{"id":"https://openalex.org/W2005282112","doi":"https://doi.org/10.1073/pnas.85.7.2176","title":"Benzo[alpha]pyrene diol epoxide I binds to DNA at replication forks.","display_name":"Benzo[alpha]pyrene diol epoxide I binds to DNA at replication forks.","publication_year":1988,"publication_date":"1988-04-01","ids":{"openalex":"https://openalex.org/W2005282112","doi":"https://doi.org/10.1073/pnas.85.7.2176","mag":"2005282112","pmid":"https://pubmed.ncbi.nlm.nih.gov/3127827","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/279952"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.85.7.2176","doi":"https://doi.org/10.1073/pnas.85.7.2176","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.85.7.2176","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.85.7.2176","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.85.7.2176","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076450281","display_name":"Richard S. Paules","orcid":"https://orcid.org/0000-0001-9106-7486","observed_orcids":["https://orcid.org/0000-0001-9106-7486"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R S Paules","raw_affiliation_strings":["Department of Pathology, University of North Carolina, Chapel Hill 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of North Carolina, Chapel Hill 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111647388","display_name":"Marila Cordeiro\u2010Stone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Cordeiro-Stone","raw_affiliation_strings":["Department of Pathology, University of North Carolina, Chapel Hill 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of North Carolina, Chapel Hill 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111651049","display_name":"M J Mass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Mass","raw_affiliation_strings":["Department of Pathology, University of North Carolina, Chapel Hill 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of North Carolina, Chapel Hill 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016404185","display_name":"Miriam C. Poirier","orcid":"https://orcid.org/0000-0002-4887-719X","observed_orcids":["https://orcid.org/0000-0002-4887-719X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Poirier","raw_affiliation_strings":["Department of Pathology, University of North Carolina, Chapel Hill 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of North Carolina, Chapel Hill 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045531616","display_name":"Stuart H. Yuspa","orcid":"https://orcid.org/0000-0003-4785-337X","observed_orcids":["https://orcid.org/0000-0003-4785-337X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S H Yuspa","raw_affiliation_strings":["Department of Pathology, University of North Carolina, Chapel Hill 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of North Carolina, Chapel Hill 27599","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024666494","display_name":"David G. Kaufman","orcid":"https://orcid.org/0000-0002-1287-5504","observed_orcids":["https://orcid.org/0000-0002-1287-5504"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D G Kaufman","raw_affiliation_strings":["Department of Pathology, University of North Carolina, Chapel Hill 27599"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of North Carolina, Chapel Hill 27599","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":1.4506,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.80607477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"85","issue":"7","first_page":"2176","last_page":"2180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.2632000148296356,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.9200000166893005},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.49000000953674316},{"id":"https://openalex.org/keywords/carcinogen-dna-adducts","display_name":"carcinogen-DNA adducts","score":0.7160000205039978},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.5789999961853027},{"id":"https://openalex.org/keywords/c3h10t1-2-cells","display_name":"C3H10T1/2 cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C2776920199","wikidata":"https://www.wikidata.org/wiki/Q408028","display_name":"Epoxide","level":3,"score":0.6894475221633911},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6188105344772339},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5564402937889099},{"id":"https://openalex.org/C2779515768","wikidata":"https://www.wikidata.org/wiki/Q421916","display_name":"Diol","level":2,"score":0.5308600068092346},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.5171696543693542},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4998311996459961},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.48409926891326904},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.47565218806266785},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4710778295993805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4697810709476471},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4478953778743744},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4029628336429596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35453301668167114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.322998583316803},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05652064085006714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0548672080039978},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004101","descriptor_name":"Dihydroxydihydrobenzopyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015123","descriptor_name":"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.85.7.2176","doi":"https://doi.org/10.1073/pnas.85.7.2176","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.85.7.2176","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.85.7.2176","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:279952","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/279952","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:3127827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3127827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.85.7.2176","doi":"https://doi.org/10.1073/pnas.85.7.2176","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.85.7.2176","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.85.7.2176","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2071352737","display_name":null,"funder_award_id":"CA20658","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005282112.pdf","grobid_xml":"https://content.openalex.org/works/W2005282112.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1494805909","https://openalex.org/W1552813369","https://openalex.org/W1902704469","https://openalex.org/W1941873609","https://openalex.org/W1973833515","https://openalex.org/W1976449151","https://openalex.org/W1978223888","https://openalex.org/W1981218329","https://openalex.org/W1997934648","https://openalex.org/W2006303534","https://openalex.org/W2011297649","https://openalex.org/W2014488380","https://openalex.org/W2036302298","https://openalex.org/W2055182772","https://openalex.org/W2055499537","https://openalex.org/W2055645726","https://openalex.org/W2059233009","https://openalex.org/W2060225598","https://openalex.org/W2062093570","https://openalex.org/W2070432039","https://openalex.org/W2073337599","https://openalex.org/W2076273950","https://openalex.org/W2077325314","https://openalex.org/W2077993101","https://openalex.org/W2082222361","https://openalex.org/W2083754050","https://openalex.org/W2099160341","https://openalex.org/W2118069325","https://openalex.org/W2126672347","https://openalex.org/W2138695470","https://openalex.org/W2140855999","https://openalex.org/W2155970962","https://openalex.org/W6605926690","https://openalex.org/W6636421103","https://openalex.org/W6821765776"],"related_works":["https://openalex.org/W100212505","https://openalex.org/W2028162102","https://openalex.org/W2076273950","https://openalex.org/W2029026387","https://openalex.org/W2411531909","https://openalex.org/W1981218329","https://openalex.org/W2059761459","https://openalex.org/W2728856520","https://openalex.org/W1994415652","https://openalex.org/W7098268613"],"abstract_inverted_index":{"The":[0,85,110],"distribution":[1],"of":[2,28,31,87,112,122,163],"lesions":[3],"in":[4,19,24,47,169],"DNA":[5,32,41,51,69,124,167],"caused":[6],"by":[7,35,63,82,150],"(+/-)-7":[8],"beta,8":[9,54],"alpha-dihydroxy-9":[10],"alpha,10":[11],"alpha-epoxy-7,8,9,10-tetrahydrobenzo":[12],"[alpha]pyrene":[13],"(B[alpha]P":[14],"diol":[15,45,77,152,157],"epoxide-I)":[16],"was":[17,98,129],"studied":[18],"synchronized":[20],"C3H/10T1/2":[21],"cells":[22],"treated":[23],"S":[25],"phase.":[26],"Sites":[27],"carcinogen":[29,91,134],"modification":[30],"were":[33,60,80,116],"identified":[34],"polyclonal":[36],"rabbit":[37],"antibodies":[38,73],"elicited":[39],"against":[40],"modified":[42],"with":[43,72,94],"B[alpha]P":[44,76,151,156],"epoxide-I":[46,78,153,158],"vitro.":[48],"This":[49],"antigenic":[50],"contained":[52],"trans-(7R)-N2-[10-(7":[53],"alpha,9":[55],"alpha-trihydroxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene)-yl]-":[56],"deoxyguanosine;":[57],"other":[58],"adducts":[59,79,92,159],"not":[61],"detected":[62,81],"liquid":[64],"chromatography.":[65],"In":[66],"this":[67],"study,":[68],"replication":[70,88,113,128,164],"forks":[71,89,114,165],"bound":[74],"to":[75,100,131,148],"electron":[83],"microscopy.":[84],"frequency":[86],"containing":[90],"associated":[93],"the":[95,120,123,139,142,161],"fork":[96,143],"junction":[97,144],"found":[99],"be":[101],"8-fold":[102],"higher":[103],"than":[104],"expected":[105],"for":[106],"an":[107],"average":[108],"distribution.":[109],"proportion":[111],"that":[115,141,155],"apparently":[117],"blocked":[118],"at":[119],"site":[121],"damage":[125],"increased":[126],"when":[127],"allowed":[130],"occur":[132],"after":[133],"exposure.":[135],"These":[136],"results":[137],"support":[138],"conclusions":[140],"is":[145],"particularly":[146],"vulnerable":[147],"adduction":[149],"and":[154],"block":[160],"displacement":[162],"during":[166],"synthesis":[168],"intact":[170],"cells.":[171]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
