{"id":"https://openalex.org/W2005271397","doi":"https://doi.org/10.3390/molecules20010879","title":"Development of Sulfadiazine-Decorated PLGA Nanoparticles Loaded with 5-Fluorouracil and Cell Viability","display_name":"Development of Sulfadiazine-Decorated PLGA Nanoparticles Loaded with 5-Fluorouracil and Cell Viability","publication_year":2015,"publication_date":"2015-01-08","ids":{"openalex":"https://openalex.org/W2005271397","doi":"https://doi.org/10.3390/molecules20010879","mag":"2005271397","pmid":"https://pubmed.ncbi.nlm.nih.gov/25580685","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6272719"},"language":"en","primary_location":{"id":"doi:10.3390/molecules20010879","doi":"https://doi.org/10.3390/molecules20010879","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules20010879","pdf_url":"https://www.mdpi.com/1420-3049/20/1/879/pdf?version=1420723721","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005271397"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/20/1/879/pdf?version=1420723721","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011529788","display_name":"Pedro Pires Goulart Guimar\u00e3es","orcid":"https://orcid.org/0000-0003-4534-2779","observed_orcids":["https://orcid.org/0000-0003-4534-2779"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Guimar\u00e3es","raw_affiliation_strings":["Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. pedropiresg@ufmg.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. pedropiresg@ufmg.br","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073769224","display_name":"Sheila Catarina de Oliveira","orcid":"https://orcid.org/0000-0002-1111-2070","observed_orcids":["https://orcid.org/0000-0002-1111-2070"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sheila Oliveira","raw_affiliation_strings":["Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. shetq@yahoo.com.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. shetq@yahoo.com.br","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034740237","display_name":"Gabrielle de C. Rodrigues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabrielle De Castro Rodrigues","raw_affiliation_strings":["Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. gabrielledecastro@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. gabrielledecastro@hotmail.com","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026199564","display_name":"S\u00e1vio Morato de Lacerda Gontijo","orcid":"https://orcid.org/0000-0002-7803-4345","observed_orcids":["https://orcid.org/0000-0002-7803-4345"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Savio Gontijo","raw_affiliation_strings":["Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. savio.morato@yahoo.com.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. savio.morato@yahoo.com.br","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089768144","display_name":"Ivana Silva Lula","orcid":"https://orcid.org/0009-0006-3987-5738","observed_orcids":["https://orcid.org/0009-0006-3987-5738"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ivana Lula","raw_affiliation_strings":["Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. ivanalula@ufmg.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. ivanalula@ufmg.br","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022007061","display_name":"Mar\u00eda Esperanza Cort\u00e9s","orcid":"https://orcid.org/0000-0002-0560-8491","observed_orcids":["https://orcid.org/0000-0002-0560-8491"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Cort\u00e9s","raw_affiliation_strings":["Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. mecortes@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Department of Restorative Dentistry, Faculty of Dentistry, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. mecortes@yahoo.com","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015735417","display_name":"\u00c2ngelo M. L. Denadai","orcid":"https://orcid.org/0000-0001-8259-6933","observed_orcids":["https://orcid.org/0000-0001-8259-6933"]},"institutions":[{"id":"https://openalex.org/I101100930","display_name":"Universidade Federal de Juiz de Fora","ror":"https://ror.org/04yqw9c44","country_code":"BR","type":"education","lineage":["https://openalex.org/I101100930"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"\u00c2ngelo Denadai","raw_affiliation_strings":["Pharmaceutical Department, Universidade Federal de Juiz de Fora,  Campus Governador Valadares-MG, Av. Dr. Raimundo Monteiro de Rezende,  330, Centro, CEP 35010-177 Governador Valadares-MG, Brazil","Pharmaceutical Department, Universidade Federal de Juiz de Fora, Campus Governador Valadares-MG, Av. Dr. Raimundo Monteiro de Rezende, 330, Centro, CEP 35010-177 Governador Valadares-MG, Brazil. angelo.denadai@ufjf.edu.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Department, Universidade Federal de Juiz de Fora,  Campus Governador Valadares-MG, Av. Dr. Raimundo Monteiro de Rezende,  330, Centro, CEP 35010-177 Governador Valadares-MG, Brazil","institution_ids":["https://openalex.org/I101100930"]},{"raw_affiliation_string":"Pharmaceutical Department, Universidade Federal de Juiz de Fora, Campus Governador Valadares-MG, Av. Dr. Raimundo Monteiro de Rezende, 330, Centro, CEP 35010-177 Governador Valadares-MG, Brazil. angelo.denadai@ufjf.edu.br","institution_ids":["https://openalex.org/I101100930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055005020","display_name":"Rub\u00e9n D. Sinisterra","orcid":"https://orcid.org/0000-0001-7656-1849","observed_orcids":["https://orcid.org/0000-0001-7656-1849"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Rub\u00e9n Sinisterra","raw_affiliation_strings":["Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. sinisterra@ufmg.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais,  Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte-MG, Brazil. sinisterra@ufmg.br","institution_ids":["https://openalex.org/I110200422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055005020"],"corresponding_institution_ids":["https://openalex.org/I110200422"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":1.1291,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.69585591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"20","issue":"1","first_page":"879","last_page":"899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfadiazine","display_name":"sulfadiazine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.9779999852180481},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.7710000276565552},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.6480000019073486},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.7049999833106995},{"id":"https://openalex.org/keywords/a431-cells","display_name":"A431 cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.6809999942779541},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.7850000262260437},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.8875255584716797},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.816969633102417},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.6550626158714294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5491953492164612},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46326473355293274},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.46192142367362976},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.42935508489608765},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.42686396837234497},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.41395068168640137},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3713541626930237},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.36270374059677124},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3256763517856598},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.30757224559783936},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22758567333221436},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17114871740341187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07913804054260254},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013411","descriptor_name":"Sulfadiazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013411","descriptor_name":"Sulfadiazine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066241","descriptor_name":"Carbon-13 Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066244","descriptor_name":"Proton Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/molecules20010879","doi":"https://doi.org/10.3390/molecules20010879","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules20010879","pdf_url":"https://www.mdpi.com/1420-3049/20/1/879/pdf?version=1420723721","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5277190","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6272719","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25580685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25580685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6272719","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6272719/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d7993a4e3f0b4fe987fb6bcfa7f62ba0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d7993a4e3f0b4fe987fb6bcfa7f62ba0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 20, Iss 1, Pp 879-899 (2015)","raw_type":"article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.698.6578","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.698.6578","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mdpi.com/1420-3049/20/1/879/pdf/","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3390/molecules20010879","doi":"https://doi.org/10.3390/molecules20010879","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules20010879","pdf_url":"https://www.mdpi.com/1420-3049/20/1/879/pdf?version=1420723721","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"},{"id":"https://openalex.org/F4320326731","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Nanobiofarmac\u00eautica","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005271397.pdf","grobid_xml":"https://content.openalex.org/works/W2005271397.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1492309119","https://openalex.org/W1964400351","https://openalex.org/W1968143647","https://openalex.org/W1977367854","https://openalex.org/W1978556565","https://openalex.org/W1978654303","https://openalex.org/W1978784740","https://openalex.org/W1980824358","https://openalex.org/W1982024247","https://openalex.org/W1992865052","https://openalex.org/W1995650484","https://openalex.org/W1998642701","https://openalex.org/W1999636899","https://openalex.org/W2001199187","https://openalex.org/W2002472122","https://openalex.org/W2004720642","https://openalex.org/W2005813454","https://openalex.org/W2009563273","https://openalex.org/W2016493521","https://openalex.org/W2019555018","https://openalex.org/W2020535635","https://openalex.org/W2020830322","https://openalex.org/W2021385919","https://openalex.org/W2023233505","https://openalex.org/W2024173945","https://openalex.org/W2025188006","https://openalex.org/W2025340904","https://openalex.org/W2026460056","https://openalex.org/W2028413548","https://openalex.org/W2028531434","https://openalex.org/W2029202873","https://openalex.org/W2030088772","https://openalex.org/W2030623460","https://openalex.org/W2031162287","https://openalex.org/W2038142952","https://openalex.org/W2039123138","https://openalex.org/W2042046525","https://openalex.org/W2042973822","https://openalex.org/W2045422540","https://openalex.org/W2046772999","https://openalex.org/W2056832429","https://openalex.org/W2059733306","https://openalex.org/W2067557497","https://openalex.org/W2070003597","https://openalex.org/W2070609818","https://openalex.org/W2070986221","https://openalex.org/W2077693652","https://openalex.org/W2082738785","https://openalex.org/W2084673355","https://openalex.org/W2085282114","https://openalex.org/W2086130473","https://openalex.org/W2089691097","https://openalex.org/W2090606649","https://openalex.org/W2091564621","https://openalex.org/W2094672113","https://openalex.org/W2095412415","https://openalex.org/W2097524602","https://openalex.org/W2106787323","https://openalex.org/W2108798093","https://openalex.org/W2112429609","https://openalex.org/W2114847750","https://openalex.org/W2115034438","https://openalex.org/W2115439624","https://openalex.org/W2119366165","https://openalex.org/W2122400711","https://openalex.org/W2124998760","https://openalex.org/W2127698840","https://openalex.org/W2128061734","https://openalex.org/W2129637849","https://openalex.org/W2131072420","https://openalex.org/W2137634849","https://openalex.org/W2144721975","https://openalex.org/W2152749024","https://openalex.org/W2164757273","https://openalex.org/W2165900465","https://openalex.org/W2313798780","https://openalex.org/W2319376540","https://openalex.org/W2462224226","https://openalex.org/W2744967148","https://openalex.org/W2952660688"],"related_works":["https://openalex.org/W2327408698","https://openalex.org/W1881487260","https://openalex.org/W2365024481","https://openalex.org/W3184348832","https://openalex.org/W2548892576","https://openalex.org/W2414029288","https://openalex.org/W2353158878","https://openalex.org/W4383313810","https://openalex.org/W2187414896"],"abstract_inverted_index":{"The":[0,21,37,86],"aim":[1],"of":[2,16,100,124,144,151,163],"this":[3],"work":[4],"was":[5,24,84,88],"to":[6,18,92,129,136,166],"synthesize":[7],"sulfadiazine-poly(lactide-co-glycolide)":[8],"(SUL-PLGA)":[9],"nanoparticles":[10],"(NPs)":[11],"for":[12,68,90,173],"the":[13,53,69,81,96,142,149,152,161,174,179],"efficient":[14],"delivery":[15],"5-fluorouracil":[17],"cancer":[19,108,131,167],"cells.":[20],"SUL-PLGA":[22,38,70],"conjugation":[23],"assessed":[25],"using":[26,42],"FTIR,":[27],"1H-NMR,":[28],"13C-NMR,":[29],"elemental":[30],"analysis":[31],"and":[32,34,44,48,58,80,104,113],"TG":[33],"DTA":[35],"analysis.":[36],"NPs":[39,102,126,154,165],"were":[40,63,120,127],"characterized":[41],"transmission":[43],"scanning":[45],"electron":[46],"microscopy":[47],"dynamic":[49],"light":[50],"scattering.":[51],"Additionally,":[52],"zeta":[54],"potential,":[55],"drug":[56],"content,":[57],"in":[59,178],"vitro":[60],"5-FU":[61,87,175],"release":[62],"evaluated.":[64],"We":[65],"found":[66,128],"that":[67,141],"NPs,":[71],"Dh":[72],"=":[73,77],"114.0":[74],"nm,":[75],"ZP":[76],"-32.1":[78],"mV":[79],"encapsulation":[82],"efficiency":[83],"49%.":[85],"released":[89],"up":[91],"7":[93],"days":[94],"from":[95],"NPs.":[97,159],"Cytotoxicity":[98],"evaluations":[99],"5-FU-loaded":[101],"(5-FU-SUL-PLGA":[103],"5-FU-PLGA)":[105],"on":[106],"two":[107,114],"cell":[109,116,132,138],"lines":[110,117,133],"(Caco-2,":[111],"A431)":[112],"normal":[115,137],"(fibroblast,":[118],"osteoblast)":[119],"compared.":[121],"Higher":[122],"cytotoxicity":[123,150],"5-FU-SUL-PLGA":[125,153,164],"both":[130],"when":[134,155],"compared":[135,156],"lines,":[139],"demonstrating":[140],"presence":[143],"SUL":[145],"could":[146],"significantly":[147],"enhance":[148],"with":[157],"5-FU-PLGA":[158],"Thus,":[160],"development":[162],"cells":[168],"is":[169],"a":[170],"promising":[171],"strategy":[172],"antitumor":[176],"formulation":[177],"future.":[180]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
