{"id":"https://openalex.org/W2005205470","doi":"https://doi.org/10.1002/pbc.22797","title":"Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program","display_name":"Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program","publication_year":2011,"publication_date":"2011-02-25","ids":{"openalex":"https://openalex.org/W2005205470","doi":"https://doi.org/10.1002/pbc.22797","mag":"2005205470","pmid":"https://pubmed.ncbi.nlm.nih.gov/21360650","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3115432"},"language":"en","primary_location":{"id":"doi:10.1002/pbc.22797","doi":"https://doi.org/10.1002/pbc.22797","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.22797","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3115432","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046943976","display_name":"Malcolm Anders Smith","orcid":"https://orcid.org/0000-0001-9880-9876","observed_orcids":["https://orcid.org/0000-0001-9880-9876"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Malcolm A. Smith","raw_affiliation_strings":["Cancer Therapy Evaluation Program, NCI, Bethesda, Maryland 20892, USA. smithm@ctep.nci.nih.gov","Cancer Therapy Evaluation Program, NCI, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapy Evaluation Program, NCI, Bethesda, Maryland 20892, USA. smithm@ctep.nci.nih.gov","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Cancer Therapy Evaluation Program, NCI, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929","observed_orcids":["https://orcid.org/0000-0002-8088-7929"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Maris","raw_affiliation_strings":["Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028049853","display_name":"Richard B. Lock","orcid":"https://orcid.org/0000-0002-3436-9071","observed_orcids":["https://orcid.org/0000-0002-3436-9071"]},"institutions":[{"id":"https://openalex.org/I4210112315","display_name":"Children's Cancer Institute Australia","ror":"https://ror.org/01x784220","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210112315"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard Lock","raw_affiliation_strings":["Children's Cancer Institute Australia for Medical Research, Randwick, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Institute Australia for Medical Research, Randwick, NSW, Australia","institution_ids":["https://openalex.org/I4210112315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009981843","display_name":"Edward Anders Kolb","orcid":"https://orcid.org/0000-0003-2854-9014","observed_orcids":["https://orcid.org/0000-0003-2854-9014"]},"institutions":[{"id":"https://openalex.org/I1326254912","display_name":"Alfred I. duPont Hospital for Children","ror":"https://ror.org/00jyx0v10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1326254912","https://openalex.org/I4210108049"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Anders Kolb","raw_affiliation_strings":["A. I. DuPont Hospital for Children, Wilmington, Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. I. DuPont Hospital for Children, Wilmington, Delaware","institution_ids":["https://openalex.org/I1326254912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032743242","display_name":"Richard Greg Gorlick","orcid":"https://orcid.org/0000-0001-8995-2929","observed_orcids":["https://orcid.org/0000-0001-8995-2929"]},"institutions":[{"id":"https://openalex.org/I4210135976","display_name":"Children's Hospital at Montefiore","ror":"https://ror.org/03n0fp725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Gorlick","raw_affiliation_strings":["The Children's Hospital at Montefiore, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital at Montefiore, Bronx, New York","institution_ids":["https://openalex.org/I4210135976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025528414","display_name":"Stephen Thomas Keir","orcid":"https://orcid.org/0000-0001-8630-3587","observed_orcids":["https://orcid.org/0000-0001-8630-3587"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen T. Keir","raw_affiliation_strings":["Duke University Medical Center, Durham, North Carolina","#N#        #N#        Duke University Medical Center, Durham, North Carolina;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"#N#        #N#        Duke University Medical Center, Durham, North Carolina;","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110170888","display_name":"Hern\u00e1n Carol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112315","display_name":"Children's Cancer Institute Australia","ror":"https://ror.org/01x784220","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210112315"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hernan Carol","raw_affiliation_strings":["Children's Cancer Institute Australia for Medical Research, Randwick, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Institute Australia for Medical Research, Randwick, NSW, Australia","institution_ids":["https://openalex.org/I4210112315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066877678","display_name":"Christopher L. Morton","orcid":"https://orcid.org/0000-0002-4027-7050","observed_orcids":["https://orcid.org/0000-0002-4027-7050"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Morton","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital, Memphis, TN","St. Jude Children\u2010s Research Hospital, Memphis, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"St. Jude Children\u2010s Research Hospital, Memphis, Tennessee","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058354009","display_name":"C. Patrick Reynolds","orcid":"https://orcid.org/0000-0002-2827-8536","observed_orcids":["https://orcid.org/0000-0002-2827-8536"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Patrick Reynolds","raw_affiliation_strings":["Texas Tech University, Health Sciences Center, Lubbock, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University, Health Sciences Center, Lubbock, Texas","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035381341","display_name":"Min H. Kang","orcid":"https://orcid.org/0000-0003-3603-7035","observed_orcids":["https://orcid.org/0000-0003-3603-7035"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min H. Kang","raw_affiliation_strings":["Texas Tech University, Health Sciences Center, Lubbock, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University, Health Sciences Center, Lubbock, Texas","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Houghton","raw_affiliation_strings":["Nationwide Children's Hospital, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nationwide Children's Hospital, Columbus, Ohio","institution_ids":["https://openalex.org/I1314135232"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5046943976"],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":0.7784,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.68728761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"57","issue":"2","first_page":"268","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyamine-analogues","display_name":"polyamine analogues","score":0.7450000047683716},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.843999981880188},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ependymoma","display_name":"ependymoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/xenograft-tumor-regression","display_name":"xenograft tumor regression","score":0.6859999895095825},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.3499999940395355},{"id":"https://openalex.org/keywords/cytostatic-effect","display_name":"cytostatic activity","score":0.6380000114440918},{"id":"https://openalex.org/keywords/ec50","display_name":"EC50","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.8061593770980835},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7942517399787903},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.6755039691925049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6681115627288818},{"id":"https://openalex.org/C2781432949","wikidata":"https://www.wikidata.org/wiki/Q1346753","display_name":"Ependymoma","level":2,"score":0.6670922040939331},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6393346190452576},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.595085620880127},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5319975018501282},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.49099019169807434},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4822703003883362},{"id":"https://openalex.org/C2993561819","wikidata":"https://www.wikidata.org/wiki/Q5097977","display_name":"Pediatric cancer","level":3,"score":0.4530382752418518},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45211705565452576},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44088226556777954},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35889333486557007},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35855570435523987},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3551836609840393},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33521121740341187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2950192391872406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17415499687194824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11908948421478271},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013096","descriptor_name":"Spermine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013096","descriptor_name":"Spermine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/pbc.22797","doi":"https://doi.org/10.1002/pbc.22797","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pbc.22797","pdf_url":null,"source":{"id":"https://openalex.org/S119714264","display_name":"Pediatric Blood & Cancer","issn_l":"1545-5009","issn":["1545-5009","1545-5017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Blood &amp; Cancer","raw_type":"journal-article"},{"id":"pmid:21360650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21360650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric blood & cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2411234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3115432","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3115432","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3115432","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pediatr Blood Cancer","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2411234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3115432","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1215897271","display_name":null,"funder_award_id":"CA108786.","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1388267649","display_name":"Pediatric Preclinical Testing Program","funder_award_id":"n01cm42216-11-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1628177865","display_name":null,"funder_award_id":"N01CM42216","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3738888336","display_name":null,"funder_award_id":"NO1\u2010CM\u201042216","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5277985768","display_name":null,"funder_award_id":"N01 CM042216","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G609259107","display_name":null,"funder_award_id":"CA21765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6374948078","display_name":null,"funder_award_id":"Z99 CA999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7200951646","display_name":"SPORE in Brain Cancer","funder_award_id":"P50CA108786","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320320501","display_name":"Cancer Australia","ror":"https://ror.org/00510tw04"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1558897349","https://openalex.org/W1571073982","https://openalex.org/W1944467204","https://openalex.org/W1966376342","https://openalex.org/W1975981207","https://openalex.org/W1982172428","https://openalex.org/W2004098260","https://openalex.org/W2018870317","https://openalex.org/W2022948223","https://openalex.org/W2058194275","https://openalex.org/W2060269194","https://openalex.org/W2064229709","https://openalex.org/W2073683178","https://openalex.org/W2084239992","https://openalex.org/W2086218289","https://openalex.org/W2091035112","https://openalex.org/W2095919371","https://openalex.org/W2096024592","https://openalex.org/W2097235831","https://openalex.org/W2111008003","https://openalex.org/W2127724114","https://openalex.org/W2134788272","https://openalex.org/W2135140338","https://openalex.org/W2143231467","https://openalex.org/W2153370321","https://openalex.org/W2170379053"],"related_works":["https://openalex.org/W2606370558","https://openalex.org/W3104372622","https://openalex.org/W3028111764","https://openalex.org/W1966376342","https://openalex.org/W2073683178","https://openalex.org/W93257264","https://openalex.org/W4248001397","https://openalex.org/W2272016941","https://openalex.org/W1965261779","https://openalex.org/W1832341193"],"abstract_inverted_index":{"BACKGROUND:":[0],"PG11047":[1,34,47,96,109,150,198,239],"is":[2,212],"a":[3,79,98,121,143,203,213],"novel":[4],"conformationally":[5],"restricted":[6],"analog":[7],"of":[8,33,81,115,138,162,165,174,177,185,197,228,238],"the":[9,38,51,73,86,116,128,133,139,166,178,225,235],"natural":[10,22],"polyamine,":[11],"spermine":[12],"that":[13],"lowers":[14],"cellular":[15],"endogenous":[16],"polyamine":[17,23],"levels":[18],"and":[19,42,171,206,224],"competitively":[20],"inhibits":[21],"functions":[24],"leading":[25],"to":[26,66,127,158,234],"cancer":[27],"cell":[28,130,136,232],"growth":[29],"inhibition.":[30],"The":[31,105,182,217],"activity":[32],"was":[35,48,70,110],"evaluated":[36,49],"against":[37,50,72],"PPTP's":[39],"in":[40,43,53,75,132,154,160,172,189],"vitro":[41,54,95],"vivo":[44,76,149],"panels.":[45],"PROCEDURES:":[46],"PPTP":[52,74],"panel":[55,119,141],"using":[56],"96":[57],"hr":[58],"exposure":[59],"at":[60,78],"concentrations":[61],"ranging":[62],"from":[63],"10":[64],"nM":[65],"100":[67,82],"\u00b5M.":[68],"It":[69],"tested":[71],"panels":[77],"dose":[80],"mg/kg":[83],"administered":[84],"by":[85],"intraperitoneal":[87],"route":[88],"weekly":[89],"for":[90,108,209,220,242],"6":[91],"weeks.":[92],"RESULTS:":[93],"In":[94,148],"demonstrated":[97],"concentration-response":[99],"pattern":[100],"consistent":[101],"with":[102],"cytostatic":[103],"activity.":[104],"median":[106,123,145],"EC(50)":[107,124,146],"71":[111],"nM.":[112],"Cell":[113],"lines":[114,131,137,233],"Ewing":[117,230],"sarcoma":[118,231],"had":[120,142],"lower":[122],"value":[125],"compared":[126,157],"remaining":[129],"panel,":[134],"while":[135],"neuroblastoma":[140],"higher":[144],"value.":[147],"induced":[151],"significant":[152],"differences":[153],"EFS":[155],"distribution":[156],"control":[159],"5":[161],"32":[163],"(15.6%)":[164],"evaluable":[167,179],"solid":[168],"tumor":[169,186],"xenografts":[170],"0":[173],"7":[175],"(0%)":[176],"ALL":[180],"xenografts.":[181],"single":[183],"case":[184],"regression":[187,218],"occurred":[188],"an":[190,221],"ependymoma":[191,222],"xenograft.":[192],"CONCLUSIONS:":[193],"Further":[194],"pediatric":[195],"development":[196],"will":[199],"require":[200],"better":[201],"defining":[202],"target":[204],"population":[205],"identifying":[207],"combinations":[208],"which":[210],"there":[211],"tumor-selective":[214],"cytotoxic":[215],"effect.":[216],"observed":[219],"xenograft":[223],"exquisite":[226],"sensitivity":[227],"some":[229],"antiproliferative":[236],"effects":[237],"provide":[240],"leads":[241],"further":[243],"preclinical":[244],"investigations.":[245]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
