{"id":"https://openalex.org/W2005244032","doi":"https://doi.org/10.1016/j.annder.2012.10.075","title":"Vemurafenib dans le m\u00e9lanome m\u00e9tastatique mut\u00e9 BRAF : analyse d\u2019efficacit\u00e9 et de tol\u00e9rance chez 46 patients","display_name":"Vemurafenib dans le m\u00e9lanome m\u00e9tastatique mut\u00e9 BRAF : analyse d\u2019efficacit\u00e9 et de tol\u00e9rance chez 46 patients","publication_year":2012,"publication_date":"2012-11-24","ids":{"openalex":"https://openalex.org/W2005244032","doi":"https://doi.org/10.1016/j.annder.2012.10.075","mag":"2005244032"},"language":"fr","primary_location":{"id":"doi:10.1016/j.annder.2012.10.075","doi":"https://doi.org/10.1016/j.annder.2012.10.075","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.annder.2012.10.075","pdf_url":null,"source":{"id":"https://openalex.org/S41786655","display_name":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie","issn_l":"0151-9638","issn":["0151-9638","2214-5451"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003635545","display_name":"F\u00e9riel Fennira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"F. Fennira","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109401670","display_name":"C\u00e9cile Pag\u00e8s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Pag\u00e8s","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086508678","display_name":"Pierre Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Schneider","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023541726","display_name":"Irina Sidina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Sidina","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018760953","display_name":"Manuelle A Viguier","orcid":"https://orcid.org/0000-0001-9049-8700","observed_orcids":["https://orcid.org/0000-0001-9049-8700"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Viguier","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059444495","display_name":"Nicole Basset\u2010S\u00e9guin","orcid":"https://orcid.org/0000-0002-9136-1244","observed_orcids":["https://orcid.org/0000-0002-9136-1244"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Basset-seguin","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031665222","display_name":"N. Madjelessi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Madjelessi","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045517885","display_name":"Christelle Comte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Comte","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035819079","display_name":"Alain Archimbaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Archimbaud","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037376216","display_name":"Delphine K\u00e9rob","orcid":"https://orcid.org/0000-0003-2816-4261","observed_orcids":["https://orcid.org/0000-0003-2816-4261"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Kerob","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078712790","display_name":"Isabelle Madelaine","orcid":"https://orcid.org/0009-0004-3779-3312","observed_orcids":["https://orcid.org/0009-0004-3779-3312","https://orcid.org/0000-0001-7793-3317"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Madelaine","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068469347","display_name":"Martine Bagot","orcid":"https://orcid.org/0000-0002-1631-5192","observed_orcids":["https://orcid.org/0000-0002-1631-5192","https://orcid.org/0000-0002-0400-1954"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Bagot","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082425768","display_name":"Maxime Battistella","orcid":"https://orcid.org/0000-0002-7053-7431","observed_orcids":["https://orcid.org/0000-0002-7053-7431"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Battistella","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007042449","display_name":"Samia Mourah","orcid":"https://orcid.org/0000-0002-9283-1068","observed_orcids":["https://orcid.org/0000-0002-9283-1068"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Mourah","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066493529","display_name":"Rapha\u00ebl Porcher","orcid":"https://orcid.org/0000-0002-5277-4679","observed_orcids":["https://orcid.org/0000-0002-5277-4679"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R. Porcher","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025478490","display_name":"C\u00e9l\u00e8ste Lebb\u00e9","orcid":"https://orcid.org/0000-0002-5854-7290","observed_orcids":["https://orcid.org/0000-0002-5854-7290"]},"institutions":[{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Lebb\u00e9","raw_affiliation_strings":["H\u00f4pital Saint-Louis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Saint-Louis, Paris, France","institution_ids":["https://openalex.org/I4210144610"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003635545"],"corresponding_institution_ids":["https://openalex.org/I4210144610"],"apc_list":{"value":2040,"currency":"USD","value_usd":2040},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08060812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"139","issue":"12","first_page":"B82","last_page":"B83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vemurafenib","display_name":"vemurafenib","score":1.0},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.859000027179718},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.8500000238418579},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9380000233650208},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.8180000185966492},{"id":"https://openalex.org/keywords/viral-rna-replication","display_name":"viral RNA replication","score":0.8289999961853027},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5996279716491699},{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.5346791744232178},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5256420373916626},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5132513046264648},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5003418922424316},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4543929696083069},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4494676887989044},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43164968490600586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3242452144622803},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.24765127897262573},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.12798058986663818},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.annder.2012.10.075","doi":"https://doi.org/10.1016/j.annder.2012.10.075","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.annder.2012.10.075","pdf_url":null,"source":{"id":"https://openalex.org/S41786655","display_name":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie","issn_l":"0151-9638","issn":["0151-9638","2214-5451"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2796527216","https://openalex.org/W2404580886","https://openalex.org/W2476446980","https://openalex.org/W4297856966","https://openalex.org/W637873005","https://openalex.org/W2896528676","https://openalex.org/W2790945713","https://openalex.org/W2955558869","https://openalex.org/W4210509865","https://openalex.org/W2147058584"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}