{"id":"https://openalex.org/W2005221644","doi":"https://doi.org/10.1111/j.1476-5381.1972.tb09586.x","title":"Hydrocortisone and the concentration of choline in the plasma of rodents","display_name":"Hydrocortisone and the concentration of choline in the plasma of rodents","publication_year":1972,"publication_date":"1972-05-01","ids":{"openalex":"https://openalex.org/W2005221644","doi":"https://doi.org/10.1111/j.1476-5381.1972.tb09586.x","mag":"2005221644","pmid":"https://pubmed.ncbi.nlm.nih.gov/5041461","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1666224"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1972.tb09586.x","doi":"https://doi.org/10.1111/j.1476-5381.1972.tb09586.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1972.tb09586.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1972.tb09586.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1972.tb09586.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019460966","display_name":"Matthew C.E. Gwee","orcid":"https://orcid.org/0000-0002-7000-3261","observed_orcids":["https://orcid.org/0000-0002-7000-3261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. C. E. Gwee","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, University of Singapore, Sepoy Lines, Singapore 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, University of Singapore, Sepoy Lines, Singapore 3","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033379807","display_name":"Hadyanto Lim","orcid":"https://orcid.org/0000-0002-7004-7491","observed_orcids":["https://orcid.org/0000-0002-7004-7491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. S. Lim","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, University of Singapore, Sepoy Lines, Singapore 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, University of Singapore, Sepoy Lines, Singapore 3","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.4213,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.60313024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"1","first_page":"133","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.24580000340938568,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.24580000340938568,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.23899999260902405,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.19599999487400055,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":1.0},{"id":"https://openalex.org/keywords/plasma-choline","display_name":"plasma choline","score":0.9269999861717224},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8130000233650208},{"id":"https://openalex.org/keywords/choline-metabolism","display_name":"choline metabolism","score":0.4790000021457672},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.6190000176429749},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.9649999737739563},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.841107964515686},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.8395968675613403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6395507454872131},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6296532154083252},{"id":"https://openalex.org/C2780484280","wikidata":"https://www.wikidata.org/wiki/Q423185","display_name":"Cortisone","level":2,"score":0.563912034034729},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.5158676505088806},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5027649402618408},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.47356995940208435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29133889079093933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25251632928848267}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006426","descriptor_name":"Hemicholinium 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006426","descriptor_name":"Hemicholinium 3","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1972.tb09586.x","doi":"https://doi.org/10.1111/j.1476-5381.1972.tb09586.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1972.tb09586.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1972.tb09586.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:5041461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5041461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1666224","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1666224/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1972.tb09586.x","doi":"https://doi.org/10.1111/j.1476-5381.1972.tb09586.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1972.tb09586.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1972.tb09586.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005221644.pdf","grobid_xml":"https://content.openalex.org/works/W2005221644.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2005780717","https://openalex.org/W2021907511","https://openalex.org/W2024149210","https://openalex.org/W2043765423","https://openalex.org/W2046005842","https://openalex.org/W2057931579","https://openalex.org/W2253345047","https://openalex.org/W2259723730","https://openalex.org/W2311930583","https://openalex.org/W2324138230","https://openalex.org/W2395936657","https://openalex.org/W2400279620"],"related_works":["https://openalex.org/W2046005842","https://openalex.org/W2432842673","https://openalex.org/W1972238181","https://openalex.org/W2334906014","https://openalex.org/W1975121279","https://openalex.org/W2279911865","https://openalex.org/W2075555451","https://openalex.org/W2000027970","https://openalex.org/W2326819159","https://openalex.org/W4407216183"],"abstract_inverted_index":{"Cortisone":[0],"has":[1],"been":[2],"reported":[3],"to":[4,58],"reduce":[5],"significantly":[6],"the":[7,21,29,43,61],"plasma":[8,30,64],"choline":[9,31],"concentration":[10,32,62],"in":[11,20,48,60],"dogs":[12],"within":[13],"30":[14],"min":[15,82],"after":[16,83],"its":[17],"injection.How-":[18],"ever,":[19],"present":[22],"experiments":[23],"hydrocortisone":[24,41],"had":[25],"no":[26],"effect":[27,39],"on":[28],"of":[33,40,46,63],"mice,":[34],"guinea-pigs":[35],"and":[36],"rabbits.The":[37],"protective":[38],"against":[42],"toxic":[44],"effects":[45],"hemicholinium":[47],"mice":[49],"which":[50],"was":[51],"described":[52],"previously":[53],"cannot,":[54],"therefore,":[55],"be":[56],"attributed":[57],"changes":[59],"choline.7":[65],"8(5-11)":[66],"(6-11)":[67],"Mice":[68],"IV":[69],"17":[70,72],"(14-18)":[71],"(14-21)":[73],"V":[74],"8":[75],"(8-9)":[76],"9":[77],"(7-12)":[78],"mean\u00b1S.E.*":[79],"32\u00b10-6":[80],"60":[81],"injection":[84],"*n=12.33\u00b10-5":[85]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}