{"id":"https://openalex.org/W2005266644","doi":"https://doi.org/10.1111/j.1600-0749.2007.00374.x","title":"A darker side to p53","display_name":"A darker side to p53","publication_year":2007,"publication_date":"2007-04-05","ids":{"openalex":"https://openalex.org/W2005266644","doi":"https://doi.org/10.1111/j.1600-0749.2007.00374.x","mag":"2005266644","pmid":"https://pubmed.ncbi.nlm.nih.gov/17516921"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0749.2007.00374.x","doi":"https://doi.org/10.1111/j.1600-0749.2007.00374.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0749.2007.00374.x","pdf_url":null,"source":{"id":"https://openalex.org/S180366410","display_name":"Pigment Cell Research","issn_l":"0893-5785","issn":["0893-5785","1600-0749"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064354901","display_name":"Supriya Gaitonde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Supriya Gaitonde","raw_affiliation_strings":["Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026512599","display_name":"Ze\u2019ev A. Ronai","orcid":"https://orcid.org/0000-0002-3859-0400","observed_orcids":["https://orcid.org/0000-0002-3859-0400"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ze'ev Ronai","raw_affiliation_strings":["*Address correspondence to Ze'ev Ronai,e-mail:","Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Address correspondence to Ze'ev Ronai,e-mail:","institution_ids":[]},{"raw_affiliation_string":"Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA, USA","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026512599"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14270413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"3","first_page":"148","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.51419997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.51419997215271,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.1949000060558319,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.1527000069618225,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9909999966621399},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.6079999804496765},{"id":"https://openalex.org/keywords/alpha-msh","display_name":"alpha-melanocyte-stimulating hormone","score":0.8420000076293945},{"id":"https://openalex.org/keywords/proopiomelanocortin","display_name":"proopiomelanocortin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/mc1r","display_name":"MC1R","score":0.7900000214576721},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.796999990940094},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/fitzpatrick-skin-type","display_name":"Fitzpatrick skin type","score":0.609000027179718},{"id":"https://openalex.org/keywords/melanocyte-differentiation","display_name":"melanocyte differentiation","score":0.5019999742507935},{"id":"https://openalex.org/keywords/tumor-suppressor-function","display_name":"tumor suppressor function","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C182843373","wikidata":"https://www.wikidata.org/wiki/Q21173746","display_name":"Melanocortin 1 receptor","level":4,"score":0.8738008737564087},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.7700006365776062},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6868943572044373},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.6762153506278992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6012929081916809},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5492361783981323},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5402703881263733},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5244736671447754},{"id":"https://openalex.org/C2780846639","wikidata":"https://www.wikidata.org/wiki/Q3749115","display_name":"Phototype","level":2,"score":0.5086385011672974},{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.4850253462791443},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.4790845513343811},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43317508697509766},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.4254250228404999},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4216309189796448},{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.4159730076789856},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4158082902431488},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4143463373184204},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.3840622007846832},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3051854968070984},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2687515616416931},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22919589281082153},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2177082598209381},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.20472267270088196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15334424376487732},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.1335260570049286},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09155771136283875}],"mesh":[{"descriptor_ui":"D002280","descriptor_name":"Carcinoma, Basal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Carcinoma, Basal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Carcinoma, Basal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Carcinoma, Basal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012880","descriptor_name":"Skin Pigmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012880","descriptor_name":"Skin Pigmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012880","descriptor_name":"Skin Pigmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0749.2007.00374.x","doi":"https://doi.org/10.1111/j.1600-0749.2007.00374.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0749.2007.00374.x","pdf_url":null,"source":{"id":"https://openalex.org/S180366410","display_name":"Pigment Cell Research","issn_l":"0893-5785","issn":["0893-5785","1600-0749"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell Research","raw_type":"journal-article"},{"id":"pmid:17516921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17516921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment cell research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1963776674","https://openalex.org/W2006809167","https://openalex.org/W2008120376","https://openalex.org/W2032172958","https://openalex.org/W2034710079","https://openalex.org/W2046585256","https://openalex.org/W2069423064","https://openalex.org/W2095916340","https://openalex.org/W2109349283"],"related_works":["https://openalex.org/W2058372909","https://openalex.org/W2103033856","https://openalex.org/W1524775751","https://openalex.org/W1995276900","https://openalex.org/W1969625965","https://openalex.org/W2002277832","https://openalex.org/W1999607409","https://openalex.org/W3136995308","https://openalex.org/W2153452328","https://openalex.org/W2085408843"],"abstract_inverted_index":{"The":[0,86,480,832],"tumor":[1,849],"suppressor":[2],"protein":[3,295,430,449],"p53":[4,46,394,448,457,470,478,501,525,548,565,601,629,662,687,693,719,764,790,889],"is":[5,63,115,165,188,214,267,349,369,765,791,812,861,915],"activated":[6],"in":[7,30,66,107,177,195,254,297,305,324,327,381,411,425,441,447,463,474,537,597,630,653,759,771,795,814,828,905,911],"response":[8,196,306,328,538,760,800],"to":[9,51,77,127,141,163,168,190,197,245,307,329,360,408,526,539,587,639,646,670,697,739,747,761,768,781,793,805,839,844,855,877,901],"various":[10],"types":[11],"of":[12,100,111,151,171,181,184,219,238,241,248,258,293,302,342,428,438,486,493,524,532,535,600,656,680,701,750,787,866],"cellular":[13],"stress":[14,333],"and":[15,18,36,53,125,136,282,310,331,353,384,415,472,497,514,578,605,665,717,752,848,869,890,909],"DNA":[16,32,204,400,642],"damage,":[17],"regulates,":[19],"chiefly":[20],"through":[21,116,216],"its":[22,225],"activity":[23],"as":[24,43,432,434],"a":[25,148,192,299,317,362,378,389,416,435,467,484,593,625,641,650,709,748,796,815],"transcription":[26,250,322],"factor,":[27],"genes":[28],"implicated":[29,825],"apoptosis,":[31],"repair,":[33],"cell":[34,49,59,419,715,845],"cycle":[35,846],"senescence":[37],"(Levine":[38],"et":[39,83,209,231,263,285,312,357,375,403,621,821],"al.,":[40,84,210,232,264,358],"2006).":[41],"In":[42,659,721,884],"much,":[44],"functional":[45],"can":[47,778],"tilt":[48],"fate":[50],"survive":[52],"repair":[54],"damage":[55],"or":[56,557],"initiate":[57],"the":[58,98,109,169,178,182,202,217,236,246,255,259,270,320,339,343,426,444,490,494,500,507,519,527,543,555,590,598,654,683,706,773,785,864,886,893],"death":[60],"program.":[61],"P53":[62],"often":[64],"dysregulated":[65],"human":[67,413,583,906],"tumors,":[68],"including":[69],"skin":[70,113,120,123,154,386,618,633,689,774,782,891,907],"cancer,":[71,908],"where":[72],"such":[73],"mutations":[74,207,776],"were":[75,668],"shown":[76,729],"result":[78,794],"from":[79,205,269,346,397,775],"sun":[80,133],"exposure":[81,309,407],"(Ananthaswamy":[82],"1997).":[85],"work":[87],"by":[88,102,173,200,371,392,574,635,730,789,819,917],"Fisher's":[89],"group,":[90],"sheds":[91],"important":[92,770,898],"new":[93],"light":[94],"into":[95],"mechanisms":[96],"underlying":[97],"protection":[99,804,904],"keratinocytes":[101,396,414,475,638],"p53.":[103],"A":[104,335],"key":[105,300],"factor":[106,251,323],"predicting":[108],"risk":[110,150],"developing":[112,152],"cancer":[114],"determining":[117],"an":[118,138,423,897],"individual's":[119],"phototype,":[121],"i.e.":[122],"color":[124],"ability":[126,162,876],"tan.":[128],"Fair":[129],"skinned":[130],"individuals,":[131],"who":[132,824],"burn":[134],"easily":[135],"have":[137],"increased":[139],"propensity":[140],"freckle":[142],"rather":[143],"than":[144,156],"tan":[145,164],"are":[146],"at":[147,338,554],"higher":[149],"non-malignant":[153],"cancers":[155],"individuals":[157],"with":[158,224,443,560,612,649,726,874],"darker":[159],"skin.":[160,186],"This":[161],"directly":[166],"related":[167],"synthesis":[170],"melanin":[172,577],"melanocytes,":[174],"typically":[175],"found":[176,767],"basal":[179,714],"layer":[180],"epidermis":[183],"vertebrate":[185],"Melanin":[187,212],"thought":[189],"play":[191],"photoprotective":[193],"role":[194,318,627],"UV":[198,308,330,372,409,454,508,540,568,588,702,762,867],"radiation":[199,410,455,703,868],"protecting":[201,772],"cell's":[203],"UV-induced":[206,522],"(Kobayashi":[208],"1993).":[211],"production":[213,257,860],"induced":[215,399,632],"association":[218],"\u03b1-melanocyte":[220],"stimulating":[221],"hormone":[222,280],"(\u03b1MSH)":[223],"receptor":[226,228],"melanocortin-1":[227],"(MC1R)":[229],"(Garc\u00eda-Borr\u00f3n":[230],"2005)":[233],"expressed":[234],"on":[235,674,863],"surface":[237],"melanocytes.":[239],"Activation":[240],"MC1R":[242],"ultimately":[243,779],"leads":[244],"activation":[247],"microphthalmia-associated":[249],"(MITF)":[252],"involved":[253],"actual":[256],"pigment":[260],"enzymes":[261],"(Rouzaud":[262],"2005).":[265],"\u03b1MSH":[266],"derived":[268],"multi-component":[271],"gene":[272,496],"pro-opiomelanocortin":[273],"(POMC),":[274],"which":[275,347,368,393,570,609,743,801],"also":[276,315,473,482,623],"codes":[277],"for":[278,319,366,477,506,576,628,734],"adrenocorticotropic":[279],"(ACTH)":[281],"\u03b2-endorphin.":[283],"D'Orazio":[284],"al.":[286,313,376,404,622,822],"(2006)":[287],"had":[288],"previously":[289,816],"demonstrated":[290,405,521,624,688],"significant":[291],"induction":[292,437,452,460,510,694,786],"\u03b1-MSH":[294,348,382,439,604,754,859],"levels":[296,383,427,599,655],"keratinocytes,":[298],"target":[301,837],"solar":[303],"radiation,":[304,589,763],"Corre":[311],"(2004)":[314],"highlighted":[316],"USF":[321],"POMC":[325,344,429,451,495,528,536,579,657,751,835],"expression":[326,431,608],"p38":[332],"signaling.":[334],"closer":[336],"look":[337],"promoter":[340,491,529],"region":[341,492,530],"gene,":[345],"derived,":[350],"led":[351],"Fisher":[352,894],"his":[354],"colleagues":[355],"(Cui":[356],"2007)":[359],"identify":[361],"consensus":[363,502],"binding":[364],"sequence":[365,503],"p53,":[367,648,681,728,735],"upregulated":[370],"radiation.":[373,541],"Cui":[374,402,620],"demonstrate":[377],"p53-dependent":[379,858],"increase":[380,424,446,595,652],"consequently":[385],"pigmentation":[387,634,690,699,758,892],"suggesting":[388,691],"novel":[390],"mechanism":[391],"protects":[395],"UV-radiation":[398],"mutations.":[401],"that":[406,499,692,777],"primary":[412],"mouse":[417],"keratinocyte":[418],"line":[420],"PAM212":[421,464,637],"caused":[422],"well":[433,611],"30-fold":[436],"secretion,":[440],"conjunction":[442],"expected":[445,792],"levels.":[450,658],"after":[453,566],"was":[456,461,504,571,585,695,737,744],"dependent":[458,862],"since":[459],"lost":[462],"cells":[465],"expressing":[466,562,685],"dominant":[468],"negative":[469],"allele":[471],"nullizygous":[476],"expression.":[479],"authors":[481,520,591,707],"constructed":[483],"series":[485],"reporter":[487],"constructs":[488],"using":[489],"showed":[498,592,708],"critical":[505],"based":[509],"observed.":[511],"Using":[512],"ChIP":[513],"electrophoretic":[515],"mobility":[516],"shift":[517],"analysis,":[518],"DNA-binding":[523],"indicative":[531],"p53s":[533,840,875],"regulation":[534,847],"At":[542],"physiological":[544],"level,":[545],"mice":[546,561,667,684],"lacking":[547],"did":[549],"not":[550,882],"appear":[551],"visibly":[552],"tanned":[553],"ears":[556],"tail":[558],"compared":[559],"wild":[563,663],"type":[564,664,798],"prolonged":[567],"exposure,":[569],"confirmed":[572],"histologically":[573],"staining":[575,733],"precursor.":[580],"When":[581],"discarded":[582],"foreskin":[584],"exposed":[586],"sequential":[594],"first":[596],"protein,":[602],"next":[603],"finally":[606],"MITF":[607],"correlates":[610],"their":[613,675,918],"proposed":[614],"signaling":[615],"cascade":[616],"involving":[617],"pigmentation.":[619],"possible":[626],"non-UV":[631],"exposing":[636],"etoposide,":[640],"damaging":[643],"agent":[644],"known":[645,678],"induce":[647,878],"correlative":[651],"vivo,":[660],"when":[661],"null":[666],"treated":[669],"5-FluoroUracil":[671],"(5-FU)":[672],"applications":[673],"ears,":[676],"another":[677],"inducer":[679],"only":[682],"wild-type":[686,718],"sufficient":[696],"achieve":[698],"independent":[700],"exposure.":[704],"Finally,":[705],"positive":[710,731],"correlation":[711],"between":[712,888],"pigmented":[713],"carcinomas":[716],"status.":[720],"Basal":[722],"Cell":[723],"Carcinoma":[724],"(BCCs)":[725],"mutant":[727],"immunohistochemical":[732],"there":[736],"reduced":[738],"no":[740],"melanocyte":[741],"colonization,":[742],"probably":[745],"due":[746],"lack":[749],"subsequent":[753,806],"induction.":[755],"By":[756],"inducing":[757],"now":[766],"be":[769,853],"lead":[780],"cancer.":[783],"However,":[784],"alpha-MSH":[788,826],"delayed":[797],"tanning":[799],"would":[802,872],"confer":[803],"exposures.":[807],"An":[808],"immediate":[809],"protective":[810],"effect":[811],"exemplified":[813],"published":[817],"report":[818],"B\u00f6hm":[820],"(2005),":[823],"function":[827],"nucleotide":[829],"excision":[830],"repair.":[831],"newly":[833],"discovered":[834],"downstream":[836],"adds":[838],"growing":[841],"resum\u00e9":[842],"contributing":[843],"prevention.":[850],"It":[851],"will":[852],"interesting":[854],"reveal":[856],"whether":[857,870],"dose":[865],"it":[871],"coincide":[873],"growth":[879],"arrest":[880],"but":[881],"apoptosis.":[883],"identifying":[885],"link":[887],"group":[895],"provides":[896],"mechanistic":[899],"insight":[900],"explain":[902],"impaired":[903],"possibly":[910],"melanoma":[912],"whose":[913],"development":[914],"affected":[916],"neighboring":[919],"keratinocytes.":[920]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
