{"id":"https://openalex.org/W2005228893","doi":"https://doi.org/10.3109/10641969009074717","title":"Effects of Dopamine on Blood Pressure and Heart Rate After Microinjection into the Hypothalamus of Spontaneously Hypertensive and Normotensive Wistar-Kyoto Rats","display_name":"Effects of Dopamine on Blood Pressure and Heart Rate After Microinjection into the Hypothalamus of Spontaneously Hypertensive and Normotensive Wistar-Kyoto Rats","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2005228893","doi":"https://doi.org/10.3109/10641969009074717","mag":"2005228893","pmid":"https://pubmed.ncbi.nlm.nih.gov/2306876"},"language":"en","primary_location":{"id":"doi:10.3109/10641969009074717","doi":"https://doi.org/10.3109/10641969009074717","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10641969009074717","pdf_url":null,"source":{"id":"https://openalex.org/S203233286","display_name":"Clinical and Experimental Hypertension","issn_l":"0148-3927","issn":["0148-3927","0730-0077","1064-1963","1525-6006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Hypertension. Part A: Theory and Practice","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005228893"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082366002","display_name":"Shiueh-Lian Mok","orcid":"https://orcid.org/0000-0001-7769-1856","observed_orcids":["https://orcid.org/0000-0001-7769-1856"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"J. S. L. Mok","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, National University of Singapore","Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore, 0511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, National University of Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore, 0511","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109658624","display_name":"J. S. Hutchinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"J. S. Hutchinson","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore, 0511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore, 0511","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108544558","display_name":"M.Kwoon Sim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"M. K. Sim","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore, 0511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore, 0511","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":null,"apc_paid":null,"fwci":1.5133,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.82328798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12","issue":"1","first_page":"15","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.49779999256134033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.49779999256134033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7940000295639038},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6909999847412109},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":1.0},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.996999979019165},{"id":"https://openalex.org/keywords/third-ventricle","display_name":"third ventricle","score":0.8539999723434448},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.8999999761581421},{"id":"https://openalex.org/keywords/metoclopramide","display_name":"metoclopramide","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.8451341390609741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7363526225090027},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7241606712341309},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6919404864311218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6482634544372559},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.632033109664917},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.6048657894134521},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5980992317199707},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5584095120429993},{"id":"https://openalex.org/C2781171461","wikidata":"https://www.wikidata.org/wiki/Q662322","display_name":"Third ventricle","level":2,"score":0.5427340269088745},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.5410827994346619},{"id":"https://openalex.org/C2778086073","wikidata":"https://www.wikidata.org/wiki/Q7579064","display_name":"Spontaneously hypertensive rat","level":3,"score":0.5166261792182922},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4553055167198181},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35166043043136597}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/10641969009074717","doi":"https://doi.org/10.3109/10641969009074717","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10641969009074717","pdf_url":null,"source":{"id":"https://openalex.org/S203233286","display_name":"Clinical and Experimental Hypertension","issn_l":"0148-3927","issn":["0148-3927","0730-0077","1064-1963","1525-6006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Hypertension. Part A: Theory and Practice","raw_type":"journal-article"},{"id":"pmid:2306876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2306876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental hypertension. Part A, Theory and practice","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/32084","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/32084","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1891793377","https://openalex.org/W1969502945","https://openalex.org/W1974791295","https://openalex.org/W1987665180","https://openalex.org/W1992601568","https://openalex.org/W2000147086","https://openalex.org/W2008490775","https://openalex.org/W2030905853","https://openalex.org/W2038137092","https://openalex.org/W2038897564","https://openalex.org/W2056700277","https://openalex.org/W2066035592","https://openalex.org/W2082906283","https://openalex.org/W2086450872","https://openalex.org/W2107198210","https://openalex.org/W2133462651","https://openalex.org/W2163815564","https://openalex.org/W2168764355","https://openalex.org/W2231804603","https://openalex.org/W2253949960","https://openalex.org/W2314101604","https://openalex.org/W2318234811","https://openalex.org/W2342033636","https://openalex.org/W2487245908","https://openalex.org/W4231058111"],"related_works":["https://openalex.org/W1992601568","https://openalex.org/W2604365029","https://openalex.org/W1969502945","https://openalex.org/W2056724958","https://openalex.org/W2291690822","https://openalex.org/W2066035592","https://openalex.org/W2018855788","https://openalex.org/W2030504853","https://openalex.org/W2001593396","https://openalex.org/W2490067374"],"abstract_inverted_index":{"In":[0],"anaesthetized":[1],"spontaneously":[2],"hypertensive":[3],"(SHR)":[4],"and":[5,26,38,110,148],"normotensive":[6,51],"Wistar-Kyoto":[7],"(WKY)":[8],"rats,":[9],"0.0125-0.4":[10],"mg/kg":[11],"dopamine":[12],"(DA)":[13],"given":[14,88],"intracerebroventricularly":[15],"(icv)":[16],"produced":[17,33],"dose-related":[18,34],"decreases":[19],"in":[20,36,59,78,84,142,159],"mean":[21],"arterial":[22],"blood":[23],"pressure":[24],"(MAP)":[25],"heart":[27],"rate":[28],"(HR),":[29],"whereas":[30],"intravenous":[31],"DA":[32,47,53,91,116,125,147],"increases":[35],"MAP":[37,58,109],"HR.":[39,79,111],"SHR":[40,143],"was":[41],"significantly":[42,56],"more":[43],"responsive":[44],"to":[45,100,115,144,153],"icv":[46],"compared":[48],"with":[49,74,90],"the":[50,66,93,97,121,127,134,150,155],"controls.":[52],"(0.02":[54],"mg/kg)":[55],"reduced":[57],"a":[60],"biphasic":[61],"manner,":[62],"when":[63],"microinjected":[64],"into":[65,92,126],"arcuate":[67,151],"nucleus":[68],"or":[69],"third":[70,94],"ventricle":[71,95],"of":[72,123],"SHR,":[73],"no":[75,105],"significant":[76,106],"changes":[77],"No":[80],"such":[81],"effect":[82,107],"occurred":[83],"WKY":[85],"rats.":[86],"Metoclopramide":[87],"concurrently":[89],"attenuated":[96],"hypotensive":[98,113],"response":[99],"DA.":[101],"Saline":[102],"injection":[103],"had":[104],"on":[108],"The":[112],"responses":[114],"were":[117],"not":[118],"confounded":[119],"by":[120],"spread":[122],"injected":[124],"adjacent":[128],"hypothalamic":[129],"areas.":[130],"These":[131],"results":[132],"support":[133],"hypothesis":[135],"that":[136,149],"there":[137],"exists":[138],"an":[139],"abnormal":[140],"sensitivity":[141],"centrally":[145],"administered":[146],"appears":[152],"be":[154],"brain":[156],"site":[157],"involved":[158],"this":[160],"abnormality.":[161]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}