{"id":"https://openalex.org/W2005200962","doi":"https://doi.org/10.1158/1538-7445.am2011-2016","title":"Abstract 2016: Combined targeting of epigenetic mechanisms has superior efficacy against human mantle cell lymphoma cells","display_name":"Abstract 2016: Combined targeting of epigenetic mechanisms has superior efficacy against human mantle cell lymphoma cells","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2005200962","doi":"https://doi.org/10.1158/1538-7445.am2011-2016","mag":"2005200962"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-2016","doi":"https://doi.org/10.1158/1538-7445.am2011-2016","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2016","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067678169","display_name":"Warren C. Fiskus","orcid":"https://orcid.org/0000-0002-7343-6214","observed_orcids":["https://orcid.org/0000-0002-7343-6214"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren C. Fiskus","raw_affiliation_strings":["1University of Kansas Cancer Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas Cancer Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108551216","display_name":"Sunil Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil Sharma","raw_affiliation_strings":["2Huntsman Cancer Institute, Salt Lake City, UT","#N#2Huntsman Cancer Institute, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Huntsman Cancer Institute, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]},{"raw_affiliation_string":"#N#2Huntsman Cancer Institute, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077507982","display_name":"Rekha Rao","orcid":"https://orcid.org/0000-0002-1873-8738","observed_orcids":["https://orcid.org/0000-0002-1873-8738"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rekha Rao","raw_affiliation_strings":["1University of Kansas Cancer Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas Cancer Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028841827","display_name":"Ramesh Balusu","orcid":"https://orcid.org/0000-0003-1441-6528","observed_orcids":["https://orcid.org/0000-0003-1441-6528"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramesh Balusu","raw_affiliation_strings":["1University of Kansas Cancer Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas Cancer Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058780394","display_name":"Jianguo Tao","orcid":"https://orcid.org/0000-0002-7632-1594","observed_orcids":["https://orcid.org/0000-0002-7632-1594"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianguo Tao","raw_affiliation_strings":["3Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108222207","display_name":"Eduardo M. Sotomayor","orcid":"https://orcid.org/0009-0009-5081-3855","observed_orcids":["https://orcid.org/0009-0009-5081-3855"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Sotomayor","raw_affiliation_strings":["3Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029250422","display_name":"Peter Wisdom Atadja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Atadja","raw_affiliation_strings":["4Novartis Institute for Biomedical Research Inc, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Novartis Institute for Biomedical Research Inc, Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008376636","display_name":"Siddhartha Ganguly","orcid":"https://orcid.org/0000-0003-4920-762X","observed_orcids":["https://orcid.org/0000-0003-4920-762X"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddhartha Ganguly","raw_affiliation_strings":["1University of Kansas Cancer Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas Cancer Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210097601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037979147","display_name":"David J. Bearss","orcid":"https://orcid.org/0000-0003-4940-9942","observed_orcids":["https://orcid.org/0000-0003-4940-9942"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Bearss","raw_affiliation_strings":["2Huntsman Cancer Institute, Salt Lake City, UT","#N#2Huntsman Cancer Institute, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Huntsman Cancer Institute, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]},{"raw_affiliation_string":"#N#2Huntsman Cancer Institute, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079069209","display_name":"Kapil N. Bhalla","orcid":"https://orcid.org/0000-0001-5209-5126","observed_orcids":["https://orcid.org/0000-0001-5209-5126"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kapil N. Bhalla","raw_affiliation_strings":["1University of Kansas Cancer Center, Kansas City, KS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Kansas Cancer Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210097601"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"2016","last_page":"2016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.8650000095367432},{"id":"https://openalex.org/keywords/suz12","display_name":"SUZ12","score":0.7919999957084656},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.597000002861023},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-1","display_name":"PRC1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bmi1","display_name":"BMI1","score":0.7170000076293945},{"id":"https://openalex.org/keywords/panobinostat","display_name":"panobinostat","score":0.8730000257492065},{"id":"https://openalex.org/keywords/dznep","display_name":"DZNep","score":0.9639999866485596},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/histone-methyltransferase-inhibitors","display_name":"histone methyltransferase inhibitors","score":0.7649999856948853},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lsd1","display_name":"LSD1","score":0.6850000023841858},{"id":"https://openalex.org/keywords/histone-demethylase","display_name":"histone demethylase","score":0.5139999985694885},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.5640000104904175},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6570000052452087},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.5830000042915344},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.8623720407485962},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.8621397018432617},{"id":"https://openalex.org/C2780225316","wikidata":"https://www.wikidata.org/wiki/Q7131441","display_name":"Panobinostat","level":5,"score":0.7204254865646362},{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.6118549704551697},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.5974631905555725},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.5761004686355591},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5646124482154846},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.5283169150352478},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5103482604026794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4679262638092041},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46549686789512634},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4490896761417389},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39087244868278503},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.38997727632522583},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34628868103027344},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.33035409450531006},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21084406971931458},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.19736811518669128},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.19377011060714722},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11723187565803528},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09682270884513855},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.08181402087211609}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-2016","doi":"https://doi.org/10.1158/1538-7445.am2011-2016","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2016","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4300000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2559058751","https://openalex.org/W2554836673","https://openalex.org/W2155491820","https://openalex.org/W2574147243","https://openalex.org/W2558947798","https://openalex.org/W2037548653","https://openalex.org/W3044196341","https://openalex.org/W2911762492","https://openalex.org/W2740213750","https://openalex.org/W2986698132"],"abstract_inverted_index":{"Abstract":[0],"Gene":[1],"silencing":[2],"is":[3],"mediated":[4,314],"by":[5,303],"multi-protein":[6],"complexes":[7],"PRC":[8],"(polycomb":[9],"repressive":[10,52],"complexes)":[11],"1":[12],"and":[13,26,64,77,104,119,138,154,170,184,192,220,232,246,248,317,332,345,358,366,374,385,393,400,425,431],"2.":[14],"Of":[15],"the":[16,30,41,70,80,93,105,116,143,174,180,226,235,261,279,295,334,423,443,452,465,470],"three":[17],"core":[18],"protein":[19,227,328],"components":[20,60],"of":[21,44,73,79,136,176,189,200,229,244,250,255,263,272,281,285,301,319,336,363,372,378,397,422,427,447,454,464,469],"PRC2,":[22],"i.e.,":[23],"EZH2,":[24,102,152,218,364,428],"SUZ12":[25,103,153,219,365],"EED,":[27],"EZH2":[28,120],"has":[29],"SET":[31],"domain":[32],"with":[33,92,115,131,214,242,257,269,294,351,356,369,383,408],"its":[34],"intrinsic":[35],"histone":[36,49],"methyltransferase":[37,107],"activity.":[38],"This":[39,239],"induces":[40],"trimethylation":[42],"(Me3)":[43],"lysine":[45],"(K)":[46],"27":[47],"on":[48,75,162],"(H)":[50],"3-a":[51],"chromatin":[53,81,252],"mark":[54],"for":[55,69,473],"gene":[56],"repression.":[57],"The":[58],"PRC1":[59],"include":[61],"BMI1,":[62,230,367],"RING1":[63],"RING2,":[65],"which":[66,266,287],"are":[67],"responsible":[68],"ubiquitylation":[71],"(Ub)":[72],"K119":[74],"H2A":[76],"compaction":[78],"at":[82],"PRC2":[83,125],"target":[84],"genes.":[85],"We":[86,110],"have":[87],"previously":[88],"reported":[89],"that":[90,113,148,418],"treatment":[91,165,276,323,350],"pan-histone":[94],"deacetylase":[95],"inhibitor":[96,297],"panobinostat":[97],"(PS,":[98],"Novartis":[99],"Pharma)":[100],"depletes":[101],"DNA":[106],"(DNMT)":[108],"1.":[109],"also":[111,166,195,204,259,277,324,387,441],"showed":[112],"co-treatment":[114,355],"S-adenosylhomocysteine":[117],"hydrolase":[118],"inhibitor,":[121],"DZNep,":[122],"further":[123],"depleted":[124,151,225,333],"complex":[126],"proteins":[127,339],"and,":[128],"in":[129,179,208,234,291,340,444,451],"combination":[130],"PS,":[132],"induced":[133,167,205,325,388,395],"synergistic":[134],"apoptosis":[135,318,396],"cultured":[137,181,236],"primary":[139,401],"AML":[140],"cells.":[141,186,212,238,274,321,438],"In":[142],"present":[144],"studies":[145,440],"we":[146],"determined":[147],"DZNep":[149,164,203,357,384],"dose-dependently":[150],"BMI1":[155],"expression":[156,228],"as":[157,159,222,224,309,311],"well":[158,223,310],"inhibited":[160],"K27Me3":[161],"H3.":[163],"p21,":[168,190],"p27":[169,191,375],"FBXO32,":[171],"while":[172],"depleting":[173],"levels":[175,262,280,335,424],"cyclin":[177,379],"D1":[178,380],"MCL":[182,211,237,273,320,402,409,437],"JeKo-1":[183],"MO2058":[185],"Similar":[187],"induction":[188,371],"FBXO32":[193],"were":[194],"observed,":[196],"following":[197],"siRNA":[198],"knockdown":[199,300],"EZH2.":[201],"Notably,":[202],"similar":[206],"perturbations":[207],"primary,":[209],"patient-derived":[210],"Treatment":[213,293],"PS":[215,275,313,322,359,386],"alone":[216],"attenuated":[217],"DNMT1,":[221],"RING2":[231],"MEL18":[233],"was":[240,267],"associated":[241,268],"attenuation":[243,377],"H3K27Me3":[245],"H2K119Ub,":[247],"augmentation":[249],"H3K4Me3":[251],"marks.":[253],"Depletion":[254],"BMI":[256],"shRNA":[258],"reduced":[260],"H2K119":[264],"Ub,":[265],"growth":[270,315,391],"inhibition":[271,316],"decreased":[278],"LSD1,":[282],"a":[283],"demethylase":[284],"H3K4Me2,":[286],"led":[288],"to":[289,349],"increase":[290],"H3K4Me3.":[292],"LSD1":[296,302,430],"CIT0665,":[298],"or":[299],"shRNA,":[304],"increased":[305],"H3K4Me2":[306],"&Me3":[307],"levels,":[308],"enhanced":[312],"heat":[326],"shock":[327],"(hsp)":[329],"90":[330],"acetylation,":[331],"hsp90":[337],"client":[338],"JeKo-1,":[341,398],"including":[342],"CDK4,":[343],"c-RAF":[344],"AKT.":[346],"As":[347],"compared":[348],"each":[352],"agent":[353],"alone,":[354],"caused":[360],"greater":[361,370],"depletion":[362,421],"accompanied":[368],"p21":[373],"but":[376],"expression.":[381],"Co-treatment":[382],"cell":[389],"cycle":[390],"arrest":[392],"synergistically":[394],"MO2058,":[399],"cells":[403],"derived":[404],"from":[405],"3":[406],"patients":[407],"(combination":[410],"indices":[411],"<1.0).":[412],"Taken":[413],"together":[414],"these":[415],"findings":[416],"indicate":[417],"combined":[419,448],"targeted":[420],"activities":[426],"HDACs,":[429],"BM1":[432],"exerts":[433],"superior":[434],"activity":[435],"against":[436],"These":[439],"support":[442],"vivo":[445],"testing":[446],"epigenetic":[449],"therapies":[450],"therapy":[453],"MCL.":[455],"Citation":[456],"Format:":[457],"{Authors}.":[458],"{Abstract":[459],"title}":[460],"[abstract].":[461],"In:":[462],"Proceedings":[463],"102nd":[466],"Annual":[467],"Meeting":[468],"American":[471],"Association":[472],"Cancer":[474,484],"Research;":[475],"2011":[476],"Apr":[477],"2-6;":[478],"Orlando,":[479],"FL.":[480],"Philadelphia":[481],"(PA):":[482],"AACR;":[483],"Res":[485],"2011;71(8":[486],"Suppl):Abstract":[487],"nr":[488],"2016.":[489],"doi:10.1158/1538-7445.AM2011-2016":[490]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
