{"id":"https://openalex.org/W2005234239","doi":"https://doi.org/10.1021/jo1003136","title":"Chemoenzymatic Synthesis of Amaryllidaceae Constituents and Biological Evaluation of their C-1 Analogues. The Next Generation Synthesis of 7-Deoxypancratistatin and trans-Dihydrolycoricidine","display_name":"Chemoenzymatic Synthesis of Amaryllidaceae Constituents and Biological Evaluation of their C-1 Analogues. The Next Generation Synthesis of 7-Deoxypancratistatin and trans-Dihydrolycoricidine","publication_year":2010,"publication_date":"2010-04-07","ids":{"openalex":"https://openalex.org/W2005234239","doi":"https://doi.org/10.1021/jo1003136","mag":"2005234239","pmid":"https://pubmed.ncbi.nlm.nih.gov/20373760","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2872072"},"language":"en","primary_location":{"id":"doi:10.1021/jo1003136","doi":"https://doi.org/10.1021/jo1003136","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo1003136","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2872072","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047532205","display_name":"Jonathan Collins","orcid":"https://orcid.org/0000-0002-5591-5772","observed_orcids":["https://orcid.org/0000-0002-5591-5772"]},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jonathan Collins","raw_affiliation_strings":["Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","institution_ids":["https://openalex.org/I186803428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068834859","display_name":"Uwe Rinner","orcid":"https://orcid.org/0000-0002-7067-9990","observed_orcids":["https://orcid.org/0000-0002-7067-9990"]},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]},{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Uwe Rinner","raw_affiliation_strings":["Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","Chemistry Department, University of Florida, Gainesville, Florida 32611","Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","institution_ids":["https://openalex.org/I186803428"]},{"raw_affiliation_string":"Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]},{"raw_affiliation_string":"Chemistry Department, University of Florida, Gainesville, Florida 32611","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Moser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]},{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Michael Moser","raw_affiliation_strings":["Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","Chemistry Department, University of Florida, Gainesville, Florida 32611","Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","BROCK UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","institution_ids":["https://openalex.org/I186803428"]},{"raw_affiliation_string":"Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]},{"raw_affiliation_string":"Chemistry Department, University of Florida, Gainesville, Florida 32611","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","institution_ids":["https://openalex.org/I74413500"]},{"raw_affiliation_string":"BROCK UNIVERSITY","institution_ids":["https://openalex.org/I186803428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053528454","display_name":"Tom\u00e1\u0161 Hudlick\u00fd","orcid":"https://orcid.org/0000-0003-3239-6815","observed_orcids":["https://orcid.org/0000-0003-3239-6815"]},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]},{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Tomas Hudlicky","raw_affiliation_strings":["Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","Chemistry Department, University of Florida, Gainesville, Florida 32611","Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","BROCK UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","institution_ids":["https://openalex.org/I186803428"]},{"raw_affiliation_string":"Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]},{"raw_affiliation_string":"Chemistry Department, University of Florida, Gainesville, Florida 32611","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","institution_ids":["https://openalex.org/I74413500"]},{"raw_affiliation_string":"BROCK UNIVERSITY","institution_ids":["https://openalex.org/I186803428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081848017","display_name":"Ion Ghiviriga","orcid":"https://orcid.org/0000-0001-5812-5170","observed_orcids":["https://orcid.org/0000-0001-5812-5170"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ion Ghiviriga","raw_affiliation_strings":["Chemistry Department, University of Florida, Gainesville, Florida 32611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, University of Florida, Gainesville, Florida 32611","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111759696","display_name":"Anntherese E. Romero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]},{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Anntherese E. Romero","raw_affiliation_strings":["Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","Chemistry Department, University of Florida, Gainesville, Florida 32611","Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","New Mexico Institute of Mining and Technology#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","institution_ids":["https://openalex.org/I186803428"]},{"raw_affiliation_string":"Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]},{"raw_affiliation_string":"Chemistry Department, University of Florida, Gainesville, Florida 32611","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","institution_ids":["https://openalex.org/I74413500"]},{"raw_affiliation_string":"New Mexico Institute of Mining and Technology#TAB#","institution_ids":["https://openalex.org/I207123951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009000319","display_name":"Alexander Kornienko","orcid":"https://orcid.org/0000-0003-2041-7367","observed_orcids":["https://orcid.org/0000-0003-2041-7367"]},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]},{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Alexander Kornienko","raw_affiliation_strings":["Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","Chemistry Department, University of Florida, Gainesville, Florida 32611","Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","New Mexico Institute of Mining and Technology#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","institution_ids":["https://openalex.org/I186803428"]},{"raw_affiliation_string":"Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]},{"raw_affiliation_string":"Chemistry Department, University of Florida, Gainesville, Florida 32611","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","institution_ids":["https://openalex.org/I74413500"]},{"raw_affiliation_string":"New Mexico Institute of Mining and Technology#TAB#","institution_ids":["https://openalex.org/I207123951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064721987","display_name":"Dennis Ma","orcid":"https://orcid.org/0000-0002-3543-5560","observed_orcids":["https://orcid.org/0000-0002-3543-5560"]},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]},{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Dennis Ma","raw_affiliation_strings":["Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","Chemistry Department, University of Florida, Gainesville, Florida 32611","Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","Univ of Windsor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","institution_ids":["https://openalex.org/I186803428"]},{"raw_affiliation_string":"Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]},{"raw_affiliation_string":"Chemistry Department, University of Florida, Gainesville, Florida 32611","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","institution_ids":["https://openalex.org/I74413500"]},{"raw_affiliation_string":"Univ of Windsor","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113608956","display_name":"Carly Griffin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]},{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Carly Griffin","raw_affiliation_strings":["Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","Chemistry Department, University of Florida, Gainesville, Florida 32611","Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","Univ of Windsor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","institution_ids":["https://openalex.org/I186803428"]},{"raw_affiliation_string":"Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]},{"raw_affiliation_string":"Chemistry Department, University of Florida, Gainesville, Florida 32611","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","institution_ids":["https://openalex.org/I74413500"]},{"raw_affiliation_string":"Univ of Windsor","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069207187","display_name":"Siyaram Pandey","orcid":"https://orcid.org/0000-0002-7273-7154","observed_orcids":["https://orcid.org/0000-0002-7273-7154"]},"institutions":[{"id":"https://openalex.org/I186803428","display_name":"Brock University","ror":"https://ror.org/056am2717","country_code":"CA","type":"education","lineage":["https://openalex.org/I186803428"]},{"id":"https://openalex.org/I207123951","display_name":"New Mexico Institute of Mining and Technology","ror":"https://ror.org/005p9kw61","country_code":"US","type":"education","lineage":["https://openalex.org/I207123951"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Siyaram Pandey","raw_affiliation_strings":["Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","Chemistry Department, University of Florida, Gainesville, Florida 32611","Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","Univ of Windsor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario L2S 3A1, Canada","institution_ids":["https://openalex.org/I186803428"]},{"raw_affiliation_string":"Chemistry Department, New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, New Mexico 87801","institution_ids":["https://openalex.org/I207123951"]},{"raw_affiliation_string":"Chemistry Department, University of Florida, Gainesville, Florida 32611","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada","institution_ids":["https://openalex.org/I74413500"]},{"raw_affiliation_string":"Univ of Windsor","institution_ids":["https://openalex.org/I74413500"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.2243,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.96156829,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"75","issue":"9","first_page":"3069","last_page":"3084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13124","display_name":"Chemical synthesis and alkaloids","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13124","display_name":"Chemical synthesis and alkaloids","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amaryllidaceae-alkaloids","display_name":"Amaryllidaceae alkaloids","score":0.925000011920929},{"id":"https://openalex.org/keywords/chemoenzymatic-synthesis","display_name":"chemoenzymatic synthesis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/epoxide-ring-opening","display_name":"epoxide ring opening","score":0.7419999837875366},{"id":"https://openalex.org/keywords/aziridine-ring-opening","display_name":"aziridine ring opening","score":0.878000020980835},{"id":"https://openalex.org/keywords/silica-gel-catalysis","display_name":"silica gel catalysis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/phenanthridone","display_name":"phenanthridone","score":0.7599999904632568},{"id":"https://openalex.org/keywords/hydroxymethyl-derivatives","display_name":"hydroxymethyl derivatives","score":0.8700000047683716},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.875},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.625}],"concepts":[{"id":"https://openalex.org/C2910425318","wikidata":"https://www.wikidata.org/wiki/Q150708","display_name":"Amaryllidaceae Alkaloids","level":3,"score":0.8009243011474609},{"id":"https://openalex.org/C2779825165","wikidata":"https://www.wikidata.org/wiki/Q101497","display_name":"Aldehyde","level":3,"score":0.7921820878982544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7012053728103638},{"id":"https://openalex.org/C2778544067","wikidata":"https://www.wikidata.org/wiki/Q409141","display_name":"Aziridine","level":3,"score":0.637162446975708},{"id":"https://openalex.org/C35753019","wikidata":"https://www.wikidata.org/wiki/Q644785","display_name":"Total synthesis","level":2,"score":0.6062129735946655},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5457467436790466},{"id":"https://openalex.org/C2780591741","wikidata":"https://www.wikidata.org/wiki/Q899405","display_name":"Hydroxymethyl","level":2,"score":0.5371950268745422},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.29381096363067627},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.2579280734062195},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.17736640572547913},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001388","descriptor_name":"Aziridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003500","descriptor_name":"Cyclization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047151","descriptor_name":"Amaryllidaceae Alkaloids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D047151","descriptor_name":"Amaryllidaceae Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047151","descriptor_name":"Amaryllidaceae Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/jo1003136","doi":"https://doi.org/10.1021/jo1003136","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jo1003136","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:20373760","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20373760","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of organic chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2099204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2872072","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2872072","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2872072","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Org Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2099204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2872072","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4952656899","display_name":"New Mexico IDeA Networks of Biomedical Research Excellence (INBRE) [P20]","funder_award_id":"P20RR016480","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W199194185","https://openalex.org/W1497884434","https://openalex.org/W1499310995","https://openalex.org/W1572708000","https://openalex.org/W1679162321","https://openalex.org/W1963706195","https://openalex.org/W1965332656","https://openalex.org/W1965507186","https://openalex.org/W1965814490","https://openalex.org/W1966114539","https://openalex.org/W1970812803","https://openalex.org/W1971232440","https://openalex.org/W1973732222","https://openalex.org/W1977412658","https://openalex.org/W1983356966","https://openalex.org/W1984567994","https://openalex.org/W1988547696","https://openalex.org/W1990290519","https://openalex.org/W1991235171","https://openalex.org/W1995617869","https://openalex.org/W1996252269","https://openalex.org/W1998821601","https://openalex.org/W2002882762","https://openalex.org/W2005071560","https://openalex.org/W2006338112","https://openalex.org/W2006496603","https://openalex.org/W2007407635","https://openalex.org/W2014920481","https://openalex.org/W2017219997","https://openalex.org/W2023498869","https://openalex.org/W2024661245","https://openalex.org/W2024789140","https://openalex.org/W2025293859","https://openalex.org/W2027856143","https://openalex.org/W2030236016","https://openalex.org/W2031070923","https://openalex.org/W2032302361","https://openalex.org/W2032873798","https://openalex.org/W2036259569","https://openalex.org/W2036707802","https://openalex.org/W2041624079","https://openalex.org/W2043157908","https://openalex.org/W2043557910","https://openalex.org/W2043563856","https://openalex.org/W2044125881","https://openalex.org/W2044404528","https://openalex.org/W2044901466","https://openalex.org/W2045650285","https://openalex.org/W2048332145","https://openalex.org/W2054830367","https://openalex.org/W2055535417","https://openalex.org/W2058815073","https://openalex.org/W2059158468","https://openalex.org/W2060573862","https://openalex.org/W2062571639","https://openalex.org/W2064789851","https://openalex.org/W2069549290","https://openalex.org/W2072891692","https://openalex.org/W2074036358","https://openalex.org/W2076454794","https://openalex.org/W2081381898","https://openalex.org/W2085978401","https://openalex.org/W2086897431","https://openalex.org/W2088067609","https://openalex.org/W2090457646","https://openalex.org/W2099284213","https://openalex.org/W2100648674","https://openalex.org/W2101559039","https://openalex.org/W2103871123","https://openalex.org/W2109838399","https://openalex.org/W2116190070","https://openalex.org/W2116653435","https://openalex.org/W2134686632","https://openalex.org/W2136587297","https://openalex.org/W2138548084","https://openalex.org/W2144400524","https://openalex.org/W2164023349","https://openalex.org/W2165663583","https://openalex.org/W2165711924","https://openalex.org/W2174790513","https://openalex.org/W2175239093","https://openalex.org/W2179832516","https://openalex.org/W2313734330","https://openalex.org/W2344618190","https://openalex.org/W2442888180","https://openalex.org/W2474208362","https://openalex.org/W2949188069","https://openalex.org/W2949201826","https://openalex.org/W2949868954","https://openalex.org/W2950030354","https://openalex.org/W2950733362","https://openalex.org/W2951334672","https://openalex.org/W2951789476","https://openalex.org/W2952172732","https://openalex.org/W2952329194","https://openalex.org/W2952652440","https://openalex.org/W2952720862","https://openalex.org/W2952940090","https://openalex.org/W2953157830","https://openalex.org/W2953243839","https://openalex.org/W3004969820","https://openalex.org/W4229849434","https://openalex.org/W4235676532","https://openalex.org/W4239450434","https://openalex.org/W4249475620"],"related_works":["https://openalex.org/W2056193241","https://openalex.org/W1806137595","https://openalex.org/W2099284213","https://openalex.org/W1996252269","https://openalex.org/W330785013","https://openalex.org/W2952720862","https://openalex.org/W4231931715","https://openalex.org/W2043157908","https://openalex.org/W1979014031","https://openalex.org/W2950733362"],"abstract_inverted_index":{"An":[0],"efficient":[1],"synthesis":[2,106,113],"of":[3,6,18,27,33,39,57,73,98,107,114],"C-1":[4,52,61,64,88],"derivatives":[5,66],"7-deoxypancratistatin":[7,115],"is":[8,67],"reported.":[9],"The":[10,55,87],"key":[11,51],"steps":[12],"include":[13],"the":[14,25,50,71,99],"following:":[15],"selective":[16],"opening":[17,32],"an":[19,28,34,84],"epoxide":[20],"with":[21,70],"aluminum":[22],"acetylide":[23],"in":[24,83],"presence":[26],"aziridine;":[29,35],"solid-state":[30],"silica-gel-catalyzed":[31],"and":[36,43,63,82,109,123],"oxidative":[37],"cleavage":[38],"a":[40,104,110],"phenanthrene":[41],"core":[42],"its":[44],"recyclization":[45],"to":[46,48,60,96],"phenanthridone":[47],"provide":[49],"aldehyde":[53,59,119],"22.":[54,120],"conversion":[56],"this":[58],"acetoxymethyl":[62,89],"hydroxymethyl":[65],"described":[68],"along":[69],"evaluation":[72],"their":[74],"biological":[75],"activity":[76,94],"against":[77],"several":[78],"cancer":[79],"cell":[80],"lines":[81],"apoptosis":[85],"study.":[86],"derivative":[90],"has":[91],"shown":[92],"promising":[93],"comparable":[95],"that":[97],"natural":[100],"product.":[101],"In":[102],"addition,":[103],"total":[105,112],"trans-dihydrolycoricidine":[108],"formal":[111],"are":[116,126],"reported":[117],"from":[118],"Detailed":[121],"experimental":[122],"spectral":[124],"data":[125],"provided":[127],"for":[128],"all":[129],"new":[130],"compounds.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
