{"id":"https://openalex.org/W2005199368","doi":"https://doi.org/10.1056/nejm197611182952114","title":"Antenatal Diagnosis of Hemoglobinopathies: An Exquisite Molecular Brew","display_name":"Antenatal Diagnosis of Hemoglobinopathies: An Exquisite Molecular Brew","publication_year":1976,"publication_date":"1976-11-18","ids":{"openalex":"https://openalex.org/W2005199368","doi":"https://doi.org/10.1056/nejm197611182952114","mag":"2005199368","pmid":"https://pubmed.ncbi.nlm.nih.gov/980025"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197611182952114","doi":"https://doi.org/10.1056/nejm197611182952114","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197611182952114","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113623635","display_name":"David G. Nathan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David G. Nathan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113623635"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"295","issue":"21","first_page":"1196","last_page":"1198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.9800000190734863},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/prenatal-genetic-testing","display_name":"prenatal genetic testing","score":0.6779999732971191},{"id":"https://openalex.org/keywords/hemoglobin-structure","display_name":"hemoglobin structure","score":0.48100000619888306},{"id":"https://openalex.org/keywords/dna-double-helix","display_name":"DNA double helix","score":0.9300000071525574},{"id":"https://openalex.org/keywords/structural-genes","display_name":"structural genes","score":0.7670000195503235},{"id":"https://openalex.org/keywords/molecular-genetics","display_name":"molecular genetics","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C111921641","wikidata":"https://www.wikidata.org/wiki/Q80756","display_name":"Polynucleotide","level":2,"score":0.7472971081733704},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.620456337928772},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5677158832550049},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5504180788993835},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5365951061248779},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5000617504119873},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42805129289627075},{"id":"https://openalex.org/C3017648133","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Single strand","level":3,"score":0.419802188873291},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3948955535888672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3294357657432556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29423201084136963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2704249620437622},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006453","descriptor_name":"Hemoglobinopathies","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006453","descriptor_name":"Hemoglobinopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1056/nejm197611182952114","doi":"https://doi.org/10.1056/nejm197611182952114","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197611182952114","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:980025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/980025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Editorial"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/536365","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/536365","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"25606","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W201050536","https://openalex.org/W1967134681","https://openalex.org/W1989934357","https://openalex.org/W2006365322","https://openalex.org/W2013241878","https://openalex.org/W2020246912","https://openalex.org/W2058583191","https://openalex.org/W2073533570","https://openalex.org/W4236887875"],"related_works":["https://openalex.org/W20271597","https://openalex.org/W4250865799","https://openalex.org/W4232635862","https://openalex.org/W2476747018","https://openalex.org/W4236038785","https://openalex.org/W4236722681","https://openalex.org/W2950383430","https://openalex.org/W7118012398","https://openalex.org/W2147541032","https://openalex.org/W2419594121"],"abstract_inverted_index":{"The":[0,22,63],"DNA":[1],"of":[2,9,18,32,81,96],"mammalian":[3],"cells":[4],"contains":[5,88],"two":[6],"complementary":[7,73],"strands":[8,84],"polydeoxynucleotides":[10],"wound":[11],"about":[12],"each":[13],"other":[14,60],"in":[15,35,42],"the":[16,26,29,33,43,59,82,89],"form":[17],"a":[19],"double":[20,64],"helix.":[21],"term":[23],"\"complementary\"":[24],"describes":[25],"fact":[27],"that":[28,79,98],"adenine":[30],"bases":[31],"nucleotides":[34],"either":[36],"strand":[37,52],"are":[38,47,93],"opposite":[39,48],"to":[40,49],"thymidines":[41],"other,":[44],"and":[45,58],"guanines":[46],"cytidines.":[50],"One":[51],"is":[53,66],"arbitrarily":[54],"designated":[55],"as":[56,61],"plus,":[57],"minus.":[62],"helix":[65],"stabilized":[67],"by":[68],"hydrogen":[69],"bonds":[70],"between":[71],"these":[72],"bases.":[74],"A":[75],"simple":[76],"model":[77],"suggests":[78],"one":[80],"helical":[83],"(the":[85],"minus":[86],"strand)":[87],"structural":[90],"genes.":[91],"These":[92],"linear":[94],"arrays":[95],"polynucleotides":[97],"serve":[99],".":[100,101,102]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}