{"id":"https://openalex.org/W2005190322","doi":"https://doi.org/10.1152/japplphysiol.00781.2002","title":"High-impact exercise strengthens bone in osteopenic ovariectomized rats with the same outcome as Sham rats","display_name":"High-impact exercise strengthens bone in osteopenic ovariectomized rats with the same outcome as Sham rats","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2005190322","doi":"https://doi.org/10.1152/japplphysiol.00781.2002","mag":"2005190322","pmid":"https://pubmed.ncbi.nlm.nih.gov/12754179"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.00781.2002","doi":"https://doi.org/10.1152/japplphysiol.00781.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00781.2002","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Akiko Honda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98940699","display_name":"Chukyo University","ror":"https://ror.org/04ajrmg05","country_code":"JP","type":"education","lineage":["https://openalex.org/I98940699"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Honda","raw_affiliation_strings":["School of Health and Sport Sciences, Chukyo University, Toyota, Aichi 470-0393, Japan. akiko@seiken. sass.chukyo-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health and Sport Sciences, Chukyo University, Toyota, Aichi 470-0393, Japan. akiko@seiken. sass.chukyo-u.ac.jp","institution_ids":["https://openalex.org/I98940699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022436211","display_name":"Naota Sogo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naota Sogo","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111630385","display_name":"Seigo Nagasawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seigo Nagasawa","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037676863","display_name":"Takuya Shimizu","orcid":"https://orcid.org/0000-0001-8444-7894","observed_orcids":["https://orcid.org/0000-0001-8444-7894"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takuya Shimizu","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022333698","display_name":"Yoshihisa Umemura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihisa Umemura","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5657,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.93563545,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"95","issue":"3","first_page":"1032","last_page":"1037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.7570000290870667},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/estrogen-deficiency","display_name":"estrogen deficiency","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bone-mass","display_name":"bone mass","score":0.9549999833106995},{"id":"https://openalex.org/keywords/bone-strength","display_name":"bone strength","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cortical-bone-area","display_name":"cortical bone area","score":0.7310000061988831},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.953000009059906},{"id":"https://openalex.org/keywords/tibia","display_name":"tibia","score":0.6570000052452087},{"id":"https://openalex.org/keywords/femur","display_name":"femur","score":0.9850000143051147},{"id":"https://openalex.org/keywords/middle-aged-female-rats","display_name":"middle-aged female rats","score":0.7540000081062317},{"id":"https://openalex.org/keywords/bone-morphometry","display_name":"bone morphometry","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.9121333360671997},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.8490023612976074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6985228657722473},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6957921981811523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.658907413482666},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.5647462606430054},{"id":"https://openalex.org/C2777236700","wikidata":"https://www.wikidata.org/wiki/Q178366","display_name":"Tibia","level":2,"score":0.562521755695343},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.5426235198974609},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5286356210708618},{"id":"https://openalex.org/C2993253760","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone mass","level":3,"score":0.4708295166492462},{"id":"https://openalex.org/C2779897013","wikidata":"https://www.wikidata.org/wiki/Q1151752","display_name":"Jumping","level":2,"score":0.46525317430496216},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.4367717206478119},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4339807629585266},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.4221609830856323},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.24545645713806152},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.18434715270996094},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13855507969856262},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.0758097767829895}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001851","descriptor_name":"Bone Diseases, Metabolic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/japplphysiol.00781.2002","doi":"https://doi.org/10.1152/japplphysiol.00781.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00781.2002","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:12754179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12754179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W657508118","https://openalex.org/W1868877217","https://openalex.org/W1968253625","https://openalex.org/W1973502921","https://openalex.org/W1978661503","https://openalex.org/W1992685631","https://openalex.org/W1996989451","https://openalex.org/W1999458286","https://openalex.org/W2001668657","https://openalex.org/W2009129699","https://openalex.org/W2012388796","https://openalex.org/W2014492486","https://openalex.org/W2015701339","https://openalex.org/W2016216451","https://openalex.org/W2027946603","https://openalex.org/W2040782764","https://openalex.org/W2047556103","https://openalex.org/W2047562911","https://openalex.org/W2048807397","https://openalex.org/W2049186511","https://openalex.org/W2050684881","https://openalex.org/W2053232248","https://openalex.org/W2055873935","https://openalex.org/W2058857396","https://openalex.org/W2066857060","https://openalex.org/W2067523932","https://openalex.org/W2076314240","https://openalex.org/W2079869276","https://openalex.org/W2089323789","https://openalex.org/W2094502595","https://openalex.org/W2127860809","https://openalex.org/W2128258124","https://openalex.org/W2162181740","https://openalex.org/W2164151337","https://openalex.org/W2256821064","https://openalex.org/W2257928302","https://openalex.org/W2284021535","https://openalex.org/W2403769555"],"related_works":["https://openalex.org/W2581535191","https://openalex.org/W2105143733","https://openalex.org/W2582342466","https://openalex.org/W2015701339","https://openalex.org/W2970044233","https://openalex.org/W2512756712","https://openalex.org/W2032408061","https://openalex.org/W2905650416","https://openalex.org/W2356092225","https://openalex.org/W2361570488"],"abstract_inverted_index":{"The":[0,124],"effect":[1],"of":[2,60,129],"jump":[3,71,152],"exercise":[4,46,153],"on":[5,110,157],"middle-aged":[6,169],"osteopenic":[7,170],"rats":[8,14,27,91,132],"was":[9,67,85],"investigated.":[10],"Forty-two":[11],"9-mo-old":[12],"female":[13],"were":[15,28,81,92],"either":[16],"sham-operated":[17],"(Sham)":[18],"or":[19,146],"ovariectomized":[20],"(OVX).":[21],"Three":[22],"months":[23],"after":[24],"surgery,":[25],"the":[26,31,45,70,74,76,111,136],"divided":[29],"into":[30],"following":[32],"groups:":[33],"Sham":[34,36,140,176],"sedentary,":[35,39],"exercised,":[37],"OVX":[38,41,90,130],"and":[40,79,83,99,106,121,127,166],"exercised.":[42],"Rats":[43],"in":[44,103,168,175],"groups":[47],"jumped":[48],"10":[49],"times/day,":[50],"5":[51],"days/wk,":[52],"for":[53,69],"8":[54],"wk,":[55],"with":[56],"a":[57],"jumping":[58],"height":[59],"40":[61],"cm.":[62],"Less":[63],"than":[64],"1":[65],"min":[66],"required":[68],"training.":[72],"After":[73],"experiment,":[75],"right":[77],"tibia":[78],"femur":[80],"dissected,":[82],"blood":[84],"obtained":[86],"from":[87],"each":[88],"rat.":[89],"observed":[93],"to":[94,134],"have":[95],"increased":[96,116,133],"body":[97],"weights":[98],"decreased":[100],"bone":[101,118,125,160,163],"mass":[102,126],"their":[104],"tibiae":[105],"femurs.":[107],"Jump-exercised":[108],"rats,":[109,142,171],"other":[112],"hand,":[113],"had":[114],"significantly":[115],"tibial":[117],"mass,":[119,161],"strength,":[120,162],"cortical":[122],"areas.":[123],"strength":[128],"exercised":[131,141],"approximately":[135],"same":[137],"extent":[138],"as":[139,172,174],"despite":[143],"estrogen":[144],"deficiency":[145],"osteopenia.":[147],"Our":[148],"data":[149],"suggest":[150],"that":[151],"has":[154],"beneficial":[155],"effects":[156],"lower":[158],"limb":[159],"mineral":[164],"density,":[165],"morphometry":[167],"well":[173],"rats.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}