{"id":"https://openalex.org/W2005231219","doi":"https://doi.org/10.1210/endo.133.1.8391426","title":"Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system","display_name":"Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W2005231219","doi":"https://doi.org/10.1210/endo.133.1.8391426","mag":"2005231219","pmid":"https://pubmed.ncbi.nlm.nih.gov/8391426"},"language":"en","primary_location":{"id":"doi:10.1210/endo.133.1.8391426","doi":"https://doi.org/10.1210/endo.133.1.8391426","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.133.1.8391426","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005231219"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027159489","display_name":"Johannes M. H. M. Reul","orcid":"https://orcid.org/0000-0002-8787-4012","observed_orcids":["https://orcid.org/0000-0002-8787-4012"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J M Reul","raw_affiliation_strings":["Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001837919","display_name":"Ingemar S.M. Stec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I Stec","raw_affiliation_strings":["Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111799825","display_name":"Monika S\u00f6der","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M S\u00f6der","raw_affiliation_strings":["Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"last","author":{"id":null,"display_name":"F Holsboer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Holsboer","raw_affiliation_strings":["Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany","Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]},{"raw_affiliation_string":"Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":6.5872,"has_fulltext":false,"cited_by_count":348,"citation_normalized_percentile":{"value":0.98134328,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"133","issue":"1","first_page":"312","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.8859999775886536},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":1.0},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8460000157356262},{"id":"https://openalex.org/keywords/adrenal-weight","display_name":"adrenal weight","score":0.8709999918937683},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.9580000042915344},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.996999979019165},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6309999823570251},{"id":"https://openalex.org/keywords/chronic-antidepressant-treatment","display_name":"chronic antidepressant treatment","score":0.8130000233650208},{"id":"https://openalex.org/keywords/neuroendocrine-regulation","display_name":"neuroendocrine regulation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/limbic-system","display_name":"limbic system","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8708522319793701},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8563249111175537},{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.8199429512023926},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.5946452617645264},{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.5483232140541077},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5278869867324829},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5201138257980347},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.518406867980957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4979076385498047},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.49230682849884033},{"id":"https://openalex.org/C189135053","wikidata":"https://www.wikidata.org/wiki/Q3454531","display_name":"Mineralocorticoid receptor","level":3,"score":0.47656846046447754},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.45912349224090576},{"id":"https://openalex.org/C2779657639","wikidata":"https://www.wikidata.org/wiki/Q908843","display_name":"Tricyclic antidepressant","level":4,"score":0.449557363986969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3205204904079437},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28008341789245605},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.2326831817626953},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000639","descriptor_name":"Amitriptyline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000639","descriptor_name":"Amitriptyline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018161","descriptor_name":"Receptors, Mineralocorticoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1210/endo.133.1.8391426","doi":"https://doi.org/10.1210/endo.133.1.8391426","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.133.1.8391426","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/en.133.1.312","doi":"https://doi.org/10.1210/en.133.1.312","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.133.1.312","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:8391426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8391426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:438146","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/438146","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrinology, v.133, 312-320 (1993)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_1629836","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-000E-8577-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrinology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/08fa9738-2502-4c95-8e79-32a298d8a470","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/08fa9738-2502-4c95-8e79-32a298d8a470","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reul, J M, Stec, I, S\u00f6der, M & Holsboer, F 1993, 'Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system', Endocrinology, vol. 133, no. 1, pp. 312-20. https://doi.org/10.1210/endo.133.1.8391426","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research-information.bris.ac.uk:publications/08fa9738-2502-4c95-8e79-32a298d8a470","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1983/08fa9738-2502-4c95-8e79-32a298d8a470","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reul, J M, Stec, I, S\u00f6der, M & Holsboer, F 1993, 'Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system', Endocrinology, vol. 133, no. 1, pp. 312-20. https://doi.org/10.1210/endo.133.1.8391426","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W177049143","https://openalex.org/W1498494065","https://openalex.org/W1775749144","https://openalex.org/W1828538530","https://openalex.org/W1964553536","https://openalex.org/W1966234499","https://openalex.org/W1971383287","https://openalex.org/W1974253960","https://openalex.org/W1977153383","https://openalex.org/W1979620819","https://openalex.org/W1988566835","https://openalex.org/W1990554466","https://openalex.org/W1992277198","https://openalex.org/W1994982647","https://openalex.org/W2003050811","https://openalex.org/W2003267121","https://openalex.org/W2007406197","https://openalex.org/W2014645713","https://openalex.org/W2015613847","https://openalex.org/W2027069212","https://openalex.org/W2031746321","https://openalex.org/W2034223321","https://openalex.org/W2036589524","https://openalex.org/W2037004891","https://openalex.org/W2050451761","https://openalex.org/W2060626931","https://openalex.org/W2069576043","https://openalex.org/W2070066942","https://openalex.org/W2087529636","https://openalex.org/W2088766302","https://openalex.org/W2090215646","https://openalex.org/W2092524391","https://openalex.org/W2094330039","https://openalex.org/W2109887747","https://openalex.org/W2113962949","https://openalex.org/W2119435176","https://openalex.org/W2166347315","https://openalex.org/W2258398984","https://openalex.org/W2312953246","https://openalex.org/W2402656846"],"related_works":["https://openalex.org/W1840450113","https://openalex.org/W2109452045","https://openalex.org/W1952378008","https://openalex.org/W2017200072","https://openalex.org/W2001668955","https://openalex.org/W2072005245","https://openalex.org/W2037004891","https://openalex.org/W2107883305","https://openalex.org/W2035929196"],"abstract_inverted_index":{"The":[0,15,173],"effects":[1],"of":[2,44,72,103,165,195,215,254,261,305],"the":[3,8,23,110,154,163,203,212,258,267,283,295],"tricyclic":[4],"antidepressant":[5,217],"amitriptyline":[6,219,274],"on":[7,266],"rat":[9],"hypothalamic-pituitary-adrenocortical":[10],"(HPA)":[11],"system":[12],"were":[13,51,79,107,118,124,137],"studied.":[14],"time-course":[16],"experiments":[17,128,249],"showed":[18,129],"that":[19,272],"amitriptyline,":[20],"given":[21],"via":[22],"drinking":[24],"water":[25],"(4.5":[26],"mg/kg.day),":[27],"produces":[28],"significant":[29,130,225],"decreases":[30,131,226],"(P":[31],"<":[32],"0.05)":[33],"in":[34,109,132,205,227,257,278,286,307],"adrenal":[35,133,166,301],"weight":[36,134,167,170],"after":[37,100],"5":[38,66,94],"(-20%)":[39],"and":[40,57,60,68,86,96,112,120,144,157,244,303],"7":[41,58,69,87,101],"weeks":[42,71,102],"(-21%)":[43],"treatment.":[45,73,104],"Hippocampal":[46,74],"mineralocorticoid":[47],"receptor":[48,76,122],"(MR)":[49],"levels":[50,78,106,123],"down-regulated":[52,81],"at":[53,63,82,93],"days":[54,83],"3":[55,84],"(-27%)":[56],"(-20%),":[59],"transiently":[61,89],"up-regulated":[62,90],"2":[64],"(+40%),":[65],"(+74%),":[67],"(+18%)":[70],"glucocorticoid":[75],"(GR)":[77],"slightly":[80],"(-8%)":[85],"(-17%),":[88],"by":[91,294],"26%":[92],"weeks,":[95,221],"indistinguishable":[97],"from":[98],"controls":[99],"MR":[105,191,206,256,280],"unchanged":[108],"hypothalamus":[111],"neocortex,":[113],"whereas":[114,185],"hypothalamic":[115],"GR":[116,178,306],"concentrations":[117],"elevated":[119],"neocortical":[121],"not":[125],"altered.":[126],"Dose-response":[127],"when":[135,162],"rats":[136],"treated":[138],"with":[139],"4.5":[140,196,222],"(-14%),":[141],"8.8":[142],"(-16%)":[143],"14.5":[145],"(-13%)":[146],"mg/kg.day":[147,160,197],"antidepressant,":[148],"but":[149],"this":[150,186],"applied":[151],"only":[152],"for":[153,190,202],"4.5-":[155],"(-14%)":[156],"8.8-":[158],"(-12%)":[159],"doses":[161],"ratio":[164],"to":[168,199],"body":[169],"was":[171,187],"considered.":[172],"dose-response":[174],"relationship":[175],"regarding":[176],"hippocampal":[177],"content":[179],"displayed":[180],"an":[181],"inverted":[182],"U-shaped":[183],"curve,":[184],"less":[188],"marked":[189],"levels.":[192,247],"A":[193],"dose":[194],"appeared":[198],"be":[200,282],"optimal":[201],"rise":[204,277],"as":[207,209,233,235,292],"well":[208,234],"GR.":[210],"Concerning":[211],"neuroendocrine":[213],"implications":[214],"chronic":[216],"treatment,":[218],"(5":[220],"mg/kg.day)":[223],"produced":[224],"basal":[228,262],"(ACTH,":[229],"-47%;":[230],"corticosterone,":[231],"-31%)":[232],"stress":[236],"(30":[237],"min":[238],"novel":[239],"environment)-induced":[240],"plasma":[241,297],"ACTH":[242],"(-38%)":[243],"corticosterone":[245],"(-57%)":[246],"Previous":[248],"have":[250],"forwarded":[251],"a":[252,276,287],"role":[253],"limbic":[255,279],"tonic":[259],"control":[260],"HPA":[263,290],"activity.":[264],"Based":[265],"present":[268],"data,":[269],"we":[270],"hypothesize":[271],"during":[273],"treatment":[275],"may":[281],"initial":[284],"phenomenon":[285],"successively":[288],"adjusting":[289],"system,":[291],"evidenced":[293],"decreasing":[296],"hormone":[298],"concentrations,":[299],"declining":[300],"size,":[302],"up-regulation":[304],"particular":[308],"brain":[309],"regions.":[310]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
