{"id":"https://openalex.org/W2005188958","doi":"https://doi.org/10.1371/journal.pone.0050630","title":"GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn\u2019s Disease Model","display_name":"GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn\u2019s Disease Model","publication_year":2012,"publication_date":"2012-11-26","ids":{"openalex":"https://openalex.org/W2005188958","doi":"https://doi.org/10.1371/journal.pone.0050630","mag":"2005188958","pmid":"https://pubmed.ncbi.nlm.nih.gov/23189208","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3506575"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0050630","doi":"https://doi.org/10.1371/journal.pone.0050630","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0050630","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050630&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050630&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039597999","display_name":"Susan E. Alters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan E. Alters","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America. salters@amunix.com","Amunix Inc., Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America. salters@amunix.com","institution_ids":["https://openalex.org/I4210131535"]},{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059354793","display_name":"Bryant McLaughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryant McLaughlin","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061800868","display_name":"Benjamin J Spink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Spink","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051837713","display_name":"Tigran Lachinyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tigran Lachinyan","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053517694","display_name":"Chia\u2010Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-wei Wang","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087393461","display_name":"Vladimir N. Podust","orcid":"https://orcid.org/0000-0002-6134-7484","observed_orcids":["https://orcid.org/0000-0002-6134-7484"]},"institutions":[{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Podust","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018783910","display_name":"Volker Schellenberger","orcid":"https://orcid.org/0000-0002-3491-8229","observed_orcids":["https://orcid.org/0000-0002-3491-8229"]},"institutions":[{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volker Schellenberger","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061394106","display_name":"Willem P.C. Stemmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Willem P. C. Stemmer","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039597999"],"corresponding_institution_ids":["https://openalex.org/I4210131535"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.6845,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.90068966,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"7","issue":"11","first_page":"e50630","last_page":"e50630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-2","display_name":"glucagon-like peptide-2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/teduglutide","display_name":"teduglutide","score":0.9100000262260437},{"id":"https://openalex.org/keywords/circulating-half-life","display_name":"serum half-life","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8970000147819519},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.8989999890327454},{"id":"https://openalex.org/keywords/indomethacin-induced-colitis","display_name":"indomethacin-induced colitis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/intestinal-growth","display_name":"intestinal growth","score":0.6240000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7450000047683716},{"id":"https://openalex.org/keywords/allometric-scaling","display_name":"allometric scaling","score":0.7409999966621399},{"id":"https://openalex.org/keywords/short-bowel-syndrome","display_name":"short bowel syndrome","score":0.6809999942779541},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9129999876022339},{"id":"https://openalex.org/keywords/recombinant-protein","display_name":"recombinant protein","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.8120449781417847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5052610039710999},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3970179855823517},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3851591944694519},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3553299903869629}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053767","descriptor_name":"Glucagon-Like Peptide 2","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D053767","descriptor_name":"Glucagon-Like Peptide 2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053767","descriptor_name":"Glucagon-Like Peptide 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0050630","doi":"https://doi.org/10.1371/journal.pone.0050630","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0050630","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050630&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3506575","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3506575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23189208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23189208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c35a68346617468b8b387601a1b942d1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c35a68346617468b8b387601a1b942d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 11, p e50630 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0050630","doi":"https://doi.org/10.1371/journal.pone.0050630","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0050630","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050630&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005188958.pdf","grobid_xml":"https://content.openalex.org/works/W2005188958.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1752824908","https://openalex.org/W1977059612","https://openalex.org/W2002149953","https://openalex.org/W2002764863","https://openalex.org/W2006360844","https://openalex.org/W2013395086","https://openalex.org/W2015811602","https://openalex.org/W2017295150","https://openalex.org/W2041556752","https://openalex.org/W2073047768","https://openalex.org/W2081576822","https://openalex.org/W2098309233","https://openalex.org/W2100093779","https://openalex.org/W2104106240","https://openalex.org/W2109406717","https://openalex.org/W2109745718","https://openalex.org/W2110584203","https://openalex.org/W2117862347","https://openalex.org/W2125311831","https://openalex.org/W2126221100","https://openalex.org/W2127068727","https://openalex.org/W2130099691","https://openalex.org/W2152026434","https://openalex.org/W2160218747","https://openalex.org/W2162105656","https://openalex.org/W2162766966","https://openalex.org/W2166360124","https://openalex.org/W2170774855","https://openalex.org/W2178262235","https://openalex.org/W2321453230","https://openalex.org/W2413398201","https://openalex.org/W2471713462","https://openalex.org/W4233800797"],"related_works":["https://openalex.org/W2791350887","https://openalex.org/W7153184943","https://openalex.org/W2884141287","https://openalex.org/W3008194890","https://openalex.org/W130675543","https://openalex.org/W4353016432","https://openalex.org/W2140551754","https://openalex.org/W2615158619","https://openalex.org/W4309656112","https://openalex.org/W4409142118"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Glucagon-like":[1],"peptide":[2,109,171],"2":[3],"(GLP2)":[4],"is":[5,228],"an":[6],"intestinal":[7,16],"growth":[8,17],"factor":[9],"that":[10,168,277],"has":[11,40],"been":[12],"shown":[13],"to":[14,47,73,110,167,212,249],"stimulate":[15],"and":[18,29,43,61,75,80,129,134,158,193,195,215,230,244,260,274],"reduce":[19],"disease":[20,176,237],"severity":[21],"in":[22,58,64,126,142,149,153,172,207,217,233,271],"preclinical":[23,59,78,272],"models":[24,60],"of":[25,69,83,89,107,118,124,161,169,182,191,200,266,287],"short":[26],"bowel":[27,31],"syndrome":[28],"inflammatory":[30],"disease.":[32,292],"Teduglutide,":[33],"a":[34,85,112,150,173,234,240,263,281],"recombinant":[35],"human":[36,264],"GLP2":[37,50],"variant":[38],"(GLP2-2G),":[39],"increased":[41,185],"half-life":[42,123,265],"stability":[44],"as":[45,210],"compared":[46,166,211],"the":[48,65,77,162,186,189,197,201,220],"native":[49],"peptide,":[51,214],"but":[52],"still":[53],"requires":[54],"twice":[55],"daily":[56,62],"dosing":[57,63,247,275],"clinic.":[66],"The":[67,121],"goal":[68],"this":[70],"study":[71],"was":[72,102,131,165],"produce":[74],"characterize":[76],"pharmacokinetic":[79],"therapeutic":[81,283],"properties":[82],"GLP2-2G-XTEN,":[84],"novel,":[86],"long-acting":[87],"form":[88],"GLP2-2G.":[90],"METHODOLOGY":[91],"AND":[92,225],"RESULTS:":[93],"A":[94],"GLP2-2G-XTEN":[95,125,146,163,183,204,221,227,278],"fusion":[96,106],"protein":[97,164],"with":[98],"extended":[99],"exposure":[100],"profile":[101],"produced":[103],"by":[104],"genetic":[105],"GLP2-2G":[108,170,213,250],"XTEN,":[111],"long,":[113],"unstructured,":[114],"non-repetitive,":[115],"hydrophilic":[116],"sequence":[117],"amino":[119],"acids.":[120],"serum":[122],"mice,":[127],"rats":[128],"monkeys":[130],"34,":[132],"38":[133],"120":[135],"hours,":[136],"respectively.":[137],"Intestinotrophic":[138],"effects":[139],"were":[140],"demonstrated":[141,205],"normal":[143],"rats,":[144],"where":[145],"administration":[147,181],"resulted":[148],"significant":[151],"increase":[152],"both":[154],"small":[155,202],"intestine":[156],"weight":[157],"length.":[159],"Efficacy":[160],"rat":[174,235,259],"Crohn's":[175,236,291],"model,":[177],"indomethacin-induced":[178],"inflammation.":[179],"Prophylactic":[180],"significantly":[184],"length,":[187],"reduced":[188,196],"number":[190],"trans-ulcerations":[192],"adhesions,":[194],"TNF\u03b1":[198],"content":[199],"intestine.":[203],"greater":[206],"vivo":[208],"potency":[209],"improvement":[216],"histopathology":[218],"supported":[219],"treatment":[222,286],"effects.":[223],"CONCLUSIONS":[224],"SIGNIFICANCE:":[226],"intestinotrophic":[229],"demonstrates":[231],"efficacy":[232],"model":[238],"requiring":[239],"lower":[241],"molar":[242],"dose":[243],"less":[245],"frequent":[246],"relative":[248],"peptide.":[251],"Allometric":[252],"scaling":[253],"based":[254],"on":[255],"pharmacokinetics":[256,273],"from":[257],"mouse,":[258],"monkey":[261],"projects":[262],"240":[267],"hours.":[268],"These":[269],"improvements":[270],"indicate":[276],"may":[279],"offer":[280],"superior":[282],"benefit":[284],"for":[285],"gastrointestinal":[288],"diseases":[289],"including":[290]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
