{"id":"https://openalex.org/W2005241078","doi":"https://doi.org/10.1007/pl00003704","title":"Chondrocyte transplantation using PGLA/Polydioxanon fleeces","display_name":"Chondrocyte transplantation using PGLA/Polydioxanon fleeces","publication_year":2000,"publication_date":"2000-02-24","ids":{"openalex":"https://openalex.org/W2005241078","doi":"https://doi.org/10.1007/pl00003704","mag":"2005241078","pmid":"https://pubmed.ncbi.nlm.nih.gov/10743632"},"language":"de","primary_location":{"id":"doi:10.1007/pl00003704","doi":"https://doi.org/10.1007/pl00003704","is_oa":false,"landing_page_url":"https://doi.org/10.1007/pl00003704","pdf_url":null,"source":{"id":"https://openalex.org/S101410500","display_name":"Der Orthop\u00e4de","issn_l":"0085-4530","issn":["0085-4530","1433-0431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Der Orthop\u00e4de","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s001320050018","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038986793","display_name":"Carsten Perka","orcid":"https://orcid.org/0000-0002-0993-581X","observed_orcids":["https://orcid.org/0000-0002-0993-581X"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Perka","raw_affiliation_strings":["Orthop\u00e4dische Klinik und Poliklinik, Humboldt-Universit\u00e4t Berlin (Charit\u00e9), , , , , , DE","Orthop\u00e4dische Klinik und Poliklinik, Humboldt-Universit\u00e4t Berlin, Charit\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthop\u00e4dische Klinik und Poliklinik, Humboldt-Universit\u00e4t Berlin (Charit\u00e9), , , , , , DE","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Orthop\u00e4dische Klinik und Poliklinik, Humboldt-Universit\u00e4t Berlin, Charit\u00e9","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012429257","display_name":"Olaf Schultz","orcid":"https://orcid.org/0009-0007-4310-8854","observed_orcids":["https://orcid.org/0009-0007-4310-8854"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O. Schultz","raw_affiliation_strings":["Medizinische Universit\u00e4tsklinik und Poliklinik III, Humboldt-Universit\u00e4t Berlin (Charit\u00e9), , , , , , DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4tsklinik und Poliklinik III, Humboldt-Universit\u00e4t Berlin (Charit\u00e9), , , , , , DE","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038061458","display_name":"Michael Sittinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Sittinger","raw_affiliation_strings":["Medizinische Universit\u00e4tsklinik und Poliklinik III, Humboldt-Universit\u00e4t Berlin (Charit\u00e9), , , , , , DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Universit\u00e4tsklinik und Poliklinik III, Humboldt-Universit\u00e4t Berlin (Charit\u00e9), , , , , , DE","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113773201","display_name":"Hartmut Zippel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Zippel","raw_affiliation_strings":["Orthop\u00e4dische Klinik und Poliklinik, Humboldt-Universit\u00e4t Berlin (Charit\u00e9), , , , , , DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthop\u00e4dische Klinik und Poliklinik, Humboldt-Universit\u00e4t Berlin (Charit\u00e9), , , , , , DE","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.6567,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.67468619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"29","issue":"2","first_page":"0112","last_page":"0119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondrocyte-transplantation","display_name":"chondrocyte transplantation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/allogeneic-chondrocytes","display_name":"allogeneic chondrocytes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pgla","display_name":"PGLa","score":0.7720000147819519},{"id":"https://openalex.org/keywords/polydioxanone","display_name":"polydioxanone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/biodegradable-polymer-scaffolds","display_name":"biodegradable polymer scaffolds","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cartilage-defects","display_name":"cartilage defects","score":0.8420000076293945},{"id":"https://openalex.org/keywords/articular-cartilage-repair","display_name":"articular cartilage repair","score":0.9039999842643738},{"id":"https://openalex.org/keywords/osteochondral-lesions","display_name":"osteochondral defects","score":0.7760000228881836},{"id":"https://openalex.org/keywords/patellar-groove","display_name":"patellar groove","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hyaline-cartilage-regeneration","display_name":"hyaline cartilage regeneration","score":0.8529999852180481},{"id":"https://openalex.org/keywords/scaffold-degradation","display_name":"scaffold degradation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2780024818","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Hyaline cartilage","level":5,"score":0.796269416809082},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7703888416290283},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7572059631347656},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6805436611175537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.645868182182312},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5996623039245605},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.543901801109314},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5312839150428772},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4139055609703064},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.41189101338386536},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3465527296066284},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33508414030075073},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.33055371046066284},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32011809945106506},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.2672368884086609},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.232613205909729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10830262303352356},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.10459977388381958},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010329","descriptor_name":"Patella","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010329","descriptor_name":"Patella","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/pl00003704","doi":"https://doi.org/10.1007/pl00003704","is_oa":false,"landing_page_url":"https://doi.org/10.1007/pl00003704","pdf_url":null,"source":{"id":"https://openalex.org/S101410500","display_name":"Der Orthop\u00e4de","issn_l":"0085-4530","issn":["0085-4530","1433-0431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Der Orthop\u00e4de","raw_type":"journal-article"},{"id":"doi:10.1007/s001320050018","doi":"https://doi.org/10.1007/s001320050018","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s001320050018","pdf_url":null,"source":{"id":"https://openalex.org/S101410500","display_name":"Der Orthop\u00e4de","issn_l":"0085-4530","issn":["0085-4530","1433-0431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Der Orthop\u00e4de","raw_type":"journal-article"},{"id":"pmid:10743632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10743632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Der Orthopade","raw_type":"English Abstract"}],"best_oa_location":{"id":"doi:10.1007/s001320050018","doi":"https://doi.org/10.1007/s001320050018","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s001320050018","pdf_url":null,"source":{"id":"https://openalex.org/S101410500","display_name":"Der Orthop\u00e4de","issn_l":"0085-4530","issn":["0085-4530","1433-0431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Der Orthop\u00e4de","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2404360677","https://openalex.org/W2372572256","https://openalex.org/W2026270570","https://openalex.org/W1980114823","https://openalex.org/W1977815690","https://openalex.org/W2149463866","https://openalex.org/W74175366","https://openalex.org/W1943677324","https://openalex.org/W2036006109","https://openalex.org/W2104387729"],"abstract_inverted_index":{"The":[0,79,91,135,169,221],"transplantation":[1,30],"of":[2,19,31,63,74,97,113,118,137,147,152,190,218,224,233,244],"chondrogenic":[3],"cells":[4,162,237],"in":[5,34,40,44,53],"a":[6,13,35,45,54,105,114,191,212],"supportive":[7,213],"carrier":[8],"structure":[9,146],"proved":[10],"to":[11,186,210],"be":[12],"promising":[14],"alternative":[15],"for":[16,179,215,241],"the":[17,23,29,64,95,98,111,119,126,138,144,148,153,180,187,196,202,205,216,231,242],"treatment":[18],"cartilage":[20,42,101,116,193,245],"defects.":[21],"In":[22],"study":[24,170],"presented":[25],"we":[26],"focused":[27],"on":[28],"allogeneic":[32,50],"chondrocytes":[33,51],"biodegradable":[36,173],"polymer":[37,56,75,139,159,206],"scaffold":[38,57],"(PGLA/Polydioxanon)":[39],"articular":[41],"defects":[43,62,71,127],"rabbit":[46],"defect":[47,157],"model.":[48],"Isolated":[49],"embedded":[52],"PGLA":[55],"were":[58,102,128],"transplanted":[59],"into":[60,201],"osteochondrogenic":[61],"patellar":[65],"groove":[66],"and":[67,72,81,88,94,158,195,230],"compared":[68],"with":[69,104,132,155],"empty":[70,156],"transplants":[73,160,208],"scaffolds":[76],"without":[77,161],"cells.":[78],"histological":[80,145],"histochemical":[82],"analysis":[83],"was":[84,121],"performed":[85],"after":[86,123],"4":[87,109],"12":[89,124],"weeks.":[90],"transplant":[92,149,194,199],"integration":[93],"architecture":[96],"newly":[99],"formed":[100],"evaluated":[103],"semiquantitative":[106],"score.":[107],"After":[108],"weeks":[110,125],"development":[112,217],"hyaline-like":[115,133],"tissue":[117],"cell-polymer-transplants":[120],"observed,":[122],"nearly":[129],"completely":[130],"filled":[131],"cartilage.":[134,220],"biodegradation":[136],"construct":[140],"did":[141],"not":[142],"affect":[143],"area.":[150],"Defects":[151],"groups":[154],"revealed":[163],"no":[164],"or":[165,227],"insufficient":[166],"healing":[167],"indices.":[168],"demonstrated":[171],"that":[172],"polymers":[174],"served":[175],"as":[176],"suitable":[177],"carriers":[178],"chondrocyte":[181],"transplantation,":[182],"which":[183],"is":[184],"due":[185],"in-vitro":[188],"establishment":[189],"semi-solid":[192],"resulting":[197],"effective":[198],"fixation":[200],"defect.":[203],"In-vivo":[204],"cell":[207],"seem":[209],"provide":[211],"microenvironment":[214],"hyaline":[219],"controlled":[222],"release":[223],"morphogenic":[225],"factors":[226],"bioactive":[228],"molecules":[229],"use":[232],"pluripotent":[234],"mesenchymal":[235],"progenitor":[236],"opens":[238],"new":[239],"perspectives":[240],"optimization":[243],"repair":[246],"procedures.":[247]},"counts_by_year":[{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}