{"id":"https://openalex.org/W2005205661","doi":"https://doi.org/10.1002/biof.121","title":"Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells","display_name":"Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells","publication_year":2010,"publication_date":"2010-09-16","ids":{"openalex":"https://openalex.org/W2005205661","doi":"https://doi.org/10.1002/biof.121","mag":"2005205661","pmid":"https://pubmed.ncbi.nlm.nih.gov/20848558"},"language":"en","primary_location":{"id":"doi:10.1002/biof.121","doi":"https://doi.org/10.1002/biof.121","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biof.121","pdf_url":null,"source":{"id":"https://openalex.org/S75531928","display_name":"BioFactors","issn_l":"0951-6433","issn":["0951-6433","1872-8081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049056014","display_name":"Kulpreet Bhui","orcid":"https://orcid.org/0009-0004-9132-0911","observed_orcids":["https://orcid.org/0009-0004-9132-0911"]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I85145500","display_name":"Indian Institute of Toxicology Research","ror":"https://ror.org/01e70mw69","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I85145500"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kulpreet Bhui","raw_affiliation_strings":["Proteomics Laboratory, Indian Institute of Toxicology Research/Council for Scientific & Industrial Research, Lucknow, India","Proteomics Laboratory, Indian Institute of Toxicology Research (CSIR), Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Laboratory, Indian Institute of Toxicology Research/Council for Scientific & Industrial Research, Lucknow, India","institution_ids":["https://openalex.org/I85145500"]},{"raw_affiliation_string":"Proteomics Laboratory, Indian Institute of Toxicology Research (CSIR), Lucknow, India","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I85145500"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shilpa Tyagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I85145500","display_name":"Indian Institute of Toxicology Research","ror":"https://ror.org/01e70mw69","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I85145500"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shilpa Tyagi","raw_affiliation_strings":["Proteomics Laboratory, Indian Institute of Toxicology Research (CSIR), Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Laboratory, Indian Institute of Toxicology Research (CSIR), Lucknow, India","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I85145500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007999027","display_name":"Bharti Prakash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bharti Prakash","raw_affiliation_strings":["Department of Zoology, Government College Ajmer, Ajmer, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Government College Ajmer, Ajmer, Rajasthan, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109279538","display_name":"Yogeshwer Shukla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I85145500","display_name":"Indian Institute of Toxicology Research","ror":"https://ror.org/01e70mw69","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I85145500"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Yogeshwer Shukla","raw_affiliation_strings":["Proteomics Laboratory, Indian Institute of Toxicology Research (CSIR), Lucknow, India","Tel.: +91-522-2963827"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Laboratory, Indian Institute of Toxicology Research (CSIR), Lucknow, India","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I85145500"]},{"raw_affiliation_string":"Tel.: +91-522-2963827","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109279538"],"corresponding_institution_ids":["https://openalex.org/I66760702","https://openalex.org/I85145500"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.4867,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.80164308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"36","issue":"6","first_page":"474","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bromelain","display_name":"bromelain","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pineapple","display_name":"pineapple","score":0.6060000061988831},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9710000157356262},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/erk2","display_name":"ERK2","score":0.7210000157356262},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9120000004768372},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8889999985694885},{"id":"https://openalex.org/keywords/lc3b","display_name":"LC3B","score":0.8240000009536743},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.8980000019073486},{"id":"https://openalex.org/keywords/3-methyladenine","display_name":"3-methyladenine","score":0.8870000243186951},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9239121675491333},{"id":"https://openalex.org/C2777334355","wikidata":"https://www.wikidata.org/wiki/Q415756","display_name":"Bromelain","level":4,"score":0.7770035266876221},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7708950638771057},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5384044647216797},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4504375159740448},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44076356291770935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34712809324264526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18619924783706665},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09663990139961243},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001963","descriptor_name":"Bromelains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001963","descriptor_name":"Bromelains","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D031230","descriptor_name":"Ananas","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/biof.121","doi":"https://doi.org/10.1002/biof.121","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biof.121","pdf_url":null,"source":{"id":"https://openalex.org/S75531928","display_name":"BioFactors","issn_l":"0951-6433","issn":["0951-6433","1872-8081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors","raw_type":"journal-article"},{"id":"pmid:20848558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20848558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1443246394","https://openalex.org/W1555054913","https://openalex.org/W1576634198","https://openalex.org/W1599366903","https://openalex.org/W1775749144","https://openalex.org/W1784425676","https://openalex.org/W1963587882","https://openalex.org/W1967085696","https://openalex.org/W1972582451","https://openalex.org/W1977767269","https://openalex.org/W1989764974","https://openalex.org/W1990411057","https://openalex.org/W1998028577","https://openalex.org/W1998079032","https://openalex.org/W1998757898","https://openalex.org/W2003852184","https://openalex.org/W2003887174","https://openalex.org/W2014626069","https://openalex.org/W2024589425","https://openalex.org/W2032792360","https://openalex.org/W2037646515","https://openalex.org/W2038264754","https://openalex.org/W2049856484","https://openalex.org/W2053944333","https://openalex.org/W2061704745","https://openalex.org/W2065803044","https://openalex.org/W2066030465","https://openalex.org/W2066800765","https://openalex.org/W2077018489","https://openalex.org/W2078911476","https://openalex.org/W2093666377","https://openalex.org/W2101108802","https://openalex.org/W2113139099","https://openalex.org/W2113179577","https://openalex.org/W2137690550","https://openalex.org/W2167907490","https://openalex.org/W2168417520","https://openalex.org/W2170008613","https://openalex.org/W2170373377","https://openalex.org/W2172201532","https://openalex.org/W2270220644","https://openalex.org/W2792139654"],"related_works":["https://openalex.org/W2021234373","https://openalex.org/W1971604889","https://openalex.org/W4414919743","https://openalex.org/W2900940789","https://openalex.org/W3092583080","https://openalex.org/W1482216374","https://openalex.org/W4400221830","https://openalex.org/W7171909138","https://openalex.org/W3099977945","https://openalex.org/W4214620330"],"abstract_inverted_index":{"Bromelain,":[0],"from":[1],"pineapple,":[2],"possesses":[3],"potent":[4],"anticancer":[5],"effects.":[6],"We":[7],"investigated":[8],"autophagic":[9,82,168],"phenomenon":[10],"in":[11,32,88,177,253],"mammary":[12],"carcinoma":[13],"cells":[14,36],"(estrogen":[15],"receptor":[16],"positive":[17],"and":[18,23,30,45,65,71,137,155,209,217,222,238],"negative)":[19],"under":[20],"bromelain":[21,39,120,248],"treatment":[22],"also":[24,84],"illustrated":[25],"the":[26,80,104,122,167,172,190,197],"relationship":[27],"between":[28],"autophagy":[29,76,94,105,232],"apoptosis":[31,109],"MCF-7":[33,35],"cells.":[34],"exposed":[37],"to":[38,86,185,195],"showed":[40],"delayed":[41],"growth":[42],"inhibitory":[43],"response":[44],"induction":[46],"of":[47,99,124,132,160,174,199,215,247],"autophagy,":[48],"identified":[49],"by":[50,56,61,236,243],"monodansylcadaverine":[51],"localization.":[52],"It":[53],"was":[54,193,233],"succeeded":[55],"apoptotic":[57,66,89],"cell":[58,63,114],"death,":[59],"evident":[60],"sub-G1":[62],"fraction":[64],"features":[67],"like":[68],"chromatin":[69],"condensation":[70],"nuclear":[72],"cleavage.":[73],"3-Methyladenine":[74],"(MA,":[75],"inhibitor)":[77],"pretreatment":[78],"reduced":[79],"bromelain-induced":[81,178,231],"level,":[83],"leading":[85],"decline":[87],"population,":[90],"indicating":[91,229],"that":[92,119,131,230],"here":[93],"facilitates":[95],"apoptosis.":[96],"However,":[97],"addition":[98,159],"caspase-9":[100],"inhibitor":[101],"Z-LEHD-FMK":[102],"augmented":[103],"levels,":[106],"inhibited":[107],"morphological":[108],"but":[110,240],"did":[111],"not":[112],"prevent":[113],"death.":[115],"Next,":[116],"we":[117],"found":[118],"downregulated":[121,153],"phosphorylation":[123],"extracellular":[125],"signal-regulated":[126],"kinase":[127,135,139,163],"\u00bd":[128],"(ERK\u00bd),":[129],"whereas":[130,220],"c-jun":[133],"N-terminal":[134],"(JNK)":[136],"p38":[138,156,221,237],"were":[140,183],"upregulated.":[141],"Also,":[142,158],"MA":[143],"had":[144],"no":[145],"influence":[146],"on":[147],"bromelain-suppressed":[148],"ERK\u00bd":[149,212],"activation,":[150],"yet,":[151],"it":[152],"JNK":[154,223,239],"activation.":[157],"mitogen-activated":[161],"protein":[162,205,227],"(MAPK)":[164],"inhibitors":[165,224],"enhanced":[166],"ratios,":[169],"which":[170],"suggested":[171],"role":[173],"MAP":[175],"kinases":[176],"autophagy.":[179],"All":[180],"three":[181],"MAPKs":[182],"seen":[184,194],"be":[186,250],"constantly":[187],"activated":[188],"over":[189],"time.":[191],"Bromelain":[192],"induce":[196],"expressions":[198,214],"autophagy-related":[200],"proteins,":[201],"light":[202],"chain":[203],"3":[204],"B":[206],"II":[207],"(LC3BII),":[208],"beclin-1.":[210],"Using":[211],"inhibitor,":[213],"LC3BII":[216],"beclin-1":[218],"increased,":[219],"decreased":[225],"this":[226],"expression,":[228],"positively":[234],"regulated":[235,242],"negatively":[241],"ERK\u00bd.":[244],"Autophagy-inducing":[245],"property":[246],"can":[249],"further":[251],"exploited":[252],"breast":[254],"cancer":[255],"therapy.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}