{"id":"https://openalex.org/W2005207972","doi":"https://doi.org/10.1111/j.1527-3458.2007.00027.x","title":"Cortagine: Behavioral and Autonomic Function of the Selective CRF Receptor Subtype 1 Agonist","display_name":"Cortagine: Behavioral and Autonomic Function of the Selective CRF Receptor Subtype 1 Agonist","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2005207972","doi":"https://doi.org/10.1111/j.1527-3458.2007.00027.x","mag":"2005207972","pmid":"https://pubmed.ncbi.nlm.nih.gov/18078427","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6494149"},"language":"en","primary_location":{"id":"doi:10.1111/j.1527-3458.2007.00027.x","doi":"https://doi.org/10.1111/j.1527-3458.2007.00027.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1527-3458.2007.00027.x","pdf_url":null,"source":{"id":"https://openalex.org/S165828461","display_name":"CNS Drug Reviews","issn_l":"1080-563X","issn":["1080-563X","1527-3458"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drug Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6494149","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062926072","display_name":"Catherine Borna Farrokhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Catherine Borna Farrokhi","raw_affiliation_strings":["Department of Psychology, University of Hawaii, Honolulu, HI 96822, USA. Farrokhi@hawaii.edu","Department of Psychology, University of Hawaii, Honolulu, HI USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Hawaii, Honolulu, HI 96822, USA. Farrokhi@hawaii.edu","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]},{"raw_affiliation_string":"Department of Psychology, University of Hawaii, Honolulu, HI USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072089670","display_name":"Philip Tovote","orcid":"https://orcid.org/0000-0002-4598-722X","observed_orcids":["https://orcid.org/0000-0002-4598-722X"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Tovote","raw_affiliation_strings":["Specialized Neuroscience Research Program II, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Specialized Neuroscience Research Program II, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110126031","display_name":"Robert J. Blanchard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Blanchard","raw_affiliation_strings":["Department of Psychology, University of Hawaii, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105207692","display_name":"D. Caroline Blanchard","orcid":"https://orcid.org/0000-0003-1888-6068","observed_orcids":["https://orcid.org/0000-0003-1888-6068"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Caroline Blanchard","raw_affiliation_strings":["Pacific Biomedical Research Center, University of Hawaii, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Biomedical Research Center, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111775835","display_name":"Yoav Litvin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoav Litvin","raw_affiliation_strings":["Department of Psychology, University of Hawaii, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045329451","display_name":"Joachim Spiess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joachim Spiess","raw_affiliation_strings":["Specialized Neuroscience Research Program II, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Specialized Neuroscience Research Program II, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062926072"],"corresponding_institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"],"apc_list":null,"apc_paid":null,"fwci":0.2232,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.17356322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"13","issue":"4","first_page":"423","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.6959999799728394},{"id":"https://openalex.org/keywords/anxiogenic-effects","display_name":"anxiogenic effects","score":0.925000011920929},{"id":"https://openalex.org/keywords/antidepressant-like-effects","display_name":"antidepressant-like effects","score":0.9929999709129333},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.6230000257492065},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":1.0},{"id":"https://openalex.org/keywords/autonomic-function","display_name":"autonomic function","score":0.6660000085830688},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.7179999947547913},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.9950000047683716},{"id":"https://openalex.org/keywords/crf-binding-protein","display_name":"CRF-binding protein","score":0.6420000195503235},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C205044023","wikidata":"https://www.wikidata.org/wiki/Q4778117","display_name":"Anxiogenic","level":4,"score":0.7664253115653992},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6592327356338501},{"id":"https://openalex.org/C2777688879","wikidata":"https://www.wikidata.org/wiki/Q904550","display_name":"Urocortin","level":3,"score":0.5637363791465759},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.5567464828491211},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5494104623794556},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5370835661888123},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.49788451194763184},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.49718478322029114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4656691551208496},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46039053797721863},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4554753303527832},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38631728291511536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3268284797668457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3072679042816162},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2629689872264862},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23711419105529785},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.21548917889595032},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.08952334523200989},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.08156105875968933},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.07459846138954163},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099052","descriptor_name":"CRF Receptor, Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018019","descriptor_name":"Receptors, Corticotropin-Releasing Hormone","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1527-3458.2007.00027.x","doi":"https://doi.org/10.1111/j.1527-3458.2007.00027.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1527-3458.2007.00027.x","pdf_url":null,"source":{"id":"https://openalex.org/S165828461","display_name":"CNS Drug Reviews","issn_l":"1080-563X","issn":["1080-563X","1527-3458"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drug Reviews","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6494149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6494149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drug Rev","raw_type":"Text"},{"id":"pmid:18078427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18078427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS drug reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6494149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6494149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drug Rev","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W110281485","https://openalex.org/W1482141418","https://openalex.org/W1495277562","https://openalex.org/W1531005638","https://openalex.org/W1556823507","https://openalex.org/W1572525448","https://openalex.org/W1624194901","https://openalex.org/W1802833855","https://openalex.org/W1896866869","https://openalex.org/W1951492130","https://openalex.org/W1964779920","https://openalex.org/W1969648359","https://openalex.org/W1972567441","https://openalex.org/W1974253960","https://openalex.org/W1975540516","https://openalex.org/W1977567826","https://openalex.org/W1982309599","https://openalex.org/W1985694975","https://openalex.org/W1986576876","https://openalex.org/W1988061941","https://openalex.org/W1989218867","https://openalex.org/W1989479458","https://openalex.org/W1992731869","https://openalex.org/W1995081746","https://openalex.org/W1996024414","https://openalex.org/W1996166611","https://openalex.org/W1996260345","https://openalex.org/W1996390701","https://openalex.org/W2000788901","https://openalex.org/W2009058487","https://openalex.org/W2012416101","https://openalex.org/W2014513374","https://openalex.org/W2014619876","https://openalex.org/W2019150852","https://openalex.org/W2022786139","https://openalex.org/W2022912683","https://openalex.org/W2022987442","https://openalex.org/W2025294582","https://openalex.org/W2027566821","https://openalex.org/W2027953236","https://openalex.org/W2031401606","https://openalex.org/W2035241965","https://openalex.org/W2036681692","https://openalex.org/W2037043198","https://openalex.org/W2040543503","https://openalex.org/W2041850455","https://openalex.org/W2041947253","https://openalex.org/W2046013541","https://openalex.org/W2047027389","https://openalex.org/W2048465808","https://openalex.org/W2052605518","https://openalex.org/W2056994786","https://openalex.org/W2057596402","https://openalex.org/W2060197642","https://openalex.org/W2061262656","https://openalex.org/W2065271760","https://openalex.org/W2071736830","https://openalex.org/W2071903454","https://openalex.org/W2074213734","https://openalex.org/W2075609074","https://openalex.org/W2077577252","https://openalex.org/W2081264545","https://openalex.org/W2085640895","https://openalex.org/W2088226858","https://openalex.org/W2089299823","https://openalex.org/W2092376180","https://openalex.org/W2092569856","https://openalex.org/W2093267260","https://openalex.org/W2095036452","https://openalex.org/W2095444610","https://openalex.org/W2098227033","https://openalex.org/W2098391261","https://openalex.org/W2098612141","https://openalex.org/W2101342324","https://openalex.org/W2107337535","https://openalex.org/W2110435413","https://openalex.org/W2114608871","https://openalex.org/W2118238128","https://openalex.org/W2124833043","https://openalex.org/W2131767872","https://openalex.org/W2140175678","https://openalex.org/W2140977742","https://openalex.org/W2141926683","https://openalex.org/W2143629083","https://openalex.org/W2147789926","https://openalex.org/W2148194000","https://openalex.org/W2151542810","https://openalex.org/W2153085409","https://openalex.org/W2159147558","https://openalex.org/W2484260316","https://openalex.org/W3015901321","https://openalex.org/W3204144416","https://openalex.org/W4242413572"],"related_works":["https://openalex.org/W2071903454","https://openalex.org/W2065271760","https://openalex.org/W2102578651","https://openalex.org/W2164292837","https://openalex.org/W2080955188","https://openalex.org/W2019164797","https://openalex.org/W7095779570","https://openalex.org/W1981304815","https://openalex.org/W3165617393","https://openalex.org/W2124894806"],"abstract_inverted_index":{"Corticotropin-releasing":[0],"factor":[1],"(CRF)":[2],"is":[3],"a":[4,59,90,114,128,156,173,226],"neuropeptide":[5],"and":[6,12,34,51,110,127,189,199,207,216,241,274],"mediating":[7],"component":[8],"of":[9,44,62,69,74,85,106,155,162,175,178,222,231,255,262,271],"neuroendocrine,":[10],"autonomic,":[11],"behavioral":[13,239],"processes":[14],"associated":[15],"with":[16,47,118],"the":[17,26,63,83,141,153,163,181,197,214,238,242,269],"stress":[18,64],"response.":[19],"The":[20],"two":[21],"receptor":[22,30],"subtypes":[23],"identified":[24],"in":[25,56,172,196,213,268],"mammalian":[27],"brain,":[28],"CRF":[29,49,75,112,142],"subtype":[31],"1":[32],"(CRF1)":[33],"CRF2,":[35],"are":[36],"suggested":[37,201],"to":[38,77,225,245],"differentially":[39],"modulate":[40],"these":[41,45,247],"processes.":[42],"Manipulation":[43],"receptors":[46],"selective":[48,86,92],"compounds":[50],"transgenic":[52],"models":[53,177],"has":[54,79,96,168],"revealed,":[55],"most":[57],"studies,":[58],"clear":[60],"potentiation":[61],"response":[65],"through":[66],"central":[67,260],"activation":[68,73,257],"CRF1.":[70],"However,":[71],"pharmacological":[72],"restricted":[76],"CRF1":[78,93,122,266],"been":[80,97,170],"limited":[81],"by":[82,152,259],"availability":[84],"peptidic":[87],"compounds.":[88],"Recently,":[89],"highly":[91,115],"agonist,":[94],"cortagine,":[95],"developed.":[98],"It":[99],"was":[100],"synthesized":[101],"from":[102],"chimeric":[103],"intermediate":[104],"sequences":[105],"ovine":[107],"CRF,":[108],"sauvagine,":[109],"human/rat":[111],"into":[113],"soluble":[116],"peptide":[117,165],"strong":[119],"affinity":[120],"for":[121,133,140],"(IC(50)":[123,135,145],"<":[124],"5":[125],"nM)":[126,148],"very":[129],"low":[130],"binding":[131,143],"preference":[132],"CRF2":[134],">":[136,146],"500":[137],"nM).":[138],"Affinity":[139],"protein":[144],"1,000":[147],"can":[149],"be":[150],"abolished":[151],"addition":[154],"glutamate":[157],"residue":[158],"on":[159],"position":[160],"21":[161],"cortagine":[164,263],"sequence.":[166],"Cortagine":[167],"recently":[169],"tested":[171],"variety":[174],"preclinical":[176],"behavior":[179],"including":[180],"elevated-plus-maze":[182],"(EPM),":[183],"forced":[184],"swim":[185],"test":[186,192],"(FST),":[187],"homecage,":[188],"rat":[190],"exposure":[191],"(RET).":[193],"Preliminary":[194],"characterization":[195],"EPM":[198],"FST":[200],"that":[202,264],"this":[203,234],"compound":[204],"elicits":[205],"anxiogenic":[206,229],"antidepressant-like":[208],"effects,":[209],"respectively.":[210],"Additional":[211],"testing":[212],"homecage":[215],"RET,":[217],"which":[218],"targets":[219],"various":[220],"elements":[221],"behavior,":[223],"directs":[224],"more":[227],"potent":[228],"profile":[230],"cortagine.":[232],"In":[233],"review,":[235],"we":[236,250],"discuss":[237,252],"findings":[240,254],"tests":[243],"used":[244],"measure":[246],"effects.":[248],"Finally,":[249],"also":[251],"preliminary":[253],"autonomic":[256],"obtained":[258],"injection":[261],"support":[265],"involvement":[267],"modulation":[270],"heart":[272,275],"rate":[273,276],"variability.":[277]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}