{"id":"https://openalex.org/W2005228833","doi":"https://doi.org/10.1016/0031-6989(86)90099-8","title":"The effects of a long term dihydroergotoxine treatment on agonist and antagonist striatal dopamine binding sites are dose and age related","display_name":"The effects of a long term dihydroergotoxine treatment on agonist and antagonist striatal dopamine binding sites are dose and age related","publication_year":1986,"publication_date":"1986-10-01","ids":{"openalex":"https://openalex.org/W2005228833","doi":"https://doi.org/10.1016/0031-6989(86)90099-8","mag":"2005228833","pmid":"https://pubmed.ncbi.nlm.nih.gov/3809237"},"language":"en","primary_location":{"id":"doi:10.1016/0031-6989(86)90099-8","doi":"https://doi.org/10.1016/0031-6989(86)90099-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0031-6989(86)90099-8","pdf_url":null,"source":{"id":"https://openalex.org/S129439886","display_name":"Pharmacological Research Communications","issn_l":"0031-6989","issn":["0031-6989","1879-2936"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112764469","display_name":"Carlo Ferretti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Ferretti","raw_affiliation_strings":["Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074418423","display_name":"Marinella Blengio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marinella Blengio","raw_affiliation_strings":["Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010244279","display_name":"Carola Eugenia Eva","orcid":"https://orcid.org/0000-0002-9638-7240","observed_orcids":["https://orcid.org/0000-0002-9638-7240"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carola Eva","raw_affiliation_strings":["Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088705154","display_name":"Piera Ghi","orcid":"https://orcid.org/0000-0003-4218-3688","observed_orcids":["https://orcid.org/0000-0003-4218-3688"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piera Ghi","raw_affiliation_strings":["Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088066296","display_name":"Maria Carla Bosco","orcid":"https://orcid.org/0000-0003-1857-7193","observed_orcids":["https://orcid.org/0000-0003-1857-7193"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Carla Bosco","raw_affiliation_strings":["Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075102488","display_name":"Paolo Portaleone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Portaleone","raw_affiliation_strings":["Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology, Medical School, University of Turin, Corso Raffaello 30, 10125 Turin Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":null,"apc_paid":null,"fwci":0.2799,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.42099057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"10","first_page":"967","last_page":"978"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydroergotoxine","display_name":"dihydroergotoxine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ergot-alkaloids","display_name":"ergot alkaloids","score":0.8799999952316284},{"id":"https://openalex.org/keywords/striatal-dopamine-receptors","display_name":"striatal dopamine receptors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/age-related-receptor-changes","display_name":"age-related receptor changes","score":0.7149999737739563},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8119999766349792},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.8169999718666077},{"id":"https://openalex.org/keywords/receptor-heterogeneity","display_name":"receptor heterogeneity","score":0.45100000500679016},{"id":"https://openalex.org/keywords/chronic-drug-administration","display_name":"chronic drug administration","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.8217787742614746},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7761848568916321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.690191924571991},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.624169111251831},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6095516085624695},{"id":"https://openalex.org/C2778258207","wikidata":"https://www.wikidata.org/wiki/Q600203","display_name":"Dopamine agonist","level":4,"score":0.4867153465747833},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.4711899757385254},{"id":"https://openalex.org/C2778539182","wikidata":"https://www.wikidata.org/wiki/Q4693408","display_name":"Agonist-antagonist","level":4,"score":0.43634361028671265},{"id":"https://openalex.org/C2781353949","wikidata":"https://www.wikidata.org/wiki/Q3271533","display_name":"Dopamine antagonist","level":4,"score":0.4182148873806},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.40127646923065186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3826315402984619},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35426920652389526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17179971933364868},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09166461229324341}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004088","descriptor_name":"Dihydroergotoxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013134","descriptor_name":"Spiperone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0031-6989(86)90099-8","doi":"https://doi.org/10.1016/0031-6989(86)90099-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0031-6989(86)90099-8","pdf_url":null,"source":{"id":"https://openalex.org/S129439886","display_name":"Pharmacological Research Communications","issn_l":"0031-6989","issn":["0031-6989","1879-2936"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research Communications","raw_type":"journal-article"},{"id":"pmid:3809237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3809237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1964998464","https://openalex.org/W1974439801","https://openalex.org/W1983432679","https://openalex.org/W1985730821","https://openalex.org/W1989371506","https://openalex.org/W2009885559","https://openalex.org/W2017110037","https://openalex.org/W2022873646","https://openalex.org/W2025407390","https://openalex.org/W2026226340","https://openalex.org/W2034407150","https://openalex.org/W2049275172","https://openalex.org/W2053234111","https://openalex.org/W2076222200","https://openalex.org/W2077055769","https://openalex.org/W2108373335","https://openalex.org/W2222995824","https://openalex.org/W2294946349","https://openalex.org/W2318851075","https://openalex.org/W2413390822","https://openalex.org/W4214747752","https://openalex.org/W4240150151","https://openalex.org/W4240975438"],"related_works":["https://openalex.org/W2026226340","https://openalex.org/W2017968040","https://openalex.org/W1974644034","https://openalex.org/W2083861856","https://openalex.org/W1994445727","https://openalex.org/W1978900411","https://openalex.org/W2222995824","https://openalex.org/W2470150524","https://openalex.org/W2040335317","https://openalex.org/W2515974265"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}