{"id":"https://openalex.org/W2005259841","doi":"https://doi.org/10.1128/jvi.00609-10","title":"JC Virus Latency in the Brain and Extraneural Organs of Patients with and without Progressive Multifocal Leukoencephalopathy","display_name":"JC Virus Latency in the Brain and Extraneural Organs of Patients with and without Progressive Multifocal Leukoencephalopathy","publication_year":2010,"publication_date":"2010-07-07","ids":{"openalex":"https://openalex.org/W2005259841","doi":"https://doi.org/10.1128/jvi.00609-10","mag":"2005259841","pmid":"https://pubmed.ncbi.nlm.nih.gov/20610709","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2937633"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00609-10","doi":"https://doi.org/10.1128/jvi.00609-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00609-10","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2937633","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018805243","display_name":"Chen Sabrina Tan","orcid":"https://orcid.org/0000-0001-7604-0824","observed_orcids":["https://orcid.org/0000-0001-7604-0824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen S. Tan","raw_affiliation_strings":["Division of Infectious Disease","Division of Neurovirology, Department of Neurology","Division of Viral Pathogenesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Disease","institution_ids":[]},{"raw_affiliation_string":"Division of Neurovirology, Department of Neurology","institution_ids":[]},{"raw_affiliation_string":"Division of Viral Pathogenesis","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090443532","display_name":"Laura C. Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura C. Ellis","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, and Program in Virology, Harvard University, Boston, Massachusetts","Division of Neurovirology, Department of Neurology","Division of Viral Pathogenesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, and Program in Virology, Harvard University, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Neurovirology, Department of Neurology","institution_ids":[]},{"raw_affiliation_string":"Division of Viral Pathogenesis","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christian Wu\u0308thrich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Wu\u0308thrich","raw_affiliation_strings":["Division of Neurovirology, Department of Neurology","Division of Viral Pathogenesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurovirology, Department of Neurology","institution_ids":[]},{"raw_affiliation_string":"Division of Viral Pathogenesis","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087979959","display_name":"Long H. Ngo","orcid":"https://orcid.org/0000-0001-9349-7981","observed_orcids":["https://orcid.org/0000-0001-9349-7981","https://orcid.org/0000-0002-8903-9352","https://orcid.org/0009-0002-7254-4464"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Long Ngo","raw_affiliation_strings":["Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022280185","display_name":"Thomas A. Broge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas A. Broge","raw_affiliation_strings":["Division of Neurovirology, Department of Neurology","Division of Viral Pathogenesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurovirology, Department of Neurology","institution_ids":[]},{"raw_affiliation_string":"Division of Viral Pathogenesis","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007961893","display_name":"Jenny Saint-Aubyn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenny Saint-Aubyn","raw_affiliation_strings":["Division of Neurovirology, Department of Neurology","Division of Viral Pathogenesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurovirology, Department of Neurology","institution_ids":[]},{"raw_affiliation_string":"Division of Viral Pathogenesis","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111638968","display_name":"Janice S. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janice S. Miller","raw_affiliation_strings":["Division of Neurovirology, Department of Neurology","Division of Viral Pathogenesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurovirology, Department of Neurology","institution_ids":[]},{"raw_affiliation_string":"Division of Viral Pathogenesis","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034232033","display_name":"Igor Jerome Koralnik","orcid":"https://orcid.org/0000-0001-6836-1468","observed_orcids":["https://orcid.org/0000-0001-6836-1468"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Igor J. Koralnik","raw_affiliation_strings":["Division of Neurovirology, Department of Neurology","Division of Viral Pathogenesis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurovirology, Department of Neurology","institution_ids":[]},{"raw_affiliation_string":"Division of Viral Pathogenesis","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034232033"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.4734,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.97690305,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"84","issue":"18","first_page":"9200","last_page":"9209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jc-virus","display_name":"JC virus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/progressive-multifocal-leukoencephalopathy","display_name":"progressive multifocal leukoencephalopathy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/viral-latency","display_name":"viral latency","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.49900001287460327},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9800000190734863},{"id":"https://openalex.org/keywords/large-t-antigen","display_name":"large T antigen","score":0.6740000247955322},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.5619999766349792},{"id":"https://openalex.org/keywords/lymph-nodes","display_name":"lymph nodes","score":0.9449999928474426},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bone","display_name":"bone","score":0.6200000047683716},{"id":"https://openalex.org/keywords/vp1","display_name":"VP1","score":0.6309999823570251},{"id":"https://openalex.org/keywords/viral-compartmentalization","display_name":"viral compartmentalization","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2780644213","wikidata":"https://www.wikidata.org/wiki/Q704930","display_name":"Progressive multifocal leukoencephalopathy","level":3,"score":0.9163349866867065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8917189240455627},{"id":"https://openalex.org/C2779150272","wikidata":"https://www.wikidata.org/wiki/Q1676563","display_name":"JC virus","level":4,"score":0.7379340529441833},{"id":"https://openalex.org/C2778583010","wikidata":"https://www.wikidata.org/wiki/Q3237081","display_name":"Leukoencephalopathy","level":3,"score":0.557299017906189},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5514284372329712},{"id":"https://openalex.org/C148632171","wikidata":"https://www.wikidata.org/wiki/Q7542129","display_name":"Slow virus","level":4,"score":0.4916844964027405},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4598378539085388},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3285321593284607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06551581621170044},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007577","descriptor_name":"JC Virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007577","descriptor_name":"JC Virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027601","descriptor_name":"Polyomavirus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D027601","descriptor_name":"Polyomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.00609-10","doi":"https://doi.org/10.1128/jvi.00609-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00609-10","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2937633","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2937633","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:20610709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20610709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.866.6317","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.866.6317","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/84/18/9200.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2937633","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2937633","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1369205153","display_name":"TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCH","funder_award_id":"R24MH059656","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4116306409","display_name":"National Neurological AIDS Bank (NNAB)","funder_award_id":"R24NS038841","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4347998881","display_name":"The Manahattan HIV Brain Bank","funder_award_id":"R24MH059724","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G453267231","display_name":null,"funder_award_id":"and K24","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4700852728","display_name":null,"funder_award_id":"R01 NS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5488030015","display_name":"Cellular Immunity/JC Virus/AIDS/Leukoencephalopathy","funder_award_id":"R01NS041198","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G587811899","display_name":"California NeuroAIDS Tissue Network","funder_award_id":"R24MH059745","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6708893279","display_name":"Role of Inflammation in Progressive Multifocal Leukoencephalopathy","funder_award_id":"R01NS047029","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7754920241","display_name":"Translational applications of Progressive Multifocal Leukoencephalopathy studies","funder_award_id":"K24NS060950","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000868151","display_name":"Molecular Basis of Viral Infectivity","funder_award_id":"T32AI007245","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000904381","display_name":"Harvard University Center for AIDS Research","funder_award_id":"P30AI060354","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000907884","display_name":"Infectious Disease and Basic Microbiological Mechanisms","funder_award_id":"T32AI007061","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G92684404","display_name":"JC Virus Primary Infection, Latency, and Reactivation","funder_award_id":"K08NS064215","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1763805368","https://openalex.org/W1970547229","https://openalex.org/W1978062641","https://openalex.org/W1978238469","https://openalex.org/W1981039623","https://openalex.org/W1984007915","https://openalex.org/W1998543206","https://openalex.org/W2000379621","https://openalex.org/W2002265283","https://openalex.org/W2012150936","https://openalex.org/W2034474749","https://openalex.org/W2046965755","https://openalex.org/W2050727996","https://openalex.org/W2053683902","https://openalex.org/W2064922726","https://openalex.org/W2082046294","https://openalex.org/W2085037389","https://openalex.org/W2093676803","https://openalex.org/W2100096978","https://openalex.org/W2104330638","https://openalex.org/W2116016714","https://openalex.org/W2117243806","https://openalex.org/W2142120271","https://openalex.org/W2145389334","https://openalex.org/W2146196951","https://openalex.org/W2150435592","https://openalex.org/W2152538841","https://openalex.org/W2152705874","https://openalex.org/W2160466522","https://openalex.org/W2167640916","https://openalex.org/W2169726349","https://openalex.org/W2172275967"],"related_works":["https://openalex.org/W2065583493","https://openalex.org/W2152705874","https://openalex.org/W2034474749","https://openalex.org/W2171232241","https://openalex.org/W1497261232","https://openalex.org/W2160466522","https://openalex.org/W2322666636","https://openalex.org/W2064922726","https://openalex.org/W2152538841","https://openalex.org/W2125050311"],"abstract_inverted_index":{"JC":[0],"virus":[1],"(JCV)":[2],"is":[3,31],"latent":[4],"in":[5,17,33,43,95,116,139,156,164,179,192,198,216,221,243,254],"the":[6,18,34,83,126,134,140,157,180,193,205,244],"kidneys":[7],"and":[8,14,42,77,105,122,177,213,218,250,258],"lymphoid":[9],"organs":[10,38,220],"of":[11,20,39,52,63,67,136,142,159,170,182,204,231,240],"healthy":[12,40],"individuals,":[13,76,104],"its":[15],"reactivation":[16],"context":[19],"immunosuppression":[21,249],"may":[22],"lead":[23],"to":[24,247],"progressive":[25],"multifocal":[26],"leukoencephalopathy":[27],"(PML).":[28],"Whether":[29],"JCV":[30,56,88,112,137,147,187,206,241,255],"present":[32],"brains":[35,141,158],"or":[36,150,174,195],"other":[37],"people":[41],"immunosuppressed":[44],"patients":[45,143,184],"without":[46,144,175],"PML":[47,71,99,162],"has":[48],"been":[49],"a":[50,166],"matter":[51],"debate.":[53],"We":[54],"detected":[55,87,115,154,191],"large":[57],"T":[58,151],"DNA":[59,91,113,138],"by":[60,92],"quantitative":[61],"PCR":[62,94],"archival":[64],"brain":[65,217,245],"samples":[66,124,169],"9/24":[68],"(38%)":[69],"HIV-positive":[70,75,98,103,161,171,183],"patients,":[72,100,163,172],"5/18":[73],"(28%)":[74],"5/19":[78],"(26%)":[79],"HIV-negative":[80,108],"individuals.":[81,109],"In":[82,110,129],"same":[84,127],"samples,":[85],"we":[86],"regulatory":[89,207],"region":[90,208],"nested":[93],"6/19":[96],"(32%)":[97],"2/11":[101],"(18%)":[102,107],"3/17":[106],"addition,":[111],"was":[114],"some":[117],"spleen,":[118],"lymph":[119,196],"node,":[120],"bone,":[121],"kidney":[123,168],"from":[125],"groups.":[128,225],"situ":[130],"hybridization":[131],"data":[132],"confirmed":[133],"presence":[135],"PML.":[145,186],"However,":[146],"proteins":[148,188],"(VP1":[149],"antigen)":[152],"were":[153,189],"mainly":[155],"23/24":[160],"only":[165],"few":[167],"with":[173,185,234],"PML,":[176],"rarely":[178],"bones":[181],"not":[190],"spleen":[194],"nodes":[197],"any":[199],"study":[200,224],"group.":[201],"Furthermore,":[202],"analysis":[203],"sequences":[209],"showed":[210],"both":[211],"rearranged":[212],"archetype":[214],"forms":[215],"extraneural":[219],"all":[222],"three":[223],"Regulatory":[226],"regions":[227],"contained":[228],"increased":[229],"variations":[230],"rearrangements":[232],"correlating":[233],"immunosuppression.":[235],"These":[236],"results":[237],"provide":[238],"evidence":[239],"latency":[242],"prior":[246],"severe":[248],"suggest":[251],"new":[252],"paradigms":[253],"latency,":[256],"compartmentalization,":[257],"reactivation.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}