{"id":"https://openalex.org/W2005194686","doi":"https://doi.org/10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","title":"Predictive value of nuclear DNA content in breast cancer in relation to clinical and morphologic factors. A retrospective study of 227 consecutive cases","display_name":"Predictive value of nuclear DNA content in breast cancer in relation to clinical and morphologic factors. A retrospective study of 227 consecutive cases","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W2005194686","doi":"https://doi.org/10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","mag":"2005194686","pmid":"https://pubmed.ncbi.nlm.nih.gov/3390793"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","doi":"https://doi.org/10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819880801%2962%3A3%3C521%3A%3AAID-CNCR2820620314%3E3.0.CO%3B2-F","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819880801%2962%3A3%3C521%3A%3AAID-CNCR2820620314%3E3.0.CO%3B2-F","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076730374","display_name":"Anders G. Fallenius","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anders G. Fallenius","raw_affiliation_strings":["Department of Tumor Pathology, Karolinska Institute and Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Pathology, Karolinska Institute and Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066704814","display_name":"Gert Auer","orcid":"https://orcid.org/0000-0003-3911-0285","observed_orcids":["https://orcid.org/0000-0003-3911-0285"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gert U. Auer","raw_affiliation_strings":["Departments of Tumor Pathology, Karolinska Institute and Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Tumor Pathology, Karolinska Institute and Hospital, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110002920","display_name":"S. Franz\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sixten A. Franz\u00e9n","raw_affiliation_strings":["Departments of Cytology, Karolinska Institute and Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cytology, Karolinska Institute and Hospital, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076730374"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":9.7472,"has_fulltext":false,"cited_by_count":115,"citation_normalized_percentile":{"value":0.98810773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"62","issue":"3","first_page":"521","last_page":"530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nuclear-dna-content","display_name":"nuclear DNA content","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/histologic-grading","display_name":"histologic grading","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ductal-carcinoma","display_name":"ductal carcinoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/axillary-lymph-node-status","display_name":"axillary lymph node status","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.968999981880188},{"id":"https://openalex.org/keywords/dna-ploidy","display_name":"DNA ploidy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7543953657150269},{"id":"https://openalex.org/C115960442","wikidata":"https://www.wikidata.org/wiki/Q769863","display_name":"Nuclear DNA","level":4,"score":0.6985387206077576},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.6708519458770752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5877808928489685},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5300720930099487},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5289269089698792},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.5246284604072571},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4915402829647064},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47001388669013977},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4501948654651642},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.447378009557724},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.44390973448753357},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.43700000643730164},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42499569058418274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21842312812805176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16677382588386536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08159580826759338},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011003","descriptor_name":"Ploidies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","doi":"https://doi.org/10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819880801%2962%3A3%3C521%3A%3AAID-CNCR2820620314%3E3.0.CO%3B2-F","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:3390793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3390793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","doi":"https://doi.org/10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19880801)62:3<521::aid-cncr2820620314>3.0.co;2-f","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819880801%2962%3A3%3C521%3A%3AAID-CNCR2820620314%3E3.0.CO%3B2-F","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2005194686.pdf"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W622709158","https://openalex.org/W1788121606","https://openalex.org/W1968691429","https://openalex.org/W1973797587","https://openalex.org/W1975561903","https://openalex.org/W1982135458","https://openalex.org/W1984173722","https://openalex.org/W1984642320","https://openalex.org/W1989169468","https://openalex.org/W1992136738","https://openalex.org/W2009989928","https://openalex.org/W2018903074","https://openalex.org/W2021601228","https://openalex.org/W2028523012","https://openalex.org/W2031715561","https://openalex.org/W2040941502","https://openalex.org/W2042131614","https://openalex.org/W2044029334","https://openalex.org/W2045171441","https://openalex.org/W2050451746","https://openalex.org/W2053551981","https://openalex.org/W2054555565","https://openalex.org/W2059912294","https://openalex.org/W2060783173","https://openalex.org/W2061890749","https://openalex.org/W2063808616","https://openalex.org/W2066547189","https://openalex.org/W2068738733","https://openalex.org/W2074946370","https://openalex.org/W2075787068","https://openalex.org/W2079655977","https://openalex.org/W2082707054","https://openalex.org/W2083275000","https://openalex.org/W2088786105","https://openalex.org/W2089763875","https://openalex.org/W2091868469","https://openalex.org/W2103402277","https://openalex.org/W2104979975","https://openalex.org/W2122594004","https://openalex.org/W2160410484","https://openalex.org/W2163299027","https://openalex.org/W2163794352","https://openalex.org/W2404329934","https://openalex.org/W2406382787","https://openalex.org/W2410314804","https://openalex.org/W2415021019","https://openalex.org/W2416817059","https://openalex.org/W2426998233","https://openalex.org/W2442170019","https://openalex.org/W2764728888","https://openalex.org/W2801690730","https://openalex.org/W3147894994","https://openalex.org/W4250417690","https://openalex.org/W4298407707","https://openalex.org/W6712968686"],"related_works":["https://openalex.org/W2088352615","https://openalex.org/W1984642320","https://openalex.org/W2052139978","https://openalex.org/W2050451746","https://openalex.org/W2317212629","https://openalex.org/W2077857519","https://openalex.org/W111690260","https://openalex.org/W2314467397","https://openalex.org/W2031303411","https://openalex.org/W2059928742"],"abstract_inverted_index":{"The":[0,35],"predictive":[1],"value":[2],"of":[3,23,30,42,73,85,94,106,181],"nuclear":[4,46,131,173],"DNA":[5,47,71,98,132,151,174],"content":[6,48,72,99,133,152],"in":[7,10,19],"breast":[8,25,74],"cancer":[9,75],"relation":[11],"to":[12,32,54,103,116,128],"clinical":[13,60],"and":[14,61,134,161],"morphologic":[15],"factors":[16,142],"was":[17,100,126],"studied":[18],"227":[20],"consecutive":[21],"cases":[22],"invasive":[24],"adenocarcinomas":[26],"with":[27,39,81,110],"follow-up":[28],"periods":[29],"8":[31],"13":[33],"years.":[34],"results":[36,168],"show":[37],"that,":[38],"the":[40,70,82,86,92,95,107,120,159,167,191],"use":[41],"Cox":[43],"multivariate":[44],"analysis":[45],"provided":[49,153],"significant":[50],"prognostic":[51,145,155,188],"information":[52,156],"additional":[53,154],"that":[55,69,139,150,172],"given":[56],"by":[57],"all":[58],"other":[59,88,121],"histomorphologic":[62],"variables":[63],"taken":[64],"together.":[65],"This":[66],"fact":[67],"indicates":[68],"cells":[76],"reflects":[77],"biological":[78,179],"properties,":[79],"associated":[80],"malignant":[83],"behavior":[84],"tumor,":[87],"than":[89],"those":[90],"determining":[91],"stage":[93],"disease.":[96],"Nuclear":[97],"strongly":[101],"correlated":[102],"histopathologic":[104],"grading":[105],"ductal":[108],"carcinomas,":[109],"poorly":[111],"differentiated":[112],"tumors":[113],"more":[114],"likely":[115],"be":[117],"aneuploid.":[118],"On":[119],"hand,":[122],"no":[123],"clear":[124],"correlation":[125],"found":[127],"exist":[129],"between":[130],"axillary":[135],"node":[136],"status,":[137],"indicating":[138],"these":[140],"two":[141],"are":[143],"independent":[144],"parameters.":[146],"It":[147],"is":[148],"noteworthy":[149],"within":[157,190],"both":[158],"node-negative":[160],"node-positive":[162],"patient":[163],"groups.":[164],"In":[165],"summary,":[166],"shown":[169],"here":[170],"indicate":[171],"content,":[175],"as":[176],"an":[177],"objective":[178],"marker":[180],"tumor":[182],"aggressiveness,":[183],"can":[184],"significantly":[185],"improve":[186],"our":[187],"capabilities":[189],"currently":[192],"designated":[193],"stages.":[194]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
