{"id":"https://openalex.org/W2005191586","doi":"https://doi.org/10.1097/01.fjc.0000166247.35992.dd","title":"Endothelin-B Receptor Blockade Inhibits Molecular Effectors of Melanoma Cell Progression","display_name":"Endothelin-B Receptor Blockade Inhibits Molecular Effectors of Melanoma Cell Progression","publication_year":2004,"publication_date":"2004-11-01","ids":{"openalex":"https://openalex.org/W2005191586","doi":"https://doi.org/10.1097/01.fjc.0000166247.35992.dd","mag":"2005191586","pmid":"https://pubmed.ncbi.nlm.nih.gov/15838263"},"language":"en","primary_location":{"id":"doi:10.1097/01.fjc.0000166247.35992.dd","doi":"https://doi.org/10.1097/01.fjc.0000166247.35992.dd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.fjc.0000166247.35992.dd","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005191586"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107977477","display_name":"Laura Rosan\u00f2","orcid":"https://orcid.org/0000-0002-9962-6411","observed_orcids":["https://orcid.org/0000-0002-9962-6411"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Rosan??","raw_affiliation_strings":["Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039788126","display_name":"Francesca Spinella","orcid":"https://orcid.org/0000-0002-2108-7075","observed_orcids":["https://orcid.org/0000-0002-2108-7075","https://orcid.org/0009-0007-9026-696X"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesca Spinella","raw_affiliation_strings":["Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033720222","display_name":"Giulia Genovesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giulia Genovesi","raw_affiliation_strings":["Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017244417","display_name":"Valeriana Di Castro","orcid":"https://orcid.org/0000-0002-1899-3683","observed_orcids":["https://orcid.org/0000-0002-1899-3683"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Valeriana Di Castro","raw_affiliation_strings":["Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054472524","display_name":"Pier Giorgio Natali","orcid":"https://orcid.org/0000-0002-2843-3313","observed_orcids":["https://orcid.org/0000-0002-2843-3313"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pier Giorgio Natali","raw_affiliation_strings":["Laboratory of Immunology, Regina Elena Cancer Institute, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, Regina Elena Cancer Institute, Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090987336","display_name":"Anna Bagnato","orcid":"https://orcid.org/0000-0002-7269-9522","observed_orcids":["https://orcid.org/0000-0002-7269-9522"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Anna Bagnato","raw_affiliation_strings":["Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy","and reprint requests to Anna Bagnato, Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi D'Oro 156, 00158 Rome, Italy. E-mail [email\u00a0protected]","reprint requests to Anna Bagnato, Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi D'Oro 156, 00158 Rome, Italy. E-mail [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]},{"raw_affiliation_string":"and reprint requests to Anna Bagnato, Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi D'Oro 156, 00158 Rome, Italy. E-mail [email\u00a0protected]","institution_ids":["https://openalex.org/I4387152244"]},{"raw_affiliation_string":"reprint requests to Anna Bagnato, Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi D'Oro 156, 00158 Rome, Italy. E-mail [email\u00a0protected]","institution_ids":["https://openalex.org/I4387152244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017244417","https://openalex.org/A5033720222","https://openalex.org/A5039788126","https://openalex.org/A5090987336"],"corresponding_institution_ids":["https://openalex.org/I4387152244"],"apc_list":null,"apc_paid":null,"fwci":0.5983,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.64768941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"44","issue":"Supplement 1","first_page":"S136","last_page":"S139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.08869999647140503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-b-receptor","display_name":"endothelin B receptor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/melanoma-progression","display_name":"melanoma progression","score":0.8069999814033508},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelin-3","display_name":"endothelin-3","score":1.0},{"id":"https://openalex.org/keywords/a-192621","display_name":"A-192621","score":0.8659999966621399},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.7749999761581421},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.8209999799728394},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.9470000267028809},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-host-interaction","display_name":"tumor-host interaction","score":0.746999979019165},{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.6819999814033508},{"id":"https://openalex.org/keywords/receptor-antagonists","display_name":"receptor antagonists","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.5481078028678894},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5101850032806396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5075253248214722},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4716227054595947},{"id":"https://openalex.org/C2909649922","wikidata":"https://www.wikidata.org/wiki/Q106318493","display_name":"Endothelins","level":4,"score":0.4594605267047882},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.450281023979187},{"id":"https://openalex.org/C2911175447","wikidata":"https://www.wikidata.org/wiki/Q18023152","display_name":"Endothelin 3","level":5,"score":0.42927655577659607},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.422385036945343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39230796694755554},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34448331594467163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21356341242790222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08872193098068237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019334","descriptor_name":"Endothelin-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044023","descriptor_name":"Receptor, Endothelin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051178","descriptor_name":"alpha Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065131","descriptor_name":"Endothelin B Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.fjc.0000166247.35992.dd","doi":"https://doi.org/10.1097/01.fjc.0000166247.35992.dd","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.fjc.0000166247.35992.dd","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:15838263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15838263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2100132196","https://openalex.org/W4242749088","https://openalex.org/W2052441869","https://openalex.org/W2005929145","https://openalex.org/W2157276028","https://openalex.org/W1980138733","https://openalex.org/W1970741424","https://openalex.org/W297339624","https://openalex.org/W2365332920","https://openalex.org/W1977621505"],"abstract_inverted_index":{"Expression":[0],"of":[1,33,39,65,71,76,119,131,144,179,196],"endothelin-B":[2,14,34,78,105,121,164,180,184],"receptor":[3,15,35,79,122,165,181,185],"gradually":[4],"increases":[5,93],"as":[6],"melanocytic":[7],"lesions":[8],"progress":[9],"to":[10,129],"melanoma,":[11],"suggesting":[12,174],"that":[13,117,175],"and":[16,20,43,48,68,95,99,110,126,139,146,149],"its":[17],"ligands,":[18],"endothelin-1":[19,125],"endothelin-":[21],"3,":[22],"play":[23],"a":[24,189],"role":[25],"in":[26,37,54,171,193],"the":[27,77,87,120,142,176,194],"melanoma":[28,56,169],"progression.":[29],"The":[30],"selective":[31],"blockade":[32],"results":[36],"inhibition":[38],"focal":[40],"adhesion":[41,151],"kinase":[42,46],"mitogen-activated":[44],"protein":[45,90,140],"phosphorylation":[47],"cell":[49,57,107],"proliferation":[50],"induced":[51],"by":[52,81,124,135,183],"endothelins":[53,62,82],"human":[55],"lines.":[58],"In":[59,112],"these":[60],"cells,":[61],"induce":[63],"downregulation":[64],"E-cadherin":[66,145,157],"expression":[67,98,143],"concomitant":[69],"upregulation":[70],"transcriptional":[72],"factor":[73],"Snail.":[74],"Activation":[75],"pathway":[80,123],"also":[83],"upregulates":[84],"N-cadherin,":[85],"phosphorylates":[86],"gap":[88],"junctional":[89],"connexin":[91],"43,":[92],"alphavbeta3":[94],"alpha2beta1":[96],"integrin":[97],"tumor":[100],"proteolytic":[101],"activity,":[102],"thus":[103],"enhancing":[104],"receptor-mediated":[106],"adhesion,":[108],"migration":[109],"invasiveness.":[111],"this":[113],"study":[114],"we":[115],"demonstrated":[116],"activation":[118],"endothelin-3":[127],"contributes":[128],"disruption":[130],"normal":[132],"host-tumor":[133],"interactions":[134],"downregulating,":[136],"at":[137],"mRNA":[138],"levels,":[141],"associated":[147],"alpha-catenin":[148],"beta-catenin":[150],"proteins,":[152],"which":[153],"are":[154],"critical":[155],"for":[156],"function.":[158],"A-192621,":[159],"an":[160],"orally":[161],"active":[162],"non-peptide":[163],"antagonist,":[166],"significantly":[167],"inhibited":[168],"growth":[170],"nude":[172],"mice,":[173],"pharmacological":[177],"interruption":[178],"signaling":[182],"antagonist":[186],"may":[187],"represent":[188],"new":[190],"therapeutic":[191],"approach":[192],"treatment":[195],"cutaneous":[197],"melanoma.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}