{"id":"https://openalex.org/W2005263625","doi":"https://doi.org/10.1136/vr.143.15.412","title":"Early manifestations of granulocytic ehrlichiosis in dogs inoculated experimentally with a Swedish Ehrlichia species isolate","display_name":"Early manifestations of granulocytic ehrlichiosis in dogs inoculated experimentally with a Swedish Ehrlichia species isolate","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2005263625","doi":"https://doi.org/10.1136/vr.143.15.412","mag":"2005263625","pmid":"https://pubmed.ncbi.nlm.nih.gov/9807790"},"language":"en","primary_location":{"id":"doi:10.1136/vr.143.15.412","doi":"https://doi.org/10.1136/vr.143.15.412","is_oa":false,"landing_page_url":"https://doi.org/10.1136/vr.143.15.412","pdf_url":null,"source":{"id":"https://openalex.org/S23243006","display_name":"Veterinary Record","issn_l":"0042-4900","issn":["0042-4900","2042-7670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Record","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079284194","display_name":"Agneta Egenvall","orcid":"https://orcid.org/0000-0002-8677-6066","observed_orcids":["https://orcid.org/0000-0002-8677-6066"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. Egenvall","raw_affiliation_strings":["Department of Small Animal Clincial Sciences; Swedish University of Agricultural Sciences; Uppsala Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Clincial Sciences; Swedish University of Agricultural Sciences; Uppsala Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004825450","display_name":"Anneli Bj\u00f6ersdorff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139554","display_name":"Landstinget i Kalmar l\u00e4n","ror":"https://ror.org/033bc9f34","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210139554"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. Bj\u00f6ersdorff","raw_affiliation_strings":["Department of Clinical Microbiology; Kalmar County Hospital; Kalmar Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Microbiology; Kalmar County Hospital; Kalmar Sweden","institution_ids":["https://openalex.org/I4210139554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043452039","display_name":"L. Lillieh\u00f6\u00f6k","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Lillieh\u00f6\u00f6k","raw_affiliation_strings":["Department of Clinical Chemistry Swedish University of Agricultural Sciences Uppsala Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry Swedish University of Agricultural Sciences Uppsala Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Olsson Engvall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330204332","display_name":"Swedish Veterinary Agency","ror":"https://ror.org/00awbw743","country_code":"SE","type":"government","lineage":["https://openalex.org/I1330204332"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E. Olsson Engvall","raw_affiliation_strings":["Department of Bacteriology National Veterinary Institute Uppsala Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology National Veterinary Institute Uppsala Sweden","institution_ids":["https://openalex.org/I1330204332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056154079","display_name":"E. Karlstam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E. Karlstam","raw_affiliation_strings":["Department of Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004781491","display_name":"Karin Artursson","orcid":"https://orcid.org/0000-0001-7721-0944","observed_orcids":["https://orcid.org/0000-0001-7721-0944"]},"institutions":[{"id":"https://openalex.org/I1330204332","display_name":"Swedish Veterinary Agency","ror":"https://ror.org/00awbw743","country_code":"SE","type":"government","lineage":["https://openalex.org/I1330204332"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"K. Artursson","raw_affiliation_strings":["Department of Bacteriology National Veterinary Institute Uppsala Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology National Veterinary Institute Uppsala Sweden","institution_ids":["https://openalex.org/I1330204332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071747335","display_name":"\u00c5ke A. Hedhammar","orcid":"https://orcid.org/0000-0001-7048-3851","observed_orcids":["https://orcid.org/0000-0001-7048-3851"]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"\u00c5. Hedhammar","raw_affiliation_strings":["Department of Small Animal Clincial Sciences; Swedish University of Agricultural Sciences; Uppsala Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Clincial Sciences; Swedish University of Agricultural Sciences; Uppsala Sweden","institution_ids":["https://openalex.org/I298625061"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033361642","display_name":"A. Gunnarsson","orcid":"https://orcid.org/0000-0002-1631-2530","observed_orcids":["https://orcid.org/0000-0002-1631-2530"]},"institutions":[{"id":"https://openalex.org/I1330204332","display_name":"Swedish Veterinary Agency","ror":"https://ror.org/00awbw743","country_code":"SE","type":"government","lineage":["https://openalex.org/I1330204332"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. Gunnarsson","raw_affiliation_strings":["Department of Bacteriology National Veterinary Institute Uppsala Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology National Veterinary Institute Uppsala Sweden","institution_ids":["https://openalex.org/I1330204332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.6452,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.81210121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"143","issue":"15","first_page":"412","last_page":"417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocytic-ehrlichiosis","display_name":"granulocytic ehrlichiosis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/canine-ehrlichiosis","display_name":"canine ehrlichiosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ehrlichia","display_name":"Ehrlichia","score":0.8659999966621399},{"id":"https://openalex.org/keywords/experimental-infection-in-dogs","display_name":"experimental infection in dogs","score":0.7300000190734863},{"id":"https://openalex.org/keywords/pathogenicity","display_name":"pathogenicity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9200000166893005},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.9589999914169312},{"id":"https://openalex.org/keywords/serological-antibody-response","display_name":"serological antibody response","score":0.8830000162124634},{"id":"https://openalex.org/keywords/16s-rrna-gene","display_name":"16S rRNA gene","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ehrlichia-equi","display_name":"Ehrlichia equi","score":0.8970000147819519},{"id":"https://openalex.org/keywords/anaplasma-phagocytophilum","display_name":"Anaplasma phagocytophilum","score":0.9869999885559082},{"id":"https://openalex.org/keywords/splenic-hyperplasia","display_name":"splenic hyperplasia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hepatitis","display_name":"hepatitis","score":0.597000002861023},{"id":"https://openalex.org/keywords/beagle","display_name":"beagle dogs","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2779657035","wikidata":"https://www.wikidata.org/wiki/Q138670","display_name":"Ehrlichia","level":3,"score":0.9498885869979858},{"id":"https://openalex.org/C2778101375","wikidata":"https://www.wikidata.org/wiki/Q2845432","display_name":"Ehrlichiosis","level":3,"score":0.8421909213066101},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7036757469177246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5876034498214722},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.5797933340072632},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.5336777567863464},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.5325201153755188},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.4813562035560608},{"id":"https://openalex.org/C143701427","wikidata":"https://www.wikidata.org/wiki/Q193566","display_name":"Incubation period","level":3,"score":0.4685538709163666},{"id":"https://openalex.org/C2777945365","wikidata":"https://www.wikidata.org/wiki/Q1891441","display_name":"Convalescence","level":2,"score":0.42708703875541687},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3760145306587219},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34181419014930725},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2281987965106964},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21802043914794922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20692187547683716},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.19894269108772278},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10011899471282959},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779620486","wikidata":"https://www.wikidata.org/wiki/Q10304508","display_name":"Tick","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000380","descriptor_name":"Agranulocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004536","descriptor_name":"Ehrlichia","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016873","descriptor_name":"Ehrlichiosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016873","descriptor_name":"Ehrlichiosis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1136/vr.143.15.412","doi":"https://doi.org/10.1136/vr.143.15.412","is_oa":false,"landing_page_url":"https://doi.org/10.1136/vr.143.15.412","pdf_url":null,"source":{"id":"https://openalex.org/S23243006","display_name":"Veterinary Record","issn_l":"0042-4900","issn":["0042-4900","2042-7670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Record","raw_type":"journal-article"},{"id":"pmid:9807790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9807790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Veterinary record","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W130878224","https://openalex.org/W289589996","https://openalex.org/W309015181","https://openalex.org/W1486304048","https://openalex.org/W1596586814","https://openalex.org/W1852073127","https://openalex.org/W1956842074","https://openalex.org/W1964225856","https://openalex.org/W1967764944","https://openalex.org/W1973548583","https://openalex.org/W1992389768","https://openalex.org/W1995762177","https://openalex.org/W2012352847","https://openalex.org/W2039862854","https://openalex.org/W2044304770","https://openalex.org/W2051647728","https://openalex.org/W2059641904","https://openalex.org/W2064006988","https://openalex.org/W2064160605","https://openalex.org/W2092541107","https://openalex.org/W2100852581","https://openalex.org/W2136733880","https://openalex.org/W2137240443","https://openalex.org/W2138829154","https://openalex.org/W2217920989","https://openalex.org/W2290596792","https://openalex.org/W2312951324","https://openalex.org/W2397280192","https://openalex.org/W2414322534","https://openalex.org/W2933648456","https://openalex.org/W4300633276","https://openalex.org/W4409131217"],"related_works":["https://openalex.org/W2051647728","https://openalex.org/W2102106844","https://openalex.org/W2004593021","https://openalex.org/W2150538673","https://openalex.org/W2094801825","https://openalex.org/W1852073127","https://openalex.org/W2162718538","https://openalex.org/W2475148489","https://openalex.org/W2029420278","https://openalex.org/W1977693283"],"abstract_inverted_index":{"Seven":[0],"beagles":[1],"were":[2,59,85,124],"inoculated":[3],"experimentally":[4],"with":[5],"a":[6,78,116],"Swedish":[7],"canine":[8],"Ehrlichia":[9,40],"species":[10],"isolate":[11,25],"to":[12,18,28,38,51,64,92,99],"study":[13],"its":[14],"pathogenicity.":[15],"With":[16],"respect":[17],"the":[19,24,29,54,70,112,127],"16S":[20],"rRNA":[21],"gene":[22],"sequence,":[23],"was":[26],"identical":[27],"human":[30],"granulocytic":[31],"ehrlichiosis":[32],"(HGE)":[33],"agent":[34],"and":[35,42,67,77,115,120,133],"closely":[36],"related":[37],"both":[39],"equi":[41],"E":[43],"phagocytophila.":[44],"After":[45],"an":[46],"incubation":[47],"period":[48],"of":[49],"four":[50,91,98],"11":[52],"days,":[53],"most":[55],"prominent":[56],"clinical":[57],"signs":[58],"high":[60],"fever":[61],"for":[62,97],"two":[63],"five":[65],"days":[66,94,118],"depression.":[68],"All":[69],"dogs":[71,128],"developed":[72],"profound":[73],"thrombocytopenia,":[74],"moderate":[75],"leukopenia":[76],"strong":[79],"serological":[80],"antibody":[81],"response.":[82],"Ehrlichial":[83,102],"inclusions":[84,123],"detected":[86,106],"in":[87],"blood":[88],"neutrophils":[89],"from":[90],"14":[93],"after":[95,121],"inoculation":[96],"eight":[100],"days.":[101],"DNA":[103],"could":[104],"be":[105],"by":[107],"polymerase":[108],"chain":[109],"reaction":[110],"during":[111],"parasitaemic":[113],"stage":[114],"few":[117],"before":[119],"microscopic":[122],"visible.":[125],"Postmortem,":[126],"showed":[129],"reactive":[130,136],"splenic":[131],"hyperplasia":[132],"non-specific":[134],"mononuclear":[135],"hepatitis.":[137]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}