{"id":"https://openalex.org/W2005196387","doi":"https://doi.org/10.1164/rccm.201012-2033oc","title":"The Inflammatory Preatherosclerotic Remodeling Induced by Intermittent Hypoxia Is Attenuated by RANTES/CCL5 Inhibition","display_name":"The Inflammatory Preatherosclerotic Remodeling Induced by Intermittent Hypoxia Is Attenuated by RANTES/CCL5 Inhibition","publication_year":2011,"publication_date":"2011-06-17","ids":{"openalex":"https://openalex.org/W2005196387","doi":"https://doi.org/10.1164/rccm.201012-2033oc","mag":"2005196387","pmid":"https://pubmed.ncbi.nlm.nih.gov/21680945"},"language":"en","primary_location":{"id":"doi:10.1164/rccm.201012-2033oc","doi":"https://doi.org/10.1164/rccm.201012-2033oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.201012-2033oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://inserm.hal.science/inserm-00786346/document","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008548334","display_name":"Claire Arnaud","orcid":"https://orcid.org/0000-0003-0964-9423","observed_orcids":["https://orcid.org/0000-0003-0964-9423"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Arnaud","raw_affiliation_strings":["INSERM U1042, Grenoble, France","UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1042, Grenoble, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034949703","display_name":"Pauline C. B\u00e9guin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pauline C. Beguin","raw_affiliation_strings":["INSERM U1042, Grenoble, France","UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1042, Grenoble, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055426359","display_name":"Sylvie Lantu\u00e9joul","orcid":"https://orcid.org/0000-0003-4310-6975","observed_orcids":["https://orcid.org/0000-0003-4310-6975"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Lantuejoul","raw_affiliation_strings":["D\u00e9partement de Pathologie","INSERM U823, Grenoble, France","UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pathologie","institution_ids":[]},{"raw_affiliation_string":"INSERM U823, Grenoble, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067706451","display_name":"Jean\u2010Louis P\u00e9pin","orcid":"https://orcid.org/0000-0003-3832-2358","observed_orcids":["https://orcid.org/0000-0003-3832-2358"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Louis Pepin","raw_affiliation_strings":["INSERM U1042, Grenoble, France","Laboratoire du Sommeil","UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1042, Grenoble, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Laboratoire du Sommeil","institution_ids":[]},{"raw_affiliation_string":"UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070189567","display_name":"Christiane Guillermet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christiane Guillermet","raw_affiliation_strings":["D\u00e9partement de Pathologie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pathologie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107853176","display_name":"Graziano Pelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Graziano Pelli","raw_affiliation_strings":["Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108617693","display_name":"Fabienne Burger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fabienne Burger","raw_affiliation_strings":["Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037433831","display_name":"Vanessa Buatois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144390","display_name":"Light Chain Bioscience (Switzerland)","ror":"https://ror.org/03a17f132","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210144390"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Vanessa Buatois","raw_affiliation_strings":["NovImmune S.A., Geneva, Switzerland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovImmune S.A., Geneva, Switzerland; and","institution_ids":["https://openalex.org/I4210144390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015148423","display_name":"Christophe Ribuot","orcid":"https://orcid.org/0000-0003-4425-6203","observed_orcids":["https://orcid.org/0000-0003-4425-6203"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Ribuot","raw_affiliation_strings":["INSERM U1042, Grenoble, France","UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1042, Grenoble, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107838994","display_name":"Jean-Philippe Baguet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Baguet","raw_affiliation_strings":["D\u00e9partement de Cardiologie et Hypertension, and","INSERM U877, Grenoble, France","UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Cardiologie et Hypertension, and","institution_ids":[]},{"raw_affiliation_string":"INSERM U877, Grenoble, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085573148","display_name":"Fran\u00e7ois Mach","orcid":"https://orcid.org/0000-0003-3178-9131","observed_orcids":["https://orcid.org/0000-0003-3178-9131"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Mach","raw_affiliation_strings":["Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023993753","display_name":"Patrick A. Levy","orcid":"https://orcid.org/0000-0003-3174-7935","observed_orcids":["https://orcid.org/0000-0003-3174-7935"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Levy","raw_affiliation_strings":["INSERM U1042, Grenoble, France","Laboratoire du Sommeil","UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1042, Grenoble, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Laboratoire du Sommeil","institution_ids":[]},{"raw_affiliation_string":"UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056329559","display_name":"Maurice Dematt\u00e9is","orcid":"https://orcid.org/0000-0002-7211-5689","observed_orcids":["https://orcid.org/0000-0002-7211-5689"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177483745","display_name":"Universit\u00e9 Joseph Fourier","ror":"https://ror.org/02aj0kh94","country_code":"FR","type":"education","lineage":["https://openalex.org/I177483745","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I2800555055","display_name":"Centre Hospitalier Universitaire de Grenoble","ror":"https://ror.org/041rhpw39","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Maurice Dematteis","raw_affiliation_strings":["INSERM U1042, Grenoble, France","P\u00f4le Pluridisciplinaire de M\u00e9decine, CHU de Grenoble, Grenoble, France","UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1042, Grenoble, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"P\u00f4le Pluridisciplinaire de M\u00e9decine, CHU de Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I2800555055"]},{"raw_affiliation_string":"UJF, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Grenoble, Grenoble, France","institution_ids":["https://openalex.org/I177483745"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5056329559"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177483745","https://openalex.org/I2800555055"],"apc_list":null,"apc_paid":null,"fwci":6.5453,"has_fulltext":true,"cited_by_count":134,"citation_normalized_percentile":{"value":0.97103886,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"184","issue":"6","first_page":"724","last_page":"731"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intermittent-hypoxia","display_name":"intermittent hypoxia","score":0.984000027179718},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.984000027179718},{"id":"https://openalex.org/keywords/ccl5-rantes","display_name":"CCL5/RANTES","score":0.9800000190734863},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/intima-media-thickening","display_name":"intima-media thickening","score":0.8939999938011169},{"id":"https://openalex.org/keywords/leukocyte-endothelial-adhesion","display_name":"leukocyte-endothelial adhesion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8009999990463257},{"id":"https://openalex.org/keywords/smooth-muscle-cell-hypertrophy","display_name":"smooth muscle cell hypertrophy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.906000018119812},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/chemokine-neutralization","display_name":"chemokine neutralization","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8629028797149658},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6215947270393372},{"id":"https://openalex.org/C116484652","wikidata":"https://www.wikidata.org/wiki/Q3492926","display_name":"CCL5","level":5,"score":0.5560829639434814},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.479453444480896},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4290198087692261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2569696307182312},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21965563297271729},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.13297998905181885},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.10284063220024109},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.08178654313087463},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07961669564247131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017539","descriptor_name":"Tunica Intima","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018946","descriptor_name":"Chemokine CCL5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1164/rccm.201012-2033oc","doi":"https://doi.org/10.1164/rccm.201012-2033oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.201012-2033oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:21680945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21680945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-00786346v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00786346","pdf_url":"https://inserm.hal.science/inserm-00786346/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine, 2011, 184 (6), pp.724-31. &#x27E8;10.1164/rccm.201012-2033OC&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:3899687","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4901161","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4901161","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4901161","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Respir Crit Care Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:HAL:inserm-00786346v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00786346","pdf_url":"https://inserm.hal.science/inserm-00786346/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine, 2011, 184 (6), pp.724-31. &#x27E8;10.1164/rccm.201012-2033OC&#x27E9;","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005196387.pdf","grobid_xml":"https://content.openalex.org/works/W2005196387.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W196835504","https://openalex.org/W199167747","https://openalex.org/W1515667338","https://openalex.org/W1539520484","https://openalex.org/W1851294306","https://openalex.org/W1977085288","https://openalex.org/W1996866382","https://openalex.org/W1997274278","https://openalex.org/W1998508489","https://openalex.org/W2002041877","https://openalex.org/W2021127773","https://openalex.org/W2030451085","https://openalex.org/W2031518179","https://openalex.org/W2036638105","https://openalex.org/W2037493697","https://openalex.org/W2051344677","https://openalex.org/W2065432525","https://openalex.org/W2071062200","https://openalex.org/W2072499657","https://openalex.org/W2073477485","https://openalex.org/W2083789006","https://openalex.org/W2084091098","https://openalex.org/W2086320912","https://openalex.org/W2095891614","https://openalex.org/W2099593277","https://openalex.org/W2103878792","https://openalex.org/W2106890887","https://openalex.org/W2113902557","https://openalex.org/W2124052130","https://openalex.org/W2128512270","https://openalex.org/W2134665522","https://openalex.org/W2135514207","https://openalex.org/W2143702903","https://openalex.org/W2146840987","https://openalex.org/W2148001826","https://openalex.org/W2149011983","https://openalex.org/W2149428511","https://openalex.org/W2152317800","https://openalex.org/W2156023431","https://openalex.org/W2157191239","https://openalex.org/W2160507976","https://openalex.org/W2162157908","https://openalex.org/W2165463540","https://openalex.org/W2166118117","https://openalex.org/W2169637885","https://openalex.org/W2227064725","https://openalex.org/W2471195096","https://openalex.org/W3023775830"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"RATIONALE:":[0],"The":[1,23],"highly":[2],"prevalent":[3],"obstructive":[4],"sleep":[5,276],"apnea":[6,277],"syndrome":[7],"(OSA)":[8],"with":[9,110,131,156,198],"its":[10,27,266],"main":[11],"component":[12],"intermittent":[13],"hypoxia":[14],"(IH)":[15],"is":[16,238],"a":[17,111,239,248,271],"risk":[18],"factor":[19],"for":[20,242,263],"cardiovascular":[21,71],"mortality.":[22],"poor":[24],"knowledge":[25],"of":[26,33,52,66,73,114,212,231,254,275],"pathophysiology":[28],"has":[29,55],"limited":[30,56],"the":[31,37,49,64,70,132,137,232,255],"development":[32],"specific":[34],"treatments,":[35],"whereas":[36],"gold":[38],"standard":[39],"treatment,":[40],"continuous":[41],"positive":[42],"airway":[43],"pressure,":[44],"may":[45,269],"not":[46],"fully":[47],"reverse":[48],"chronic":[50],"consequences":[51],"OSA":[53],"and":[54,79,121,153,158,162,172,185,206,217,227,265],"acceptance":[57],"in":[58,83,107,190,251],"some":[59],"patients.":[60],"OBJECTIVES:":[61],"To":[62],"examine":[63],"contribution":[65],"IH-induced":[67,243],"inflammation":[68,147],"to":[69,87,100],"complications":[72],"OSA.":[74],"METHODS:":[75],"We":[76],"investigated":[77],"systemic":[78,146],"vascular":[80,174],"inflammatory":[81,173,228,256],"changes":[82],"C57BL6":[84],"mice":[85,108],"exposed":[86],"IH":[88,138,144,168],"(21-5%":[89],"Fi(O(2)),":[90],"60-s":[91],"cycle)":[92],"or":[93,130],"normoxia":[94],"8":[95],"hours":[96],"per":[97],"day":[98],"up":[99],"14":[101],"days.":[102],"Vascular":[103],"alterations":[104],"were":[105,179],"reassessed":[106],"treated":[109],"blocking":[112],"antibody":[113],"regulated":[115],"upon":[116],"activation,":[117],"normal":[118],"T-cell":[119],"expressed":[120],"secreted":[122],"(RANTES)/CC":[123],"chemokine":[124,154,250],"ligand":[125],"5":[126],"(CCL5)":[127],"signaling":[128],"pathway,":[129],"IgG":[133],"isotype":[134],"control":[135],"throughout":[136],"exposure.":[139],"MEASUREMENTS":[140],"AND":[141],"MAIN":[142],"RESULTS:":[143],"induced":[145,170],"combining":[148],"increased":[149,195],"splenic":[150],"lymphocyte":[151],"proliferation":[152],"expression,":[155],"early":[157],"predominant":[159],"RANTES/CCL5":[160,221],"alterations,":[161,201,229],"enhanced":[163],"splenocyte":[164],"migration":[165],"toward":[166],"RANTES/CCL5.":[167],"also":[169],"structural":[171],"alterations.":[175],"Leukocyte-endothelium":[176],"adhesive":[177],"interactions":[178],"increased,":[180],"attested":[181],"by":[182],"leukocyte":[183],"rolling":[184],"intercellular":[186,207],"adhesion":[187,208],"molecule-1":[188,209],"expression":[189],"mesenteric":[191],"vessels.":[192],"Aortas":[193],"had":[194],"intima-media":[196,225],"thickness":[197],"elastic":[199],"fiber":[200],"mucoid":[202],"depositions,":[203],"nuclear":[204],"factor-\u03baB-p50":[205],"overexpression,":[210],"hypertrophy":[211],"smooth-muscle":[213],"cells":[214],"overexpressing":[215],"RANTES/CCL5,":[216,247],"adventitial-periadventitial":[218],"T-lymphocyte":[219],"infiltration.":[220],"neutralization":[222],"prevented":[223],"both":[224],"thickening":[226],"independently":[230],"IH-associated":[233],"proatherogenic":[234],"dyslipidemia.":[235],"CONCLUSIONS:":[236],"Inflammation":[237],"determinant":[240],"mechanism":[241],"preatherosclerotic":[244],"remodeling":[245],"involving":[246],"key":[249],"atherogenesis.":[252],"Characterization":[253],"response":[257],"could":[258],"allow":[259],"identifying":[260],"at-risk":[261],"patients":[262],"complications,":[264],"pharmacologic":[267],"manipulation":[268],"represent":[270],"potential":[272],"complementary":[273],"treatment":[274],"consequences.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}
