{"id":"https://openalex.org/W2005199012","doi":"https://doi.org/10.1164/ajrccm.151.4.7697278","title":"Interfacing between Spontaneous Breathing and Mechanical Ventilation Affects Ventilation-Perfusion Distributions in Experimental Bronchoconstriction","display_name":"Interfacing between Spontaneous Breathing and Mechanical Ventilation Affects Ventilation-Perfusion Distributions in Experimental Bronchoconstriction","publication_year":1995,"publication_date":"1995-04-01","ids":{"openalex":"https://openalex.org/W2005199012","doi":"https://doi.org/10.1164/ajrccm.151.4.7697278","mag":"2005199012","pmid":"https://pubmed.ncbi.nlm.nih.gov/7697278"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.151.4.7697278","doi":"https://doi.org/10.1164/ajrccm.151.4.7697278","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.151.4.7697278","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040689704","display_name":"Christian Putensen","orcid":"https://orcid.org/0000-0003-1599-9809","observed_orcids":["https://orcid.org/0000-0003-1599-9809"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Putensen","raw_affiliation_strings":["Department of Anesthesiology, University of South Florida, College of Medicine, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of South Florida, College of Medicine, Tampa, Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078701434","display_name":"Jukka O Rasanen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J R\u00e4s\u00e4nen","raw_affiliation_strings":["Department of Anesthesiology, University of South Florida, College of Medicine, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of South Florida, College of Medicine, Tampa, Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080608380","display_name":"Frank A. L\u00f3pez","orcid":"https://orcid.org/0009-0008-5337-2234","observed_orcids":["https://orcid.org/0009-0008-5337-2234"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F A L\u00f3pez","raw_affiliation_strings":["Department of Anesthesiology, University of South Florida, College of Medicine, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of South Florida, College of Medicine, Tampa, Florida","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":null,"apc_paid":null,"fwci":1.8923,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.85309159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"151","issue":"4","first_page":"993","last_page":"999"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10830","display_name":"Airway Management and Intubation Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spontaneous-breathing","display_name":"spontaneous breathing","score":0.6380000114440918},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ventilation-perfusion-distribution","display_name":"ventilation-perfusion distribution","score":0.75},{"id":"https://openalex.org/keywords/bronchoconstriction","display_name":"bronchoconstriction","score":0.8889999985694885},{"id":"https://openalex.org/keywords/methacholine","display_name":"methacholine","score":0.7229999899864197},{"id":"https://openalex.org/keywords/pressure-support-ventilation","display_name":"pressure support ventilation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/biphasic-positive-airway-pressure","display_name":"biphasic positive airway pressure","score":0.9900000095367432},{"id":"https://openalex.org/keywords/shunt","display_name":"shunt","score":0.5609999895095825},{"id":"https://openalex.org/keywords/dead-space","display_name":"dead space","score":0.7360000014305115},{"id":"https://openalex.org/keywords/gas-exchange","display_name":"gas exchange","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.7829999923706055},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.8500000238418579},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.3009999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7679337859153748},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.6889652013778687},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6241183876991272},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.4977426826953888},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3632768988609314},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.24154722690582275},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001982","descriptor_name":"Bronchial Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001982","descriptor_name":"Bronchial Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001982","descriptor_name":"Bronchial Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014692","descriptor_name":"Ventilation-Perfusion Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014692","descriptor_name":"Ventilation-Perfusion Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014692","descriptor_name":"Ventilation-Perfusion Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1164/ajrccm.151.4.7697278","doi":"https://doi.org/10.1164/ajrccm.151.4.7697278","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.151.4.7697278","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"doi:10.1164/ajrccm/151.4.993","doi":"https://doi.org/10.1164/ajrccm/151.4.993","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm/151.4.993","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:7697278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7697278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2935909890","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W2748952813","https://openalex.org/W1531601525"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,25,98,195,200,233,241],"interfacing":[3],"between":[4],"spontaneous":[5,26,43,56,68,165,213,220,242],"and":[6,19,23,47,66,80,101,132,154,183,202,210,243],"mechanical":[7,60,244],"ventilation":[8,17,84,217,234,245],"on":[9],"ventilation-perfusion":[10],"(VA/Q)":[11],"distributions":[12],"was":[13,206,236],"determined":[14],"during":[15,28,91,208,222,238,246,256],"pressure-support":[16],"(PSV)":[18],"in":[20,34,74,177,192],"the":[21,59,99,193],"presence":[22],"absence":[24],"breathing":[27,44,57,90,157,166,221],"biphasic":[29],"positive":[30],"airway":[31],"pressure":[32],"(BIPAP)":[33],"10":[35],"pigs":[36],"with":[37,63,65,219,227],"methacholine-induced":[38],"bronchoconstriction.":[39],"Whereas":[40],"BIPAP":[41,53,64,92,164,211,223,247],"without":[42,67,212],"provides":[45],"full":[46],"PSV":[48,70,148,209,228],"breath-to-breath":[49],"synchronized":[50],"ventilatory":[51,75],"support,":[52],"allows":[54],"unrestricted":[55],"throughout":[58],"cycle.":[61],"Compared":[62],"breathing,":[69],"effected":[71],"an":[72],"increase":[73,151,188],"rate":[76],"(p":[77,86,115,129,145,174,189,229],"<":[78,87,116,130,146,175,190,230],"0.05)":[79,176,191],"a":[81,169,184],"higher":[82],"minute":[83],"(VE)":[85],"0.05).":[88,147,231],"Spontaneous":[89,156],"accounted":[93,167],"for":[94,168],"15":[95,170],"+/-":[96,108,112,121,125,138,142,171,186],"1%":[97],"VE":[100],"increased":[102],"cardiac":[103],"output":[104],"(CO)":[105],"from":[106,119,136],"4.5":[107],"0.2":[109,113],"to":[110,123,140,180],"5.3":[111],"L/min":[114],"0.05),":[117,131],"Pao2":[118],"55":[120],"3":[122],"80":[124],"4":[126],"mm":[127],"Hg":[128],"oxygen":[133,161],"delivery":[134],"(DO2)":[135],"442":[137],"39":[139],"630":[141],"43":[143],"ml/min":[144],"did":[149,158],"not":[150,159],"CO,":[152],"Pao2,":[153],"DO2.":[155],"affect":[160],"consumption.":[162],"During":[163],"2%":[172,187],"decrease":[173],"blood":[178],"flow":[179],"shunt":[181,201],"units":[182,205],"16":[185],"perfusion":[194],"normal":[196,203],"VA/Q":[197,204,254],"units.":[198],"Perfusion":[199],"similar":[207],"breathing.":[214],"Dead":[215],"space":[216],"decreased":[218],"by":[224,251],"12%":[225],"compared":[226],"Dispersion":[232],"distribution":[235],"lowest":[237],"BIPAP.":[239],"Uncoupling":[240],"improved":[248],"gas":[249],"exchange":[250],"allowing":[252],"better":[253],"matching":[255],"experimental":[257],"bronchoconstriction.(ABSTRACT":[258],"TRUNCATED":[259],"AT":[260],"250":[261],"WORDS)":[262]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}