{"id":"https://openalex.org/W2005263665","doi":"https://doi.org/10.1359/jbmr.060812","title":"QTL With Pleiotropic Effects on Serum Levels of Bone-Specific Alkaline Phosphatase and Osteocalcin Maps to the Baboon Ortholog of Human Chromosome 6p23-21.3","display_name":"QTL With Pleiotropic Effects on Serum Levels of Bone-Specific Alkaline Phosphatase and Osteocalcin Maps to the Baboon Ortholog of Human Chromosome 6p23-21.3","publication_year":2006,"publication_date":"2006-09-29","ids":{"openalex":"https://openalex.org/W2005263665","doi":"https://doi.org/10.1359/jbmr.060812","mag":"2005263665","pmid":"https://pubmed.ncbi.nlm.nih.gov/17002583"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.060812","doi":"https://doi.org/10.1359/jbmr.060812","is_oa":true,"landing_page_url":"https://doi.org/10.1359/jbmr.060812","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.060812","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.060812","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109231677","display_name":"Lorena M. Havill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lorena M Havill","raw_affiliation_strings":["Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089124760","display_name":"Jeffrey Rogers","orcid":"https://orcid.org/0000-0002-7374-6490","observed_orcids":["https://orcid.org/0000-0002-7374-6490"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Rogers","raw_affiliation_strings":["Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA","Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I1289525096"]},{"raw_affiliation_string":"Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083082611","display_name":"Laura A. Cox","orcid":"https://orcid.org/0000-0002-8836-3783","observed_orcids":["https://orcid.org/0000-0002-8836-3783","https://orcid.org/0000-0003-0387-0039"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura A Cox","raw_affiliation_strings":["Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039056655","display_name":"Michael C. Mahaney","orcid":"https://orcid.org/0000-0002-1341-3950","observed_orcids":["https://orcid.org/0000-0002-1341-3950"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C Mahaney","raw_affiliation_strings":["Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA","Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I1289525096"]},{"raw_affiliation_string":"Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I1289525096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109231677"],"corresponding_institution_ids":["https://openalex.org/I1289525096"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":2.8359,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.902638,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"21","issue":"12","first_page":"1888","last_page":"1896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.47999998927116394,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.47999998927116394,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.14920000731945038,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.1340000033378601,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.5590000152587891},{"id":"https://openalex.org/keywords/baboons","display_name":"baboons","score":0.5690000057220459},{"id":"https://openalex.org/keywords/osteoblast-activity","display_name":"osteoblast activity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mineral-and-bone-metabolism","display_name":"bone mineral metabolism","score":0.42899999022483826},{"id":"https://openalex.org/keywords/genetic-variance","display_name":"genetic variance","score":0.46000000834465027},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.7490000128746033},{"id":"https://openalex.org/keywords/primates","display_name":"primates","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.7512482404708862},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.6542251706123352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6207091808319092},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5674788355827332},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.5573195219039917},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.5523701906204224},{"id":"https://openalex.org/C2779594886","wikidata":"https://www.wikidata.org/wiki/Q159429","display_name":"Baboon","level":2,"score":0.5442190766334534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45474478602409363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4505515694618225},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.44564497470855713},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.42664653062820435},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26363271474838257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09656816720962524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09160152077674866},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07201024889945984},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002896","descriptor_name":"Chromosomes, Human, Pair 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002896","descriptor_name":"Chromosomes, Human, Pair 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002896","descriptor_name":"Chromosomes, Human, Pair 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002896","descriptor_name":"Chromosomes, Human, Pair 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048529","descriptor_name":"Papio hamadryas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048529","descriptor_name":"Papio hamadryas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048529","descriptor_name":"Papio hamadryas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048529","descriptor_name":"Papio hamadryas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1359/jbmr.060812","doi":"https://doi.org/10.1359/jbmr.060812","is_oa":true,"landing_page_url":"https://doi.org/10.1359/jbmr.060812","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.060812","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:17002583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17002583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1359/jbmr.060812","doi":"https://doi.org/10.1359/jbmr.060812","is_oa":true,"landing_page_url":"https://doi.org/10.1359/jbmr.060812","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.060812","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8026000261306763}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2167357153","display_name":null,"funder_award_id":"F32 AR049694","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4311092909","display_name":null,"funder_award_id":"P51 RR013896","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G451542874","display_name":"The Southwest National Primate Research Center","funder_award_id":"P51RR013986","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8536394691","display_name":null,"funder_award_id":"R01 RR00878","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005263665.pdf","grobid_xml":"https://content.openalex.org/works/W2005263665.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W97722187","https://openalex.org/W191965805","https://openalex.org/W1674786313","https://openalex.org/W1870878643","https://openalex.org/W1967245007","https://openalex.org/W1971265121","https://openalex.org/W1972679805","https://openalex.org/W1973772928","https://openalex.org/W1976741643","https://openalex.org/W1984673404","https://openalex.org/W1986593290","https://openalex.org/W1989534548","https://openalex.org/W1990541138","https://openalex.org/W1991062093","https://openalex.org/W1998234512","https://openalex.org/W2002000090","https://openalex.org/W2010964594","https://openalex.org/W2015844309","https://openalex.org/W2016549203","https://openalex.org/W2021656154","https://openalex.org/W2027852937","https://openalex.org/W2028360574","https://openalex.org/W2031777038","https://openalex.org/W2032685907","https://openalex.org/W2034210974","https://openalex.org/W2037950861","https://openalex.org/W2041296030","https://openalex.org/W2042108905","https://openalex.org/W2048258242","https://openalex.org/W2056523046","https://openalex.org/W2062781570","https://openalex.org/W2066930140","https://openalex.org/W2067027353","https://openalex.org/W2067287049","https://openalex.org/W2068509699","https://openalex.org/W2069528459","https://openalex.org/W2073019665","https://openalex.org/W2078249213","https://openalex.org/W2088094983","https://openalex.org/W2089221493","https://openalex.org/W2089565962","https://openalex.org/W2091656394","https://openalex.org/W2093544232","https://openalex.org/W2101110154","https://openalex.org/W2112729869","https://openalex.org/W2115335486","https://openalex.org/W2120122580","https://openalex.org/W2123477383","https://openalex.org/W2141591906","https://openalex.org/W2156059881","https://openalex.org/W2159367236","https://openalex.org/W2171236148","https://openalex.org/W2410855834","https://openalex.org/W2411268690","https://openalex.org/W2419277001","https://openalex.org/W2955504961","https://openalex.org/W4250968608","https://openalex.org/W4252160132","https://openalex.org/W4302219957","https://openalex.org/W6685241695","https://openalex.org/W6832843088"],"related_works":["https://openalex.org/W1972679805","https://openalex.org/W1967245007","https://openalex.org/W2016549203","https://openalex.org/W2023476973","https://openalex.org/W2073019665","https://openalex.org/W2123477383","https://openalex.org/W7221036657","https://openalex.org/W2069208705","https://openalex.org/W2083845818","https://openalex.org/W2056404514"],"abstract_inverted_index":{"UNLABELLED:":[0],"Bone":[1],"ALP":[2,76,100,131,139,162,184,198,225,289,317],"and":[3,29,57,101,123,132,140,166,185,226,285,290,318,321,363],"OC":[4,102,170,227,319],"are":[5,67,95],"under":[6,68],"partial":[7,69],"genetic":[8,34,70,93,221,300],"control.":[9,71],"This":[10,294],"study":[11,351],"of":[12,32,52,64,116,126,196,205,219,233,306,352,355],"591":[13,117],"pedigreed":[14,119],"baboons":[15,120],"shows":[16],"a":[17,114,167,241,311],"QTL":[18,242],"corresponding":[19,246],"to":[20,82,91,113,121,247,272,334],"human":[21,206,248,277],"6p23-21.3":[22],"that":[23,128,133,310,330,340],"accounts":[24],"for":[25,148,158,175,181,193,255,287,298,345],"25%":[26],"(bone":[27],"ALP)":[28],"20%":[30],"(OC)":[31,59],"the":[33,89,160,178,202,220,234,244,252,276,353],"variance.":[35],"A":[36,142,188],"gene":[37],"affecting":[38],"osteoblast":[39,61,307],"activity,":[40],"number,":[41],"or":[42],"recruitment":[43],"likely":[44],"resides":[45],"in":[46,85,156,223,243,275,357],"this":[47,331,358],"area.":[48],"INTRODUCTION:":[49],"Serum":[50],"levels":[51,195],"bone":[53,75,99,130,138,149,161,183,197,224,288,316,324,361],"alkaline":[54],"phosphatase":[55],"(ALP)":[56],"osteocalcin":[58],"reflect":[60],"activity.":[62],"Both":[63],"these":[65],"measures":[66],"Genetic":[72],"effects":[73,94,125,136,232,301],"on":[74,137,177,201,302,315,323,336,360],"have":[77,134],"not":[78],"been":[79,103],"previously":[80],"localized":[81],"chromosomal":[83,207],"regions":[84],"primates,":[86],"nor":[87],"has":[88,341],"degree":[90],"which":[92,159],"shared":[96,299],"(pleiotropic)":[97],"between":[98],"studied.":[104],"MATERIALS":[105],"AND":[106],"METHODS:":[107],"We":[108],"applied":[109],"variance":[110,222],"components":[111],"methods":[112],"sample":[115],"adult":[118],"detect":[122],"quantify":[124],"genes":[127,356],"influence":[129],"pleiotropic":[135,231,313],"OC.":[141,186],"univariate":[143,169],"linkage":[144,152,171,176,238,257],"analysis":[145,172,239],"was":[146],"conducted":[147,155],"ALP.":[150],"Bivariate":[151,237],"analyses":[153],"were":[154],"areas":[157],"results":[163],"presented":[164],"here":[165],"previous":[168],"showed":[173],"evidence":[174,254],"same":[179,235],"chromosome":[180,249,338],"both":[182],"RESULTS:":[187],"quantitative":[189],"trait":[190],"locus":[191],"(QTL)":[192],"serum":[194,304],"is":[199,228,283,326],"evident":[200],"baboon":[203],"ortholog":[204],"region":[208,245,332,359],"6p":[209],"(LOD":[210,260],"2.93).":[211],"Thirty-seven":[212],"percent":[213],"(genetic":[214],"correlation":[215],"[rho(G)]":[216],"=":[217,261],"0.61)":[218],"caused":[229],"by":[230],"gene(s).":[236],"revealed":[240],"6p23-21.3,":[250],"with":[251],"strongest":[253],"bivariate":[256],"near":[258],"D6S422":[259,270],"2.97":[262],"at":[263],"22":[264],"cM":[265],"from":[266],"our":[267],"pter-most":[268],"marker).":[269],"maps":[271],"20.4":[273],"Mb":[274],"genome.":[278],"The":[279,328],"QTL-specific":[280],"heritability":[281],"(h2)":[282],"0.25":[284],"0.20":[286],"OC,":[291],"respectively.":[292],"CONCLUSIONS:":[293],"first":[295],"formal":[296],"test":[297],"two":[303],"markers":[305],"activity":[308],"indicates":[309],"significant":[312],"effect":[314,354],"levels,":[320],"thus":[322],"formation,":[325],"detectible.":[327],"fact":[329],"corresponds":[333],"one":[335],"mouse":[337],"13":[339],"repeatedly":[342],"yielded":[343],"QTLs":[344],"BMD":[346],"should":[347],"encourage":[348],"more":[349],"intensive":[350],"maintenance":[362],"turnover.":[364]},"counts_by_year":[{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}