{"id":"https://openalex.org/W2005267351","doi":"https://doi.org/10.1097/01.hjh.0000242405.68461.84","title":"Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-\u03b3 activation","display_name":"Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-\u03b3 activation","publication_year":2006,"publication_date":"2006-08-15","ids":{"openalex":"https://openalex.org/W2005267351","doi":"https://doi.org/10.1097/01.hjh.0000242405.68461.84","mag":"2005267351","pmid":"https://pubmed.ncbi.nlm.nih.gov/16915030"},"language":"en","primary_location":{"id":"doi:10.1097/01.hjh.0000242405.68461.84","doi":"https://doi.org/10.1097/01.hjh.0000242405.68461.84","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.hjh.0000242405.68461.84","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081323409","display_name":"J\u00fcrgen Janke","orcid":"https://orcid.org/0000-0003-0113-4118","observed_orcids":["https://orcid.org/0000-0003-0113-4118"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210138940","display_name":"Helios Kliniken","ror":"https://ror.org/04fjkxc67","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR","TR"],"is_corresponding":true,"raw_author_name":"J\u00fcrgen Janke","raw_affiliation_strings":["Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin, Berlin, Germany. juergen.janke@charite.de","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)","e-mail: [email\u00a0protected]","fax: +49 30 9417 2206","requests for reprints to J\u00fcrgen Janke, PhD, Franz-Volhard Klinik \u2013 Charit\u00e9, Wiltberg Strasse 50, 13125 Berlin, Germany Tel: +49 30 9417 2271"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin, Berlin, Germany. juergen.janke@charite.de","institution_ids":["https://openalex.org/I4210138940","https://openalex.org/I7877124"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +49 30 9417 2206","institution_ids":[]},{"raw_affiliation_string":"requests for reprints to J\u00fcrgen Janke, PhD, Franz-Volhard Klinik \u2013 Charit\u00e9, Wiltberg Strasse 50, 13125 Berlin, Germany Tel: +49 30 9417 2271","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067641817","display_name":"Michael Schupp","orcid":"https://orcid.org/0000-0003-3720-1052","observed_orcids":["https://orcid.org/0000-0003-3720-1052"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":null,"type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR","TR"],"is_corresponding":false,"raw_author_name":"Michael Schupp","raw_affiliation_strings":["Center for Cardiovascular Research, Institute for Pharmacology and Toxicology of the Charit\u00e9, Berlin, Germany","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Research, Institute for Pharmacology and Toxicology of the Charit\u00e9, Berlin, Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090963996","display_name":"Stefan Engeli","orcid":"https://orcid.org/0000-0002-3087-971X","observed_orcids":["https://orcid.org/0000-0002-3087-971X"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210138940","display_name":"Helios Kliniken","ror":"https://ror.org/04fjkxc67","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR","TR"],"is_corresponding":false,"raw_author_name":"Stefan Engeli","raw_affiliation_strings":["Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","institution_ids":["https://openalex.org/I4210138940","https://openalex.org/I7877124"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012806193","display_name":"Kerstin Gorzelniak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210138940","display_name":"Helios Kliniken","ror":"https://ror.org/04fjkxc67","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR","TR"],"is_corresponding":false,"raw_author_name":"Kerstin Gorzelniak","raw_affiliation_strings":["Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","institution_ids":["https://openalex.org/I4210138940","https://openalex.org/I7877124"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054591711","display_name":"Michael Boschmann","orcid":"https://orcid.org/0000-0002-0114-7114","observed_orcids":["https://orcid.org/0000-0002-0114-7114"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210138940","display_name":"Helios Kliniken","ror":"https://ror.org/04fjkxc67","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR","TR"],"is_corresponding":false,"raw_author_name":"Michael Boschmann","raw_affiliation_strings":["Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","institution_ids":["https://openalex.org/I4210138940","https://openalex.org/I7877124"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011261170","display_name":"Lilian Sauma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]},{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]}],"countries":["FR","SE","TR"],"is_corresponding":false,"raw_author_name":"Lilian Sauma","raw_affiliation_strings":["Department of Medicine and Care, Diabetes Research Centre, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Care, Diabetes Research Centre, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060423672","display_name":"Fredrik Hans Nystr\u00f6m","orcid":"https://orcid.org/0000-0002-1680-1000","observed_orcids":["https://orcid.org/0000-0002-1680-1000"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]},{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]}],"countries":["FR","SE","TR"],"is_corresponding":false,"raw_author_name":"Fredrik H Nystrom","raw_affiliation_strings":["Department of Medicine and Care, Diabetes Research Centre, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Care, Diabetes Research Centre, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017690840","display_name":"Jens Jordan","orcid":"https://orcid.org/0000-0003-4518-0706","observed_orcids":["https://orcid.org/0000-0003-4518-0706"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210138940","display_name":"Helios Kliniken","ror":"https://ror.org/04fjkxc67","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR","TR"],"is_corresponding":false,"raw_author_name":"Jens Jordan","raw_affiliation_strings":["Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","institution_ids":["https://openalex.org/I4210138940","https://openalex.org/I7877124"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056794023","display_name":"Friedrich Cameron Luft","orcid":"https://orcid.org/0000-0002-8635-1199","observed_orcids":["https://orcid.org/0000-0002-8635-1199"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210138940","display_name":"Helios Kliniken","ror":"https://ror.org/04fjkxc67","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","FR","TR"],"is_corresponding":false,"raw_author_name":"Friedrich C Luft","raw_affiliation_strings":["Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty of the Charit\u00e9, Franz Volhard Clinic, HELIOS Klinikum-Berlin","institution_ids":["https://openalex.org/I4210138940","https://openalex.org/I7877124"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003445142","display_name":"Arya Mitra Sharma","orcid":"https://orcid.org/0000-0001-9360-6519","observed_orcids":["https://orcid.org/0000-0001-9360-6519"]},"institutions":[{"id":"https://openalex.org/I3018075036","display_name":"Sanofi (France)","ror":"https://ror.org/02n6c9837","country_code":"FR","type":"company","lineage":["https://openalex.org/I3018075036"]},{"id":"https://openalex.org/I4210139898","display_name":"Sanofi (Turkey)","ror":"https://ror.org/040k92z84","country_code":"TR","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","FR","TR"],"is_corresponding":false,"raw_author_name":"Arya M Sharma","raw_affiliation_strings":["Department of Medicine, McMaster University, Hamilton, Ontario, Canada","A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","F.H.N., Boehringer (modest)","J.J., Sanofi-Aventis (significant)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"A.M.S., Glaxo Smith-Kline, Sanofi-Aventis, Boehringer (modest and significant). M.S., S.E., K.G. M.B., L.S. and F.C.L. have no conflicts of interest","institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210139898"]},{"raw_affiliation_string":"Authors' conflicts of interest: We have received honoraria for speaking engagements and/or consulting and/or have received funds to the laboratory in order to conduct research from the following companies: J.J., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"F.H.N., Boehringer (modest)","institution_ids":[]},{"raw_affiliation_string":"J.J., Sanofi-Aventis (significant)","institution_ids":["https://openalex.org/I3018075036"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5081323409"],"corresponding_institution_ids":["https://openalex.org/I3018075036","https://openalex.org/I4210138940","https://openalex.org/I4210139898","https://openalex.org/I7877124"],"apc_list":null,"apc_paid":null,"fwci":3.8039,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.94024392,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"9","first_page":"1809","last_page":"1816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.6740000247955322},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/irbesartan","display_name":"irbesartan","score":0.8140000104904175},{"id":"https://openalex.org/keywords/telmisartan","display_name":"telmisartan","score":0.9950000047683716},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.9900000095367432},{"id":"https://openalex.org/keywords/eprosartan","display_name":"eprosartan","score":0.9909999966621399},{"id":"https://openalex.org/keywords/preadipocytes","display_name":"preadipocytes","score":0.8159999847412109},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9179999828338623},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":1.0},{"id":"https://openalex.org/keywords/gw9662","display_name":"GW9662","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":0.8799999952316284},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6299999952316284},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":0.7329999804496765},{"id":"https://openalex.org/keywords/luciferase-reporter","display_name":"luciferase reporter","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.7407606840133667},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7313922047615051},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7105661034584045},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6078504920005798},{"id":"https://openalex.org/C2780259554","wikidata":"https://www.wikidata.org/wiki/Q947266","display_name":"Irbesartan","level":3,"score":0.607819139957428},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.604590892791748},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.5947110056877136},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5710640549659729},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.5618346929550171},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.5144286751747131},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42692068219184875},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.425418496131897},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32607483863830566},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.14466598629951477},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.10797280073165894},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077333","descriptor_name":"Telmisartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077333","descriptor_name":"Telmisartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077333","descriptor_name":"Telmisartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077405","descriptor_name":"Irbesartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077405","descriptor_name":"Irbesartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077405","descriptor_name":"Irbesartan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019808","descriptor_name":"Losartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050156","descriptor_name":"Adipogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/01.hjh.0000242405.68461.84","doi":"https://doi.org/10.1097/01.hjh.0000242405.68461.84","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.hjh.0000242405.68461.84","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:16915030","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16915030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:8428","doi":null,"is_oa":false,"landing_page_url":"https://edoc.mdc-berlin.de/8428/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W131003225","https://openalex.org/W1972866300","https://openalex.org/W1972990982","https://openalex.org/W1989603944","https://openalex.org/W1990950873","https://openalex.org/W2009658649","https://openalex.org/W2020337065","https://openalex.org/W2027494269","https://openalex.org/W2031125972","https://openalex.org/W2035918403","https://openalex.org/W2038365356","https://openalex.org/W2048748448","https://openalex.org/W2061597050","https://openalex.org/W2066160102","https://openalex.org/W2077764615","https://openalex.org/W2091673549","https://openalex.org/W2101847314","https://openalex.org/W2108822928","https://openalex.org/W2109542667","https://openalex.org/W2113101845","https://openalex.org/W2113273743","https://openalex.org/W2120192015","https://openalex.org/W2127550817","https://openalex.org/W2129697991","https://openalex.org/W2141616248","https://openalex.org/W2154399799","https://openalex.org/W2160848960","https://openalex.org/W2160904785","https://openalex.org/W2162112945","https://openalex.org/W2163810943","https://openalex.org/W2165391345","https://openalex.org/W2170381403","https://openalex.org/W4252272548"],"related_works":["https://openalex.org/W2416592866","https://openalex.org/W2369831138","https://openalex.org/W2349328099","https://openalex.org/W2389642767","https://openalex.org/W2375916719","https://openalex.org/W2010062988","https://openalex.org/W2351251703","https://openalex.org/W2417150366","https://openalex.org/W2022729051","https://openalex.org/W2030341456"],"abstract_inverted_index":{"OBJECTIVE:":[0],"In":[1,150,202],"clonal":[2],"animal":[3],"cells,":[4],"certain":[5],"angiotensin":[6],"receptor":[7],"blockers":[8],"(ARB)":[9],"activate":[10,216],"the":[11,34,40,119,131,145,151,174,194],"peroxisome":[12],"proliferator-activated":[13],"receptor-gamma":[14],"(PPARgamma).":[15],"The":[16],"aim":[17],"of":[18,36,42,90,113,206],"this":[19],"work":[20],"was":[21,85,116],"to":[22,100,176,193,215],"validate":[23],"that":[24,178],"observation":[25],"in":[26,51,63,147,186,218],"human":[27,52,64,187],"cells":[28],"and":[29,39,46,92,97,99,107,142,182,199],"humans.":[30],"METHODS:":[31],"We":[32,54],"investigated":[33],"induction":[35],"in-vitro":[37],"adipogenesis":[38,106,181],"activation":[41,62],"PPARgamma-target":[43,109,114,183],"genes,":[44],"adiponectin":[45,91,164],"lipoprotein":[47,93,166],"lipase,":[48],"by":[49,118],"ARB":[50,129,146,179],"preadipocytes.":[53],"also":[55],"studied":[56],"PPARgamma":[57,120,135,217],"response-element-driven":[58],"luciferase":[59,132],"reporter":[60,133],"gene":[61,184],"adipocytes.":[65,188],"Finally,":[66],"we":[67],"treated":[68],"14":[69],"obese":[70],"men":[71],"for":[72,87],"10":[73],"days":[74],"with":[75,79,140,144],"placebo":[76],"crossed":[77],"over":[78],"150":[80],"mg/day":[81],"irbesartan.":[82],"Subcutaneous":[83],"fat":[84],"analyzed":[86],"mRNA":[88,168],"expression":[89,185],"lipase.":[94],"RESULTS:":[95],"Telmisartan":[96],"irbesartan,":[98],"a":[101],"lesser":[102],"degree":[103],"losartan,":[104],"induced":[105],"activated":[108,130],"genes.":[110],"This":[111],"stimulation":[112],"genes":[115],"prevented":[117],"antagonist":[121],"GW9662.":[122],"Eprosartan":[123],"had":[124,160],"no":[125,161],"effect.":[126],"Paradoxically,":[127],"all":[128,148],"gene.":[134],"activity":[136],"increased":[137],"approximately":[138],"two-fold":[139],"pioglitazone":[141],"1.5-fold":[143],"assays.":[149],"cross-over":[152],"clinical":[153],"study,":[154],"irbesartan":[155],"lowered":[156],"blood":[157],"pressure":[158],"but":[159],"effect":[162],"on":[163,197],"or":[165,210],"lipase":[167],"expression.":[169],"CONCLUSIONS:":[170],"Our":[171],"data":[172],"are":[173],"first":[175],"show":[177],"induce":[180],"Pharmacokinetic":[189],"differences":[190],"may":[191,212],"contribute":[192],"heterogeneous":[195],"effects":[196],"metabolism":[198],"preadipocyte":[200],"differentiation.":[201],"humans,":[203],"larger":[204],"doses":[205],"ARB,":[207],"longer":[208],"treatments,":[209],"both":[211],"be":[213],"required":[214],"adipose":[219],"cells.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}