{"id":"https://openalex.org/W2005276133","doi":"https://doi.org/10.1167/iovs.11-8785","title":"A Subgroup of Age-Related Macular Degeneration is Associated With Mono-Allelic Sequence Variants in the ABCA4 Gene","display_name":"A Subgroup of Age-Related Macular Degeneration is Associated With Mono-Allelic Sequence Variants in the ABCA4 Gene","publication_year":2012,"publication_date":"2012-03-17","ids":{"openalex":"https://openalex.org/W2005276133","doi":"https://doi.org/10.1167/iovs.11-8785","mag":"2005276133","pmid":"https://pubmed.ncbi.nlm.nih.gov/22427542"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.11-8785","doi":"https://doi.org/10.1167/iovs.11-8785","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.11-8785","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/933465/i1552-5783-53-4-2112.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/933465/i1552-5783-53-4-2112.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006257131","display_name":"Lars G. Fritsche","orcid":"https://orcid.org/0000-0002-2110-1690","observed_orcids":["https://orcid.org/0000-0002-2110-1690"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Lars G. Fritsche","raw_affiliation_strings":["Institute of Human Genetics and Department of Ophthalmology, University of Regensburg, Regensburg, Germany","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics and Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020915049","display_name":"Monika Fleckenstein","orcid":"https://orcid.org/0000-0001-8321-8037","observed_orcids":["https://orcid.org/0000-0001-8321-8037"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Monika Fleckenstein","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042856999","display_name":"Britta S. Fiebig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Britta S. Fiebig","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076944459","display_name":"Steffen Schmitz-Valckenberg","orcid":"https://orcid.org/0000-0003-3358-9942","observed_orcids":["https://orcid.org/0000-0003-3358-9942"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Steffen Schmitz-Valckenberg","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082616634","display_name":"Almut Bindewald-Wittich","orcid":"https://orcid.org/0000-0002-8151-3953","observed_orcids":["https://orcid.org/0000-0002-8151-3953"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Almut Bindewald-Wittich","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054912372","display_name":"Claudia N. Keilhauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Claudia N. Keilhauer","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111709543","display_name":"Agnes B. Renner","orcid":"https://orcid.org/0009-0005-5258-6220","observed_orcids":["https://orcid.org/0009-0005-5258-6220"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Agnes B. Renner","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074113962","display_name":"Friederike Mackensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Friederike Mackensen","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088255869","display_name":"Andreas M\u00f6\u00dfner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Andreas M\u00f6\u00dfner","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031797997","display_name":"Daniel Pauleikhoff","orcid":"https://orcid.org/0000-0003-3691-291X","observed_orcids":["https://orcid.org/0000-0003-3691-291X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Daniel Pauleikhoff","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000558929","display_name":"Christine Adrion","orcid":"https://orcid.org/0000-0003-2408-2533","observed_orcids":["https://orcid.org/0000-0003-2408-2533"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Christine Adrion","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057302175","display_name":"Ulrich Mansmann","orcid":"https://orcid.org/0000-0002-9955-8906","observed_orcids":["https://orcid.org/0000-0002-9955-8906"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Ulrich Mansmann","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059328359","display_name":"Hendrik P. N. Scholl","orcid":"https://orcid.org/0000-0002-7312-0316","observed_orcids":["https://orcid.org/0000-0002-7312-0316"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Hendrik P. N. Scholl","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016922490","display_name":"Frank Gerhard Holz","orcid":"https://orcid.org/0000-0001-8019-9272","observed_orcids":["https://orcid.org/0000-0001-8019-9272"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Frank G. Holz","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059517063","display_name":"Bernhard H. F. Weber","orcid":"https://orcid.org/0000-0002-8808-7723","observed_orcids":["https://orcid.org/0000-0002-8808-7723","https://orcid.org/0000-0001-7637-8526"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210149651","display_name":"St. Franziskus Hospital","ror":"https://ror.org/051nxfa23","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210149651"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Bernhard H. F. Weber","raw_affiliation_strings":["From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","3Department of Ophthalmology, University of Bonn, Bonn, Germany","4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany; 3Department of Ophthalmology, University of Bonn, Bonn, Germany; 4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany; 6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany; 7Department of Ophthalmology, University of Leipzig, Leipzig, Germany; 8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany; 9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany; 10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"]},{"raw_affiliation_string":"10Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"3Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"4Department of Ophthalmology, University of Wuerzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"6Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"7Department of Ophthalmology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"8Department of Ophthalmology, St. Franziskus Hospital, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210149651"]},{"raw_affiliation_string":"9Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilian University, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"From the 1Institute of Human Genetics and 5Department of Ophthalmology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5000558929","https://openalex.org/A5006257131","https://openalex.org/A5016922490","https://openalex.org/A5020915049","https://openalex.org/A5031797997","https://openalex.org/A5042856999","https://openalex.org/A5054912372","https://openalex.org/A5057302175","https://openalex.org/A5059328359","https://openalex.org/A5059517063","https://openalex.org/A5074113962","https://openalex.org/A5076944459","https://openalex.org/A5082616634","https://openalex.org/A5088255869","https://openalex.org/A5111709543"],"corresponding_institution_ids":["https://openalex.org/I135140700","https://openalex.org/I145311948","https://openalex.org/I223822909","https://openalex.org/I25974101","https://openalex.org/I4210149651","https://openalex.org/I60668342","https://openalex.org/I8204097","https://openalex.org/I926574661"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":8.455,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.97964105,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"53","issue":"4","first_page":"2112","last_page":"2112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.09319999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/abca4","display_name":"ABCA4","score":0.8199999928474426},{"id":"https://openalex.org/keywords/monoallelic-variants","display_name":"monoallelic variants","score":0.8299999833106995},{"id":"https://openalex.org/keywords/stargardt-disease","display_name":"Stargardt disease","score":0.8240000009536743},{"id":"https://openalex.org/keywords/geographic-atrophy","display_name":"geographic atrophy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/fundus-autofluorescence","display_name":"fundus autofluorescence","score":0.8119999766349792},{"id":"https://openalex.org/keywords/complement-factor-h","display_name":"complement factor H","score":0.7770000100135803},{"id":"https://openalex.org/keywords/arms2","display_name":"ARMS2","score":0.996999979019165},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.7409999966621399},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.609000027179718},{"id":"https://openalex.org/keywords/macular-dystrophy","display_name":"macular dystrophy","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2779460726","wikidata":"https://www.wikidata.org/wiki/Q21115224","display_name":"ABCA4","level":4,"score":0.9757323265075684},{"id":"https://openalex.org/C2780604041","wikidata":"https://www.wikidata.org/wiki/Q1317319","display_name":"Stargardt disease","level":3,"score":0.7074185013771057},{"id":"https://openalex.org/C14356644","wikidata":"https://www.wikidata.org/wiki/Q14911975","display_name":"Factor H","level":4,"score":0.6298339366912842},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6279014945030212},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6103395819664001},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.6032358407974243},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4806988835334778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4745180010795593},{"id":"https://openalex.org/C2781116099","wikidata":"https://www.wikidata.org/wiki/Q3842207","display_name":"Maculopathy","level":4,"score":0.4434019923210144},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.41386598348617554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35030680894851685},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3284735083580017},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28050145506858826},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.20898544788360596},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.17458489537239075},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0957072377204895},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.09467357397079468},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000080362","descriptor_name":"Stargardt Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080362","descriptor_name":"Stargardt Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080362","descriptor_name":"Stargardt Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1167/iovs.11-8785","doi":"https://doi.org/10.1167/iovs.11-8785","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.11-8785","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/933465/i1552-5783-53-4-2112.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},{"id":"pmid:22427542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22427542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:35152","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/35152/","pdf_url":"http://iovs.arvojournals.org/article.aspx?articleid=2188493","source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1167/iovs.11-8785","doi":"https://doi.org/10.1167/iovs.11-8785","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.11-8785","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/933465/i1552-5783-53-4-2112.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Life on land","id":"https://metadata.un.org/sdg/15","score":0.550000011920929}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4007769953","display_name":null,"funder_award_id":"SPP 1088","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4381413615","display_name":null,"funder_award_id":"WE 1259/19-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4488331590","display_name":null,"funder_award_id":"Ho 1926/1-3","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4991918859","display_name":null,"funder_award_id":"LSHG-CT-2005-512036","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320310992","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05"},{"id":"https://openalex.org/F4320318017","display_name":"Inselspital, Universit\u00e4tsspital Bern","ror":"https://ror.org/01q9sj412"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320881","display_name":"Universit\u00e4t Heidelberg","ror":"https://ror.org/038t36y30"},{"id":"https://openalex.org/F4320323650","display_name":"Deutsche Ophthalmologische Gesellschaft","ror":"https://ror.org/03wjq7x76"},{"id":"https://openalex.org/F4320324900","display_name":"Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn","ror":"https://ror.org/041nas322"},{"id":"https://openalex.org/F4320325356","display_name":"Julius-Maximilians-Universit\u00e4t W\u00fcrzburg","ror":"https://ror.org/00fbnyb24"},{"id":"https://openalex.org/F4320336488","display_name":"Medizinische Fakult\u00e4t, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn","ror":null},{"id":"https://openalex.org/F4320337578","display_name":"Alcon Research Institute","ror":"https://ror.org/028fhxy95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005276133.pdf","grobid_xml":"https://content.openalex.org/works/W2005276133.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W157005264","https://openalex.org/W952155934","https://openalex.org/W1520073890","https://openalex.org/W1525112357","https://openalex.org/W1573040585","https://openalex.org/W1577316231","https://openalex.org/W1970516922","https://openalex.org/W1989558725","https://openalex.org/W1990057691","https://openalex.org/W1991544676","https://openalex.org/W1997288094","https://openalex.org/W1997616950","https://openalex.org/W2007691367","https://openalex.org/W2010542360","https://openalex.org/W2011255179","https://openalex.org/W2018910159","https://openalex.org/W2022817398","https://openalex.org/W2027567557","https://openalex.org/W2032463068","https://openalex.org/W2033785387","https://openalex.org/W2046008887","https://openalex.org/W2059145105","https://openalex.org/W2069109673","https://openalex.org/W2069824067","https://openalex.org/W2070314210","https://openalex.org/W2071120499","https://openalex.org/W2076357933","https://openalex.org/W2077069863","https://openalex.org/W2082625132","https://openalex.org/W2092148373","https://openalex.org/W2092784580","https://openalex.org/W2094384984","https://openalex.org/W2099781499","https://openalex.org/W2100163534","https://openalex.org/W2108852798","https://openalex.org/W2113491654","https://openalex.org/W2113784410","https://openalex.org/W2117386992","https://openalex.org/W2125236492","https://openalex.org/W2125422830","https://openalex.org/W2129572698","https://openalex.org/W2133598188","https://openalex.org/W2140653050","https://openalex.org/W2148158102","https://openalex.org/W2157642717","https://openalex.org/W2164929411","https://openalex.org/W2169243280","https://openalex.org/W2171777347","https://openalex.org/W2582743722","https://openalex.org/W2764992207","https://openalex.org/W3145351529","https://openalex.org/W4238550599","https://openalex.org/W6631484893","https://openalex.org/W7073678623"],"related_works":["https://openalex.org/W3151109984","https://openalex.org/W2443366138","https://openalex.org/W4384119948","https://openalex.org/W4235587654","https://openalex.org/W1176855676","https://openalex.org/W4383066835","https://openalex.org/W846831161","https://openalex.org/W4388562925","https://openalex.org/W4245430697","https://openalex.org/W1979123026"],"abstract_inverted_index":{"Purpose.":[0],"Age-related":[1],"macular":[2,59],"degeneration":[3],"(AMD)":[4],"is":[5,147,203],"a":[6,57,229,238],"heterogeneous":[7],"condition":[8],"of":[9,50,76,84,110,116,157,232,237,241],"high":[10],"prevalence":[11],"and":[12,101,135,164,170,211,222],"complex":[13,230],"etiology":[14,236],"involving":[15],"genetic":[16],"as":[17,19],"well":[18],"environmental":[20],"factors.":[21],"By":[22],"fundus":[23],"autofluorescence":[24],"(FAF)":[25],"imaging,":[26],"AMD":[27,122,158,216],"can":[28],"be":[29],"classified":[30],"into":[31],"several":[32],"distinct":[33],"phenotypes,":[34],"with":[35,43,53,97,103,150,173,243],"one":[36],"subgroup":[37],"characterized":[38],"by":[39,62,206,213],"fine":[40],"granular":[41],"pattern":[42],"peripheral":[44],"punctate":[45],"spots":[46],"(GPS[+]).":[47],"Some":[48],"features":[49],"GPS[+]":[51,99,146,169,201],"overlap":[52],"Stargardt":[54],"disease":[55],"(STGD1),":[56],"recessive":[58],"dystrophy":[60],"caused":[61],"biallelic":[63],"sequence":[64,153],"variants":[65,208],"in":[66,86,94,168,177,209,234],"the":[67,82,98,190,200,214,235],"ATP-binding":[68],"cassette":[69],"transporter":[70],"4":[71],"(ABCA4)":[72],"gene.":[73],"The":[74,89],"aim":[75],"this":[77],"study":[78],"was":[79,92],"to":[80,181],"investigate":[81],"role":[83,231],"ABCA4":[85,90,152,210,233],"GPS[+].":[87],"Methods.":[88],"gene":[91],"sequenced":[93],"25":[95],"patients":[96,242],"phenotype":[100,202],"29":[102],"geographic":[104],"atrophy":[105],"(GA)-AMD":[106],"but":[107],"no":[108],"signs":[109],"GPS":[111],"(GPS[-]).":[112],"In":[113],"addition,":[114],"frequencies":[115,156,176],"risk-increasing":[117,159,217],"alleles":[118,160,218],"at":[119,161,219],"three":[120],"known":[121],"susceptibility":[123,132],"loci,":[124],"including":[125],"complement":[126,136],"factor":[127],"H":[128],"(CFH),":[129],"age-related":[130],"maculopathy":[131],"2":[133],"(ARMS2),":[134],"component":[137],"3":[138],"(C3),":[139],"were":[140],"evaluated.":[141],"Results.":[142],"We":[143],"demonstrate":[144],"that":[145,199],"associated":[148],"significantly":[149],"monoallelic":[151,207],"variants.":[154],"Moreover,":[155],"CFH,":[162,220],"ARMS2,":[163,221],"C3":[165],"are":[166],"similar":[167],"STGD1":[171],"patients,":[172],"risk":[174],"allele":[175],"both":[178],"subcategories":[179],"comparable":[180],"population-based":[182],"control":[183],"individuals":[184,188],"estimated":[185],"from":[186,189],"3,510":[187],"NHLBI":[191],"Exome":[192],"Sequencing":[193],"Project.":[194],"Conclusions.":[195],"Our":[196],"data":[197],"suggest":[198],"accounted":[204],"for":[205,228],"unlikely":[212],"well-established":[215],"C3.":[223],"These":[224],"findings":[225],"provide":[226],"support":[227],"minor":[239],"proportion":[240],"AMD.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}