{"id":"https://openalex.org/W2005282195","doi":"https://doi.org/10.1126/science.1200508","title":"A Packing Mechanism for Nucleosome Organization Reconstituted Across a Eukaryotic Genome","display_name":"A Packing Mechanism for Nucleosome Organization Reconstituted Across a Eukaryotic Genome","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2005282195","doi":"https://doi.org/10.1126/science.1200508","mag":"2005282195","pmid":"https://pubmed.ncbi.nlm.nih.gov/21596991","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4852979"},"language":"en","primary_location":{"id":"doi:10.1126/science.1200508","doi":"https://doi.org/10.1126/science.1200508","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1200508","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005282195"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4852979/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058638624","display_name":"Zhenhai Zhang","orcid":"https://orcid.org/0000-0002-4310-0525","observed_orcids":["https://orcid.org/0000-0002-4310-0525"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenhai Zhang","raw_affiliation_strings":["Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044272206","display_name":"Christian J. Wippo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260761","display_name":"Adolf-Butenandt-Institut f\u00fcr Physiologische Chemie, Physikalische Biochemie und Zellbiologie","ror":"https://ror.org/0480tmh03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260761","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian J. Wippo","raw_affiliation_strings":["Adolf-Butenandt-Institut, Universit\u00e4t M\u00fcnchen, Munich, 80336, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adolf-Butenandt-Institut, Universit\u00e4t M\u00fcnchen, Munich, 80336, Germany","institution_ids":["https://openalex.org/I4405260761","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055717272","display_name":"Megha Wal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megha Wal","raw_affiliation_strings":["Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103430860","display_name":"Elissa Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elissa Ward","raw_affiliation_strings":["Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074285928","display_name":"Philipp Korber","orcid":"https://orcid.org/0000-0001-7526-6549","observed_orcids":["https://orcid.org/0000-0001-7526-6549"]},"institutions":[{"id":"https://openalex.org/I4405260761","display_name":"Adolf-Butenandt-Institut f\u00fcr Physiologische Chemie, Physikalische Biochemie und Zellbiologie","ror":"https://ror.org/0480tmh03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260761","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Philipp Korber","raw_affiliation_strings":["Adolf-Butenandt-Institut, Universit\u00e4t M\u00fcnchen, Munich, 80336, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adolf-Butenandt-Institut, Universit\u00e4t M\u00fcnchen, Munich, 80336, Germany","institution_ids":["https://openalex.org/I4405260761","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046527896","display_name":"B. Franklin Pugh","orcid":"https://orcid.org/0000-0001-8341-4476","observed_orcids":["https://orcid.org/0000-0001-8341-4476"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B. Franklin Pugh","raw_affiliation_strings":["Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046527896","https://openalex.org/A5074285928"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I4405260761","https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":15.3002,"has_fulltext":false,"cited_by_count":330,"citation_normalized_percentile":{"value":0.99562434,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"332","issue":"6032","first_page":"977","last_page":"980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleosome-positioning","display_name":"nucleosome positioning","score":0.8809999823570251},{"id":"https://openalex.org/keywords/nucleosome-packing","display_name":"nucleosome packing","score":0.7789999842643738},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.6769999861717224},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.7440000176429749},{"id":"https://openalex.org/keywords/nucleosome-spacing","display_name":"nucleosome spacing","score":0.6050000190734863},{"id":"https://openalex.org/keywords/nucleosome-occupancy","display_name":"nucleosome occupancy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/yeast-genes","display_name":"yeast genes","score":0.5210000276565552},{"id":"https://openalex.org/keywords/transcription-initiation","display_name":"transcription initiation","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.8669401407241821},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6799396276473999},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.589201033115387},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4876619577407837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.469326913356781},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45477813482284546},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.42252326011657715},{"id":"https://openalex.org/C22322919","wikidata":"https://www.wikidata.org/wiki/Q5533501","display_name":"Genomic organization","level":4,"score":0.413329154253006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38271939754486084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37049293518066406},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34771835803985596},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.24457913637161255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17396456003189087},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11392456293106079},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011067","descriptor_name":"Poly dA-dT","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024363","descriptor_name":"Transcription Initiation Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/science.1200508","doi":"https://doi.org/10.1126/science.1200508","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1200508","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:21596991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21596991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4852979","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4852979/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4852979","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4852979/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5065602119","display_name":null,"funder_award_id":"HG004160","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6146525957","display_name":"High Resolution Mapping of Functional Elements in the Yeast Genome","funder_award_id":"R56HG004160","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G7920247583","display_name":"High Resolution Mapping of Functional Elements in the Yeast Genome","funder_award_id":"R01HG004160","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000069367","display_name":null,"funder_award_id":"HG004160","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1564217760","https://openalex.org/W1660332899","https://openalex.org/W1766348042","https://openalex.org/W1979668925","https://openalex.org/W1980716967","https://openalex.org/W2010730368","https://openalex.org/W2017550851","https://openalex.org/W2029873987","https://openalex.org/W2039564969","https://openalex.org/W2043009382","https://openalex.org/W2044481966","https://openalex.org/W2060789589","https://openalex.org/W2063679723","https://openalex.org/W2065670261","https://openalex.org/W2073374533","https://openalex.org/W2081032844","https://openalex.org/W2088724683","https://openalex.org/W2106448802","https://openalex.org/W2107432248","https://openalex.org/W2114803986","https://openalex.org/W2127079829","https://openalex.org/W2135363003","https://openalex.org/W2143617365","https://openalex.org/W2154109129","https://openalex.org/W2165618847","https://openalex.org/W2171432823","https://openalex.org/W4301879524"],"related_works":["https://openalex.org/W1979620025","https://openalex.org/W2312804350","https://openalex.org/W2106448802","https://openalex.org/W2065441847","https://openalex.org/W993284824","https://openalex.org/W2058578718","https://openalex.org/W2081969394","https://openalex.org/W2585955833","https://openalex.org/W2732051782","https://openalex.org/W2029873987"],"abstract_inverted_index":{"Near":[0],"the":[1,19,69,92,114],"5'":[2,70,93,115],"end":[3],"of":[4,24,29,45,58,72,95,117],"most":[5,73],"eukaryotic":[6],"genes,":[7],"nucleosomes":[8],"form":[9],"highly":[10],"regular":[11],"arrays":[12],"that":[13],"begin":[14],"at":[15,91,98,113],"canonical":[16],"distances":[17],"from":[18],"transcriptional":[20],"start":[21],"site.":[22],"Determinants":[23],"this":[25],"and":[26,63,87],"other":[27],"aspects":[28],"genomic":[30],"nucleosome":[31,60,100,106],"organization":[32],"have":[33],"been":[34],"ascribed":[35],"to":[36],"statistical":[37],"positioning,":[38,41,61],"intrinsically":[39],"DNA-encoded":[40],"or":[42],"some":[43],"aspect":[44],"transcription":[46],"initiation.":[47],"Here,":[48],"we":[49],"provide":[50],"evidence":[51],"for":[52],"a":[53],"different":[54],"explanation.":[55],"Biochemical":[56],"reconstitution":[57],"proper":[59],"spacing,":[62],"occupancy":[64],"levels":[65],"was":[66],"achieved":[67],"across":[68],"ends":[71,94,116],"yeast":[74],"genes":[75,96,118],"by":[76],"adenosine":[77],"triphosphate-dependent":[78],"trans-acting":[79],"factors.":[80],"These":[81],"transcription-independent":[82],"activities":[83],"override":[84],"DNA-intrinsic":[85],"positioning":[86],"maintain":[88],"uniform":[89],"spacing":[90],"even":[97],"low":[99],"densities.":[101],"Thus,":[102],"an":[103],"active,":[104],"nonstatistical":[105],"packing":[107],"mechanism":[108],"creates":[109],"chromatin":[110],"organizing":[111],"centers":[112],"where":[119],"important":[120],"regulatory":[121],"elements":[122],"reside.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":38},{"year":2013,"cited_by_count":43},{"year":2012,"cited_by_count":41}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}