{"id":"https://openalex.org/W2005196809","doi":"https://doi.org/10.1016/j.amjhyper.2005.03.471","title":"Effect of manidipine-simvastatin combination on fibrinolysis, adhesion molecules and C-reactive protein in hypertensive hypercholesterolemic patients","display_name":"Effect of manidipine-simvastatin combination on fibrinolysis, adhesion molecules and C-reactive protein in hypertensive hypercholesterolemic patients","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W2005196809","doi":"https://doi.org/10.1016/j.amjhyper.2005.03.471","mag":"2005196809"},"language":"en","primary_location":{"id":"doi:10.1016/j.amjhyper.2005.03.471","doi":"https://doi.org/10.1016/j.amjhyper.2005.03.471","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.amjhyper.2005.03.471","pdf_url":"https://academic.oup.com/ajh/article-pdf/18/S4/171A/313237/18_S4_171A.pdf","source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ajh/article-pdf/18/S4/171A/313237/18_S4_171A.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111657847","display_name":"R Fogari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R FOGARI","raw_affiliation_strings":["Department of Internal Medicine, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021841408","display_name":"Giuseppe Derosa","orcid":"https://orcid.org/0000-0003-3573-4760","observed_orcids":["https://orcid.org/0000-0003-3573-4760"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G DEROSA","raw_affiliation_strings":["Department of Internal Medicine, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112548254","display_name":"M. Destro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M DESTRO","raw_affiliation_strings":["Department of Internal Medicine, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085524838","display_name":"Luca Corradi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L CORRADI","raw_affiliation_strings":["Department of Internal Medicine, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039188583","display_name":"Andrea Rinaldi","orcid":"https://orcid.org/0000-0003-3234-0563","observed_orcids":["https://orcid.org/0000-0003-3234-0563"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A RINALDI","raw_affiliation_strings":["Department of Internal Medicine, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110390795","display_name":"Carlo Pasotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C PASOTTI","raw_affiliation_strings":["Department of Internal Medicine, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111544287","display_name":"Amedeo Mugellini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A MUGELLINI","raw_affiliation_strings":["Department of Internal Medicine, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I25217355"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":0.3172,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.65695719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"5","first_page":"A171","last_page":"A171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.2524000108242035,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.06970000267028809,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manidipine","display_name":"manidipine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.996999979019165},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cholesterol-lowering","display_name":"cholesterol lowering","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.905389666557312},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.884753406047821},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.7586658596992493},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.6877840161323547},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.5935277938842773},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.5210965871810913},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4842047691345215},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48212409019470215},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4027249217033386},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3431224822998047},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20153072476387024}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.amjhyper.2005.03.471","doi":"https://doi.org/10.1016/j.amjhyper.2005.03.471","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.amjhyper.2005.03.471","pdf_url":"https://academic.oup.com/ajh/article-pdf/18/S4/171A/313237/18_S4_171A.pdf","source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmh:oai:zenodo.org:163370","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/163370","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.163370","doi":"https://doi.org/10.5281/zenodo.163370","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.163370","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Image"}],"best_oa_location":{"id":"doi:10.1016/j.amjhyper.2005.03.471","doi":"https://doi.org/10.1016/j.amjhyper.2005.03.471","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.amjhyper.2005.03.471","pdf_url":"https://academic.oup.com/ajh/article-pdf/18/S4/171A/313237/18_S4_171A.pdf","source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005196809.pdf","grobid_xml":"https://content.openalex.org/works/W2005196809.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2008430792","https://openalex.org/W2029241561","https://openalex.org/W2094943671","https://openalex.org/W2009534908","https://openalex.org/W2162960610","https://openalex.org/W2071658217","https://openalex.org/W1999958779","https://openalex.org/W2141423682","https://openalex.org/W2367039836","https://openalex.org/W2074955122"],"abstract_inverted_index":{"Aim":[0],"of":[1,9,101,107,201],"this":[2],"study":[3],"was":[4,113,120],"to":[5,67,79,129],"evaluate":[6,130],"the":[7,96,102,123,127,147,173,177,199],"effect":[8],"manidipine-simvastatin":[10,76,170,195],"combination":[11,171,196],"on":[12,22,30],"plasma":[13,23,131,137,178],"tissue":[14],"plasminogen":[15],"activator":[16],"(t-PA)":[17],"and":[18,29,53,106,115,133,139,180,190],"inhibitor":[19],"(PAI-1)":[20],"activity,":[21,135],"intercellurar":[24],"adhesion":[25],"molecule":[26],"type-1":[27],"(ICAM-1)":[28],"serum":[31],"C-reactive":[32],"protein":[33],"(CRP)":[34],"in":[35,126,146,166,203],"hypertensive,":[36,167],"hypercholesterolemic":[37,57,205],"patients.":[38,206],"After":[39],"4":[40],"week":[41,91],"placebo":[42,103,161],"run-in":[43,104],"period,":[44],"36":[45],"hypertensive":[46,204],"[diastolic":[47],"blood":[48,111,118],"pressure":[49,112],"(DBP)":[50],">":[51,61],"90":[52],"<":[54,152,155,158],"105":[55],"mmHg],":[56],"[total":[58],"cholesterol":[59,189],"(TC)":[60],"200":[62],"mg/dl]":[63],"patients":[64,94,169],"were":[65],"randomized":[66],"manidipine":[68],"20":[69],"mg":[70,74],"or":[71,75],"simvastatin":[72],"40":[73],"combination,":[77],"according":[78],"a":[80,116],"3":[81,83],"x":[82],"cross":[84],"over":[85],"design;":[86],"each":[87,108],"treatment":[88,109,200],"had":[89],"12":[90],"duration.":[92],"Thirty":[93],"completed":[95],"study.":[97],"The":[98,141,187],"last":[99],"day":[100],"period":[105,110],"measured":[114],"venous":[117],"sample":[119],"taken":[121],"(at":[122],"same":[124],"hour":[125],"morning)":[128],"t-PA":[132],"PAI-1":[134],"TC,":[136],"ICAM-1":[138,179],"CRP.":[140],"main":[142],"results":[143,163],"are":[144],"shown":[145],"table.":[148],"Main":[149],"Results":[150],"*p":[151],"0.05;":[153],"**p":[154],"0.01;":[156],"***p":[157],"0.001":[159],"vs":[160],"These":[162],"suggest":[164],"that":[165,194],"hyperchoelsterolemic":[168],"improves":[172],"fibrinolytic":[174],"balance,":[175],"reduces":[176],"decreases":[181],"BP":[182],"more":[183],"than":[184],"single":[185],"monotherapy.":[186],"concomitant":[188],"CRP":[191],"reduction":[192],"suggests":[193],"could":[197],"be":[198],"choice":[202]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
