{"id":"https://openalex.org/W2005227706","doi":"https://doi.org/10.1186/1476-9255-4-9","title":"Perfluorochemical (PFC) liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 (AdvIL-10) expression in rodent lung","display_name":"Perfluorochemical (PFC) liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 (AdvIL-10) expression in rodent lung","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2005227706","doi":"https://doi.org/10.1186/1476-9255-4-9","mag":"2005227706","pmid":"https://pubmed.ncbi.nlm.nih.gov/17472748","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1868755"},"language":"en","primary_location":{"id":"doi:10.1186/1476-9255-4-9","doi":"https://doi.org/10.1186/1476-9255-4-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-9255-4-9","pdf_url":"https://journal-inflammation.biomedcentral.com/track/pdf/10.1186/1476-9255-4-9","source":{"id":"https://openalex.org/S24701539","display_name":"Journal of Inflammation","issn_l":"1476-9255","issn":["1476-9255"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journal-inflammation.biomedcentral.com/track/pdf/10.1186/1476-9255-4-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"John T Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John T Li","raw_affiliation_strings":["University of California, San Francisco, Moffitt M-680, 505 Parnassus Ave, San Francisco, CA 94143, USA. John.Li@ucsf.edu","Seattle Children's Hospital & Regional Medical Center, B-9524 Critical Care, Seattle, USA","University of California, San Francisco, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, Moffitt M-680, 505 Parnassus Ave, San Francisco, CA 94143, USA. John.Li@ucsf.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Seattle Children's Hospital & Regional Medical Center, B-9524 Critical Care, Seattle, USA","institution_ids":["https://openalex.org/I1295499534"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089588652","display_name":"Laura Bonneau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura L Bonneau","raw_affiliation_strings":["University of Wisconsin School of Medicine, Health Sciences, 750 Highland Ave, Madison, WI, 53705, USA","University of Wisconsin School of Medicine, Health Sciences, Madison, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin School of Medicine, Health Sciences, 750 Highland Ave, Madison, WI, 53705, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin School of Medicine, Health Sciences, Madison, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064694471","display_name":"Jerry J. Zimmerman","orcid":"https://orcid.org/0000-0002-6936-3139","observed_orcids":["https://orcid.org/0000-0002-6936-3139"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry J Zimmerman","raw_affiliation_strings":["Seattle Children's Hospital & Regional Medical Center, B-9524 Critical Care, 4800 Sand Point Way NE, Seattle, WA, 98105, USA","Seattle Children's Hospital & Regional Medical Center, B-9524 Critical Care, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Hospital & Regional Medical Center, B-9524 Critical Care, 4800 Sand Point Way NE, Seattle, WA, 98105, USA","institution_ids":["https://openalex.org/I1295499534"]},{"raw_affiliation_string":"Seattle Children's Hospital & Regional Medical Center, B-9524 Critical Care, Seattle, USA","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101459958","display_name":"Daniel J. Weiss","orcid":"https://orcid.org/0000-0002-5515-8062","observed_orcids":["https://orcid.org/0000-0002-5515-8062"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J Weiss","raw_affiliation_strings":["University of Vermont, room 226C HSRF, 149 Beaumont Ave, Burlington, VT, 05405, USA","University of Vermont, room 226C HSRF, Burlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, room 226C HSRF, 149 Beaumont Ave, Burlington, VT, 05405, USA","institution_ids":["https://openalex.org/I111236770"]},{"raw_affiliation_string":"University of Vermont, room 226C HSRF, Burlington, USA","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1295499534","https://openalex.org/I180670191"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.3559,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.62998914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"4","issue":"1","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.07639999687671661,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viral-interleukin-10","display_name":"viral interleukin-10","score":0.8939999938011169},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7889999747276306},{"id":"https://openalex.org/keywords/gene-therapy-delivery","display_name":"gene therapy delivery","score":0.6759999990463257},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.7540000081062317},{"id":"https://openalex.org/keywords/intratracheal-instillation","display_name":"intratracheal instillation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.9020000100135803},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.5270000100135803},{"id":"https://openalex.org/keywords/inflammatory-lung-disease","display_name":"inflammatory lung disease","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.7047109603881836},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6079127788543701},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5156844854354858},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5118762254714966},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.478725403547287},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4401646852493286},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.43800684809684753},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.43401381373405457},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.4257078170776367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.237254798412323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22189012169837952},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.21851253509521484},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/1476-9255-4-9","doi":"https://doi.org/10.1186/1476-9255-4-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-9255-4-9","pdf_url":"https://journal-inflammation.biomedcentral.com/track/pdf/10.1186/1476-9255-4-9","source":{"id":"https://openalex.org/S24701539","display_name":"Journal of Inflammation","issn_l":"1476-9255","issn":["1476-9255"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1868755","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1868755","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Inflamm (Lond)","raw_type":"Text"},{"id":"pmid:17472748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17472748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of inflammation (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:356b18db6327494aacafbe14d0265065","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/356b18db6327494aacafbe14d0265065","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Inflammation, Vol 4, Iss 1, p 9 (2007)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1476-9255-4-9","doi":"https://doi.org/10.1186/1476-9255-4-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-9255-4-9","pdf_url":"https://journal-inflammation.biomedcentral.com/track/pdf/10.1186/1476-9255-4-9","source":{"id":"https://openalex.org/S24701539","display_name":"Journal of Inflammation","issn_l":"1476-9255","issn":["1476-9255"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005227706.pdf","grobid_xml":"https://content.openalex.org/works/W2005227706.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W39104836","https://openalex.org/W1503200131","https://openalex.org/W1819104259","https://openalex.org/W1964982794","https://openalex.org/W1977905350","https://openalex.org/W1981915536","https://openalex.org/W1984824806","https://openalex.org/W1985556669","https://openalex.org/W1993987479","https://openalex.org/W2004143324","https://openalex.org/W2008896173","https://openalex.org/W2010401549","https://openalex.org/W2022968301","https://openalex.org/W2024909718","https://openalex.org/W2026343159","https://openalex.org/W2042089608","https://openalex.org/W2042745519","https://openalex.org/W2047999732","https://openalex.org/W2048046456","https://openalex.org/W2054629245","https://openalex.org/W2060361910","https://openalex.org/W2060546545","https://openalex.org/W2068856650","https://openalex.org/W2092168085","https://openalex.org/W2098829747","https://openalex.org/W2122238292","https://openalex.org/W2137784781","https://openalex.org/W2139459897","https://openalex.org/W2144284373","https://openalex.org/W2145381334","https://openalex.org/W2150195134","https://openalex.org/W2156885594","https://openalex.org/W2310246579","https://openalex.org/W2403443087","https://openalex.org/W4301847566"],"related_works":["https://openalex.org/W7100479471","https://openalex.org/W2164543979","https://openalex.org/W6990908934","https://openalex.org/W2003751959","https://openalex.org/W2334197066","https://openalex.org/W2139459897","https://openalex.org/W2022968301","https://openalex.org/W1975479943","https://openalex.org/W2042089608","https://openalex.org/W2055628715"],"abstract_inverted_index":{"Adenovirus":[0],"and":[1,21,30,45,122,129,182,218],"cationic":[2],"liposome":[3],"mediated":[4],"transfer":[5],"of":[6,27,36,48,96,139,147,151,157,163,189,243,263],"Interleukin-10":[7],"(IL-10),":[8],"a":[9,80,148,244],"potent":[10],"anti-inflammatory":[11,72,266],"cytokine,":[12],"has":[13],"been":[14],"shown":[15],"to":[16,33,61,84,102,179,239,256,268],"decrease":[17],"pro-inflammatory":[18,46,75],"cytokine":[19],"levels":[20,115,156],"overall":[22],"lung":[23,28,87,123,199,271],"inflammation":[24],"in":[25,110,198,208,211],"models":[26],"transplantation":[29],"injury.":[31],"Limitations":[32],"current":[34],"approaches":[35],"IL-10":[37,50,67],"gene":[38,108],"therapy":[39],"include":[40],"poor":[41],"vector":[42],"delivery":[43,242],"methods":[44],"properties":[47],"human":[49],"under":[51],"certain":[52],"conditions.":[53],"We":[54,249],"hypothesize":[55],"that":[56,171,183],"using":[57],"perfluorochemical":[58],"(PFC)":[59],"liquid":[60,98,141,173,185,194,238],"deliver":[62,103],"the":[63,94,106,145,155,187,206,233,241,261,264],"highly":[64],"homologous":[65],"viral":[66],"(vIL-10),":[68],"which":[69],"is":[70,232],"predominantly":[71,265],"with":[73],"minimal":[74],"activities,":[76],"can":[77,253],"potentially":[78,245],"be":[79,254],"more":[81],"effective":[82],"strategy":[83,252],"combat":[85],"inflammatory":[86,270],"diseases.":[88,272],"In":[89,229],"this":[90,231,251],"study,":[91],"we":[92,135],"compare":[93],"use":[95,138,146,188,262],"PFC":[97,140,167,172,184,193,237],"versus":[99],"aerosolized":[100],"method":[101],"adenovirus":[104],"encoding":[105],"vIL-10":[107,114,159,176,197,210,267],"(AdvIL-10)":[109],"C57Bl6":[111],"mice.":[112],"Detectable":[113],"were":[116],"measured":[117],"from":[118],"bronchoalveolar":[119],"lavage":[120],"fluid":[121,213],"homogenates":[124,200],"at":[125,160,201,215],"one,":[126],"four,":[127],"ten":[128,180],"thirty":[130,224],"days":[131,217,225],"after":[132,226],"AdvIL-10.":[133],"Furthermore,":[134],"determined":[136],"if":[137],"could":[142],"allow":[143],"for":[144],"lower":[149],"dose":[150],"AdvIL-10":[152,164],"by":[153,177,223],"comparing":[154],"detectable":[158,175,196,209],"different":[161],"doses":[162],"delivered":[165],"+/-":[166],"liquid.":[168],"Results":[169],"showed":[170],"enhanced":[174],"up":[178],"fold":[181],"allowed":[186],"ten-fold":[190],"less":[191],"vector.":[192],"increased":[195],"all":[202],"time":[203],"points;":[204],"however,":[205],"increase":[207],"BAL":[212],"peaked":[214],"four":[216],"was":[219],"no":[220],"longer":[221],"evident":[222],"intratracheal":[227],"instillation.":[228],"summary,":[230],"first":[234],"report":[235],"utilizing":[236],"enhance":[240],"therapeutic":[246],"molecule,":[247],"vIL-10.":[248],"believe":[250],"used":[255],"perform":[257],"future":[258],"studies":[259],"on":[260],"treat":[269]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}