{"id":"https://openalex.org/W2005272317","doi":"https://doi.org/10.1074/jbc.m111055200","title":"Deletions in the Acidic Lipid-binding Region of the Plasma Membrane Ca2+ Pump","display_name":"Deletions in the Acidic Lipid-binding Region of the Plasma Membrane Ca2+ Pump","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2005272317","doi":"https://doi.org/10.1074/jbc.m111055200","mag":"2005272317","pmid":"https://pubmed.ncbi.nlm.nih.gov/11821403"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111055200","doi":"https://doi.org/10.1074/jbc.m111055200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111055200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m111055200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006119831","display_name":"Felicitas de Tezanos Pinto","orcid":"https://orcid.org/0000-0002-4070-0605","observed_orcids":["https://orcid.org/0000-0002-4070-0605"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210149401","display_name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas","ror":"https://ror.org/0469ejq24","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210149401","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Felicitas de Tezanos Pinto","raw_affiliation_strings":["IQUIFIB-Facultad de Farmacia y Bioquimica (UBA) Junin 956, 1113 Buenos Aires, Argentina","From the IQUIFIB-Facultad de Farmacia y Bioqu\u0131\u0301mica (UBA) Jun\u0131\u0301n 956, 1113 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IQUIFIB-Facultad de Farmacia y Bioquimica (UBA) Junin 956, 1113 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210149401"]},{"raw_affiliation_string":"From the IQUIFIB-Facultad de Farmacia y Bioqu\u0131\u0301mica (UBA) Jun\u0131\u0301n 956, 1113 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210149401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045928290","display_name":"Hugo Pedro Adamo","orcid":"https://orcid.org/0000-0002-1712-8049","observed_orcids":["https://orcid.org/0000-0002-1712-8049"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210149401","display_name":"Instituto de Qu\u00edmica y Fisicoqu\u00edmica Biol\u00f3gicas","ror":"https://ror.org/0469ejq24","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210149401","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Hugo P. Adamo","raw_affiliation_strings":["IQUIFIB-Facultad de Farmacia y Bioqu\u0131\u0301mica (UBA) Jun\u0131\u0301n 956, 1113 Buenos Aires, Argentina","From the IQUIFIB-Facultad de Farmacia y Bioqu\u0131\u0301mica (UBA) Jun\u0131\u0301n 956, 1113 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IQUIFIB-Facultad de Farmacia y Bioqu\u0131\u0301mica (UBA) Jun\u0131\u0301n 956, 1113 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210149401"]},{"raw_affiliation_string":"From the IQUIFIB-Facultad de Farmacia y Bioqu\u0131\u0301mica (UBA) Jun\u0131\u0301n 956, 1113 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210149401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045928290"],"corresponding_institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210149401"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.3828,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.50344157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"277","issue":"15","first_page":"12784","last_page":"12789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-membrane-ca2-pump","display_name":"plasma membrane Ca2+ pump","score":0.9020000100135803},{"id":"https://openalex.org/keywords/plasma-membrane-calcium-atpase","display_name":"plasma membrane calcium ATPase","score":0.8059999942779541},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.753000020980835},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":0.949999988079071},{"id":"https://openalex.org/keywords/autoinhibition","display_name":"autoinhibition","score":0.675000011920929},{"id":"https://openalex.org/keywords/p-type-atpase","display_name":"P-type ATPase","score":0.7820000052452087},{"id":"https://openalex.org/keywords/ca2-transport","display_name":"Ca2+ transport","score":0.6610000133514404},{"id":"https://openalex.org/keywords/membrane-lipid-composition","display_name":"membrane lipid composition","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.8167188167572021},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.6056156754493713},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49075397849082947},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.46756845712661743},{"id":"https://openalex.org/C39271989","wikidata":"https://www.wikidata.org/wiki/Q649056","display_name":"Diaphragm pump","level":3,"score":0.4609859883785248},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4577464461326599},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.44110843539237976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3992403745651245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39798253774642944},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3852732479572296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38094133138656616},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29170799255371094},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13382557034492493},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08741798996925354},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06790411472320557},{"id":"https://openalex.org/C100082104","wikidata":"https://www.wikidata.org/wiki/Q183759","display_name":"Piezoelectricity","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m111055200","doi":"https://doi.org/10.1074/jbc.m111055200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111055200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11821403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11821403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111055200","doi":"https://doi.org/10.1074/jbc.m111055200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111055200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W259594741","https://openalex.org/W1497503028","https://openalex.org/W1523503670","https://openalex.org/W1563717135","https://openalex.org/W1571495929","https://openalex.org/W1580329175","https://openalex.org/W1593574040","https://openalex.org/W1599011232","https://openalex.org/W1603617892","https://openalex.org/W1605242131","https://openalex.org/W1854629375","https://openalex.org/W1947155521","https://openalex.org/W1965886505","https://openalex.org/W1983205633","https://openalex.org/W1992155962","https://openalex.org/W1997912356","https://openalex.org/W2002027111","https://openalex.org/W2010865351","https://openalex.org/W2020559793","https://openalex.org/W2024157372","https://openalex.org/W2024493352","https://openalex.org/W2034409936","https://openalex.org/W2044804548","https://openalex.org/W2050870721","https://openalex.org/W2056007296","https://openalex.org/W2063401411","https://openalex.org/W2093928625","https://openalex.org/W2100837269","https://openalex.org/W2102100103","https://openalex.org/W2118128739","https://openalex.org/W2153331570","https://openalex.org/W2163862717","https://openalex.org/W2208288328","https://openalex.org/W2248451819","https://openalex.org/W2323651872","https://openalex.org/W2410119390"],"related_works":["https://openalex.org/W1976515437","https://openalex.org/W1604190368","https://openalex.org/W2035768520","https://openalex.org/W6957951912","https://openalex.org/W2090081233","https://openalex.org/W2313284257","https://openalex.org/W173886673","https://openalex.org/W2052654181","https://openalex.org/W2010741141","https://openalex.org/W1593574040"],"abstract_inverted_index":{"The":[0,143],"C-terminal":[1,294],"segment":[2,86,97],"of":[3,14,28,43,53,98,117,121,128,145,155,168,179,185,188,192,200,219,230,236,245,264,269,276,283,289],"the":[4,15,34,44,54,62,68,85,96,115,119,129,148,151,157,165,174,183,190,198,201,217,243,249,253,266,270,273,277,281,284,290,293],"loop":[5],"between":[6],"transmembrane":[7,36],"helices":[8],"2":[9],"and":[10,67,150,160,181,279],"3":[11],"(A(L)":[12],"region)":[13],"plasma":[16],"membrane":[17],"Ca(2+)":[18,55,90,138,153,180,267],"pump":[19,56],"(PMCA)":[20],"is":[21,287],"not":[22,171,214],"conserved":[23],"in":[24,61,73,84,182],"other":[25],"P-ATPases.":[26],"Part":[27],"this":[29],"region,":[30],"just":[31],"upstream":[32],"from":[33,242],"third":[35],"domain,":[37],"has":[38],"been":[39],"associated":[40],"with":[41,59,82],"activation":[42],"PMCA":[45,237,271],"by":[46,173,292],"acidic":[47,246,259],"lipids.":[48],"cDNAs":[49],"coding":[50],"for":[51,110,137],"mutants":[52],"isoform":[57],"h4xb":[58],"deletions":[60,83,94],"A(L)":[63,250,254,285],"region":[64,255,286],"were":[65,70,102,170],"constructed,":[66],"proteins":[69],"successfully":[71],"expressed":[72],"either":[74],"COS":[75],"or":[76],"Chinese":[77],"hamster":[78],"ovary":[79],"cells.":[80],"Mutants":[81],"296-349":[87,232],"had":[88],"full":[89],"transport":[91],"activity,":[92],"but":[93,134],"involving":[95],"amino":[99],"acids":[100],"350-356":[101],"inactive":[103],"suggesting":[104],"that":[105,127,164,227,240],"these":[106,209,224],"residues":[107,231],"are":[108],"required":[109],"a":[111,234],"functional":[112],"PMCA.":[113],"In":[114,206],"absence":[116],"calmodulin":[118,146,169],"V(max)":[120,149],"mutant":[122,220],"d296-349":[123,161],"was":[124,139],"similar":[125,238],"to":[126,239,272],"recombinant":[130,202],"wild":[131,158,203],"type":[132,159,204],"pump,":[133],"its":[135],"K(0.5)":[136],"about":[140,196],"5-fold":[141],"lower.":[142],"addition":[144,191],"increased":[147,195],"apparent":[152],"affinity":[154,268],"both":[156],"enzymes":[162],"indicating":[163],"activating":[166],"effects":[167],"affected":[172],"deletion.":[175],"At":[176],"low":[177],"concentrations":[178],"presence":[184],"saturating":[186],"amounts":[187],"calmodulin,":[189],"phosphatidic":[193,211],"acid":[194,212],"2-fold":[197],"activity":[199,218],"pump.":[205],"contrast,":[207],"under":[208],"conditions":[210],"did":[213],"significantly":[215],"change":[216],"d296-349.":[221],"Taken":[222],"together":[223],"results":[225],"suggest":[226],"(a)":[228],"deletion":[229],"recreates":[233],"form":[235],"resulting":[241],"binding":[244],"lipids":[247],"at":[248],"region;":[251],"(b)":[252],"acts":[256],"as":[257],"an":[258],"lipid-binding":[260],"inhibitory":[261],"domain":[262],"capable":[263],"adjusting":[265],"lipid":[274],"composition":[275],"membrane;":[278],"(c)":[280],"function":[282],"independent":[288],"autoinhibition":[291],"calmodulin-binding":[295],"region.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}