.":[226],"From":[227],"temperatures,":[233],"appears":[236],"remain":[238],"B":[241],"conformation":[242,262],"until":[243],"is":[247,263],"reached,":[248],"time":[251],"progresses":[254],"disordered":[257],"random\u2010coil":[258],"form.":[259],"No":[260],"A\u2010form":[261],"either":[265],"region.":[272]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":10},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}